• Journal of Life Science
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• v.25 no.2
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• pp.223-230
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• 2015

Regulator of calcineurin 1 (RCAN1) is an endogenous calcineurin inhibitor that plays an important role in the pathogenesis of diseases related to the calcineurin-NFATc1 signaling pathway. The RCAN1-4 isoform is subject to NFATc1-dependent regulation. During receptor activator of nuclear factor kappa-B ligand (RANKL)-stimulated osteoclastogenesis, the calcineurin-NFATc1 pathway is critical. Because there is little information available on the role of RCAN1 in osteoclast differentiation, this study investigated whether changes in RCAN1 expression are related to the calcineurin-NFATc1 pathway and osteoclast differentiation. Mouse bone marrow monocytes (BMMs) were treated with 50 ng/ml of RANKL and M-CSF. Expression levels of NFATc1, calcineurin, and RCAN1 isoforms were determined using RT-PCR and Western blotting. Osteoclast differentiation was examined using tartrate-resistent acid phosphatase (TRAP) staining. To evaluate the effect of RCAN1 overexpression on osteoclastogenesis, cells were transfected with a mouse RCAN1-4 cDNA plasmid. After RANKL stimulation of BMMs, expression of NFATc1 and RCAN1 was increased at the mRNA and protein level, while calcineurin expression was unchanged. When the RCAN1-4 gene construct was transfected, the expression of RCAN1 protein was not increased despite several-fold increases in RCAN1-4 mRNA expression. Regardless of RANKL stimulation, over-expression of RCAN1-4 tended to reduce NFATc1 expression and knock-down of RCAN1 increase it. While BMMs transfected with the RCAN1-4 vector were differentiated into distinct osteoclasts, their phenotypes did not vary from those of mock controls. These results suggest that RCAN1 has a limited effect on the calcineurin-NFATc1 pathway during RANKL-stimulated osteoclast differentiation.

• Journal of muscle and joint health
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• v.7 no.2
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• pp.281-293
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• 2000

This study was conducted to identify the relationships among self-care agency, family support, qualify of life in patients with rheumatoid arthritis. The subjects were 120 rheumatoid arthritis patients who attended RA O.P.D. at a university hospital, located in Daegu city, from 10th of May in 1998 to 30th of July in 1998. Three structure questionnaires were administered for explore three main research variables; 소향숙's self-care agency scale, 강현숙's family support scale, and 김종임's quality of life scale of RA patien. Data analysis was conducted with SPSS program including percentage, mean, standard deviation, mean score, Pearson Correlation Coefficient, multiple regression, and Cronbach's Alpha. Results are summarized as follows; 1. The mean of RA patient's self-care agency was 136.62, the mean of family support 37.38, and the mean of qualify of life 134.41. 2. Subject's self-care agency was positively correlated with family support(r=.2446) and with quality of life(r=.4341). Subject's family support was positively correlated with quality of life(r=.2630). 3. Stepwise multiple regression was used to determine the predictors of subject's quality of life. Significant predictors for subject's quality of life were self-care agency(t=4.873 p=0.0000), family support(t=4.480 p=0.0000) and the severity of arthralgia(t=-3.838, p=0.0002). The number of joints involved and the periods of illness did not show significant contribution to subject's quality of life. Self-care agency, family support, and family support explained 40. 39% of the variance in RA patient's quality of life. Given this results, it is suggested that a repeated study to measure RA patient's self-care practice in their own life may be needed to develope and validate an optimum level of nursing intervention for RA patient with which family support will be encouraged and patient's self-care agency will be facilitated.

• Journal of the Korea Convergence Society
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• v.7 no.2
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• pp.43-52
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• 2016

The purpose of this study was to suggest the effective squat exercise position to strengthening vastus medialis oblique, and vastus lateralis in quadriceps. Subjects were twenty patients with patellofemoral pain syndrome (PFPS) volunteered to participate in this study. All subjects were applied to static squat convergence exercise with knee flexed $45^{\circ}$, $60^{\circ}$, and $90^{\circ}$ for 30 seconds total 5 times. Measurement variables were maximal voluntary isometric contraction (MVIC) of the quadriceps, Q angle and length of thigh. Those were measured before and after the squat exercise on knee joint angle, change rate of which were used for statistical analysis. As a result, squat exercise with knee flexed $90^{\circ}$ increase significantly among knee joint angle in the MVIC change rates of quadriceps (p<.05), however the rates of Q-angle and length change of thigh showed no significant difference. Therefore, this findings suggest that squat exercise with knee flexed $90^{\circ}$ strengthen quadriceps effectively in patients with PFPS.

• The Journal of Korean Academy of Sensory Integration
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• v.15 no.2
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• pp.22-34
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• 2017

Objective : The purpose of this study was to draw up sensory integration intervention competency model for occupational therapist and was to confirm a competency model through validation. Methods : We conducted literature review, expert opening survey, and expert focus meeting to draw up draft competency model. And then, we carried out Delphi survey twice and consulted an expert to confirm the sensory integration intervention competency model for occupational therapist. Results : The sensory integration intervention competency model for occupational therapist developed in this study was structured into 4 competency cluster, 15 competency, 60 competency indicators. 4 competency clusters had expertise, professionalism, interpersonal skills, and personal characteristics. Conclusion : The competency model revealed in this study can be used as basic critical data to foster development of competency based curriculum of Korean Academy of Sensory Integration (KASI).

• Women's Health Nursing
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• v.7 no.3
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• pp.241-255
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• 2001

This is a cross-sectional descriptive study which compares the level of postpartum women's physical, phychological, neurosensory fatigue between rooming-in and non rooming-in groups. The data were collected by using self-report questionnaire from April 1 to May 31, 2001. Subjects were 68 mothers who opted the rooming-in choice and 98 mothers who did not choose the rooming-in at one hospital in Seoul, Korea. They all had NSVD. The research questionnaire consisted of 36 items on general chracteristics and 30 items on postpartum fatigue developed by Pugh (1993). The data were analyzed by using the SPSS 10.0 window program. The results of this study were as follow: 1. There was significant statistical difference in general characteristics between rooming-in and non rooming-in groups in prenatal class attendance ($x^2$=3.935, p=0.047), maternal fetal attachment score (t=2.130, p=0.035), husband attendance during the labor and delivery ($x^2$=9.147, p=0.002), breast feeding ($x^2$=12.503, p=0.000), and self feeding time including bottle feeding (t=4.588, p=0.000). 2. There was no significant statistical difference in the level of total fatigue score between two groups (t=0.282, p=0.780). 3. The physical and neurosensory fatigue scores were slightly higher in rooming-in group ($21.63{\pm}4.92$, $18.53{\pm}4.60$) than those ($20.71{\pm}5.78$, $18.23{\pm}5.39$) of non rooming-in group. And the phychological fatigue score was slightly higher in non rooming-in group ($17.67{\pm}4.95$) than that ($17.04{\pm}4.63$) of rooming-in group. However, there was no significant statistical difference in the level of three sub-dimension fatigue between two groups (t=1.068, p=0.287; t=-0.827, p=0.410; t=0.368, p=0.714). 4. Even after controlling characteristics showed significant differences between two groups, there was no significant statistical difference in the level of fatigue between two groups (F=0.135, p=0.714). According to this study, there was no significant statistical difference in the level of postpartum fatigue whether they were rooming-in or not. Based on this result, the common notion of rooming-in mothers will be more fatigue than non rooming-in mothers is proved to be false. However, it is necessary to develop appropriate nursing interventions to meet the need of mothers who decide to rooming-in.

• Progress in Medical Physics
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• v.24 no.4
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• pp.290-294
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• 2013

Stereotactic Radiosurgery require high accuracy and precision of patient positioning and target localization. We evaluate the real time positioning accuracy of isocenter using optic guided patient positioning system, ExacTrac (BrainLab, Germany), during spinal radiosurgery procedure. The system is based on real time detect multiple body markers attached on the selected patient skin landmarks. And a custom designed patient positioning verification tool (PPVT) was used to check the patient alignment and correct the patient repositioning before radiosurgery. In this study, We investigate the selected 8 metastatic spinal tumor cases. All type of tumors commonly closed to thoracic spinal code. To evaluate the isocenter positioning, real time patient alignment and positioning monitoring was carried out for comparing the current 3-dimensional position of markers with those of an initial reference positions. For a selected patient case, we have check the isocenter positioning per every 20 millisecond for 45 seconds during spinal radiosurgery. In this study, real time average isocenter positioning translation were $0.07{\pm}0.17$ mm, $0.11{\pm}0.18$ mm, $0.13{\pm}0.26$ mm, and $0.20{\pm}0.37$ mm in the x (lateral), y (longitudinal), z (vertical) directions and mean spatial error, respectively. And body rotations were $0.14{\pm}0.07^{\circ}$, $0.11{\pm}0.07^{\circ}$, $0.03{\pm}0.04^{\circ}$ in longitudinal, lateral, table directions and mean body rotation $0.20{\pm}0.11^{\circ}$, respectively. In this study, the maximum mean deviation of real time isocenter positioning translation during spinal radiosurgery was acceptable accuracy clinically.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7648-7655
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• 2015

Nursing service quality can vary depending on the work attitude and behavior of nurses. Nursing attitude and behavior that can be described as voluntary and proactive organizational citizenship behavior(OCB). OCB affects the work performance of nurses in clinical practice is very important and organizational justice is an important influencing factors of OCB. The purpose of this study was to determine the influential factors of organizational justice on OCB of nurses. The descriptive-correlational method was applied. The study was carried out less than a 500-bed hospital. Participants of the study included 230 nurses working in secondary hospitals. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient and multiple regression with the 18.0 SPSS/Window program. Considering the components of organizational justice, there was a significant positive correlation(r=.172~.540, p=.000) between OCB and distributive, procedural and interactional justice. Also, Total organizational justice explained 29.1% of total OCB with influencing factor (${\beta}$=.540) and was statistically significant(F=93.777, p=.000). The influencing factors to OCB were distributive justice(${\beta}$=.283) and interactional justice(${\beta}$=.249) except procedural justice. The findings suggest that strategies of nursing management are needed to focus on distributive justice for compensation and interactional justice for social relationship in order to induce nurses' organizational citizenship behavior.

• Clinics in Shoulder and Elbow
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• v.17 no.2
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• pp.68-76
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• 2014

Background: Recently, reverse total shoulder arthroplasty (RTSA) has been accepted as a main treatment option in irreparable massive rotator cuff tear with cuff arthropathy. The purpose of this study was to evaluate the early complication incidence and the preliminary clinical results of RTSAs performed in single institute. Methods: Fifty-seven RTSAs (56 patients) were performed between April 2011 and March 2013. The indications for RTSA were cuff tear arthropathy and irreparable massive rotator cuff tear with or without pseudoparalysis. Exclusion criteria were revision, preoperative infections and fractures. At final follow-up, 45 shoulders were enrolled. Mean follow-up duration was 12.5 months (range, 6-27 months). The mean age at the time of surgery was 73.6 years (range, 58-87 years). All the patients were functionally accessed via Constant score, American Shoulder and Elbow Surgeons (ASES) score, pain and functional visual analogue scale (VAS) scores and active range of motion. Complications were documented as major and minor. Major complications include fractures, infections, dislocations, nerve palsies, aseptic loosening of humeral or glenoid components, or glenoid screw problems. Minor complications include radiographic scapular notching, hematomas, heterotopic ossification, algodystrophy, intraoperative dislocations, intraoperative cement extravasation, or radiographic lucent lines of the glenoid. Results: The mean Constant score increased from 31.4 to 53.8 (p < 0.001). The pain and functional VAS scores improved (5.2 to 2.7, p < 0.001, 4.0 to 6.7, p < 0.001) and active forward flexion improved from $96.9^{\circ}$ to $125.6^{\circ}$ (p = 0.011). One or more complications occurred in 16 (35.6%) of 45 shoulders, with one failure (2.2%) resulting in the removal of implants by late infection. The single most common complication was scapular notching (9 [20%]). There were 4 (8.9%) axillary nerve palsies postoperatively (n=3: transient n. palsy, n=1: Symptom existed at 11 months postoperatively but improving). Conclusions: In a sort term follow-up, RTSA provided substantial gain in overall function. Most common early complications were scapular notching and postoperative neuropathy. Although overall early complication rate was as high as reported by several authors, most of the complications can be observable without compromise to patients' clinical outcome. Long term follow-up is required to clarify the clinical result and overall complication rate.

• Radiation Oncology Journal
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• v.7 no.2
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• pp.197-203
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• 1989

Of 34 evaluated patients with primary spinal cord tumors, 32 were irradiated at our institution between 1969 and 1983. The results are reported of 32 patients, 16 with ependymoma and 16 with astrocytoma, who were treated with post-operative external beam radiotherapy following biopsy or subtotal resection Twenty-nine patients received $45\~55Gy$ megavoltage beam irradiation in $5\~6$ weeks and the remaining three patients received less than 40Gy. Spinal cord was in the irradiated field for six patients who received more than 50Gy. The minimum follow-up was five years. Five and ten year acturaial survival rates for entire group of patients were $73\%(22/30)\;and\;50\%(8/16)$, including three patients who were salvaged by surgery after radiation failures. Corresponding five and ten year relapse free survival rates were $60\%(18/30)\;and\;32\%(6/19)$, respectively. Of the 29 patients who recived more than 45Gy, relapse free survival at five years was $63\%(17/27)$. Treatment failed in 13 patients and all of those failures were in the irradiated portal. Patients with ependymomas have significantly better relapse free survival than those with astrocytomas, $80\%\;vs.\;40\%$ (p<0.05). There was significant difference in survival between patients with tumors involving the cervical spine and those with tumors in the other loactions, $45\%$ vs. $89\%(p<0.05)$. There was no significant differnece in survival between patients with cauda equina tumors and those with tumors at spinal cord, $100\%\;vs.\;68\%(p>0.05)$. No radiotherapy related neurological deficit was noted with a maximum 20 year follow-up. This study confirms that external beam radiotherapy is a safe and effective treatment modality for primary spinal cord tumors.

• Journal of Veterinary Clinics
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• v.19 no.3
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• pp.303-311
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• 2002

Isolation and identification of causative microorganisms and susceptibility testing are important in selecting appropriate antimicrobial agent. The purpose of this study was to determine the antimicrobial susceptibility patterns and identification of bacteria for the selection of a therapeutic antibiotic agent for treatment. Specimens were cultured aerobically from dog patients brought to the veterinary medical teaching hospital of Seoul National University between July 1999 and September 2000. A total of 157 isolates were from skin(63), urine(45), ear canal(31) and conjunctiva(18). The result is that the most common organisms isolated from dog patients were S. intermedius was the most common isolates from the skin, ear canal, and conjunctiva. E. coli was the most common isolated from urine. Most of gram-positive isolates were resistant to ampicillin(80.6%), erythromycin(68.8%), penicillin(86.2%), tetracycline(89.2%). Otherwise most of gam-negative isolates were resistant to ampicillin(73.4%), trimethoprim-sulfa(53.3%). E. coli was resistant to ciprofloxacin(61.5%), piperacillin (69.2%). Antimicrobial susceptibility pattern by the sampling site was not remarkably different except 5. aureus isolated from urine.