• 대한방사선협회지
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• 제25권1호
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• pp.377-388
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• 1999

• 대한관절경학회:학술대회논문집
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• 대한관절경학회 2008년도 춘계 공동 학술대회
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• pp.14-14
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• 2008

• 대한방사선기술학회지:방사선기술과학
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• 제18권1호
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• pp.77-79
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• 1995

• 대한정형외과스포츠의학회:학술대회논문집
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• 대한정형외과스포츠의학회 2004년도 The 7th korea-japan joint meeting of orthopaedic sports medicine
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• pp.56-56
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• 2004

• 대한생식의학회:학술대회논문집
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• 대한불임학회 2002년도 제43차 추계학술대회
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• pp.87.1-87.1
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• 2002

• Korean Circulation Journal
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• 제52권5호
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• pp.398-400
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• 2022

• BMB Reports
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• 제52권9호
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• pp.566-571
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• 2019

Lymphoma is one of the most curable types of cancer. However, drug resistance is the main challenge faced in lymphoma treatment. Peroxisomal acyl-CoA oxidase 1 (ACOX1) is the rate-limiting enzyme in fatty acid ${\beta}$-oxidation. Deregulation of ACOX1 has been linked to peroxisomal disorders and carcinogenesis in the liver. Currently, there is no information about the function of ACOX1 in lymphoma. In this study, we found that upregulation of ACOX1 promoted proliferation in lymphoma cells, while downregulation of ACOX1 inhibited proliferation and induced apoptosis. Additionally, overexpression of ACOX1 increased resistance to doxorubicin, while suppression of ACOX1 expression markedly potentiated doxorubicin-induced apoptosis. Interestingly, downregulation of ACOX1 promoted mitochondrial location of Bad, reduced mitochondrial membrane potential and provoked apoptosis by activating caspase-9 and caspase-3 related apoptotic pathway. Overexpression of ACOX1 alleviated doxorubicin-induced activation of caspase-9 and caspase-3 and decrease of mitochondrial membrane potential. Importantly, downregulation of ACOX1 increased p73, but not p53, expression. p73 expression was critical for apoptosis induction induced by ACOX1 downregulation. Also, overexpression of ACOX1 significantly reduced stability of p73 protein thereby reducing p73 expression. Thus, our study indicated that suppression of ACOX1 could be a novel and effective approach for treatment of lymphoma.

• Tuberculosis and Respiratory Diseases
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• 제73권2호
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• pp.107-114
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• 2012

Background: This study attempted to investigate the main causes of hemoptysis, the type of examinations used for diagnosis, the treatment modalities and outcomes. Methods: A retrospective study was conducted on the medical records of 221 patients admitted to the Chonnam National University Hospital, between January 2005 and February 2010, with hemoptysis. Results: Bronchiectasis (32.6%), active pulmonary tuberculosis (18.5%), fungus ball (10.8%), and lung cancer (5.9%) accounted for most causes of hemoptysis. Computed tomography scan was the most sensitive diagnostic test when employed alone, with positive yield of 93.2%. There were 161 cases of conservative treatment (72.9%), 42 cases of bronchial artery embolization (BAE) (19.0%), and 18 cases of surgery (8.1%). Regarding the amount of hemoptysis, 70 cases, out of 221 cases, were mild (31.5%), 36 cases moderate (16.2%), and 115 cases massive hemoptysis (52.0%). Most of the patients were treated conservatively, but if there was more bleeding present, BAE or surgery was more commonly performed than the conservative treatment ($p{\leq}0.0001$). In the multivariate model, severe hemoptysis and lung cancer were independently associated with short-term recurrence. BAE was independently associated with long-term recurrence, and lung cancer was associated with in-hospital mortality. The overall in-hospital mortality rate was 11.3%. Conclusion: Hemoptysis is a common symptom with a good prognosis in most cases. However, patients exhibiting massive bleeding or those with malignancy had a poorer prognosis. In-hospital mortality was strongly related to the cause, especially in lung cancer.

• 동서간호학연구지
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• 제9권1호
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• pp.74-82
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• 2004

Purpose: This study has been conducted as a quality improvement activity in order to confirm the assessment of patients, their guardians and nurses by providing them with a Life in Hospital Guide. Method: Nursing with Life in Hospital Guide provision was conducted at an University Hospital with patients admitted within 5 days or less and their guardians, a control group of 375 persons and a comparison group of 372 persons, and the data have been collected from the 26th of May to the 10th of October 2003. A Life in Hospital Guide, in the form of a leaflet, that contained useful information such as meals, facilities, car parking, documents, linen products etc, was used. The collected data have been analysed using SPSS windows programme 11.0 for percentage, $X^2$-test, and t-test. Result: The comparison group who were provided with a Life in Hospital Guide will know better about the articulars needed to live in hospital than the control group who were not,' the average of the comparison group (4.04) was higher than the control group (3.04), which is a significant difference (t=-27.06, p=.000). Conclusion: As a results of this study, it was confirmed that life in hospital guidance through a leaflet each as a quality improvement activity, are effective.

• Journal of Korean Neurosurgical Society
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• 제59권4호
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• pp.414-419
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• 2016

A 35 years old woman presented with an acute meningeal syndrome following an intra ventricular haemorrhage without subarachnoid haemorrhage. The angiography demonstrated a 6 mm partially thrombosed saccular aneurysm at the plexal point of the right anterior choroidal artery (AChoA). It was surgically approached inside the ventricle through a trans-temporal corticotomy. The aneurysm was excised after distal exclusion of the feeding artery under motor-evoked potentials monitoring. Of the 19 cases of distal AChoA aneurysm neurosurgical treatment, this is the only one performed under electrophysiology monitoring, a simple and safe method to detect and prevent motor tract ischemia. We discuss this rare case, along with a comprehensible review of the literature of the previous surgical cases of distal AChoA aneurysms.