• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.3
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• pp.149-174
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• 2020

Objectives: This study was aimed to figure out the effect of Onkyung-tang (OKT) on cold hypersensitivity on feet in female patients. Methods: This study was designed to implement multi-center randomized clinical trial in three korean medical hospitals. The female patients who were enrolled in this study were 112 women who suffered from cold hypersensitivity on feet. They were randomly allocated into OKT group or control group in 1:1 ratio. The primary outcome was change in score of visual analogue scale of hypersensitivity on feet, and the secondary outcomes were thermometer of LU4, PC8, ST32, LR3, visual analogue scale of hypersensitivity on hands, result of cold stress test, and score of World Health Organization Quality of Life-BREF. Results: In both group, the VAS of hypersensitivity on feet and hands was decreased while taking the medicine, and the effect of decreasing the VAS continues for the 4 weeks after the end of medication (p<0.001, 0.003, 0.001). In OKT group, the body temperature difference in lower extremity (ST32-LR3) was steadily decreased at every visit and it was statistically significant(p=0.003, <0.001). On the other hand, in control group, the body temperature difference in lower extremity was decreased only while taking the medicine (p<0.001). Conclusions: OKT significantly reduced discomfort coldness on feet in patients, and the effect of treatment was maintained at least for four weeks after medication.

• The Journal of Korean Medicine
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• v.41 no.2
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• pp.96-106
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• 2020

Objectives: The purpose of this study was to research the demographical and gynecologic characteristics, quality of life, and analyze the pattern identification in female patients with cold hypersensitivity of hands and feet. Methods: 112 participants were recruited from May 2018 to April 2019 from three korean medical hospitals. The data was composed of general characteristics, degree of coldness of hands and feet, gynecological questionnaire, score of WHOQOL-BREF and pattern identification. We divided data into 2 groups: The group of patients who meet the criteria for diagnosis of coldness on feet and the group of patients who meet the criteria for diagnosis of coldness on feet and hands. We tried to compare data by groups using Excel 2016 for windows and SPSS for windows (Ver. 23.0). Results: Throughout the study, we found differences between 2 groups in weight, body mass index (BMI), VAS score of cold hypersensitivity on feet, temperature of PC8, ST32, and pattern identification. Conclusions: After the study, we confirmed that even though both groups suffer from cold hypersensitivity of hands and feet, they show clinical differences in each group and differences in pattern identification.

• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.3
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• pp.190-200
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• 2016

The aim of this study was to suggest the standard process in developing Questionnaire of Pattern Identification (QPI). The process in developing QPI was researched from validated and developed questionnaire and the standard process in developing QPI was suggested through review of the experts in research, statistics and clinics. Check list was also provided. The number of QPI reviewed in this research was 17(4 in disease in Korea Medicine, 5 in Pathological symptoms, 6 in Sasang constitutional Diagnosis, and 2 in etc), The standard process in developing QPI consisted of 11 phage and 33 check lists. 1) Composition of Research Member(3check lists), 2)Set up of the Aim(5), 3) Review for advanced research(3), 4) Finding an Important Index(3), 5) Review of item selection(4), 6) Developing the questions using items(5), 7) Developing Draft of Questionnaire(2), 8) 1^st Survey of Reliability and Validity(2), 9) Revision and Correction of Item(1), 10) 2^st Survey of Reliability and Validity(2), 11) Completion and Application(3). This study suggests the standard process in developing QPI for the first time in Korea. This following step may help A new QPI development.

• The Journal of Pediatrics of Korean Medicine
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• v.14 no.1
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• pp.127-136
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• 2000

The frequency of weak children, derived from constitutional and functional factors, has increased recently, but their symptoms have never been observed and analysed. A survey was conducted to evaluate and understand the characteristics of weak children. 311 children who had visited in the weak child clinic of Kyunghee Oriental Medical Hospital from January, 1999 to August, 1999, were the respondents of the Weak Child Questionnaire. They were divided into 4 groups by age and birth weight, and statistical significances were tested by one way analysis of variances and bivariate correlation analysis among groups. The results obtained were as follows: 1. Distribution of sex : male 191 cases, female 120 cases 2. The distribution of age showed the highest in $2{\sim}6$ years(45.3%), followed by $7{\sim}12$ years(31.8%), $0{\sim}1$ years(18.0%), over 13 years(4.8%) in order. There was a statistical difference of all symptoms' mean, except respiratory symptoms, among groups(p<0.01). 3. The distribution of birth weight showed the highest in $2.5{\sim}3.3kg(43.4%)$, followed by $3.3{\sim}4.1kg(39.5%)$, under 2.5kg(5.1%), over 4.lkg(2.1%) in order. There was a statistical difference of digestive symptoms' and total score mean among groups(p<0.01, p<0.05 respectively). 4. The correlation coefficient between general symptoms' mean and other symptoms´ is the highest(p<0.01). From the above results, it was suggested that general symptoms are representative of weak children's characteristics.

• Journal of Pharmacopuncture
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• v.17 no.3
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• pp.70-73
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• 2014

Sexual dysfunction (SD) is a health problem which occurs during any phase of the sexual response cycle that keeps the individual or couple from experiencing satisfaction from the sexual activity. SD covers a wide variety of symptoms like in men, erectile dysfunction and premature or delayed ejaculation, in women, spasms of the vagina and pain with sexual intercourse, in both sexes, sexual desire and response. And pharmacopuncture, i.e. injection of subclinical doses of drugs, mostly herb medicine, in acupoints, has been adopted with successful results. This case report showed the effect of bee venom on SD. A 51-year-old male patient with SD, who had a past history of taking Western medication to treat his SD and who had previously undergone surgery on his lower back due to a herniated disc, received treatments using pharmacopuncture of sweet bee venom (SBV) at Gwanwon (CV4), Hoeeum (CV1), Sinsu (BL23), and Gihaesu (BL24) for 20 days. Objectively, the patient showed improvement on most items on the International Index for Erectile Dysfunction (IIEF) like 28 to 29 out of perfect score 30 for erectile function, 10 to 10 out of perfect score 10 for orgasmic function, 6 to 8 out of perfect score 10 for sexual desire, 10 to 13 out of perfect score 15 for satisfaction with intercourse, and 6 to 8 out of perfect score 10 for overall satisfaction; subjectively, his words, the tone of his voice and the look of confidence in his eyes all indicated improvement. Among the variety of effects of SBV pharmacopuncture, urogenital problems such as SD may be health problems that pharmacopuncture can treat effectively.

• Herbal Formula Science
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• v.8 no.1
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• pp.213-224
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• 2000

Objectives: We intented to find out the effect of Gami-Eumcheonyijintang to patients who complain with coughing and to make it useful for treating the patients with the symptom. Materials and Methods: We examined the medical of 33 patients who visited with the symptoms of coughing, sputum in Kyungsan University, Hospital of Oriental Medicine from April, 1996 to February, 1999. and we collected the result of the administration with Gami-Eumcheonyijintong. We aimed to find any change in the symptoms, reappearance after recovery, and any special facts with the medicine surveying by telephoning to the patients. Results : the results are as follows, 1. It showed that patients who were under thirties showed higher rate of recovery(75.00%) than who were over thirties(52.94% ). 2, The acute-stage patients who were recovered in less than four weeks showed higher rate of recovery than those chronic-stage patients who were recovered in more than eight weeks. 3. The patients who didn't have the symptoms of sputum or had less serious problems of it with severe coughing showed relatively the highest rate of recovery(73.91% ). 4. The patients who showed the coughing symptom right after URI without any past constitutional history showed the highest rate of recovery(73.68% ). Conclusion : From the above result, we found that Gami-Eumcheonyijintang is more effective in early coughing symptom after URI than chronic stage coughing symptom. It is thought that more studies about medicine composition are needed in the further.

• Journal of Oriental Neuropsychiatry
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• v.22 no.3
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• pp.13-22
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• 2011

Objectives : This study was to research the relationship between Hwa-Byung and Framingham coronary risk score(FRS), cardiovascular disease. Methods : 649 people participated in the community based cohort study in Wonju City of South Korea from July 2nd to August 30th in 2006. Educated investigators checked up systolic & diastolic blood pressure and surveyed Hwa-Byung Diagnostic Interview Schedule(HBDIS), cohort questionnaire about gender, age, smoking, diabetes. Blood sample was collected from participants to analyze total cholesterol, HDL-cholesterol. FRS was calculated from collected data. 10-year prediction of coronary heart disease was determined from FRS by using score sheet that is estimated by Wilson et al. Collected data were analyzed by the chi-square test. Results : 1. Low risk number of people was 18(52.9%) in Hwa-Byung group, 263(42.8%) in non Hwa-Byung group. p-value was 0.472. Difference of the two group was invalid. 2. The number of people below or equal to average 10-year prediction of coronary heart disease as gnder & age, Hwa-Byung group was 19(55.9%), non Hwa-Byung group was 412(67.0%). p-value was 0.251. Difference of the two group was invalid. Conclusions : There was no correlationship Between Hwa-Byung and 10-year prediction of coronary heart disease.

• Journal of Acupuncture Research
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• v.35 no.2
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• pp.88-94
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• 2018

Background: Length of hospitalization for patients with lower back pain sustained in road traffic accidents was assessed clinically. Methods: In total, 170 patients with lower back pain injury sustained in road traffic accidents, were included in the study. They were divided into 2 groups: Group A with a shorter hospitalization period (1-7 days) and Group B with a longer hospitalization period (8-14 days). Each group was treated daily with traditional Korean medicine including: acupuncture, herbal acupuncture, herbal decoction medicine, and chuna treatment. To compare the treatment effects between the 2 groups, health-related quality of life, Oswestry disability index, and numeric rating scale were used. Statistical analysis between the 2 groups was assessed using Chi-square test, independent t test, and paired t test. Results: After hospitalization, Group A and Group B both showed a significant increase in their health-related quality of life scores and significant decreases in Oswestry disability index and numeric rating scale scores. In addition, Group B, with a longer hospitalization period than Group A, showed a significant improvement over Group A in its health-related quality of life and numeric rating scale scores. Conclusion: This study suggests that control of pain caused by lower back injury sustained in a road traffic accident, may be more effectively achieved in patients receiving 8-14 days of hospitalization and traditional Korean medicine treatment, compared to those receiving < 7 days of hospitalization treatment. In the future, more systematic and large-scale studies are needed to ascertain the effects of other variables.

• Journal of Sasang Constitutional Medicine
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• v.9 no.2
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• pp.245-261
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• 1997

The investigation were carried out the 37 patient with cerebrovascular accidents who had been treated in Oriental Medical Hospital in Kyung Hee University and in KangNam Uy Lim, and the 10 examinees who had been worked in Medical Hospital in Kyung Hee University. The consitution which had discriminated by survey, which had discriminated by study on the morphological diagrammings, which had discriminated by the result of the impatient of hospital on a dosage of constitutial prescription. The Prostaglandin E2 in blood for 47 persons (37 patients & 10 examinees) was measured. The following results were obtained. 1.In the constitution which had discriminated by survey, in the value of Prostaglandin E2 in bood of ammong four constitutiens didn,t showed significant differance. 2.In the constitution which had discriminated by study on the morphological diagrammings, in the value of Prostaglandin E2 in bood of ammong four constitutiens didn,t showed significant differance. 3.In the constitution which had discriminated by the result of patient of hospital on a dosage of constitutial prescription, the value of Prostaglandin E2 in blood of among four constitutions didn,nt showed signicant differance. 4.In the constitution which had discriminated by colligated three methods(survey, morphological diagrammings,the result of patient of hospital on a dosage of constitutial prescription), the value of Prostaglandin E2 in blood of ammong four constituion didn,t showed significant differnce. 5.In the constitution which had discriminated by survey, a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others was conducted. Only the value of Prostaglandin E2 in blood between in the TAE-EUM-IN(太陰人) and the others of female showed significant differance. 6.In the constitution which had discriminated by study on the morphological diagrammings,a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others was conducted. Only the value of Prostaglandin E2 in blood between in the SO-EUM-IN(少陰人) and the others of male showed significant differance. 7.In the constitution whichhad discriminated by the result of patient of hospital on a dosage of constitutial prescription,a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others was conducted. Only the value of Prostaglandin E2 in blood between in the TAE-EUM-IN(太陰人) and the others of male showed significant differance. 8.In the constitution which had discriminated was the colligated three methods(survey,morphological diagrammings,the result of patient of hospital on a dosage of constitutial prescription),a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others didn,t showed significant differnce. In this connected study is inadequete at present. But if the study is done persistently,the analysis of various ingredient in the body enables objectification in differentiation of four types of physical constitution as the supplemental method.

• Journal of Sasang Constitutional Medicine
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• v.12 no.1
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• pp.186-200
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• 2000

The purpose of this research was to investigate the effects of Indongdeungjikolpitang water extract(IJTE) on the complication of diabetes. IJTE did not affect the level of blood glucose in alloxan- or streptozotocin-induced hyperglycemic mice, but inhibited the motility of gastrointestine. IJTE inhibited the writhing syndrome induced by acetic acid, the permeability of evans blue into peritoneal cavity induced by acetic acid, the paw edema induced by histamine, and the formation of cotton pellet granuloma. IJTE increased the cell viability of thymocytes and splenocytes. IJTE decreased the release of ${\gamma}-interferone$(${\gamma}-IFN$) and interleukin-2(IL-2), but did not affect the release of interleukin-4(IL-4) from murine thymocytes. IJTE increased the release of IL-4 and decreased the release of tumor necrosis $factor-{\alpha}$($TNF-{\alpha}$) and $interleukin-1{\beta}$($IL-1{\beta}$), but did not affect of ${\gamma}-IFN$ and IL-2 from murine splenocytes. IJTE decreased the release of $TNF-{\alpha}$ and $IL-1{\beta}$ from murine peritoneal macrophages. IJTE decreased the production of niric oxide(NO) from murine peritioneal macrophages and increased the phagocytic activity of murine peritoneal macrophages. These results suggest that IJTE has an anti-inflammatory action via the inhibition of $TNF-{\alpha}$, $IL-1{\beta}$ and NO production from immune cells.