• 한국정보전자통신기술학회논문지
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• 제9권3호
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• pp.266-272
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• 2016

본 연구에서는 국제특허분류(IPC) 코드를 활용하여 사물인터넷 특허 163건의 기술 융복합을 분석하였다. 분석 결과, IPC 코드의 대표적인 주분류-부분류 조합은 G06Q 50/24-G06Q 50/22(6건), H04L 29/02-H04L 12/28(4건), G06F 15/16-G06F 3/048(3건), G06F 15/16-G06F 9/44(3건), G06Q 50/22-G06Q 50/24(3건)이다. 또한 사물인터넷 특허 중 '건강관리(G06Q 50/22)'와 '환자기록 관리(G06Q 50/24)'의 기술 융복합에 의해 '헬스 케어' 사업 분야의 특허 출원이 9건으로 가장 많았다. 사물인터넷 특허의 상호 연결망 분석에 의해 사물인터넷 특허의 핵심 IPC 코드는 G06F 15/16, G06Q 50/22, G06Q 50/24, H04L 12/28임을 확인하였다.

• Clinical and Experimental Pediatrics
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• 제54권6호
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• pp.267-271
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• 2011

Distal duplication, or trisomy 15q, is an extremely rare chromosomal disorder characterized by prenatal and postnatal overgrowth, mental retardation, and craniofacial malformations. Additional abnormalities typically include an unusually short neck, malformations of the fingers and toes, scoliosis and skeletal malformations, genital abnormalities, particularly in affected males, and, in some cases, cardiac defects. The range and severity of symptoms and physical findings may vary from case to case, depending upon the length and location of the duplicated portion of chromosome 15q. Most reported cases of duplication of the long arm of chromosome 15 frequently have more than one segmental imbalance resulting from unbalanced translocations involving chromosome 15 and deletions in another chromosome, as well as other structural chromosomal abnormalities. We report a female newborn with a de novo duplication, 15q24- q26.3, showing intrauterine overgrowth, a narrow asymmetric face with down-slanting palpebral fissures, a large, prominent nose, and micrognathia, arachnodactyly, camptodactyly, congenital heart disease, hydronephrosis, and hydroureter. Chromosomal analysis showed a 46,XX,inv(9)(p12q13),dup(15)(q24q26.3). Array comparative genomic hybridization analysis revealed a gain of 42 clones on 15q24-q26.3. This case represents the only reported patient with a de novo 15q24-q26.3 duplication that did not result from an unbalanced translocation and did not have a concomitant monosomic component in Korea.

• Genomics & Informatics
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• 제1권2호
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• pp.101-107
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• 2003

Loss of heterozygosity (LOH) has been used to detect deleted regions of a specific chromosome in cancer cells. LOH on chromosome 16q has been reported to occur frequently in progressed hepatocellular carcinoma (HCC). Liver tissues from 37 Korean HCC patients were analyzed for LOH by using 25 polymorphic microsatellite markers distributed along 16q. Out of the 37 HCC patients studied, 21 patients (56.8%) showed LOH in various regions of 16q with at least one polymorphic marker. Puring the analysis of these 21 LOH cases, 6 patients showed interstitial LOHs in which the boundary of the LOH region was defined. With two rounds of LOH analysis, five commonly occurring interstitial LOH regions were identified; 16q21-22.1, 16q22.2 - 22.3, 16q22.3, 16q23.2 and 16q23.3 - 24.1. Among the five LOH regions the 16q23.3 - 24.1 region has been reported to be related with chromosome instability. A complete physical map, which covers the 3.2 Mb region of 16q23.3 - 24.1 (D16S402 and D16S486), was constructed to identify novel candidate tumor suppressor genes. We provide the minimally tiling path map consisting of 28 BAC clones. There was one gap between NT_10422.11 and NT_019609.9 of the human genome sequence contig (NCBI sequence build 33, April 29, 2003). This gap can be filled by sequencing the R-1425M20 clone which bridges these sequence contigs.

• Journal of applied mathematics & informatics
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• 제24권1_2호
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• pp.421-426
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• 2007

The problem of vertex labeling with a condition at distance two in a graph, is a variation of Hale's channel assignment problem, which was first explored by Griggs and Yeh. For positive integer $p{\geq}q$, the ${\lambda}_{p,q}$-number of graph G, denoted ${\lambda}(G;p,q)$, is the smallest span among all integer labellings of V(G) such that vertices at distance two receive labels which differ by at least q and adjacent vertices receive labels which differ by at least p. Van den Heuvel and McGuinness have proved that ${\lambda}(G;p,q){\leq}(4q-2){\Delta}+10p+38q-24$ for any planar graph G with maximum degree ${\Delta}$. In this paper, we studied the upper bound of ${\lambda}_{p,q}$-number of some planar graphs. It is proved that ${\lambda}(G;p,q){\leq}(2q-1){\Delta}+2(2p-1)$ if G is an outerplanar graph and ${\lambda}(G;p,q){\leq}(2q-1){\Delta}+6p-4q-1$ if G is a Halin graph.

• 성인간호학회지
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• 제24권6호
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• pp.647-658
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• 2012

Purpose: This study was to analyzed the types of subjectivity that elderly who live alone caregivers have about the lonely death. Methods: This study objectified the subjective area by applying the Q methodology. It studied 24 caregivers in H region, who responded to 34 Q sample statements. The method of forced distribution was practiced regarding the results on a 9 points Q sample distribution chart. The collected data was analyzed using PC QUANL program. Results: The caregivers' perception of lonely death has been classified into four types: Type 1 ('type of fate-receptive invitation of lonely death'), Type 2 ('type of afterlife-expectantly invitation of lonely death'), Type 3 ('type of death preparation invitation of lonely death'), and type 4 ('type of rejection of lonely death due to attachment with life'). Conclusion: The present study attempts to provide basic resources for the development of nursing-intervention program to solve the problems with lonely death by grasping and understanding the types of the caregivers' perception of lonely death through which it also aims to yield information necessary to improve the quality of life in their remaining years.

• 한국식품과학회지
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• 제27권5호
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• pp.748-752
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• 1995

현재 국내에서 유통되고 있는 캔 및 병 오렌지쥬스를 20, 30, 40, $50^{\circ}C$에서 24주 동안 저장하면서 4주 간격으로 개봉하여 중금속(Sn, Fe, Pb) 함량, 비타민 C 함량, 갈색도와 pH의 변화에 대한 측정치로부터 온도별 활성화 에너지와 $Q_{10}$값을 계산한 다음 shelf-life를 예측하였다. 캔쥬스의 품질지표로 삼을 수 있는 것은 Pb, Sn, Fe 함량, 비타민 C 함량이었고, 병쥬스에서는 비타민 C 함량, 갈색도이었으며 이들 품질지표에 대한 $Q_{10}$값은 $1.3{\sim}2.0$이었다. 쥬스를 $50^{\circ}C$에 저장시 품질 허용한계에 도달하는데 요하는 기간과 $Q_{10}$ 대푯값으로 부터 shelf-life를 계산하면 캔쥬스의 경우 10, 20, $30^{\circ}C$에서 각각 10, 6, 3개월이었고, 병쥬스의 경우 각각 24, 12, 6개월이었다. 국내에서의 쥬스 유통온도를 평균 $15^{\circ}C$로 가정할 때 적정 품질수명은 캔쥬스 8개월, 병쥬스 18개월로 평가되었다. 캔 오렌지쥬스의 안전성을 확보하기 위해서는 식품공전상의 권장 유통기한(캔쥬스 24개월, 병쥬스 12개월) 및 Pb 허용기준(0.3 mg/kg)의 재검토와 아울러 캔 재질의 개선을 위한 연구노력이 요구된다.

• 지구물리
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• 제3권3호
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• pp.193-200
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• 2000

지진파가 전달되면 진폭이 감쇠되는 정도를 나타내는 감쇠상수 $Q^{-1}$는 지구내부 물질의 물리적 성질을 나타내는 중요한 척도이며, 구조물의 내진설계에 있어서 지반의 강진동을 정량적으로 예측하기 위해 필수적이다. 경상북도 덕정리에 위치한 지진관측기기에 기록된 80지진과 76단일 관측망 기록자료를 바탕으로 한국남동부의 P, S 실체파 감쇠상수를 Coda확장규격화법에 의해 구하였다. 구하여진 $Q_P^{-1}$및 $Q_S^{-1}$는 각각 1.5Hz에서 $1{\times}10^{-2}$ 와 $9{\times}10^{-3}$, 24 Hz에서 $6{\times}10^{-4}$ 와 $5{\times}10^{-4}$로 줄어들고, $Q_P^{-1}=0.01\;f^{-1.07}$ 및 $Q_S^{-1}=0.01\;f^{-1.03}$의 강한 주파수 의존성을 보였다.

• Journal of Plant Biotechnology
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• 제39권3호
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• pp.169-174
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• 2012

Quantitative trait loci (QTLs), which were related to the ability of callus induction and plant regeneration in seed culture of rice, were analyzed using a mapping population from a cross between the rice cultivars 'Samgang' (tongil type) and 'Nagdong' (japonica). A tongil type rice cultivar, 'Samgang' showed lower frequency (20%) of plant regeneration than that (35%) of japonica rice, 'Nagdong'. Transgressive segregations were observed for the ability of callus induction and plant regeneration from the seed-derived calli of 58 doubled haploid (DH) lines. The ability of plant regeneration of 58 doubled haploid lines showed a continuous distribution with comparatively wide range (10.0 to 66.7%) of variation. Composite interval mapping analysis was used to identify the QTLs controlling callus induction and plant regeneration ability. Four significant QTLs, qCWS6, qCWS8, qCWS9 and qCWS11, associated with callus weight per seed were detected on chromosomes 6, 8, 9, and 11 with LOD values of 3.30, 2.60, 2.70 and 2.43, explaining 36% of the total phenotypic variation. Three significant QTLs, qPR1, qPR6, and qPR11, for the ability of plant regeneration were located on chromosome 1, 6, and 11 at LOD score of 2.25, 2.15 and 2.55, accounting for 24 % of the total phenotypic variation. The present study should be useful for improving the efficiency of plant regeneration in tissue culture of indica rice by means of marker-assisted selection.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권3호
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• pp.245-253
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• 2000

The development and progression of oral cancer is associated with an accumulation of multiple genetic alterations through the multistep processes. Comparative genomic hybridization(CGH), newly developed cytogenetic and molecular biologic technique, has been widely accepted as a useful method to allow the detection of genetic imbalance in solid tumors and the screening for chromosome sites frequently affected by gains or losses in DNA copy number. The authors examined 19 primary oral squamous cell carcinomas using CGH to identify altered chromosome regions that might contain novel oncogenes and tumor suppressor genes. Interrelationship between these genetic aberrations detected and major oncogenes and tumor suppressor genes previously recognized in carcinogenesis of oral cancers was studied. 1. Changes in DNA copy number were detected in 14 of 19 oral cancers (78.9%, mean: 5.58, range: $3{\sim}13$). High level amplification was present in 4 cases at 9p23, $12p21.1{\sim}q13.1$, 3q and $8q24{\sim}24.3$. Fourteen cases(78.9%, mean: 3.00, range: $1{\sim}8$) showed gains of DNA copy number and 12 cases(70.5%, mean: 2.58, range: $1{\sim}9$) revealed losses of DNA copy number. 2. The most common gains were detected on 3q(52.6%), 5p(21.0%), 8q(21.0%), 9p(21.0%), and 11q(21.0%). The losses of DNA copy number were frequently occurred at 9p(36.8%), 17q(36.8%), 13q(26.3%), 4p(21.0%) and 9p(21.0%). 3. The minimal common regions of gains were repeatedly observed at $3q24{\sim}26.7$, $3q27{\sim}29$, $1q22{\sim}31$, $5p12{\sim}13.3$, $8q23{\sim}24$, and 11q13.1-13.3. The minimal common regions of losses were detected at $9q11{\sim}21.3$, 17p31, $13q22{\sim}34$, and 14p16. 4. In comparison of CGH results with tumor stages, the lower stage group showed more frequent gain at 3q, 5q, 9p, and 14q, whereas gains at 1q($1q22{\sim}31$) and 11q($11q13.1{\sim}13.3$) were mainly detected in higher stage group. The loss at $13q22{\sim}34$ was exclusively detected in higher stage. The results indicate that the most frequent genetic alterations in the development of oral cancers were gains at $3q24{\sim}26.3$, $1q22{\sim}31$, and $5p12{\sim}13.3$ and losses at $9q11{\sim}21.3$, 17p31, and 13q. It is suggested that genetic alterations manifested as gains at $3q24{\sim}26.3$, $3q27{\sim}29$, $5p12{\sim}13.3$ and 5p are associated with the early progression of oral cancer. Gains at $1q22{\sim}31$ and $11q13.1{\sim}13.3$ and loss at 13q22-34 could be involved in the late progression of oral cancers.

• Journal of Forest and Environmental Science
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• 제35권4호
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• pp.232-239
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• 2019

This study was carried out to establish an efficient selection condition for cold-tolerant individuals among evergreen Quercus spp. To select higher cold-tolerant individuals among four species of evergreen Quercus spp. (Q. acuta, Q. glauca, Q. myrsinaefoila, and Q. salicina), an-year-old seedlings of each species were exposed to low temperature in serial, and then examined for the death of cell tissue and the surface temperature was monitored. It was shown that the higher numbers of seedlings of Q. myrsinaefolia were survived than the others when those seedlings are exposed to cold stress. Thus, selection of the cold tolerant individuals was conducted on Q. myrsinaefolia seedlings. The limit low temperature condition for selecting cold-tolerant individuals was -6℃ for 24 hrs because no seedling of Q. myrsinaefolia was survived after exposed to -7℃ for 24 hours. It was shown that the leaf surface temperature of the selected individuals was higher than those of the non-selected individuals when they were exposed to cold-stress while monitoring them using thermal graphic camera. The results in this study can be used for expanding afforestation area of tree species of the warm temperate zone for preparation of climate change.