• The Journal of the Acoustical Society of Korea
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• v.37 no.6
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• pp.451-456
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• 2018

UAComm (Underwater Acoustic Communication) is an active research area, and many experiment has been performed to develop UAComm system. In this paper, we investigate the possibility of modifying and applying VirTEX (Virtual Time series EXperiment) to medium long range MIMO (Multiple-Input Multiple-Output) UAComm of about 20 km range for the analysis and performance prediction of UAComm system. Since VirTEX is a time-domain simulator, the generated time series can be used in HILS (Hardware In the Loop Simulation) to develop UAComm system. The developed package is verified through comparing with the sea-going FAF05 (Focused Acoustic Field 2005) experimental data. The developed simulator can be used to predict the performance of UAComm system, and even replace the expensive sea-going experiment.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.4
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• pp.105-117
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• 2015

In this paper, we consider 19 cells with the two tiers for polar-rectangular coordinates (PRCs) and provide the cell edge performance of cellular networks based on distance from cell center i.e., BS (base station). When FFR is applied(or adopted) to cell edge, it is expected that BS cooperation, or a coordinated multipoint (CoMP) multiple access strategy will further improve the system performance. We proposed a new method to evaluate the sum rate capacity of the MIMO DC of multicell system. We improve the performance of cell edge users for intercell interference cancelation in cooperative downlink multicell systems. Simulation results show that the proposed scheme outperforms the reference schemes, in terms of cell edge SINR (signal-to-interference-noise ratio) with a minimal impact on the network path loss exponent. We show 13 dB improvements in cell-edge SINR by using reuse of three relative to reuse of one. BS cooperation has been proposed to mitigate the cell edge effect.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.6B
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• pp.1024-1031
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• 1999

In order to transmit high-speed wide band signals efficiently in multipath fading environments, M-ary QAM signalling combined with OFDM transmission technique is applied. In this paper, the effect of synchronization error caused by carrier frequency offset and SER(Symbol Error Rate) performance of OFDM-16QAM and OFDM-64QAM are theoretically analyzed. Our result shows that as the number of sub-carrier in OFDM system increases the frequency-offset caused inter-channel interference(ICI) increases significantly, and that an error floor occurs even at high SNR of OFDM system. For OFDM-64QAM, the error floor occurs at SER=1$\times$10-7 when a normalized frequency-offset is 0.001, in which the SNR degradation is much greater than that of OFDM-16QAM. From this study the maximum allowable frequency-offset of OFDM-16QAM and OFDM-64QAM systems can be determined to meet the specific SER requirement.

• Korean Journal of Acupuncture
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• v.23 no.3
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• pp.73-80
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• 2006

목 적 : 씨클로포스파미드(Cyclophosphamide, CP)는 많은 종양 질환에서 단독 혹은 다른 화학요법과 함께 사용되는 항암제이다. CP의 독성과 부작용으로 출혈성 방광염이 많은 문제를 일으키고 있다. CP로 유도된 방광염 모델은 하부요로의 통증질환을 이해하기 위한 내장성 통증의 주요한 모델로 사용되고 있다. 본 연구는 암컷 백서에서 CP로 유도된 방광의 과활동성에 대한 침의 효과를 관찰하기 위해 요류역학검사를 수행하였다. 방 법 : CP (200 mg/kg) 투여 18시간 후에, 지속적 생리식염수 관류 (분당 0.04 ml) 로 방광내압 측정을 통해 방광기능을 평가하였다. 관류 2시간 이후부터, 위중/곤륜 100 Hz, 위중/곤륜 2 Hz, 족삼리/삼음교 100 Hz, 족삼리/삼음교 2Hz 전침 자극을 하여 자침 전후의 방광수축간격(intercontraction interval, ICI)을 비교하였다. 결 과 : 방광내압 측정하는 동안, 방광수축간격은 CP로 유도된 방광염 모델에서 정상군에서 보다 유의하게 짧았다. CP로 유도된 방광염 모델에서, 위중/곤륜 100Hz 전침 자극은 자침 전보다 통계적으로 유의하게 $40.6\;{\pm}\;10.9\;%$ 증가시켰고, 2Hz 전침 자극은 자침 전보다 현저하게 $22.1\;{\pm}\;13.7\;%$ 증가시켰다. 반면에, 족삼리/삼음교 전침 자극은 100Hz, 강 2Hz 전침 자극 각각 $13.7\;{\pm}\;8.1\;%,\;8.7\;{\pm}\;4.5\;%$ 약간 증가시켰다. 결 론 : 족태양방광경의 경혈에 100Hz 전칩 자극을 하여 CP로 유도된 방광의 과활동성을 억제하였다. 이러한 결과는 침 자극으로 CP로 유도된 혹은 다른 종류의 방광염을 치료하는데 효과적일 것임을 시사한다. 또한, 특정 경락의 경혈과 해당 장부의 질환의 치료에 연관성을 보여준다.

• Tuberculosis and Respiratory Diseases
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• v.87 no.4
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• pp.483-493
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• 2024

Background: The use of immune checkpoint inhibitors (ICIs) in patients with advanced lung cancer is increasing. Despite ongoing studies to predict the efficacy of ICIs, its use in clinical practice remains difficult. Thus, we aimed to discover a predictive marker by analyzing blood cell characteristics and developing a scoring system for patients treated with ICIs. Methods: This was a prospective multicenter study in patients with advanced non-small cell lung cancer (NSCLC) who received ICIs as second-line treatment from June 2021 to November 2022. Blood cell parameters in routine blood samples were evaluated using an automated hematology analyzer. Immune checkpoint inhibitor score (IChIS) was calculated as the sum of neutrophil count score and immature granulocyte score. Results: A total of 143 patients from four institutions were included. The treatment response was as follows: partial response, 8.4%; stable disease, 37.1%; and progressive disease, 44.8%. Median progression-free survival and overall survival after ICI treatment was 3.0 and 8.3 months, respectively. Median progression-free survival in patients with an IChIS of 0 was 4.0 months, which was significantly longer than 1.9 months in patients with an IChIS of 1 and 1.0 month in those with an IChIS of 2 (p=0.001). The median overall survival in patients with an IChIS of 0 was 10.2 months, which was significantly longer than 6.8 and 1.8 months in patients with an IChIS of 1 and 2, respectively (p<0.001). Conclusion: Baseline IChIS could be a potential biomarker for predicting survival benefit of immunotherapy in NSCLC.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2003.10a
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• pp.57-69
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• 2003

It is well known that many pesticides possess hormonal activity, and affect the developments of wildlife and mammals including human. Currently, pyrethroid insecticides are in worldwide use to control in and outdoor pests, providing potential far environmental exposure. Hormonal activities of these pyrethroid insecticides, however, have been little studied, and the developmental effects of them were no reported. Therefore, we firstly examined the potential estrogenic activities of some pyrethroid insecticides (permethrin, cypermethrin, tetramethrin, deltamethrin, sumithrin, fenvalerate and bioallethrin) by immature rat uterotrophic assay, luciferase reporter gene assay and Calbindin-D$\sub$9k/ (CaBP-9k) gene expression assay. Uterine wet weights were increased by permethrin and the permethrin-induced weights were inhibited by ICI 182780 in the uterolrophic assay. On the other hand tetramethrin significantly reduced uterine and vaginal wet weights, and also inhibited the E2-induced weight increases at all doses tested. Cypermethrin and sumithrin had a tendency to increase uterine weights, although not statistically significant. Permethrin and cypermethrin dose-dependently increased the luciferase activity in reporter gene assay. Northern blot analysis showed that permethrin induced CaBP-9k mRNA expression whereas tetramethrin inhibted. Subsequent studies were conducted to investigate the possible developmental effects of four pyrethroid insecricides (permethrin, cypermethrin, sumithrin and teramethrin). Either diethlbestrol (DES) or 17${\beta}$ -estradiol (E2) was used as a reference control in this study. Pyrethroid insecticides were administered to Sprague Dawley rats via subcutaneous injection at 6 to 18 days of gestation or 1 to 5 days after birth. In utero treatment of permethrin (10mg/kg/day) in female rat resulted in significant increases in uterine and ovarian weights while significant decreases in serum E2 concentration, uterine and ovarian ER${\alpha}$ mRNA levels. Sumithrin and permethrin led to acceleration in vaginal opening of female rat, while delay in preputial separation of male after neonatal treatment. Anogenital distances of PND 18 were significantly reduced in sumthrin-treated, and permerhrin-treated male rats after neonatal treatment. All the pyrethroid insecticides tested caused significant increases in uterine weights on PND 18, while significant reductions in the first diestrus phase when neonataly treated. In addition, exposure to pyrethroids in neonatal period led to significant reduction in relative brain weight in female rat on PND 18, but its weight was recovered in diestrus phase. In summary, Our experimental data demonstrate the possibilities of developmental effects of pyrethroid insecticides via estrogenic or antiestrogenic activity.

• Journal of dental hygiene science
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• v.6 no.4
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• pp.295-302
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• 2006

This study was conducted to study the effects of the TA Theory and the TA Program, an educational testing tool developed to improve functional communication skills for dental hygienists. The results taken from the experiment using the TA program has been verified by Examination Tool for Personnel Communication developed by Chung(2001). 44 in two experimental groups and 16 in control group took part in TA Program training sessions. The experimental Group I received TA technique training session for 12 hours per day in a period of three days and Group II for 6 hours per day in a period of two days. From this experiment, the following conclusion was obtained. The results are as follows: 1) As it can be seen from the results of the examination taken prior to the experiment, the subjects of the control group and experimental groups were homogenous in all categories including self-disclosure, awareness, evaluation and acceptance of feedback, self-expression, coping with feelings, clearness, avoidance, dominance, handling of differences, and perceived acceptance. 2) After the training of TA Program was completed on Group I and II, the examination results are as follows: Control Group (1.5158), Group I (1.8260) / Control Group (1.4684), Group II (1.9985). The results of Group I and II (1.7970 and 1.9985 respectively) therefore showed a meaningful difference. 3) From the results of the experiment it is shown that dental hygienists' communication skills improved after receiving the TA Program training. Therefore TA Program may be used as an effective tool for such purpose. 4) As it can be observed from the data, Group I and II showed difference in the degree of improvements. Therefore, there needs to be a further investigation on the effects of the difference in training period. 5) This program is not only limited to the education of dental hygienists but may be widely applied to various forms of education and teaching methods.