• Proceedings of the Korea Inteligent Information System Society Conference
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• 2000.04a
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• pp.65-65
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• 2000

• Journal of Life Science
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• v.17 no.1 s.81
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• pp.18-23
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• 2007

Fe65, a neuron-specific adaptor protein, has two phosphotyrosine binding (PTB) domains. The second PTB (PTB2) domain interacts with intracellular domain fragment (AICD) of amyloid beta precursor protein (APP). Recent studies suggested that tile complex is composed of AICD and Fe65 transactivates genes that are responsible for neuronal cell death in Alzheimer's disease (AD). Therefore, a compound inhibiting the interaction between Fe65 and AICD can be a drug candidate to treat AD. However, it remains unclear how Fe65 recognizes AICD at a molecular level. Here, we report high-level production of the PTB2 domain of Fe65 in the baculovirus system. We found that the baculovirus system is an efficient method to obtain the Fe65 PTB2 domain, compared with the bacterial and mammalian expression systems. The purified recombinant protein was used for crystallization to determine its crystal structure helping to understand the molecular mechanism of Fe65-dependent signaling and to design its inhibitors.

• Atmosphere
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• v.22 no.2
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• pp.267-277
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• 2012

The objectives of this study are to develop a real-time drought monitoring and prediction system on the East Asia domain and to evaluate the performance of the system by using past historical drought records. The system is mainly composed of two parts: drought monitoring for providing current drought indices with meteorological and hydrological conditions; drought outlooks for suggesting future drought indices and future hydrometeorological conditions. Both parts represent the drought conditions on the East Asia domain (latitude $21.15{\sim}50.15^{\circ}$, longitude $104.40{\sim}149.65^{\circ}$), Korea domain (latitude $30.40{\sim}43.15^{\circ}$, longitude $118.65{\sim}135.65^{\circ}$) and South Korea domain (latitude $30.40{\sim}43.15^{\circ}$, longitude $118.65{\sim}135.65^{\circ}$), respectively. The observed meteorological data from ASOS (Automated Surface Observing System) and AWS (Automatic Weather System) of KMA (Korean Meteorological Administration) and model-driven hydrological data from LSM (Land Surface model) are used for the real-time drought monitoring, while the monthly and seasonal weather forecast information from UM (Unified Model) of KMA are utilized for drought outlooks. For the evaluation of the system, past historical drought records occurred in Korea are surveyed and are compared with the application results of the system. The results demonstrated that the selected drought indices such as KMA drought index, SPI (3), SPI (6), PDSI, SRI and SSI are reasonable, especially, the performance of SRI and SSI provides higher accuracy that the others.

• Proceedings of the Korea Institute of Applied Superconductivity and Cryogenics Conference
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• 2003.10a
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• pp.171-175
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• 2003

The sub-cooled nitrogen cooling system at 65 K with GM cryo-cooler is developed for cooling down the DC reactor of 6.6 ㎸-200 A class HTS Fault Current Limiter(SFCL). The sub-cooled nitrogen cooling is more economic than saturated nitrogen cooling, because the length of HTS wire is reduced in the same capacity, as well as, more stable. The cooling system with the GM cryo-cooler installed on the cryostat is not only compact but also efficient for energy saving. In the nitrogen vessel, after evacuating with vacuum pump to saturated nitrogen at 65 K, sub-cooled nitrogen at 65 K is made by putting in gas helium to 1 atm. During the short circuit test occurring the fault current of 1000 A, the sub-cooled nitrogen cooled DC reactor for SFCL is kept the state of sub-cooled nitrogen at 65 K.

• 한국전기화학회:학술대회논문집
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• 2003.04a
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• pp.65-65
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• 2003

• Proceedings of the Optical Society of Korea Conference
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• 1997.08a
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• pp.65-65
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• 1997

• Journal of the Chungcheong Mathematical Society
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• v.31 no.1
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• pp.65-73
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• 2018

We investigate the optimal consumption and investment problem of working agent who faces tax system on consumption, labor income, savings and investment. By applying martingale method, we obtain the closed-form solutions so it is possible to verify the effect of tax system analytically.

• Proceedings of the KWS Conference
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• 2001.05a
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• pp.146-149
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• 2001

• Microbiology and Biotechnology Letters
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• v.39 no.3
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• pp.313-316
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• 2011

We isolated and identified a novel probiotic strain, Lactobacillus sakei proBio65 from Kimchi. To determine whether L. sakei proBio65 has an immunomodulatory effect, we investigated cells via an in vitro screening system which co-cultured freshly isolated mesenteric lymphocyte with probiotics. A significant increase of $Foxp3^+$ transcription regulatory factor expression was observed, followed by an increase in anti-inflammatory cytokines transcription regulatory factor. L. sakei proBio65 exhibited high levels of the IL-10/IL-12 production ratio and enhanced Foxp3 expression in vitro. L. sakei proBio65 may thus be therapeutically useful for the modulation of inflammatory immune disorders.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.11
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• pp.1854-1859
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• 2016

Consider a linear fourth-order system with no zero that is represented in terms of four specific parameters: two damping ratios and two natural frequencies. We investigate several interesting questions about the maximum overshoot of the system with respect to the four-tuple parameters. Some remarkable results are presented.