• The Transactions of the Korean Institute of Power Electronics
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• v.7 no.6
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• pp.554-562
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• 2002

This paper presents a new sensorless control scheme using simple duty signal feedback technique in DC/DC converters. The proposed Duty Feedback Control(DFC) has the characteristics that they show the same as operation performance of current mode control by using duty feedback technique without current sensor as well as present faster dynamic response performance than conventional Sensorless Current Mode(SCM) control in case that input source is perturbed by step change or DC input source includes the harmonics. Also, the proposed control scheme has good noise immunity and simple control circuits since they have one feedback loop, and can be applied to all DC/DC converters. The concept and control principles of the proposed control scheme are explained in detail and the validity of the proposed control scheme is verified through several interesting simulated and experimental results.

• Journal of Microbiology and Biotechnology
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• v.11 no.6
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• pp.979-985
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• 2001

A fluorometric detection technique for HDL (High Density Lipoprotein) and LDL (Low Density Lipoprotein) was developed for application in a fiber-optic immunosensor using a protein A Langmuir-Blodgget (LB) film. For the fluorescence immunoassay, antibodies specific to HDL or LDL were imobilied on the protein A LB film, and a fluorescence amplification method was developed to overcome their weak fluorescence. The deposition of protein A using the LB technique was monitored using a surface pressure-are $({\pi}-A)$ curve, and the antibody immobilization of the protein A LB film was experimentally verified. The immobilized antibody was used to separate only HDL and LDL from a sample, then the fluorescence of he separated HDL or LDL was amplified. The amount of LDL or HDL was measured using the developed fiber optic fluorescence detection system. The optical properties resulting from the reaction of HDL or LDL with o-phtaldialdehyde, detection range, response time, and stability of the immunoassay were all investigated. The respective detection ranges for HDL and LDL were sufficient to diagnose the risk of coronary heart disease. The amplification step increased the sensitivity, while selective separation using the immobilized antibody led to linearity in the sensor signal. The regeneration of the antibody-immobilized substrate could produce a stable and reproducible immunosensor.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.6
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• pp.1095-1106
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• 1994

This paper presents a method for determining optimal grayscale function processing(FP) morphological filters under the least square (LMS) error criterion. The optimal erosion and dilation filters with a grayscale structuring element(GSE) are determined by minimizing the mean square error (MSE) between the desired signal and the filter output. It is shown that convergence of the erosion and dilation filters can be achieved by a proper choice of the step size parameter of the LMS algorithm. In an attempt to determine optimal closing and opening filters, a matrix representation of both opening and closing with a basis matrix is proposed. With this representation, opening and closing are accomplished by a local matrix operation rather than cascade operations. The LMS and back-propagation algorithm are utilzed for obtaining the optimal basis matrix for closing and opening. Some results of optimal morphological filters applied to 2-D images are presented.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.44 no.6
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• pp.16-23
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• 2007

Changeable biometrics has been developed as a solution to problem of enhancing security and privacy. The idea is to transform a biometric signal or feature into a new one for the purposes of enrollment and matching. In this paper, we propose a changeable biometric system that can be applied to appearance based face recognition system. In the first step when using feature extraction, ICA(Independent Component Analysis) coefficient vectors extracted from an input face image are replaced randomly using their mean and variation. The transformed vectors by replacement are scrambled randomly and a new transformed face coefficient vector (transformed template) is generated by combination of the two transformed vectors. When this transformed template is compromised, it is replaced with new random numbers and a new scrambling rule. Because e transformed template is generated by e addition of two vectors, e original ICA coefficients could not be easily recovered from the transformed coefficients.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.6A
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• pp.603-610
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• 2006

This paper considers the problem of mitigating CCI(Co-channel Interference) in cellular OFDMA downlink systems. The users in the cell-edge area suffer from large CCIs, and their SINR requirements are hard to be maintained. To guarantee their QoS, we propose a new exclusive sub-carrier allocation and power control algorithm. The performance of the proposed two-step algorithm is simulated in SUI-A path-loss model, and it is compared with that of the conventional algorithm. The simulation results show that the data transmission rate in the cell-edge area was increased by 600Kbps within the same power constraint. The results indicate that with proposed algorithm, the data rate stability can be achieved independently of the user location in the cell.

• Genomics & Informatics
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• v.8 no.3
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• pp.131-137
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• 2010

Genome-wide association studies (GWASs) have greatly contributed to the identification of common variants responsible for numerous complex traits. There are, however, unavoidable limitations in detecting causal and/or rare variants for traits in this approach, which depends on an LD-based tagging SNP microarray chip. In an effort to detect potential casual and/or rare variants for complex traits, such as type 2 diabetes (T2D) and triglycerides (TGs), we conducted a targeted resequencing of loci identified by the Korea Association REsource (KARE) GWAS. The target regions for resequencing comprised whole exons, exon-intron boundaries, and regulatory regions of genes that appeared within 1 Mb of the GWA signal boundary. From 124 individuals selected in population-based cohorts, a total of 0.7 Mb target regions were captured by the NimbleGen sequence capture 385K array. Subsequent sequencing, carried out by the Roche 454 Genome Sequencer FLX, generated about 110,000 sequence reads per individual. Mapping of sequence reads to the human reference genome was performed using the SSAHA2 program. An average of 62.2% of total reads was mapped to targets with an average 22X-fold coverage. A total of 5,983 SNPs (average 846 SNPs per individual) were called and annotated by GATK software, with 96.5% accuracy that was estimated by comparison with Affymetrix 5.0 genotyped data in identical individuals. About 51% of total SNPs were singletons that can be considered possible rare variants in the population. Among SNPs that appeared in exons, which occupies about 20% of total SNPs, 304 nonsynonymous singletons were tested with Polyphen to predict the protein damage caused by mutation. In total, we were able to detect 9 and 6 potentially functional rare SNPs for T2D and triglycerides, respectively, evoking a further step of replication genotyping in independent populations to prove their bona fide relevance to traits.

• The Korean Journal of Pharmacology
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• v.31 no.2
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• pp.219-231
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• 1995

Vasoactive intestinal polypeptide(VIP) and ${\beta}-adrenergic$ agonists have immunomodultory effects on the peripheral blood T-lymphocytes of rat through their own receptors. Both of them utilize the same signal transduction pathway. That is, the stimulatory guanine nucleotide binding protein(G protein) mediates the receptor-adenylyl cyclase coupling, producing intracellular increase of cyclic adenosine monophosphate(cAMP). In the previous experiment, propranolol, a ${\beta}-adrenergic$ receptor blocker, inhibited the VIP-induced protein phosphorylation in lymphocytes. However, propranolol could not block the effect induced by forskolin. Therefore, this study was designed to elucidate the mechanism of the inhibitory action of propranolol on the effects of VIP. Using peripheral blood lymphocytes of rats, the effect of propranolol on the receptor binding characteristics of VIP was observed. And the effects of propranolol were compared to the effects of timolol on the cAMP increase induced by isoproterenol, VIP or forskolin. The results obtained are as follows. 1) Receptor binding study showed no significant differences in the affinity or density of VIP receptor between the control and propranolol-pretreated groups. 2) VIP-induced increase of cAMP was inhibited by propranolol, but not by timolol. 3) Both propranolol and timolol suppressed the isoproterenol-induced cAMP increase. 4) Propranolol also inhibited the histamine-induced cAMP increase. 5) Propranolol did not inhibit the increase of cAMP stimulated by forskolin. 6) Lidocaine did not block the VIP-induced cAMP increase. These results show that the inhibitory mechanism of propranolol is not related to ${\beta}-adrenergic$ receptor or its membrane stabilizing effect, and it is suggested that propranolol can block the effects of VIP by inhibiting the intermediate step between the VIP receptor and adenylyl cyclase.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.6 no.1
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• pp.115-123
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• 2002

In this paper, we present two types of vision algorithm that mobile robot has CCD camera. for obstacle avoidance and path plan. One is simple algorithm that compare with grey level from input images. Also, The mobile robot depend on image processing and move command from PC host. we has been studied self controlled mobile robot system with CCD camera. This system consists of TMS320F240 digital signal processor, step motor, RF module and CCD camera. we used wireless RF module for movable command transmitting between robot and host PC. This robot go straight until 95 percent filled screen from input image. And the robot recognizes obstacle about 95 percent filled something, so it could avoid the obstacle and conclude new path plan. Another is complex algorithm that image preprocessing by edge detection, converting, thresholding and image processing by labeling, segmentation, pixel density calculation.

• Molecules and Cells
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• v.42 no.9
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• pp.646-660
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• 2019

Abscisic acid (ABA) is a phytohormone essential for seed development and seedling growth under unfavorable environmental conditions. The signaling pathway leading to ABA response has been established, but relatively little is known about the functional regulation of the constituent signaling components. Here, we present several lines of evidence that Arabidopsis Raf-like kinase Raf10 modulates the core ABA signaling downstream of signal perception step. In particular, Raf10 phosphorylates subclass III SnRK2s (SnRK2.2, SnRK2.3, and SnRK2.6), which are key positive regulators, and our study focused on SnRK2.3 indicates that Raf10 enhances its kinase activity and may facilitate its release from negative regulators. Raf10 also phosphorylates transcription factors (ABI5, ABF2, and ABI3) critical for ABA-regulted gene expression. Furthermore, Raf10 was found to be essential for the in vivo functions of SnRK2s and ABI5. Collectively, our data demonstrate that Raf10 is a novel regulatory component of core ABA signaling.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.1
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• pp.8-14
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• 2003

Multistep detection was peformed to identify irradiated dried anchovy. In thermoluminescence (TL) analysis, non-irradiated samples represented a lower peak at about 28$0^{\circ}C$, but irradiated samples showed a higher peak at around 20$0^{\circ}C$. The normalization with a re-irradiation step at 1 kGy could verify the identification results. Electron spin resonance (ESR) spectroscopy for bones separated from irradiated anchovy revealed specific signals (g=2.002,1.998) derived from a hydroxyapatite radical, which intensities were in proportion to the irradiation doses and still detectable even after 6 months of storage at -2$0^{\circ}C$. Six kinds of hydrocarbons (HC) were observed in dried anchovy samples and 1,7-hexadecadiene and 1-hexadecene were only detected in irradiated anchovy at 1 kGy or more. Also among 3 kinds of radiation-induced 2-alkylcyclobutanones (2-ACB) observed, 2-dodecylcy-clobutanone and 2-tetradecylcyclobutanone were unique in irradiated anchovy. As a result, the concentration of radiation-induced HCs and 2-ACBs were dependent on the irradiation dose and detectable after 6 months of storage. However, TL and ESR analyses were found simpler than the other methods for identification of irradiated boiled-dried anchovy.