• Health Policy and Management
• /
• v.21 no.4
• /
• pp.493-510
• /
• 2011

Objectives : This study aims to explore how social support and social network are related with health behavior. Methods : The target population was 12,449 people in Chungcheongbuk-do. The sample was accrued for the period of 3 months in 2008 by face to face interview of direct visiting from systematic sampling method. The instruments used in this study were social support, social network and health behavior. Results : There was significant difference in the level of social support and social network by sex, age, educational level, occupation, and monthly income(p<0.05). There was significant difference in the level of social support by alcohol drinking, physical exercise. There was significant difference in the level of social network by smoking, alcohol drinking, physical exercise, obesity(p<0.05). Multivarite analysis shows significant difference in the level of social instrumental support by smoking, physical exercise. It shows significant difference in the level of social emotional support by smoking. It also shows significant difference in the level of social network by smoking, physical exercise. Conclusion : These results suggest that social support and social network may be associated with health behavior. Because this study was cross sectional research, the order was not found between social support, social network and health behavior. Through a study on monitoring, we will obtain more information for relationship.

• Food Science and Biotechnology
• /
• v.18 no.1
• /
• pp.48-52
• /
• 2009

Eoyukjang is a traditional Korean sauce made of cooked soypaste or meju supplemented with fish and meats at least 1 year of fermentation period. Eoyukjang was recovered according to the traditional method and stored under the ground in a pot without plastic packaging (13G: 13 month fermentation under the ground) or in an incubator wrapped with plastic packaging (6I, 12I, and 18I: 6, 12, and 18 month fermentation, respectively). Distribution of isoflavones and fatty acids were monitored by high performance liquid chromatography (HPLC) and gas chromatography (GC), respectively. Total isoflavones in 13G, 6I, 12I, and 18I were 3.792, 0.387, 0.460, and $0.510{\mu}mol/g$, respectively. Samples of 13G had at least 8.24 times higher isoflavone contents than samples from 12I. Aglycones were the major isoflavones in eoyukjang and were found more than 92% in 13G and 39-63% in incubated samples. In fatty acid analysis, the ratios of unsaturated to saturated fatty acids from 13G were higher than those from 6I, 12I, and 18I. Traditional fermentation methods using a pot may allow more migration of air and moisture than samples wrapped with plastic packaging, which caused the difference in the distribution of isoflavones and fatty acids.

• YAKHAK HOEJI
• /
• v.55 no.6
• /
• pp.510-515
• /
• 2011

Isoquinoline compounds including berberine enhance L-DOPA-induced cytotoxicity in PC12 cells. In this study, the effects of berberine on L-DOPA therapy in unilateral 6-hydroxydopamine (6-OHDA)-induced rat models of parkinsonism were investigated. Rats were prepared for the models of Parkinson's disease by 6-OHDA-lesioning for 14 days and then treated with L-DOPA (10 mg/kg) with or without berberine (5 and 30 mg/kg, i.p.) for 21 days. Treatment with berberine (5 and 30 mg/kg, i.p.) showed a dopaminergic cell loss in substantia nigra of 6-OHDA-lesioned rats treated with L-DOPA: 30 mg/kg berberine was more intensive neurotoxic. The levels of dopamine were also decreased by berberine (5 and 30 mg/ kg) in striatum-substantia nigra of 6-OHDA-lesioned rats treated with L-DOPA. These results suggest that berberine aggravates cell death of dopaminergic neurons in L-DOPA-treated 6-OHDA-lesioned rat models of Parkinson's disease. Therefore, the long-term L-DOPA therapeutic patients with isoquinoline compounds including berberine may need to be checked for the adverse symptoms.

• Journal of the Korean Ceramic Society
• /
• v.43 no.12 s.295
• /
• pp.823-828
• /
• 2006

One of the main issues of Solid Oxide Fuel Cells (SOFCs) is to reduce the operating temperature to $750^{\circ}C$ or less. It has advantages of improving the life of component parts and the long-term stability of a system, so the production cost could be decreased. In order to achieve that, the ohmic and polarization loss of a single cell should be minimized first. This paper presents.to fabricate anode-supported single cells with controlling microstructure as a function of particle size and volume of graphite and NiO-YSZ weight ratio. By means of optimizing the manufactural condition through microstructure analysis and performance evaluation, the single cell which had NiO-YSZ=6:4, graphite volume of 24% and graphite size of $75{\mu}m$ as the anode composition showed a distinguished power density of $510mW/cm^2$ at $650^{\circ}C$ and $810mW/cm^2$ at $700^{\circ}C$, respectively.

• Geomechanics and Engineering
• /
• v.9 no.3
• /
• pp.373-395
• /
• 2015

Comprehensive results from cyclic plate loading at a diameter of 300 mm supported by layers of geocell are presented. The plate load tests were performed in a test pit measuring $2000{\times}2000mm$ in plane and 700 mm in depth. To simulate half and full traffic loadings, fifteen loading and unloading cycles were applied to the loading plate with amplitudes of 400 and 800 kPa. The optimum embedded depth of the first layer of geocell beneath the loading plate and the optimum vertical spacing of geocell layers, based on plate settlement, are both approximately 0.2 times loading plate diameter. The results show that installation of the geocell layers in the foundation bed, increase the resilient behavior in addition to reduction of accumulated plastic and total settlement of pavement system. Efficiency of geocell reinforcement was decreased by increasing the number of the geocell layers for all applied stress levels and number of cycles of applied loading. The results of the testing reveal the ability of the multiple layers of geocell reinforcement to 'shakedown' to a fully resilient behavior after a period of plastic settlement except when there is little or no reinforcement and the applied cyclic pressure are large. When shakedown response is observed, then both the accumulated plastic settlement prior to a steady-state response being obtained and the resilient settlements thereafter are reduced. The use of four layers of geocell respectively decreases the total and residual plastic settlements about 53% and 63% and increases the resilient settlement 145% compared with the unreinforced case. The inclusion of the geocell layers also reduces the vertical stress transferred down through the pavement by distributing the load over a wider area. For example, at the end of the load cycle of the applied pressure of 800 kPa, the transferred pressure at the depth of 510 mm is reduced about 21.4%, 43.9%, 56.1% for the reinforced bases with one, two, and three layers of geocell, respectively, compared to the stress in the unreinforced bed.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.26 no.4
• /
• pp.506-510
• /
• 2012

Bone homeostasis is regulated by the balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoporosis, rheumatoid arthritis and periodontal disease are related with up-regulated osteoclast formation and its activity. Gol-Swae-Bo(Drynariae Rhizoma) is widely used on skeletal disease. In this study, we sought to examine the effect of Drynariae Rhizoma in RANKL-induced osteoclast differentiation. The extract of Drynariae Rhizoma inhibited RANKL-induced osteoclast differentiation in a dose dependent manner without cytotoxicity. receptor activator of nuclear factor-${\kappa}B$ ligand(RANKL) mediated $I{\kappa}B$ degradation in bone marrow macrophages(BMMs). However, the extract of Drynariae Rhizoma inhibited RANKL induced $I{\kappa}B$ degradation in BMMs. And mRNA expression of OSCAR, TRAP, c-Fos and NFATc1 was suppressed by the extract of Drynariae Rhizoma. Moreover, the extract of Drynariae Rhizoma inhibited the protein expression of NFATc1 and c-Fos induced by RANKL. After all the analysis, these results suggest that Drynariae Rhizoma may be good candidate of medicine in the treatment of bone-related disease.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2005.07a
• /
• pp.463-465
• /
• 2005

The $ZnGa_2O_4$:Mn phosphor was synthesized through solid-state reactions at the various molar ratio of Mn from 0.002 % to 0.01 %. Structural and optical properties of the $ZnGa_2O_4$:Mn phosphor was investigated by using X-ray diffraction (XRD), and cathodoluminescence (CL) measurements. The XRD patterns show that the Mn-doped $ZnGa_2O_4$ has a (311) main peak and a spinel phase. Also the emission wavelength shifts from 420 to 510 nm in comparison with $ZnGa_2O_4$ when Mn is doped in $ZnGa_2O_4$. These results indicate that $ZnGa_2O_4$:Mn phosphors hold promise for potential applications in field-emission display devices with high brightness operating in green spectral regions.

• Macromolecular Research
• /
• v.16 no.6
• /
• pp.510-516
• /
• 2008

New antitumor active polymers, poly(methacryloyl-2-oxy-1,2,3-propanetricarboxylic acid-co-exo-3,6-epoxy-l,2,3,6-tetrahydrophthalic acid) [poly(MTCA-co-ETAc)], poly(methacryloyl-2-oxy-l,2,3-propanetricarboxylic acid-co-hydrogen ethyl-exo-3,6-epoxy-l,2,3,6-tetrahydrophthalate) [poly(MTCA-co-HEET)], and poly(methacryloyl-2-oxy-l,2,3-propanetricarboxylic acid-co-a-ethoxy-exo-3,6-epoxy-1,2,3,6-tetrahydrophthaloyl-5-fluorouracil) [poly(MTCA-co-EETFU)] were synthesized and characterized. Their antitumor activity, inhibition of DNA replication and antiangiogenesis were examined. The structures of the polymers were identified by FT-IR, $^1H$ and $^{13}C$-NMR spectroscopy. The number average molecular weights of the fractionated polymers determined by GPC ranged from 9,400 to 14,900, and polydispersity indices were less than 1.7. The in vitro cytotoxicity of these polymers was determined and their antitumor activity was evaluated. The $IC_{50}$ values (the drug concentration at inhibition of 50% tumor growth) indicated that the synthesized polymers were much better inhibitors of cancer cells and showed lower cytotoxicity than the free 5-FU. The in vivo antitumor activity of the conjugates was examined using mice bearing the sarcoma 180 tumor cell line. The life spans (TIC) of the mice treated with the conjugates were higher than those treated with the free 5-FU. In addition, the synthesized conjugates showed excellent antiangiogenic activity based on an embryo chorioallantoic membrane assay.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2010.02a
• /
• pp.356-356
• /
• 2010

Tribological behaviors of the hard film on soft substrate system were explored using the hard thin film of diamond-like carbon (DLC) coated the soft polymer of polydimethysiloxane (PDMS). A DLC film with the Young's modulus of 100 GPa was coated on PDMS substrate with Young's modulus of 10 MPa using plasma enhanced chemical vapor deposition (PECVD) technique. The deposition time was varied from 10 sec to 10 min, resulting in nanoscale roughness of wrinkle patterns with the thickness of 20 nm to 510 nm, respectively, at a bias voltage of $400\;V_b$, working pressure 10 mTorr. Nanoscale wrinkle patterns with 20-100 nm in width and 10-30 nm height were formed on DLC coating due to the residual stress in compression and difference in Young's modulus. Nanoscale roughness effect on tribological behaviors was observed by performing a tribo-experiment using the ball-on-disk type tribometer with a steel ball of 6 mm in diameter at the sliding speed of 220 rpm, normal load of 1N and 25% humidity at ambient temperature of $25^{\circ}C$. Friction force were measured with respect to thickness change of coated DLC thin film on PDMS. It was found that with increases the thickness of DLC coating on PDMS, the coefficient of friction decreased by comparison to that of the uncoated PDMS. The wear tracks before and after tribo-test were analyzed using SEM and AFM.

• Journal of the Korean Ceramic Society
• /
• v.37 no.5
• /
• pp.505-510
• /
• 2000

In this investigation, we fabricated RBSN (Reaction Bonded Silicon Nitride) using the static nitriding system which could be advantageous for commercialization. Firstly, Si compacts of different sizes were made, and then nitridation rates were investigated as a function of added static gas pressure. The reaction schedule was obtained by pre-experiments. In case of small samples, the variation of ${\alpha}$, ${\beta}$ phases between the inside and the outside region of the specimens was examined after the samples were nitrided under 1 bar and 1.5 bar reaction pressure. On the other hand, large samples of Si compact with the size of 36 mm for diameter and 23 mm for thickness were nitrided for 26 hours of the total nitridation time, which showed a complete and homogeneous nitriding reaction from the outside to the inside of the samples, although the time was considerably shorter than that needed for convertional nitridation. Nitridation rates obtained at the early stage of reaction were proportional to the reaction gas pressures. The sequences of the nitridation reaction with the thickness were as follows 1) the outside, 2) the inside and 3) the intermediate area of the specimen. These results wer eobtained from the coloration of cross sectioned specimens that had various nitridation rates. Total nitriding reaction kinetics was controlled by chemical reaction, not by diffusion of the nitrogen gas.