• Journal of The Korean Digital Architecture Interior Association
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• v.11 no.2
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• pp.103-114
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• 2011

The purpose of this study is to find good references for the administration & operating system of Korea Architects License Examination. It is because we may predict to discuss with its system to develop the international level. To achieve this goal, the 'Architect Registration $Examination^{(R)}$($ARE^{(R)}$)' in the USA was selected and analysed as one of the role models. As a result, the analysed key contents and study scopes are as below; 1) Consideration the evolutionary process to the administration & operating system of the Architect Registration $Examination^{(R)}$ in the USA 2) Working role the National Council of Architectural Registration Boards(NCARB) for the $ARE^{(R)}$ 3) Analysis the carrying out system of the cooperation network & infrastructure for the $ARE^{(R)}$ 4) Analysis the operating regulation & system of the newest version in the $ARE^{(R)}4.0$ 5) Consideration the administration & operating system's know-how of the Computer Based Examination in the $ARE^{(R)}$ 6) Research the taking exam.'s full process of the $ARE^{(R)}4.0$ from the beginning to the end 7) Comparative analysis between the Korea Architects License Examination and the $ARE^{(R)}4.0$.

• Journal of the Korean Chemical Society
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• v.26 no.5
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• pp.310-319
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• 1982

Cobalt(III) complexes with sexidentate ligands, N,N,N',N'-tetrakis(2-amino-ethyl)-1,2-ethanediamine (ten), -1,3-propanediamine (ttn), -1,4-butanediamine (ttmd), -(R,R)-and -(R,S)-2,4-pentanediamine (tptn) were prepared, and the characterization of d-d absorption band on the variation of chelate ring size and conformation of these complexes were studied by means of electronic spectra. The first d-d absorption bands of $[Co(L)]^{3+}$ complexes are shifted to smaller wave numbers in the order. ttn > (R,R)-tptn > ten > ttmd${\simeq}$(R,S)-tptn for (L). The UV, $^{13}C$ NMR, and Circular Dichroism studies indicate that the R,S-tptn ligand of $[Co(R,S-tptn)]^{3+}$ complex coodinates to cobalt(Ⅲ) ion as a sexidentate with one methyl group in axial position.

• Natural Product Sciences
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• v.29 no.1
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• pp.10-16
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• 2023

We previously reported that dried Lysimachia christinae whole plant extract exerted significant neuroprotective activity. In this study, we tried to isolate neuroprotective compounds of L. christinae. We evaluated the neuroprotective activity of the four fractions (hexane, chloroform, ethyl acetate, and n-butanol fractions) of methanol extract. Among them, ethyl acetate and n-butanol fractions showed most potent neuroprotective activity against glutamate excitotoxicity. Nine compounds were isolated from ethyl acetate and n-butanol fractions of L. christinae extract and identified as cynaroside (1), (3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-yl)methyl-3-hydroxy-2-octyldopentaconta-23,33-dienoate (2), androst-16-ene-3,6-diol (3), 2-hydroxy-24-propoxytetracos-4-enoic acid (4), 2-hydroxy-24-methoxytetracos-4-enoic acid (5), 12-(stearoyloxy)octadec-9-enoic acid (6), β-sitosterol (7), (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-yl palmitate (8) and (1S,2S,3R,4R)-4-(((2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5R,6R)-2-(3,4-dimethoxyphenethoxy)-3,5-dihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-4-yl)oxy)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-3-yl)oxy)cyclohexane-1,2,3-triol (9) by spectroscopic data such as UV, IR, NMR, Mass spectroscopy. Their neuroprotective activity was evaluated by MTT assay. Cynaroside (1) and androst-16-ene-3,6-diol (3) had significant neuroprotective activity against glutamate-injured HT22 cells. The neuroprotective efficacy of cynaroside (1) and androst-16-ene-3,6-diol (3) was related to their anti-oxidative activity.

• Communications of the Korean Mathematical Society
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• v.26 no.4
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• pp.661-667
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• 2011

In this paper, we introduce the notions of fuzzy strongly (r, s)-preopen and preclosed mappings on intuitionistic fuzzy topological spaces in $\check{S}$ostak's sense. The relationships among fuzzy (r, s)-open, fuzzy strongly (r, s)-semiopen, fuzzy (r, s)-preopen, and fuzzy strongly (r, s)-preopen mappings are discussed. The characterizations for the fuzzy strongly (r, s)-preopen and preclosed mappings are obtained.

• Journal of the Chungcheong Mathematical Society
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• v.27 no.4
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• pp.603-614
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• 2014

We introduce the concepts of ($\mathcal{T}^{{\mu}{\gamma}}$, $\mathcal{U}^{{\mu}{\gamma}}$)-double (r, s) (u, v)-semiclosures and ($\mathcal{T}^{{\mu}{\gamma}}$, $\mathcal{U}^{{\mu}{\gamma}}$)-double (r, s)(u, v)-semiinteriors. Using the notions, we investigate some of characteristic properties of double pairwise (r, s)(u, v)-semicontinuous, double pairwise (r, s)(u, v)-semiopen and double pairwise (r, s)(u, v)-semiclosed mappings.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.11
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• pp.4940-4950
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• 2011

cis-(3R,5R)-Atorvastatin Ca (1) used for hyperlipidemia have four stereomers. However, It is very difficult to prepare stereoselective stereomers. In this paper, the reduction of 3,5-diketo atorvastatin ester (3) was performed using $Me_4NHB(OAc)_3$ in acetic acid as a reductant and showed excellent stereoselectivity in the double reduction of 3,5-diketo atorvastatin ester (3). As a result, reduction of compound 3 by $Me_4NHB(OAc)_3$ was purely obtained with cis-(3R,5R)-atorvastatin ester (4) of 1.5% and trans-(3R,5S)-atorvastatin ester (5) of 98.5%. Also, cis-(3R,5R)-atorvastatin Ca (1) and trans-(3R,5S)-atorvastatin Ca (7) were used to determine efficacy in the treatment of liver damage and hyperlipidemia induced by a high-fat diet in rats and to study the performance of the January 2010 experient was conducted. As a result, total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), and triglyceride (TG) levels of compound 1 and 7 groups were $93.0{\pm}0.5$, $43.5{\pm}0.8$, $40.4{\pm}1.4$, $45.6{\pm}0.9\;mg/d{\ell}$ and $110.0{\pm}0.7$, $33.3{\pm}0.6$, $65.8{\pm}1.9$, $54.8{\pm}1.2\;mg/d{\ell}$, respectively. Atherogenic index (AI) and cardiac risk factor (CRF) in compound 1 and 7 were $1.14{\pm}0.05$, $2.14{\pm}0.05$ and $2.31{\pm}0.06$, $3.31{\pm}0.06$, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were $51.9{\pm}4.6$, $16.0{\pm}2.1\;IU/{\ell}$ and $75.8{\pm}4.4$, $35.1{\pm}9.7\;IU/{\ell}$. Taken together, while compound 1 treat against high-fat diet-induced hyperlipidemia by attenuating hepatic lipid depots and reducing oxidative stress, compound 7 group had a low curative effect on hyperlipidemia induced by a high-fat diet in rats. These findings suggest that new method about synthesis of stereoselective stereomers and indicate that it may consider using in a clinical trial.

• Journal of Microbiology and Biotechnology
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• v.14 no.4
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• pp.693-697
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• 2004

YH-1715R, (2R,3R)-2-(2,4-difluorophenyl)-3-(3-methoxy-1,2,4-isothiazol-3-yl-thio)-1-( 1H-1,2,4-triazol-l-yl)-2-butanol, a new triazole derivative obtained by the structural modification of fluconazole, was found to exhibit potent anti-Candida activity against a wide variety of Candida albicans (C. albicans) (MIC: 0.4-12.5 mg/l). To investigate the mode of action of YH-1715R, its effect on ergosterol biosynthesis in cell-free extracts and whole cells of C. albicans was examined. The inhibitory activity of YH-1715R was approximately ten-fold higher than that of fluconazole. To determine the primary action mechanism of YH-1715R, its inhibitory activity against lanosterol $14\alpha$-demethylase (14$\alpha$-DM), a major target for azole, was measured using gas-liquid chromatography. YH-1715R and fluconazole were found to inhibit 14a-DM with an $IC_{50}$ of 0.015 $\mu$M and 0.01$8\mu$M, respectively, plus the mode of inhibition of YH-1715R and fluconozole was noncompetitive with a $K_i$ of 0.0533$\mu$M and 0.0975$\mu$M.

• Journal of Animal Science and Technology
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• v.45 no.6
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• pp.967-974
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• 2003

This experiment was carried out to investigate the relationship of morphological characteristics between reticulum and abomasum of Korean native young goats age from 2 days to 150 days. Number of traits investigated in the reticulum in this experiment were 12[body weight, chest girth, body length, right and left reticulum length(R.L.), upper and lower reticulum length(U.L.), reticulum weight(R.W.), reticulum area(R.A.), upper and lower length of one polygon located at central part of reticulum(U.P.C.R.), right and left length of one polygon located at central part of reticulum(R.P.C.R.), thickness of polygon wall located at central part of reticulum(T.P.C.R.), thickness of polygon wall located at middle part of reticulum(T.P.M.R.), and thickness of polygon wall locared at edge part of reticulum(T.P.E.R.)] and items for abomasum were 12[length of between ostium omaso-abomasicum part and pylosica part in the abomasum(L.B.O.P.), broadest outer part of the abomasum(B.O.A.), weight of abomasum(W.O.A.), area of abomasum(A.O.A.), number of plicae abomasi in the abomasum(N.P.A.A.), thickness of abomasum well at cranial part(ostium omasoabomasicum) in the abomasum(T.A.C.A.), thickness of abomasum well at central part in the abomasum(T.A.P.A.), thickness of abomasum wall at light upper area of pylosica part in the abomasum(T.A.L.A.), length measured from the longest plica abomasi in the abomasum(L.L.P.A.), broadest measured from the longest plica abomasi in the abomasum(B.L.P.A.), area measured from the longest plica abomasi in the abomasum(A.L.P.A.), weight of longest plica abomasi in the abomasum(W.L.P.A.)]. The results were summarized as follows: 1. Number of coefficient of correlation obtained among 12 traits of the abomasum and 12 of the reticulum were 144, and coefficient of correlation of 114 were significant(P〈0.05). 2. Trait of abomasum weight have high correlation with 12 traits of reticulum. 3. Correlation coefficients and regression equation between body weight. VS. abomasum weight(r$_1$), and upper and lower length of one polygon located at central part of reticulum(U.P.C.R.) VS. abomasum weight(r$_2$) were r$_1$=0.8954$^{**}$ and Y=10.703+3.374X, r$_2$=0.8430$^{**}$ and Y=5.689+4.311X, respectively. 4. Correlation coefficients and regression equation between chest girth VS. abomasum weight(r$_1$), and body weight VS. abomasum weight(r$_2$) were r$_1$=0.8708$^{**}$ and Y=-17.219+1.227X, r$_2$=0.8589$^{**}$ and Y=- 17.616+1.290X, respectively.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2017.05a
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• pp.549-558
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• 2017

바야흐로 4차 산업혁명의 시대가 도래하면서, 4차 산업혁명과 관련된 기술에 대한 관심 또한 나날이 높아져 가고 있다. 이런 시대적 상황에 맞춰, 본 연구에서는 웹 검색트래픽을 활용하여 4차 산업혁명 관련 기술의 국내 외 트렌드를 비교하고 관련된 기술에 대한 국내 정부R&D 과제 현황에 대해 분석해 보고자 한다. 본 분석은 먼저 관련 기술에 대한 정부 R&D 현황 과제 현황을 네트워크 분석하고 분석된 기술을 4차 산업혁명의 3가지 카테고리로 구분한다. 이후 카테고리별로 선별된 각각의 기술에 대해 구글의 웹 검색트래픽을 활용하여 관련된 기술의 국내 외 트렌드를 비교 분석한다. 본 연구를 통해 4차 산업혁명 관련 기술에 대한 과거와 현재의 관심 동향을 확인할 수 있을 것으로 예상된다. 또한, 해당 기술과 관련된 정부 R&D 과제 현황을 네트워크 분석하고 시각화하여 4차 산업혁명 관련 R&D 현황에 대한 직관적인 정보를 제공하고자 한다. 본 연구는 인류 최대의 혁명으로 정의되는 4차 산업혁명 기술에 대한 국내 외 트렌드 정보와 함께 현재까지 진행되어온 정부의 R&D 현황을 직관적으로 볼 수 있게 제공함으로써, 4차 산업혁명과 함께 다가오는 미래에 대한 올바른 정책 방향 설정에 기여할 것으로 기대된다.

• Journal of Korea Water Resources Association
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• v.36 no.1
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• pp.13-21
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• 2003

The purpose of this study is to estimate Z-R relationships of between radar reflectivity and rainfall rate. The Z-R relationships estimated that rainfall events are selected at Yeongchun water level station where the discharge recorded from 1,000cms to 8,519cms in chungju dam basin. The result of Z-R relationship distributed at thirty two raingage sites, the constant values of A and $\beta$ are distributed between 26.4 and 7.4, 0.9 and 1.56 respectively. The correlation coefficients of standard Z-R relationships(Z=200Rl.6)shows that 0.63 lower than each other raingage sites(0.65~0.748).