• Women's Health Nursing
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• v.22 no.4
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• pp.275-286
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• 2016

Purpose: This study explored influencing factors on quality of life (QoL) above middle-aged women in relation to demographic factors, health-related factors, menopausal status, metabolic syndrome (MS) and its risk factors. Methods: This study was secondary data analysis from the Sixth Korea National Health and Nutrition Examination Survey 2013~2015 that utilized a complex, multi-stage probability sample design. Study sample of 2,310 was inclusive of (28.8%) of women who were over 40. To evaluate the factors that would influence an impaired quality of life, $x^2$ test, GLM, and logistic regression analysis were done. Results: Level of quality of life was lower in women with late post-menopause(over 10 years since menopause) than women with pre-menopause. Factors influencing impaired QoL were as follows: graduated middle school and elementary school or less (OR=2.43, 4.42, respectively, p<.05), no job (OR=1.92, p<.001), stress (OR=1.92, p=.001), depression (OR=1.93, p=.001), insufficient sleep (OR=1.64, p=.003), late post-menopause (OR=2.61, p=.044) and over 85cm of waist circumference (OR=1.76, p=.01). Conclusion: These results suggest that late post-menopause may be an independent factor influencing an impaired QoL. To promote post-menopausal womens' health, a nursing strategy is required to teach women how to manage levels of stress, depression, insufficient sleep, and abdominal obesity through health education, nutritional counselling, and physical activity program.

• Journal of Korean Clinical Nursing Research
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• v.23 no.3
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• pp.398-406
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• 2017

Purpose: The purpose of this study was to evaluate food carving among hemodialysis patients and to identify factors affecting the food carving. Methods: A descriptive correlational study was conducted. Data were collected from 129 patients receiving hemodialysis between March 15 and April 15, 2017. Measurement instruments included the general food craving questionnaire trait, the center for epidemiological studies-depression scale, and stress response inventory-modified form. The statistical analysis included t-test, analysis of variance, pearson correlation analysis, and stepwise multiple regression analysis. Results: Mean food craving score was $53.00{\pm}12.36$. Food craving was higher in patients younger than 40 years (F=4.36 p=.006) and having occupation (t=2.18 p=.031). Patients receiving hemodialysis demonstrated higher levels of depression ($21.37{\pm}9.62$) and stress ($39.68{\pm}15.95$). Factors influencing food craving were depression (${\beta}=.52$, p<.001), stress (${\beta}=.65$, p<.001), and age 50~59 years old (${\beta}=-.28$, p=.001) and 60~69 years old (${\beta}=-.19$, p=.026), which accounted for 25.6% of total variance. Conclusion: Food craving among hemodialysis patients was influenced by patients' depression, stress and age. Assessment and management of depression and stress needs to be incorporated as a nursing strategy for dietary management for hemodialysis patients.

• International journal of advanced smart convergence
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• v.11 no.2
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• pp.194-204
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• 2022

This study is a one-group pretest-posttest design to evaluate the effect of problem-based learning (PBL) for patient safety on self-leadership, patient safety competencies, and reflective thinking of nursing students. The research was conducted from March 2 to April 15, 2022, in which 57 nursing students participated. PBL for patient safety was examined in a total of 8 sessions in the order of motivation, problem identification, task performance planning, problem-solving methods, summary and solution, presentation, and evaluation. The following topics of patient safety were selected for each team: nursing records, high-alert medication, medication error and intravenous fluid regulation, blood transfusion care, fall, bedsore, infection control, and pain management. We provided feedback on the learning process and outcomes of nursing students. According to the results, self-leadership showed a statistically significant improvement in self-expectations (t=2.60, p=0.01), goal setting (t=2.84, p<0.01), self-reward (t=3.32, p<0.01), and self-criticism (t=2.32, p=0.02). Patient safety competencies showed a statistically significant improvement in patient safety knowledge (t=13.05, p<0.001) and patient safety skills (t=4.87, p<0.001) but not in reflective thinking. The results prove that PBL for patient safety is an effective teaching-learning strategy to improve self-leadership and patient safety competencies. Future studies must develop and validate specific and long-term teaching-learning methods to improve reflective thinking.

• BMB Reports
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• v.47 no.4
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• pp.221-226
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• 2014

Drug-resistance and imbalance of apoptotic regulation limit chemotherapy clinical application for the human hepatocellular carcinoma (HCC) treatment. The reactivation of p53 is an attractive therapeutic strategy in cancer with disrupted-p53 function. Nutlin-3, a MDM2 antagonist, has antitumor activity in various cancers. The post-translational modifications of p53 are a hot topic, but there are some controversy ideas about the function of phospho-$Ser^{392}$-p53 protein in cancer cell lines in response to Nutlin-3. Therefore, we investigated the relationship between Nutlin-3 and phospho-$Ser^{392}$-p53 protein expression levels in SMMC-7721 (wild-type TP53) and HuH-7 cells (mutant TP53). We demonstrated that Nutlin-3 induced apoptosis through down-regulation phospho-$Ser^{392}$-p53 in two HCC cells. The result suggests that inhibition of p53 phosphorylation on $Ser^{392}$ presents an alternative for HCC chemotherapy.

• Journal of Korean Public Health Nursing
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• v.31 no.3
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• pp.505-517
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• 2017

Purpose: This study was conducted to investigate factors affecting the somatizationof 4th grade elementary school students in South Korea. Methods: The research used cross-sectional data of 2,031 first grade elementary school students that participated in 4th-year Korean Children and Youth Panel Survey (KCYPS). Data analysis, which included descriptive statistics, t-tests, one-way ANOVA, Pearson's correlation, and hierarchical regression,was performed using SPSS/WIN 23.0. Results: Aggression (r=0.60, p<.001) and depression (r=0.69, p<.001) showed significant positive correlation, while affection (r=-0.22, p<.001), reasonable explanation (r=-0.28, p<.001), peer relationship (r=-0.06, p=.001), and teacher relationship (r=-0.20, p<.001) were negatively correlated with somatization of elementary school students. Hierarchical regression analysis revealed that depression (${\beta}=0.52$, t=25.52, p<.001), aggression (${\beta}=0.27$, t=13.30, p<.001), reasonable explanation (${\beta}=0.05$, t=2.99, p=.002), and affection (${\beta}=0.04$, t=2.13, p=.031) were significant predictors of somatization. This regression model has an explanatory power of 52.8%. Conclusion: To reduce somatization, it is necessary to develop a therapeutic intervention to change student emotions into a positive coping mechanism and strategy. The results of this study will contribute to the development of programs and practices for healthy school life.

• Journal of the Korea Society of Computer and Information
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• v.29 no.2
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• pp.145-152
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• 2024

This study was conducted to investigate the effects of self-efficacy, major satisfaction, and clinical practice stress on the confidence in performing core nursing skills of nursing students. Data were collected through a structured questionnaire for 142 3,4th graders of K University's nursing department in Gyeongsangbukdo and analyzed using the SPSS/WIN 22.0 program. As a result of the study, the confidence in performing core nursing skills according to general characteristics showed a significant difference in grade(F=-2.08, p<0.05). Confidence in performing core nursing skills showed a significant positive correlation with self-efficacy(r=.50, p<.001) and major satisfaction(r=.62, p<.001), and factors influencing confidence in performing core nursing care were found to have 41.7% explanatory power with major satisfaction(β=.49, p=.002) and self-feeicacy(β=.24, p<.001). Based on the results of this study, it seems necessary to establish an educational strategy to improve the confidence in performing core nursing skills and to improve self-efficacy and major satisfaction.

• The Korean Journal of Pain
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• v.25 no.4
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• pp.267-271
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• 2012

The Nuss procedure for the correction of Pectus Excavatum (PE) is associated with intense postoperative pain. Our strategy to control early postoperative pain is to combine epidural with intravenous analgesia. Our aim was to analyse our pain control strategy by reviewing all the PE cases treated at our institution. Sixty consecutive patients, aged between 12 and 26 years old, received the PE operation at our institution from January, 2007 to September, 2010. The median age was 16 (12-27) with a male/female ratio of about 7/1. An epidural catheter was employed in all the cases, with 38 patients (63%) requiring additional drugs to control pain, which remained in place for 74 hours (72-96). The pain score was higher in male patients, but lower in those younger than 16 years old. Moreover, patients that consumed benzodiazepines had a significant decrease in cumulative opioid intake (P = 0.0408). Both gender and age had an impact on pain control, while we noticed a synergistic effect between opiates and tranquillizers.

• KSBB Journal
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• v.30 no.4
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• pp.166-174
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• 2015

In this study, an efficient whole cell-based biotransformation for the production of liquiritigenin was developed using Laetiporus sulphureus CS0218 as biocatalyst and aqueous extracts of Glycyrrhiza uralensis as co-substrate, respectively. In order to determine the efficacy of this method, the optimal bioconversion conditions including mycelial growth, three important enzyme activities (${\beta}$-glucosidase, ${\alpha}$-rhamnosidase and ${\beta}$-xylosidase), and apparent viscosity of culture broth were monitored. After optimization, aqueous extracts of G. uralensis were added to the culture medium to directly produce algycone liquiritigenin. By applying this strategy, 67.5% of liquiritin was converted to liquiritigenin at pH 3.0 after 9 days of incubation and finally liquiritigenin was purified from the reaction mixture. And then, their biological activities including anti-oxidant and superoxide dismutase were observed. In fact, purified liquiritigenin was capable of bi-directional functions (i.e., either up-regulation or down-regulation of SIRT1 which is associated with aging). The results indicate that this strategy would be beneficial to produce biologically active liquiritigenin and could be used in pharmaceutical, cosmetic and food applications.

• Journal of Power Electronics
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• v.15 no.4
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• pp.1093-1104
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• 2015

A standard repetitive controller (RC) is theoretically able to replace a bank of resonant controllers in harmonic signals tracking applications. However, the traditional RC has some drawbacks such as a poor dynamic response and a complex structure to compensate grid frequency deviations for an effective unified power quality conditioner (UPQC) control scheme. In order to solve these problems, an improved RC with an outstanding dynamic response and a simplified grid frequency adaptive scheme is proposed for UPQC control systems in this paper. The control strategy developed for the UPQC has delay time, i.e., one-sixth of a fundamental period (T_p/6), repetitive controllers. As a result, the UPQC system can provide a fast dynamic response along with good compensation performance under both nonlinear and unbalanced loads. Furthermore, to guarantee the excellent performance of the UPQC under grid frequency deviations, a grid frequency adaptive scheme was developed for the RC using a simple first order Padé's approximation. When compared with other approaches, the proposed control method is simpler in structure and requires little computing time. Moreover, the entire control strategy can be easily implemented with a low-cost DSP. The effectiveness of the proposed control method is verified through various experimental tests.

• Journal of the Korean Applied Science and Technology
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• v.40 no.3
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• pp.462-475
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• 2023

This study is descriptive research to identify the effect of COVID-19 stress on premenstrual syndrome in female college students and the mediating effect of depression and coping with premenstrual syndrome. The data were collected through an on-line survey for 20 days from November 11 to November 30, 2021, targeting female college students attending C College located in S city. As a result of analyzing a total of 161 data, COVID-19 stress was positively correlated with premenstrual syndrome(r=.383, p<.001) and depression(r=.436, p<.001), and coping with premenstrual syndrome had a positive correlation only in premenstrual syndrome(r=.190, p=.016). As a result of verifying the mediating effect of depression and coping with premenstrual syndrome between COVID-19 stress and premenstrual syndrome, COVID-19 stress had a significant direct effect on premenstrual syndrome(β=4.907, p=.002), and depression(β=6.780, p<.001), and depression had a significant direct effect on premenstrual syndrome(β=.383, p=<.001), coping with premenstrual syndrome had a direct effect on premenstrual syndrome(β=4.292, p=.030) respectively. The indirect effect of verifying the mediating effect in the relationship between COVID-19 stress and premenstrual syndrome confirmed that there was a statistically significant effect only in the path via depression(95% CI, 1.282 to 4.140). Therefore, it is necessary to develop an intervention strategy to reduce depression and alleviate premenstrual syndrome symptoms by controlling related stress, such as COVID-19 stress, in preparation for the outbreak of new infectious diseases and pandemic situations such as COVID-19.