• Bulletin of the Korean Chemical Society
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• 제29권12호
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• pp.2517-2520
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• 2008

• Bulletin of the Korean Chemical Society
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• 제29권8호
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• pp.1617-1620
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• 2008

• Bulletin of the Korean Chemical Society
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• 제29권2호
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• pp.511-514
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• 2008

• 약학회지
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• 제48권5호
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• pp.303-308
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• 2004

The synthesis of new 6-triazole exomethylenepenams was described. The 6,6-dibromopenam 5 was reacted with $CH_3$MgBr and substituted triazole 4 to afford the 6-bromo penicillanate 6, which was treated with acetic anhydride to give acetoxy compound 7. The deacetobromination of acetoxy compound 7 with zinc and acetic acid gave 6-exomethylene penams 8 and 9, which were oxidized to sulfones 10 and 11 by m-CPBA. The p-methoxybenzyl compounds 6-11 were deprotected by AlCl$_3$ and neutralized to give the sodium salts 12-17.

• Archives of Pharmacal Research
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• 제28권4호
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• pp.438-442
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• 2005

A series of 3-[1-(4-(2-methylpropyl) phenyl) ethyl]-1,2,4-triazole-5-thione (I) and its bicyclic condensed derivatives 6-benzylidenethiazolo[3,2-b]-1, 2,4-triazole-5(6H)-ones (IIa-IIf) were investigated for the prevention of ethanol-induced oxidative stress in liver and brain of mice. Administration of ethanol (0.1 mL/mice, p.o.) resulted in a drop of total thiol groups (T-SH) and non-protein thiol groups (NP-SH), and an increase in thiobarbituric acid reactive substances (TBARS) in both liver and brain tissue of mice (p<0.001). Among the compounds investigated (at a dose of 200 mg/kg, p.o.), I and IId ameliorated the peroxidative injury in these tissues effectively. Compounds IIa, IIc and IIe improved the peroxidative tissue injury only in brain. These findings suggest that certain condensed thiazolo-triazole compounds may contribute to the control of ethanol-induced oxidative stress in an organ selective manner.

• Bulletin of the Korean Chemical Society
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• 제27권10호
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• pp.1677-1680
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• 2006

• Bulletin of the Korean Chemical Society
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• 제30권10호
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• pp.2467-2470
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• 2009

• 생물환경조절학회지
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• 제16권3호
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• pp.205-209
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• 2007

공정육묘의 양질묘 생산을 목적으로 여름철 고온기 및 장마기, 겨울철 약광 등 환경조건의 영향을 받지 않고 묘의 도장을 억제하면서도 안정적으로 생육 및 수량을 확보할 수 있는 triazole계 생장조절제의 약제 선발, 처리량 및 처리시기를 구명하고자 수행하였다. 토마토 플러그묘에 트리아졸계 생장조절제 처리시 관행구에 비하여 초장 및 엽면적이 억제되었으며, 처리시기가 빠르고 처리량이 많을수록 억제효과가 컸다. 생육의 회복정도는 Hexaconazole 처리에서 정식 4주후 안정적으로 회복되었다. Diniconazole과 hexaconazole처리시 1화방의 착과높이가 낮아졌으며, 화방별 착과수는 관행구에 비하여 차이가 없었다.

• Bulletin of the Korean Chemical Society
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• 제35권5호
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• pp.1495-1500
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• 2014

Two new complexes with 5-methyl-1-(pyridine-3-yl)-1H-1,2,3-triazole-4-carboxylic acid (Hmptc) ligand: [$Cd(mptc)_2(H_2O)_4$] (1) and $[Cu(mptc)_4{\cdot}2H_2O]_n$ (2) were prepared and their crystal structures were determined by single crystal X-ray diffraction analyses. In complex 1, the Cd(II) ions coordinates with the pyridyl nitogen atom from the Hmptc ligand, forming a mononuclear Cd(II) compound. Complex 2 exhibits a novel two-dimensional (2D) polymer in which four Hmptc ligands stabilize the Cu(II) atom. And the coordination involves one nitrogen atom of the triazole, one oxygen atom of the carboxylic acid and the pyridyl nitrogen atom. In addition, FT-IR and solid-state fluorescent emission spectroscopy of two compounds have been determined.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.159-159
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• 1996

6-Substituted exomethylene 기를 갖는 penam계 화합물이 $\beta$-lactamase 억제제로서 강력한 활성을 보여주고 있어서, 6-exomethylene기 도입에 필요한 1-substituted thioalkyl-1,2,3-triazole-4-carboxaldehyde를 합성하였다. Haloalkanol에 NaN$_3$를 반응시켜서 합성한 azidoalkanol과 propargyl alcohol을 산화시킨 propargyl aldehyde를 반응시켜서 1-(2-hydroxyalkyl-1,2,3-triazole-4-carboxaldehyde을 얻었다. 이것을 trifluoromethanesulfonic anhydride와 triethylamine 존재 하에 mercapto 화합물과 반응시켜서 목적물을 합성하였다.