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Evaluation of the Response of Radiotherapy to Squamous Cell Carcinoma of the Head and Neck using $^{18}FDG-PET$ (두경부 편평상피세포암종에서 $^{18}FDG-PET$을 이용한 방사선치료 반응평가)

  • Lee Sang-Wook;Ryu Jin-Sook;Yi Byong-Yong;Kim Jong-Hoon;Ahn Seung-Do;Shin Seong-Soo;Kim Sang-Yoon;Nam Soon-Yuhl;Song Si-Yeol;Yoon Sang-Min;Park Jin-Hong;Kim Sung-Bae;Kim Jae-Seung
    • Korean Journal of Head & Neck Oncology
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    • v.19 no.1
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    • pp.58-62
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    • 2003
  • Purpose: To evaluate the efficacy of positron emission tomography with 2-[F-18] fluoro-2-deoxy-D-glucose in discrimination of response in the nasopharyngeal carcinoma patients who treated with radiotherapy. Methods and Materials: Twenty-four patients who underwent FDG-PET scan before and after radiotherapy for no disseminated head and neck carcinoma at the Asan Medical Center between August 2001 and September 2002 were evaluate by prospective analysis. First FDG-PET scan performed before radiotherapy within 1 month, and second FDG-PET scan performed 1 month after radiotherapy. FDG-PET images were analyzed by standard uptake value (SUV). Follow-up period was more than 6 months. Results: The pretreatment SUV was 3.4-14.0 (median: 6.0) and posttreatment SUV was ground level-7.7 (median: 2.0). The overall sensitivity and specicity of FDG-PET to evaluate residual tumors in the nasopharyngeal carcinoma patients were 94% and 94%. Conclusion: FDG-PET is effective in evaluation of radiation response in the nasopharyngeal carcinoma. We think that the timing of one month after finished radiotherapy FDG-PET scan was not too fast to evaluation of radiation response.

Red fluorescence of oral bacteria interacting with Porphyromonas gingivalis (Porphyromonas gingivalis가 일부 구강미생물의 형광 발현에 미치는 영향)

  • Kim, Se-Yeon;Woo, Dong-Hyeob;Lee, Min-Ah;Kim, Ji-Soo;Lee, Jung-Ha;Jeong, Seung-Hwa
    • Journal of Korean Academy of Oral Health
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    • v.41 no.1
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    • pp.22-27
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    • 2017
  • Objectives: Dental plaque is composed of 700 bacterial species. It is known that some oral microorganisms produce porphyrin, and thus, they emit red fluorescence when illuminated with blue light at a specific wavelength of <410 nm. Porphyromonas gingivalis belongs to the genus Porphyromonas, which is characterized by the production of porphyrin. The aim of this study was to evaluate red fluorescence emission of some oral microorganisms interacting with P. gingivalis. Methods: Five bacterial strains (P. gingivalis, Streptococcus mutans, Lactobacillus casei, Actinomyces naeslundii, and Fusobacterium nucleatum) were used for this study. Tryptic soy agar medium supplemented with hemin, vitamin K3, and sheep blood was used as a growth medium. The fluorescence emission of bacterial colonies was evaluated under 405 nm-wavelength blue light using a Quantitative Light-induced Fluorescence Digital (QLF-D) camera system. Each bacterium was cultured alone and co-cultured in close proximity with P. gingivalis. The red/green (R/G) ratio of fluorescence image was calculated and the differences of R/G ratio according to each growth condition were compared using the Mann-Whitney test (P<0.05). Results: Single cultured S. mutans, L. casei and A. naeslundii colonies emitted red fluorescence (R/G ratio=$2.15{\pm}0.06$, $4.31{\pm}0.17$, $5.52{\pm}1.29$, respectively). Fusobacterium nucleatum colonies emitted green fluorescence (R/G ratio=$1.36{\pm}0.06$). The R/G ratios of A. naeslundii and F. nucleatum were increased when P. gingivalis was co-cultured with each bacterium (P<0.05). In contrast, the R/G ratios of S. mutans and L. casei were decreased when P. gingivalis was co-cultured with each bacterium (P=0.002, 0.003). Conclusions: This study confirmed that P. gingivalis could affect the red fluorescence of other oral bacteria under 405 nm-wavelength blue light. Our findings concluded that P. gingivalis has an important role for red fluorescence emission of dental biofilm.

Evaluation of Surface Condition and Food Solution on the Color Stability of Dental Restoration Materials (표면 상태와 용액에 따른 치과용 수복재료의 색안정도 평가)

  • Woo, Hee-Sun;Kim, Hyo-Jin;Jun, Soo-Kyung
    • The Journal of the Korea Contents Association
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    • v.19 no.4
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    • pp.359-367
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    • 2019
  • For this study, specimens were prepared using five types of composite resin and resin-reinforced glass ionomer Fuji II LC, and 29 days precipitation was done in four kinds of solution, which were soy sauce, gochujang, wine, and distilled water. Ten specimens for each coloring sample were divided into two groups, one those surfaces was polyester film and the other with 1200-grit abrasive paper, and 20 specimens per materials. Color change (${\Delta}{\ast}ab$) in the colored specimens is measured in 2days, 7days, 14days and 29days using spectrophotometer (CM-2600d, Konica, Minolta, Ramsey, NJ). All values were considered significant when P<0.05. 1. Each material is discolored over time under the influence of different storage solutions. 2. In soy source, among the specimens polished with polyester film, color change was observed in resin-modified glass ionomer Fuji II LC, prodigy and compomer F-2000 on day 2. Meanwhile, Fuji II LC showed noticeable color change in specimens prepared with 1200-grit sandpaper on day 2, which was followed by flowable resin on day 7. 3. On day 2, there was a color change with the specimens of flowable resin, resin-modified glass ionomer Fuji II LC and Prodigy among the hybrid specimen in the groups of polyester film in gochujang.

Vitamin E improves antioxidant status but not lipid metabolism in laying hens fed a aged corn-containing diet

  • Ding, X.M.;Mu, Y.D.;Zhang, K.Y.;Wang, J.P.;Bai, S.P.;Zeng, Q.F.;Peng, H.W.
    • Animal Bioscience
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    • v.34 no.2
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    • pp.276-284
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    • 2021
  • Objective: The objective of this study was to determine whether a dietary vitamin E (VE) supplement could alleviate any detrimental effects of aged corn on lipid metabolism and antioxidant status in laying hens. Methods: The experiment consisted of a 2×3 factorial design with two corn types (normal corn and aged corn (stored for 4 yr) and three concentrations of VE (0, 20, and 100 IU/kg). A total of 216 Lohmann laying hens (50 wk of age) were randomly allocated into six treatment diets for 12 wk. Each treatment had 6 replicates of 6 hens per replicate. Results: The results show that aged corn significantly decreased the content of low-density lipoprotein cholesterol (p<0.05), and reduced chemokine-like receptor 1 (CMKLR1) mRNA expression (p<0.05) in the liver compared to controls. Diet with VE did not alter the content of crude fat and cholesterol (p>0.05), or acetyl-CoA carboxylase, lipoprotein lipase, fatty acid synthase or CMKLR1 mRNA expression (p>0.05) in the liver among treatment groups. Aged corn significantly increased the content of malondialdehyde (MDA) (p<0.05) and decreased superoxide dismutase (SOD) activity (p<0.05) in the liver. The VE increased the content of MDA (p<0.05) but decreased glutathione peroxidase (GSH-Px) activity in serum (p<0.01) and in the ovaries (p<0.05). Adding VE at 20 and 100 IU/kg significantly increased GSH-Px activity (p<0.05) in liver and in serum (p<0.01), 100 IU/kg VE significantly increased SOD activity (p<0.05) in serum. Aged corn had no significant effects on GSH-Px mRNA or SOD mRNA expression (p<0.01) in the liver and ovaries. Addition of 100 IU/kg VE could significantly increase SOD mRNA expression (p<0.01) in the liver and ovary. Conclusion: Aged corn affected lipid metabolism and decreased the antioxidant function of laying hens. Dietary VE supplementation was unable to counteract the negative effects of aged corn on lipid metabolism. However, addition of 100 IU/kg VE prevented aged corninduced lipid peroxidation in the organs of laying hens.

Optimal Management Scheme for Phosphorus Discharged from Public Sewage Treatment Plant Located in Upstream Basin of Paldang Lake (팔당호 상류수계에 위치한 공공 하수종말처리시설의 총인 배출 최적관리)

  • Woo, Younggug;Park, Eunyoung;Jeon, Yangkun;Jeong, Myungsuk;Rim, Jaymyung
    • Journal of Korean Society on Water Environment
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    • v.27 no.2
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    • pp.200-209
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    • 2011
  • The purpose of the study is to optimally manage sewage treatment plant with analysis of phosphorus contribution and improvement of water quality contributing rate in the effect of inflowing point of effluent and Pal-Dang lake after reducing T-P discharge from large scale public sewage treatment plant at upstream of Pal-Dang lake. Also, this study, for enforcement of T-P in effluent, plans optimal management of effluent T-P through examining propriety of environmental, technological, and economical aspect such as water quality standard of domestic and foreign T-P and related policy. In regarding optimal management of T-P discharged from public sewage treatment plant located in upstream of Pal-Dang lake, the study drew following conclusions. With the optimal management of public sewage treatment plant, it showed that a pollution level became higher in the order of Sumgang E in South-Han river, C in Dalcheon, B1 B2, A in North-Han river, and J in Kyungancheon, and it is required reduction of T-P first. The highest value in analysis of benefit-costs from sewage treatment plant in the selected research area was Kyungan B, and the others are with the order of Jojong A, Bokha A, Kyungan A, and Yanghwa A. With result of this study, all 14 areas are required more enforced phosphorus treatment. The study resulted that the most top priority areas were Hangang F, Sumgang B, and Gyungan A, top priority areas were Bokha A, Dalcheon B, and Cheongmi A, priority areas were Hangang E, Heukcheon A, Gyungan B, and Jojong A, and potential areas were Sumgang A, Yanghwa A, Dalcheon A, and Hangang D. It seems to be appropriate to apply 0.2 mg/L of T-P treatment for water supply source reservation, 0.5 mg/L for the other areas by locally, and 0.2~0.5 mg/L for biological nitrogen phosphorus treatment method and 0.5~1 mg/L for Conventional Activated Sludge by technologically. Also, it may be appropriate to apply 0.2 mg/L for the most top priority area(I), 0.3 mg/L for the top priority area(II), 0.4 mg/L for priority area(III), and 0.5 mg/L for potential area(IV) by the separation of priority area.

The Characteristics of Microbial Population Community Structure by an Addition of External Carbon Source in BNR Process for Low C/N Ratio Sewage Treatment (낮은 C/N비 하수의 외부 탄소원 주입에 따른 생물학적 질소제거에서 미생물 군집 구조특성)

  • Yoon, Cho-Hee
    • Journal of Korean Society of Environmental Engineers
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    • v.30 no.8
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    • pp.831-838
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    • 2008
  • This study investigated the characteristics of nitrogen removal and microbial community in a lab-scale A$_2$O activated sludge process filled with the fluidized media at an aerebic basin. The change of microbial community was monitored based on quinone profiles of activated sludge according to feeding sewage with/without external carbon source. Low C/N ratio(COD$_{Cr}$/T-N of 1.24) sewage was fed. The obtained results from this study were as follows; Ubiquinone(UQ) in the influent was in the descending order of UQ-8, UQ-10 and UQ-9. Menaquinone(MK) was simpler and much less than UQ. The ratio of UQ/MK was less than 0.41 and the dissimilarity was below 0.26. Without an external carbon source, MK-8 was the dominant species and there were 3 kinds of quinone species and low DQ and EQ values in an anaerobic basin. The ratio of UQ/MK increased to 2.3 in an anoxic basin. In an oxic basin, UQ-7 and UQ-8 were the dominant species. UQ-7 was dominating in suspended microorganisms, while UQ-8 was in attached microorganisms. With an external carbon source addition, MK-8 decreased but UQ-8 increased in an anaerobic basin. So did quinone species, DQ and EQ values. There was also a change in an anoxic basin with the improvement of denitrification. UQ-8 decreased instead, MK-7 and MK-8 increased. UQ/MK ratio decreased 2.3 to 1.4. It means that the dominant species change from Pseudomonas sp. to Bacillus and Micrococcus species. etc. In an oxic basin, UQ-8 replaced UQ-7 in suspended microorganisms and UQ-10 replaced UQ-8 in attached microbials. This seemed related with the growth of Nitrosomonas and Nitrobactor species.

Effect of Oral Health Education Practice and Self-efficacy of Teacher on Oral Health Attitude (교사의 구강보건교육 실천과 자기효능감이 구강보건교육 태도에 미치는 영향)

  • Cho, Young-Sik;Hwang, Yoo-Jin;Bae, Hyun-Sook;Kim, Seo yune
    • Journal of dental hygiene science
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    • v.9 no.1
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    • pp.99-108
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    • 2009
  • The purpose of this study was to investigate the effect of oral health education practice and schoolteacher's self-efficacy on oral health attitude. The data of 217 dental hygienists was subjected to path analysis using AMOS 16.0. Oral health knowledge, attitude, self-efficacy and oral health education practice of schoolteacher were measurement variables of three path models. The goodness of fitness of Knowledge-Attitude-Practice model and Knowledge-Attitude-Self efficacy -Practice model were acceptable. The regression weights of two models were statistically significant. Oral health education practice of schoolteacher gave impact on oral health attitude by mediation of self-efficacy of schoolteacher. Self-efficacy of schoolteacher was a important determinant of oral health education practice. Oral health attitude and practice were supposed to be mutual determinants of health behavior models.

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Molecular-epidemiologic study on outbreak of colonization by extended spectrum β-lactamase producing Klebsiella pneumoniae in neonatal intensive care unit (신생아 중환자실에서 extended spectrum β-lactamase를 생성하는 Klebsiella pneumoniae 집단 보균 발생의 분자 역학적 조사 및 추적관찰)

  • Jun, Nu-Lee;Kim, Mi-Na;Jeong, Jae-Sim;Kim, Yang-Soo;Kim, Ellen Ai-Rhan;Kim, Ki-Soo;Pi, Soo-Young
    • Clinical and Experimental Pediatrics
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    • v.49 no.2
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    • pp.150-156
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    • 2006
  • Purpose : The aims of this study included assessment of molecular-epidemiologic features during an outbreak of colonization of extended spectrum ${\beta}$-lactamase producing Klebsiella pneumoniae(ESBL-KPN) and re-evaluation of their colonized status one year later. Methods : Rectal swab cultures for ESBL-KPN from all hospitalized infants and newly admitted infants were obtained during the outbreak of colonization from July to December, 2000. The pattern of XbaI-digested chromosomal DNA of isolates were analyzed by pulsed-field gel electrophoresis. Weekly rectal swab cultures were obtained during the outbreak until patients were either discharged or decolonized. Patients discharged after being colonized had follow up stool cultures a year later. Results : A total of 80 patients(28.5 percent) were colonized. Of those, 53 whose pulsed-field gel electrophoresis(PFGE) was possible only once, were ESBL-KPN grouped into six cluster clones and 10 single clones : 28 patients(52.8 percent) were colonized with type A, the most common clone, followed by type B in 11 patients(20.8 percent). Of those 12 patients in whom serial PFGE was done more than twice, type A was predominant. Narrowed-down in strains occurred from types A, B, C, D and three single clones at initiation of the study into types A and type B after three months of strict infection control. Among 75 patients(93.7 percent) who were sent home after being colonized, 30 patients were re-called for stool cultures a year later : All of them were decolonized. Conclusion : This study demonstrates the importance of infection control as the diversity of ESBL-KPN strains could be narrowed into fewer strains. Colonization of ESBL-KPN could be reversed upon return to the community.

Studies on the Physical Properties of Major Tree Barks Grown in Korea -Genus Pinus, Populus and Quercus- (한국산(韓國産) 주요(主要) 수종(樹種) 수피(樹皮)의 이학적(理學的) 성질(性質)에 관(關)한 연구(硏究) -소나무속(屬), 사시나무속(屬), 참나무속(屬)을 중심(中心)으로-)

  • Lee, Hwa Hyoung
    • Journal of Korean Society of Forest Science
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    • v.33 no.1
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    • pp.33-58
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    • 1977
  • A bark comprises about 10 to 20 percents of a typical log by volume, and is generally considered as an unwanted residue rather than a potentially valuable resourses. As the world has been confronted with decreasing forest resources, natural resources pressure dictate that a bark should be a raw material instead of a waste. The utilization of the largely wasted bark of genus Pinus, Quercus, and Populus grown in Korea can be enhanced by learning its physical and mechanical properties. However, the study of tree bark grown in Korea have never been undertaken. In the present paper, an investigative study is carried out on the bark of three genus, eleven species representing not only the major bark trees but major species currently grown in Korea. For each species 20 trees were selected, at Suweon and Kwang-neung areas, on the same basis of the diameter class at the proper harvesting age. One $200cm^2$ segment of bark was obtained from each tree at brest height. Physical properties of bark studied are: bark density, moisture content of green bark (inner-, outer-, and total-bark), fiber saturation point, hysteresis loop, shrinkage, water absorption, specific heat, heat of wetting, thermal conductivity, thermal diffusivity, heat of combustion, and differential thermal analysis. The mechanical properties are studied on bending and compression strength (radial, longitudinal, and tangential). The results may be summarized as follows: 1. The oven-dry specific gravities differ between wood and bark, further more even for a given bark sample, the difference is obersved between inner and outer bark. 2. The oven-dry specific gravity of bark is higher than that of wood. This fact is attributed to the anatomical structure whose characters are manifested by higher content of sieve fiber and sclereids. 3. Except Pinus koraiensis, the oven-dry specific gravity of inner bark is higher than that of outer bark, which results from higher shrinkage of inner bark. 4. The moisture content of bark increases with direct proportion to the composition ratio of sieve components and decreases with higher percent of sclerenchyma and periderm tissues. 5. The possibility of determining fiber saturation point is suggested by the measuring the heat of wetting. With the proposed method, the fiber saturation point of Pinus densiflora lies between 26 and 28%, that of Quercus accutissima ranges from 24 to 28%. These results need be further examined by other methods. 6. Contrary to the behavior of wood, the bark shrinkage is the highest in radial direction and the lowest in longitudinal direction. Quercus serrata and Q. variabilis do not fall in this category. 7. Bark shows the same specific heat as wood, but the heat of wetting of bark is higher than that of wood. In heat conductivity, bark is lower than wood. From the measures of oven-dry specific gravity (${\rho}d$) and moisture fraction specific gravity (${\rho}m$) is devised the following regression equation upon which heat conductivity can be calculated. The calculated heat conductivity of bark is between $0.8{\times}10^{-4}$ and $1.6{\times}10^{-4}cal/cm-sec-deg$. $$K=4.631+11.408{\rho}d+7.628{\rho}m$$ 8. The bark heat diffusivity varies from $8.03{\times}10^{-4}$ to $4.46{\times}10^{-4}cm^2/sec$. From differential thermal analysis, wood shows a higher thermogram than bark under ignition point, but the tendency is reversed above ignition point. 9. The modulus of rupture for static bending strength of bark is proportional to the density of bark which in turn gives the following regression equation. M=243.78X-12.02 The compressive strength of bark is the highest in radial direction, contrary to the behavior of wood, and the compressive strength of longitudinal direction follows the tangential one in decreasing order.

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Relationship Between Standardized Precipitation Index and Groundwater Levels: A Proposal for Establishment of Drought Index Wells (표준강수지수와 지하수위의 상관성 평가 및 가뭄관측정 설치 방안 고찰)

  • Kim Gyoo-Bum;Yun Han-Heum;Kim Dae-Ho
    • Journal of Soil and Groundwater Environment
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    • v.11 no.3
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    • pp.31-42
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    • 2006
  • Drought indices, such as PDSI (palmer Drought Severity Index), SWSI (Surface Water Supply Index) and SPI (Standardized Precipitation Index), have been developed to assess and forecast an intensity of drought. To find the applicability of groundwater level data to a drought assessment, a correlation analysis between SPI and groundwater levels was conducted for each time series at a drought season in 2001. The comparative results between SPI and groundwater levels of shallow wells of three national groundwater monitoring stations, Chungju Gageum, Yangpyung Gaegun, and Yeongju Munjeong, show that these two factors are highly correlated. In case of SPI with a duration of 1 month, cross-correlation coefficients between two factors are 0.843 at Chungju Gageum, 0.825 at Yangpyung Gaegun, and 0.737 at Yeongju Munjeong. The time lag between peak values of two factors is nearly zero in case of SPI with a duration of 1 month, which means that groundwater level fluctuation is similar to SPI values. Moreover, in case of SPI with a duration of 3 month, it is found that groundwater level can be a leading indicator to predict the SPI values I week later. Some of the national groundwater monitoring stations can be designated as DIW (Drought Index Well) based on the detailed survey of site characteristics and also new DIWs need to be drilled to assess and forecast the drought in this country.