• ETRI Journal
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• v.28 no.2
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• pp.162-174
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• 2006

Several photogrammetric and geographic information system applications such as surface matching, object recognition, city modeling, environmental monitoring, and change detection deal with multiple versions of the same surface that have been derived from different sources and/or at different times. Surface registration is a necessary procedure prior to the manipulation of these 3D datasets. This need is also applicable in the field of medical imaging, where imaging modalities such as magnetic resonance imaging (MRI) can provide temporal 3D imagery for monitoring disease progression. This paper will present a general automated surface registration procedure that can establish correspondences between conjugate surface elements. Experimental results using light detection and ranging (LIDAR) and MRI data will verify the feasibility, robustness, and accuracy of this approach.

• Progress in Medical Physics
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• v.9 no.4
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• pp.207-215
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• 1998

There have been many radiation measurement methods so far among which film dosimetry, TLD, and ion chamber are the most frequently used methods. But this study describes a new radiation measurement method which uses polymer gel and magnetic resonance imaging(MRI). The objective of this study is to fabricate a polymer gel sensitive to radiation and to generate a dose to MRI contrast relationship, and to apply this results to the radiation measurement for the brachytherapy. To do this, 12 cm diameter cylindrical gel phantom was made, and the phantom was irradiated using the 30 mm diameter circular collimator which was used for radiosurgery. And this irradiated phantom was scanned with MRI. To find out the relationship between the radiation dose and the transversal relaxation time, an image processing software(IDL) was used. From this study it is found out that the radiation dose showed linear relationship to the transversal relaxation time of the gel up to 17 Gy($R^2$=0.993) and they had a different relationship above 17 Gy. The dose distributions were calculated using these results for the Ir-192 sources, one for the HDR afterloading system and the other for a 2 mCi seed source. And these calculated dose distributions were compared to the ones from the treatment planning computers. From this study the dose to the irradiated gel's transversal relaxation time relationship was examined, and this result was tried for the measurement of the brachytherapy.

• Journal of Biomedical Engineering Research
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• v.19 no.1
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• pp.91-100
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• 1998

In magnetic resonance imaging, the fast spin echo imaging technique is a widely used clinical imaging method. since its scanning time is much shorter than the conventional spin echo imaging and it gives the almost same image quality. However, the fast spin echo technique has two times longer imaging time for the dual echo acquisition which can obtain a spin density image and a T-give the same qulity images at the single echo imaging time. T he proposed technique reduces the imaging time by overlapping most of were obtained at the 0.3T permanent MRI system are presented.

• Journal of Biomedical Engineering Research
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• v.27 no.6
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• pp.318-322
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• 2006

The purpose of this study is to examine differences between 20s and 40s in visuospatial performance and brain activation areas using functional Magnetic Resonance Imaging (fMRI). Eight male college students in their twenties ($21.5{\pm}2.3$ years old) and six male adults in their forties ($45.7{\pm}2.6$ years old) who were graduated from college participated in the study. A visuospatial task was presented while brain images were acquired by a 3T fMRI system. Compared to the 20s the 40s showed lower visuospatial performance. There were more activations observed at the parietal and superior frontal areas at 20s compared to 40s. There were more activations observed at the middle frontal and occipital areas at 40s compared to 20s. The results of this study show that the lowering of visuospatial performance with aging was correlated to the decrease of activation area at the parietal lobe and the change of activation area at the frontal lobe.

• Journal of Biomedical Engineering Research
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• v.26 no.1
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• pp.1-7
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• 2005

This study aimed to investigate the hypothesis that administration of the air with 30% oxygen compared with normal air (21% oxygen) enhances cognitive functioning through increased activation in the brain. Seventeen college students (right­handed, average age of 24.3) were selected as subjects for this study. An oxygen supply equipment that provides 21% and 30% oxygen at a constant rate of 8L/min was developed. In order to measure the performance level of visuospatial and verbal cognition, two psychological tests were developed. The experiment consisted of two runs, one for cognition task with normal air (21% oxygen) and the other for cognition task with hyperoxic air (30% oxygen). Visuospatial and verbal tasks were presented while brain images were scanned by a 3T fMRI system using the single-shot EPI method. The results showed that there was an improvement in performance and also increased activation in several brain areas in the higher oxygen condition. These results suggest that while performing cognitive tasks, high concentrations of oxygen administration make oxygen administration sufficient, thus making neural network activate more, and the ability to perform cognitive tasks increase.

• Proceedings of the KSMRM Conference
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• 2002.11a
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• pp.104-104
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• 2002

목적： SAAV sequence를 이용하여 동시에 획득한 동맥과 정맥의 두 MRA 영상을 Color Mapping으로 동맥과 정맥을 구분하여 한 영상에 나타냄으로써 AVM 이나 DAVF 등과 같은 혈관질환의 임상적 진단 및 치료에 도움을 주고자 하였다. 대상 및 방법： 일반적으로 MRA 영상은 사전 포화방법(presaturation)을 이용한 2D TOF 기법을 통하여 동맥과 정맥을 구분하여 영상을 획득한다. 이러한 일반적인 사전포화방법을 응용한 SAAV 기법은 일정영역을 미리 포화(saturation)시킨 후 포화영역의 위, 아래의 영역을 한번에 영상화하여 동맥과 정맥의 구분된 영상을 한번에 획득할 수 있다. 마산 삼성병원의 0.3T MRI system(Megfinder, AILab. Korea)에서 SAAV sequence를 이용하여 정상적인 피험자로부터 목 부위의 동맥과 정맥 혈관영상을 동시에 얻었다. 이들의 각 2D 영상을 Color Mapping으로 조합한 후 Maximum Intensity Projection(MIP) 기법을 통해 3D Artery-Vein Color Mapping(AVCM) MRA 영상으로 재구성하였다. 3명의 피험자에 대한 SAAV MRA data를 256$\times$256$\times$64(resolution： 0.89$\times$0.89$\times$2㎣)로 획득하였다.

• Investigative Magnetic Resonance Imaging
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• v.18 no.1
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• pp.1-6
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• 2014

Purpose : $T_2{^*}$ relaxation time which includes susceptibility information represents unique feature of tissue. The objective of this study was to investigate $T_2{^*}$ relaxation times of the normal glandular tissue and fat of breast using a 3T MRI system. Materials and Methods: Seven-echo MR Images were acquired from 52 female subjects (age $49{\pm}12 $years; range, 25 to 75) using a three-dimensional (3D) gradient-echo sequence. Echo times were between 2.28 ms to 25.72 ms in 3.91 ms steps. Voxel-based $T_2{^*}$ relaxation times and $R_2{^*}$ relaxation rate maps were calculated by using the linear curve fitting for each subject. The 3D regions-of-interest (ROI) of the normal glandular tissue and fat were drawn on the longest echo-time image to obtain $T_2{^*}$ and $R_2{^*}$ values. Mean values of those parameters were calculated over all subjects. Results: The 3D ROI sizes were $4818{\pm}4679$ voxels and $1455{\pm}785$ voxels for the normal glandular tissue and fat, respectively. The mean $T_2{^*}$ values were $22.40{\pm}5.61ms$ and $36.36{\pm}8.77ms$ for normal glandular tissue and fat, respectively. The mean $R_2{^*}$ values were $0.0524{\pm}0.0134/ms$ and $0.0297{\pm}0.0069/ms$ for the normal glandular tissue and fat, respectively. Conclusion: $T_2{^*}$ and $R_2{^*}$ values were measured from human breast tissues. $T_2{^*}$ of the normal glandular tissue was shorter than that of fat. Measurement of $T_2{^*}$ relaxation time could be important to understand susceptibility effects in the breast cancer and the normal tissue.

• Journal of Biomedical Engineering Research
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• v.36 no.6
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• pp.241-250
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• 2015

Noninvasive temperature monitoring is feasible with Magnetic Resonance Imaging (MRI) based on temperature sensitive MR parameters such as $T_1$ and $T_2$ relaxation times, Proton Resonance Frequency shift (PRFs), diffusion, exchange process, magnetization transfer contrast, chemical exchange saturation transfer, etc. While the temperature monitoring is very useful to guide the thermal treatment such as RF hyperthermia or thermal ablation, the optimization of the MR thermometry method is essential because the range of temperature measurement depends on the choice of the measurement methods. Useful temperature range depends on the purpose of treatment methods, for example, $42^{\circ}C$ to $45^{\circ}C$ for RF hyperthermia and over $50^{\circ}C$ for thermal ablation. In this paper, MR thermometry methods using $T_1$ and $T_2$ relaxation times and PRFs-based MR thermometry are tried on a 3.0 T MRI system and their results are reported and compared. In addition, the scanning protocol and temperature calculation algorithms from $T_1$ and $T_2$ relaxation times and PRFs are optimized for the different temperature ranges for the purpose of RF hyperthermia and/or thermal ablation.

• Radiation Oncology Journal
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• v.11 no.1
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• pp.91-96
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• 1993

From September 1989 to June 1992,22 patients with nasopharyngeal carcinoma were treated in Asan Medical Center with an external beam of 60 Gy followed by a boost dose of 15 Gy HDR brachytherapy. There were 5 females and 17 males with median age of 44 years (range: 20-69 years). All patients were histologically confirmed and staged by physical examination, CT scan and/or MRI. By the AJCC TNM staging system, there were 2 patients with stge II (T2NO), 4 with stage III (T3NO, T1-3N1), and 16 with stage IV (T4 or N2-3). Four patients received chemotherapy with 5-FU and cisplatin prior to radiotherapy. All patients were followed up periodically by a telescopic examination and radiologic imaging study of CT scan or MRI with a median follow-up time of 13 months (range: 3-34 months). Twenty one patients showed a complete response ore month after completing therapy and one patient showed a complete response after three months. At the time of this analysis, seventeen patients remain alive without evidence of disease, but four patients developed distant metastasis and one patient died a month after treatment. The local control rate was $100{\%}$ in a median follow-up time of 13 months. The two year overall and disease free survival rates by the Kaplan-Meier method were $94{\%}$ and $67{\%}$, respectively. Serious radiation sequelae have not been observed yet. Although longer follow-up is needed, this retrospective analysis suggests that HDR brachytherap. given as a boost therapy for nasoharyngeal carcinoma may improve the local control. To reduce the incidence of distant metastasis, we need to develop a more effective systemic chemotherapy.

• Investigative Magnetic Resonance Imaging
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• v.5 no.2
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• pp.138-148
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• 2001

Purpose : Within a clinically acceptable time frame, we obtained the high resolution MR images of the human brain, knee, foot and wrist from 3T whole-body MRI system which was equipped with the world first 37 active shield magnet. Materials and Methods : Spin echo (SE) and Fast Spin Echo (FSE) images were obtained from the human brain, knee, foot and wrist of normal subjects using a homemade birdcage and transverse electromagnetic (TEM) resonators operating in quadrature and tuned to 128 MHz. For acquisition of MR images of knee, foot and wrist, we employed a homemade saddle shaped RF coil. Topical common acquisition parameters were as follows: matrix=$512{\times}512$, field of view (FOV) =20 cm, slice thickness = 3 mm, number of excitations (NEX)=1. For T1-weighted MR images, we used TR = 500 ms, TE = 10 or 17.4 ms. For T2-weighted MR images, we used TR=4000 ms, TE = 108 ms. Results : Signal to noise ratio (SNR) of 3T system was measured 2.7 times greater than that of prevalent 1.5T system. MR images obtained from 3T system revealed numerous small venous structures throughout the image plane and provided reasonable delineation between gray and white matter. Conclusion The present results demonstrate that the MR images from 3T system could provide better diagnostic quali\ulcorner of resolution and sensitivity than those of 1.5T system. The elevated SNR observed in the 3T high field magnetic resonance imaging can be utilized to acquire images with a level of resolution approaching the microscopic structural level under in vivo conditions. These images represent a significant advance in our ability to examine small anatomical features with noninvasive imaging methods.