• 제목/요약/키워드: 3T MRI System

검색결과 197건 처리시간 0.03초

기능적 자기공명영상의 언어기능검사 시 image를 이용한 자극방법의 타당성 연구 (A feasibility study on new stimulation method in fMRI language examinations using custom designed images)

  • 최관우;손순룡;정미애;민정환
    • 한국산학기술학회논문지
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    • 제12권11호
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    • pp.5005-5011
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    • 2011
  • 본 연구는 자기공명영상을 이용한 뇌 언어 인지기능의 영상화에 있어서 기존의 text를 이용한 자극방법의 단점을 개선하기 위하여 음절이나 단어에 부합하는 image를 자체 개발하여 적용함으로써 인지기능 영상화 구현의 타당성을 알아보고자 하였다. 연구대상은 2011년 3월부터 동년 5월까지 언어기능검사가 필요한 성인 5명을 대상으로 text를 이용한 자극방법과 text를 대체한 image를 이용한 자극방법으로 나누어 각각 3회 시행하였다. 실험 장비는 3.0T 초전도 자기공명영상장치와 Invivo사의 Eloquene를 이용하였고, EPI-BOLD 기법으로 기능적 자기공명영상을 획득하였다. 영상의 후처리는 SPM 99를 이용하여 각 자극별로 95%의 신뢰수준에서 활성화 신호를 결정하였고, 관심영역인 Broca's area의 활성화 cluster 수와 활성화도를 비교하였다. 연구결과, 5명 모두 관심 영역인 Broca's area에서 활성화를 보였으며, 활성화 cluster 수와 활성화도는 약간의 차이가 있었으나, 통계적 유의성은 없었다. 결론적으로 image를 이용한 자극방법은 언어장벽이 있더라도 image 자체가 쉽게 인지할 수 있는 공통된 인식표기 수단이고 단어나 음절보다 시각적 효과가 크므로 인지기능이 저하된 외국인이나 문맹자나 영유아, 장애자, 노약자 등의 검사시 text를 이용한 자극방법의 대체가 가능하리라 사료된다.

Acute Disseminated Encephalomyelitis Presenting as Rhombencephalitis: An Atypical Case Presentation

  • Hwang, Joonseok;Lee, A Leum;Chang, Kee Hyun;Hong, Hyun Sook
    • Investigative Magnetic Resonance Imaging
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    • 제19권3호
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    • pp.186-190
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    • 2015
  • Acute disseminated encephalomyelitis (ADEM) is a demyelinating and inflammatory condition of the central nervous system, occurring predominantly in white matter. ADEM involving the rhombencephalon without affecting the white matter is very rare. Here, we present an unusual case of ADEM involving only the rhombencephalon in a 4-year-old Asian girl. The patient complained of pain in the right lower extremities, general weakness, ataxia, and dysarthria. The initial brain CT showed subtle ill-defined low-density lesions in the pons and medulla. On brain MRI, T2 high signal intensity (T2-HSI) lesions with mild swelling were present in the pons, both middle cerebellar peduncles, and the anterior medulla. The initial diagnosis was viral encephalitis involving the rhombencephalon. Curiously, a cerebrospinal fluid (CSF) study revealed no cellularity, and negative viral marker findings. Three weeks later, follow up brain MRI showed that the extent of the T2-HSI lesions in the brain stem had decreased. After reinvestigation, it was found that she had a prior history of upper respiratory infection. In this case, we report the very rare case of a patient showing isolated involvement of the rhombencephalon in ADEM, mimicking viral rhombencephalitis on CT and MR imaging. ADEM can involve unusual sites such as the rhombencephalon in isolation, without involvement of the white matter or deep gray matter and, therefore, should be considered even when it appears in unusual anatomical areas. Thorough history taking is important for making a correct diagnosis.

The Feasibility of Event-Related Functional Magnetic Resonance Imaging of Power Hand Grip Task for Studying the Motor System in Normal Volunteers; Comparison with Finger Tapping Task

  • Song, In-Chan;Chang, Kee-Hyun;Han, Moon-Hee
    • 대한자기공명의과학회:학술대회논문집
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    • 대한자기공명의과학회 2001년도 제6차 학술대회 초록집
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    • pp.111-111
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    • 2001
  • 목적: To evaluate the feasibility of the event-related functional MR study using power grip studying the hand motor system 대상 및 방법: Event-related functional MRI was performed on a 1.5T MR unit in seven norm volunteers (man=7, right-handedness=2, left-handedness=5, mean age: 25 years). A single-shot GRE-EPI sequence (TR/TE/flip angle: 1000ms/40ms/90, FOV = 240 mm matrix= 64$\times$64, slice thickness/gap = 5mm/0mm, 7 true axial slices) was used for functiona MR images. A flow-sensitive conventional gradient echo sequence (TR/TE/flip angl 50ms/4ms/60) was used for high-resolution anatomical images. To minimize the gross hea motion, neck-holders (MJ-200, USA) were used. A series of MR images were obtained in axial planes covering motor areas. To exclude motion-corrupted images, all MR images wer surveyed in a movie procedure and evaluated using the estimation of center of mass of ima signal intensities. Power grip task consisted of the powerful grip of all right fingers and hand movement ta used very fast right finger tapping at a speed of 3 per 1 second. All tasks were visual-guid by LCD projector (SHARP, Japan). Two tasks consisted of 134 phases including 7 activatio and 8 rest periods. Active stimulations were performed during 2 seconds and rest period were 15 seconds and total scan time per one task was 2 min 14 sec. Statistical maps we obtained using cross-correlation method. Reference vector was time-shifted by 4 seconds an Gaussian convolution with a FWHM of 4 seconds was applied to it. The threshold in p val for the activation sites was set to be 0.001. All mapping procedures were peformed usin homemade program an IDL (Research Systems Inc., USA) platform. We evaluated the activation patterns of the motor system of power grip compared to hand movement in t event-related functional MRI.

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저자장 자기공명영상에서 위상-크기 결합 밀도 함수를 이용한 자동 불균일 자장 보정 물-지방 영상 기법 (Water-Fat Imaging with Automatic Field Inhomogeneity Correction Using Joint Phase Magnitude Density Function at Low Field MRI)

  • 김판기;안창범
    • Investigative Magnetic Resonance Imaging
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    • 제15권1호
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    • pp.57-66
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    • 2011
  • 목적 : 0.35 Teslas의 저자장 자기공명영상 시스템에서 인체 조직의 물 성분 또는 지방 성분의 영상을 얻는데 있어서 주자장의 불균일도를 two-point Dixon 방법을 기반으로 보정하는 새로운 방법을 모색하였다. 대상 및 방법 : Two-point Dixon 방법을 사용하여 물과 지방의 위상이 동상일 때와 역상일 때의 영상들을 얻은 후 그 영상들로부터 위상과 크기의 위상 크기 결합 밀도 함수를 계산하고, 이를 통해 물과 지방의 영역을 분리하여 3차원 볼륨의 물 영역에서의 주자장의 불균일도 패턴을 분석하고 이를 반복적으로 보정하여 주자장의 불균일도를 개선하였다. 결과 : 제안한 영상 기법으로 인체의 여러 부위에서 주자장의 불균일도를 보정한 물과 지방 영상을 얻을 수 있었다. 삼차원 보정을 통하여 멀티 슬라이스 전체 영상에서 균일하게 물 또는 지방만의 영상을 얻을 수 있었다. 결론 : 위상-크기 결합 밀도 함수를 통하여 물과 지방의 영역을 분리할 수 있었고, 이를 이용하여 자장의 불균일도를 분석하고 보정할 수 있었다. 제안한 방법을 통해 주자장의 불균일도가 월등히 개선된 물 또는 지방 영상을 얻을 수 있었다.

Biases in the Assessment of Left Ventricular Function by Compressed Sensing Cardiovascular Cine MRI

  • Yoon, Jong-Hyun;Kim, Pan-ki;Yang, Young-Joong;Park, Jinho;Choi, Byoung Wook;Ahn, Chang-Beom
    • Investigative Magnetic Resonance Imaging
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    • 제23권2호
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    • pp.114-124
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    • 2019
  • Purpose: We investigate biases in the assessments of left ventricular function (LVF), by compressed sensing (CS)-cine magnetic resonance imaging (MRI). Materials and Methods: Cardiovascular cine images with short axis view, were obtained for 8 volunteers without CS. LVFs were assessed with subsampled data, with compression factors (CF) of 2, 3, 4, and 8. A semi-automatic segmentation program was used, for the assessment. The assessments by 3 CS methods (ITSC, FOCUSS, and view sharing (VS)), were compared to those without CS. Bland-Altman analysis and paired t-test were used, for comparison. In addition, real-time CS-cine imaging was also performed, with CF of 2, 3, 4, and 8 for the same volunteers. Assessments of LVF were similarly made, for CS data. A fixed compensation technique is suggested, to reduce the bias. Results: The assessment of LVF by CS-cine, includes bias and random noise. Bias appeared much larger than random noise. Median of end-diastolic volume (EDV) with CS-cine (ITSC or FOCUSS) appeared -1.4% to -7.1% smaller, compared to that of standard cine, depending on CF from (2 to 8). End-systolic volume (ESV) appeared +1.6% to +14.3% larger, stroke volume (SV), -2.4% to -16.4% smaller, and ejection fraction (EF), -1.1% to -9.2% smaller, with P < 0.05. Bias was reduced from -5.6% to -1.8% for EF, by compensation applied to real-time CS-cine (CF = 8). Conclusion: Loss of temporal resolution by adopting missing data from nearby cardiac frames, causes an underestimation for EDV, and an overestimation for ESV, resulting in underestimations for SV and EF. The bias is not random. Thus it should be removed or reduced for better diagnosis. A fixed compensation is suggested, to reduce bias in the assessment of LVF.

복류(復溜)(K7) 전침자극(電鍼刺戟)이 functional MRI상 뇌기능(腦機能) 변화(變化)에 미치는 영향(影響) (A fMRI study on the cerebral activity induced by Electro-acupuncture on K7(Fuliu))

  • 강재희;이현;이병렬;홍권의;임윤경;김연진
    • Journal of Acupuncture Research
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    • 제20권4호
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    • pp.66-84
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    • 2003
  • Objectve : Recent stuides suggested that there is a strong correlation between acupuncture stimulation and its cortical activation. Another study showed that either positive or negative BOLD effects could be observed depending on anatomical structure in acupuncture. Methods : 1) Subjects and paradigms: Two separate stimulation paradigms were performed in this study. To see the effects of electro-acupuncture stimulation on K7(Fuliu), the experiment was carried out on six healthy volunteers, using the gradient echo sequence with the 3.0T whole-body MRI system(ISOL). After the needle insertion on right K7(Fuliu), 2 Hz of electric stimulation was given for 30 seconds, repeated five times, with 30 seconds' intervals. During the intervals while there was no electro-stimulation, the subjects performed motor task as a reference. The image analysis including motion correction, talairach transformation, and smoothing was done using SPM99. Results: The electro-acupuncture stimulation on K7(Fuliu) activated Brodmann's Areas of 9, 19, 23, 24, 31, 32, 39 which may be the central pathways of the electro-acupuncture stimulation on K7(Fuliu) and those brain areas may be related with the function of the electro-acupuncture stimulation on K7(Fuliu).

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컴퓨터 단층촬영, 자기공명영상, 뇌혈관촬영을 이용한 정위적 수술시스템의 개발 (Development of Stereotactic Surgery system with CT, MR Imaging, and Angiography)

  • 김성현;서태석
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1998년도 추계학술대회
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    • pp.117-118
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    • 1998
  • The aim of this work is to develop 3-D stereotactic localization system in order to determine the precise shape, size and location of the lesion in the brain in the field of Stereotactic Radiosurgery(SRS) and neurosurgery using CT/MRI/angiography and multi-purpose QA phantom. The algorithms to obtain a 3-D stereotactic coordinates of the target have been developed, and targets on each CT image were superimposed each other on MR/angiography images without distortion corretion. This system was implented in Visual C++ as a PC-based application program.

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IBASPM을 이용한 해마체적 측정에서 뇌 Atlases에 대한 고찰 (A Study of brain Atlases in Hippocampus Volume Measurement Using IBASPM)

  • 김주호;이주원;김성후
    • 한국정보통신학회:학술대회논문집
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    • 한국정보통신학회 2014년도 추계학술대회
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    • pp.981-984
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    • 2014
  • IBASPM(Individual Brain Atlases using Statistical Parametric Mapping Software)를 이용하여 해마의 체적 측정시, Atlas의 종류(Atlas69, Atlas71, Atlas84, Atlas116)에 따른 체적의 변화를 평가하기 위해 20대 정상 성인 10명(남5/여5, $23.3{\pm}2.66$)으로부터 뇌 영상을 획득하였다. 1.5T MRI system(Siemens, Avanto, Erlangen, Germany)의 머리 격자코일(Head matrix coil)을 사용하여 3차원 경사에코 펄스 열(3-D gradient echo pulse sequence)인 MPRAGE(Magnetization Prepared Rapid Acquisition Gradient Echo)영상을 획득하였다. Atlas의 종류에 따라 획득된 해마의 체적을 이용하여 대응표본 t 검정(Paired t-test)을 수행한 결과, 좌측 해마옆이랑(parahippocampal gyrus - left) Atlas69-Altas84, Atlas69-Atlas116(p=0.729, 0.729), 우측 해마형성체(hippocampal formation - right) Atlas69-Atlas84, Atlas69-Atlas116(p=0.219, 0.219)는 유의한 차이가 없었으며, 이를 제외한 부분에서 유의한 차이가 있었다(p=0.000). 그러고 Atlas84와 Atlas116을 이용한 해마의 체적은 모두 동일한 값을 나타내어 유의한 차이가 없었다(p=0.000). Atlas영상과 원본 영상의 overlay를 이용한 영상분석에서는 Atlas71에서만 해마의 부위가 잘 못 정합되는 것을 발견할 수 있었다. 본 연구에 사용된 Atlas의 경우에는 서양인을 바탕으로 개발되었기 때문에 동양인의 뇌와는 차이가 있으며, 정확성 높은 체적의 측정을 위해서는 상황에 맞는 Atlas의 개발이 필요할 것으로 사료된다.

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CT 보험급여 전후의 CT 및 MRI검사의 이용량과 수익성 변화 (Analysis of utilization and profit for CT and MRI after implementation of insurance coverage for CT)

  • 서종록;유승흠;전기홍;남정모
    • 한국병원경영학회지
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    • 제2권1호
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    • pp.1-21
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    • 1997
  • In order to analyze the shifts in the volume and profits of Computed Tomography(CT) and Magnetic Resonance Imaging(MRI) utilization for a year before and after the implementation of insurance coverage for CT, this study has been undertaken examining CT and MRI cost data from 'Y' University Hospital situated in Seoul, Korea. Following are the results of this study: 1. The medical insurance payment for CT, implemented on January 1, 1996, increased CT utilization from January 1996 to April 1996 due to low insurance premiums: however, from May 1996 the number of CT cases significantly decreased as a result of strengthened medical cost reviews and the new 'Detailed standards for approval of CT' announced near the end of April 1996 by the insurer. 2. Since the implementation of insurance coverage for CT, CT fee reduction rates for reimbursements by the insurer to the hospital were 50% and 40% for January and February, respectively, and 31% and 15% for March and April. A significant point in the lowering of the reduction rate was reached in May at 11%; furthermore, since June the reduction rate fell below the average reduction rate for reimbursements for all procedures. If the 'Detailed standards for approval of CT' had been announced before the implementation of insurance coverage for CT, CT utilization would not have been so high due to the need to meet those 'standards'. In addition, loss of hospital profits resulting from the reduction for reimbursements would not have occurred. 3. The shifts in MRI utilization showed that there was no particular change with the beginning of insurance coverage for CT, and the introduction of the 'Detailed standards for approval of CT' made MRI utilization increase because MRI is free of restrictions imposed by the insurer. 4. The relationship between CT utilization and MRI utilization showed that they were supplementary to each other before insurance coverage for CT, but that CT was substituted for MRI because of strengthened medical cost reviews after t~e beginning of insurance coverage for CT. 5. The shifts in volume by patient characteristics showed that the number of inappropriate case patients, according to the insurer's "Standards for approval", decreased more than the number of appropriate case patients after the introduction of insurance coverage for CT. Therefore, the health insurance fee schemes for CT have influenced patient care. 6. The shifts in profits from CT utilization showed a net profit decrease of 31.6%. In order to match the pre-coverage profit level, 5,471 more cases would need to be seen and productivity would need to be increased by 32.7%. This profit decrease resulted from a decrease of CT utilization and low reimbursements. With insurance coverage, net profits from CT were 24.4%, and a margin of safety ratio was 39.6%. Because of the net profits and margin of safety ratio, CT utilization fees for insured appropriate cases could not be considered inappropriate. 7. The shifts in profits from MRI utilization before and after the introduction of CT coverage showed that in order to match pre-CT coverage profit levels, 2,011 more cases would need to be seen and productivity would need to be increased by 9.2%. The reasons for needing to increase the number of cases and productivity result from cost burdens created by adding new MRI units. But with CT coverage already begun, MRI utilization increased. Combined with a minor increase in the MRI fee schedule, MRI utilization showed a net profit increase of 18.5%. Net profits of 62.8% and a 'margin of safety ratio' of 43.1% for MRI utilization showed that the hospital relied on this non-covered procedure for profits. 8. The shifts in profits from CT and MRI utilization showed the net profits from CT decreased by 2.33billion Won while the net profits from MRI increased by 815.7million Won. Overall, these two together showed a net profit decrease of 1.51billion Won. The shifts in utilization showed a functional substitutionary relationship, but the shifts in profits did not show a substitutionary relationship. From these results, We can conclude that if insurance is to be expanded to include previously uncovered procedures using expensive medical equipment, detailed standards should be prepared in advance. The decrease in profits from the shifts in coverage and changes in fees is a difficult burden that should be shared, not carried by the hospital alone. Also, a new or improved fee schedule system should include revised standards between items listed and the appropriateness of the fee schedule should constantly be ensured. This study focused on one university hospital in Seoul and is therefore limited in general applicability. But it is valuable for considering current issues and problems, such as the influence of CT coverage on hospital management. Future studies will hopefully expand the scope of the issues considered here.

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3.0T MREIT 시스템을 위한 정전류원의 설계 및 성능검증 (Design and Performance Analysis of Current Source for 3.0T MREIT System)

  • 김규식;오동인;백상민;오석훈;우응제;이수열;이정한
    • 대한의용생체공학회:의공학회지
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    • 제25권3호
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    • pp.165-169
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    • 2004
  • 본 논문에서는 자기공명 임피던스 단층촬영기(MREIT, magnetic resonance electrical impedance tomography)에서 인체에 일정한 전류를 주입해주는 전류주입장치의 설계 및 성능 검증을 다루었다. MREIT는 인체에 전류를 주입하고, 주입전류에 의해 유기된 인체내부의 자속밀도 분포와 인체표면의 전압을 측정하여, 내부의 도전율 분포를 영상화하는 임피던스 영상기술이다. DSP(digital signal processor)를 기반으로 전류주입장치를 설계하였고, 극성을 가지는 펄스 형태로 전류를 주입할 수 있도록 하였다. 3.0T MREIT 시스템의 펄스열(pulse sequence)과 주입전류 파형이 동기화 되도록 제어하였고, 펄스의 폭과 크기를 변경할 수 있도록 하였다. 또한 계측용 증폭기를 사용하여 주입전류에 의해 유기된 전압을 측정하였다. 이러한 모든 기능은 DSP와 직렬통신으로 연결되는 PC가 제어하며 제어용 프로그램은 현재 주입되고 있는 전류의 크기와 파형을 모니터링 할 수 있도록 하였다. 본 논문은 이러한 전류주입장치의 설계와 구현을 기술하며, 전해질 용액 팬텀을 사용한 실험결과를 통한 성능의 분석을 다룬다.