• Bulletin of the Korean Chemical Society
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• v.30 no.7
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• pp.1531-1534
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• 2009

(2S,3R)-3-Hydroxy-2-(hydroxymethyl)-3,6-dihydro-2H-pyridine 8, an important precursor for the synthesis of polyhydroxylated piperidine azasugars, has been prepared from L-serine. Highly stereoselective nucleophilic addition to amino aldehyde 5 gave the corresponding allylic alcohol 6 which proceeded to give dihydro-2H-piridine 7a via a Grubbs II catalyzed RCM. Stereoselective H-bond directed epoxidation of allylic alcohol led to the oxiranyl alcohol 9 which was easily converted to L-deoxyaltronojirimycin by regioselective ring opening.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.19 no.1
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• pp.40-45
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• 1983

The paper describes an experimental investigation of axisymmetric diesel spray and flame which is held in rapid compression machine (RCM) with electromagnetic single injection nozzle. The axisymmetric diesel spray and flame are taken with high speed photograph and analysis it with image processor. The data presented include fuel concentration of spray, flame temperature, soot concentration of flame in axial and radial direction at a moment and compared it with each other.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.183.3-183.3
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• 2003

Phenanthroindolizidine alkaloid, (-)-antofine has attracted attention because of its extremely potent inhibition of cancer cell growth (Its $IC_50$ values have the low nanomolar range). The frist asymmetric total synthesis of (-)-antofine is described. An important feature of this synthesis is the creation of a stereogenic center by enantioselective alkylation using the phase transfer catalyst (PTC) and ring-closing metathesis (RCM) for pyrrolidine ring construction. This synthesis is efficient to allow the asymmetric preparation of other naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloid.

• Journal of Korea Water Resources Association
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• v.51 no.5
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• pp.395-404
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• 2018

This research evaluated the change in rainfall quantile during S1, S2, and S3 by using Representative Concentration Pathways (RCP) 4.5 climate scenario HadGEM3-RA Regional Climate Model (RCM) produced by downscaling and bias correlation compared to the past standard observation data S0. Also, the maximum flood peak volume and flood area were calculated by using the urban runoff model and the impact of climate change was analyzed in each period. For this purpose, Gumbel distribution was used as an appropriate model based on the method of maximum likelihood. As a result, in the case of the 10 year-frequency which is the design of most urban drainage facilities, the rainfall quantile is in increased about 10% if we assume 50 years from now with the $3^{rd}$ quarter value and about 20% if we assume 70 years from now. This result implies that the installed urban drainage facility based on the currently set design flood volume cannot be met the design criteria in the future. Therefore, it is necessary to reflect future climate conditions to current urban drainage facilities.

• Korean Journal of Food Science and Technology
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• v.53 no.6
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• pp.775-784
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• 2021

After isolating the DIMO 52 strain with a large inhibition zone diameter for Clostridium perfringens and maximum butyric acid production from the fecal sample of a breastfeeding infant, it was identified as Clostidium butyricum. The maximum growth of the DIMO 52 strain was reached 24 h after inoculation, and the maximum butyric acid concentration was approximately 34.73±4.27 mM. The DIMO 52 strain survived approximately 67.5% of the initial inoculum at pH 2.0, and approximately 64.9% survived in RCM broth supplemented with 0.3% (w/v) oxgall. In addition, DIMO 52 showed antibacterial activity against Escherichia coli KCTC 2441 and Salmonella Typhimurium KCTC 1925. In LPS-stimulated RAW264.7 cells, 1×10³ CFU/mL viable cells of the DIMO 52 strain also exhibited significant NO (nitric oxide) production inhibitory activity (33%, p<0.01). This result suggests that C. butyricum DIMO 52 has anti-inflammatory activity related to NO radical-scavenging activity. In conclusion, C. butyricum DIMO 52 isolated in this study has the potential to be used as a probiotic.

• Journal of Korea Water Resources Association
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• v.49 no.2
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• pp.107-119
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• 2016

Since future climate scenarios indicate that extreme precipitation events will intensity, probable maximum precipitations (PMPs) without being taken climate change into account are very likely to be underestimated. In this study future PMPs in accordance with the variation of future rainfall are estimated. The hydro-meteorologic method is used to calculate PMPs. The orographic transposition factor is applied in place of the conventional terrain impact factor which has been used in previous PMPs estimation reports. Future DADs are indirectly obtained by using bias-correction and moving-averaged changing factor method based on daily precipitation projection under KMA RCM (HEDGEM3-RA) RCP 8.5 climate change scenario. As a result, future PMPs were found to increase and the spatially-averaged annual PMPs increase rate in 4-hour and $25km^2$ was projected to be 3 mm by 2045. In addition, the increased rate of future PMPs is growing increasingly in the future, but it is thought that the uncertainty of estimating PMPs caused by future precipitation projections is also increased in the distant future.

• Bulletin of the Korean Chemical Society
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• v.32 no.4
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• pp.1146-1152
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• 2011

The discovery of 2'-spirocyclopropyl-ribocytidine (J. Med. Chem. 2010, 53, 8150-8160) as a potent inhibitor of RNA synthesis by NS5B ($IC_{50}=7.3{\mu}M$), the RNA polymerase encoded by hepatitis C Virus (HCV), has led to the synthesis and biological evaluation of several carbocyclic versions of 2'-spiropropyl-nucleosides. The cyclopentenol intermediate 7 was successfully constructed via ring-closing metathesis (RCM) from divinyl 6. Spirocyclopropanation of enone 8 was effected by using (2-chloroethyl)-dimethylsulfonium iodide and potassium tert-butoxide to form the desired intermediate 9. The synthesized nucleoside analogues 21-24 were assayed for their ability to inhibit HCV RNA replication in a subgenomic replicon Huh7 cell line. Among them, the cytosine nucleoside analogue 22 exhibited significant anti-HCV activity ($EC_{50}= 8.2{\mu}M$).

• Bulletin of the Korean Chemical Society
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• v.32 no.2
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• pp.411-416
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• 2011

Steric and electronic parameters of 4'-substituents play significant roles in steering the conformation of nucleoside analogues. In order to investigate the relationship of 4'-group with antiviral enhancement, novel 4'-hydroxymethyl-5'-norcarbocyclic adenosine phosphonic acid analogues were designed and synthesized from 2,2-dimethyl-1,3-dioxolane-4-ethanol (5) using reiterative Grignard addition and ring-closing metathesis (RCM) as key reactions. The synthesized adenosine phosphonic acids analogues (22) and (23) were subjected to antiviral screening against HIV-1. Compound (23) exhibited moderate anti-HIV activity ($EC_50$ = 8.61 ${\mu}M$) in the CEM cell line.

• KCI Concrete Journal
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• v.11 no.3
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• pp.99-107
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• 1999

In designing the Prestressed concrete box-girder bridge. dead load, prestressing force, creep and shrinkage of concrete are the main factors which influence the camber and deflection of segmental concrete structure under construction. Among these factors the creep and shrinkage are the functions of the time-dependent property which. therefore, must be considered with time. The prediction model for estimating creep and shrinkage of concrete has been suggested by ACI, CEB/FIP, JSCE and KSCE design code and EMM, AEMM, RCM, IDM and SSM has been suggested for analytical method in consideration of time-dependent characteristics. In this study the creep test was carried out for four different curing ages of concrete which were applied to the Prestressed concrete structure at the construction site, and the results of test were compared with the values of creep prediction proposed by the design code. Also the creep test was performed with step-wise incremental stresses and the results were compared to the analytical values.

• International Journal of Railway
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• v.3 no.1
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• pp.34-37
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• 2010

In recent, the railway system consists of subsystems as rolling stock and infrastructures as signaling, telecommunication, power supply, overhead contact and platform screen door, etc. Furthermore, each subsystem has complicated interface so as not to understand these relationship. Consequently, to operate the railway system continuously with required safety and availability, the failure data should be corrected and analyzed systematically during operation. To achieve this object effectively, this paper presents the method which is evaluating the operational risk quantitatively using failure data, and selecting the critical equipment. Following this analysis, the improvement plan is established and applied to reduce the operational risk on system or equipment. From this study, the critical equipments of system could be determined and prioritized by risk analysis. Also, the effective maintenance to prevent critical failure could be implanted by this suggested methodology.