• 약학회지
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• 제41권6호
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• pp.829-836
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• 1997

Studies on the effect of quinones on cardiac function has been conducted with normal hearts. But not with injured hearts, I.e. ischemia/reperfusion-injured heart. Quinone compounds are known to produce oxygen free radicals during metabolism, and for this reason, quinones are implicated in the aggravation of ischemia/reperfusion injury or cardioprotection, as in the case of ischemic preconditioning depending on the experimental conditions. The present study was carried out to examine the effect of 2-chloro-3-(4-cyanophenylamino)-1.4-naphthoquinone (NQ-Y15) on cardiac function of ischemic/reperfused and normal rat hearts. In isolated perfused hearts, various functional parameters such as left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (EDP) and maximum positive and negative dP/dt ($[\pm}dP/dt_{max}$), time to contracture, heart rate (HR) and coronary flow rate (CFR) were measured before and 30 min after dosing and following 25 min ischemia/30min reperfusion. NQ-Y15 increased LVDP, +dP/$d_{max}$and -dP/$dt_{min}$ by 18%. 30%, and 40%, respectively. There were no significant changes in other haemodynamic parameters. After ischemia/reperfusion injury, pretreatment with NQ-Y15 induced a significant decrease in LVDP and $[\pm}dP/dt_{max}$, but an increase in EDP. LDH-release was not significantly increased. These results suggested that NQ-Y15 may augment the ventricular contractility but it makes hearts more vulnerable to ischemia/reperfusion injury.

• 한국농공학회지
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• 제15권1호
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• pp.2853-2877
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• 1973

Models of cross-sections and channels were made in order to measure seepage losses. Cross-sections were made of sand, sandy clay loam and loam, their thicknesses being 30cm and 40cm, respectively. Flow depths kept in the cross-sections were 4cm, 6cm, 8cm and 10cm. Straight and curved channel models were provided so as to measure seepage losses, when constant water depths maintained at the heads of the channels were 7.3cm and 5.7cm, respectively. The results obtained in this experiment are presented as follows: 1) A cumulative seepage loss per unit length at a point in the channel varies in accordance with time and flow depth. The general equation of cumulative seepage loss may be as follows(Ref. to Table V.25): $$q_{cum}=\int_{o}^aq(a)dt+\int_a^bq(b)dt+\int_b^tq(c)dt$$ 2) In case that the variation of water depth through the channel is slight, the total seepage loss may be computed by applying the following general equation: $$\={q}_{cum}{\cdot}x=\int_o^tq_{cum}\frac{{\partial}x}{{\partial}t}dt$$ 3) Because seepage loss varies considerably according to water depth in case that the variation of flow depth through the channel is great, seepage loss should be computed by taking account of the change of flow depth. 4) The relation between time and traveling distance of water flow may be presented as the following general equation(Ref. to Table V.29): $$x=pt^r$$ 5) The ratios of the seepage losses of the straight channel to the curved channel are 1:1.03 for a flow depth of 7.3cm and 1:1.068 for that of 5.7cm. 6) The ratios of the seepage losses occurring through the bottom to those through the inclined plane in the channel cross-section are 1:2.24 for a water depth of 8cm and 1:2.47 for a depth of 10cm in case that soil-layer is 30cm in thickness. Similarly, those ratios are 1:2.62 and 1:2.93 in case of a soil-layer thickness of 40cm(Ref. to Table V.5).

• 구강회복응용과학지
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• 제33권4호
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• pp.260-268
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• 2017

목적: 치과 보철물을 적층 가공 기술로 제작하는 것은 많은 이점이 있으나 아직까지 연구 결과 부족으로 인하여 임상에서 널리 적용되고 있지 못하는 실정이다. 이 연구에서는 디지털 광학 기술 방식의 적층 가공 기술을 이용하여 제작한 치과 보철물에 있어서 재료에 따라 굴곡강도에 유의한 차이가 있는지 연구하기로 한다. 연구 재료 및 방법: 3유닛 고정성 보철 형태의 시편 제작을 위한 금속 지그를 제작하였다. 지그에 맞게 시편을 디자인하였다. 디자인 한 시편에 대하여 NC, DP-1, DT-1의 세 가지 재료로 디지털 광학 기술 방식의 출력을 하였다. 각 재료마다 5개의 시편을 제작하되 출력 각도를 수평면에 $30^{\circ}$로 하였다. 시편을 지그 위에 안착시키고 만능시험기로 굴곡강도를 측정하고 기록하였다. 기록한 데이터는 SPSS 상에서 일원배치분산분석법을 통하여 재료에 따른 파절 강도 차이의 유의성을 조사하였다. 사후 검정(Tukey Honestly Significant Difference test)은 그룹 간의 통계적 차이를 비교하여 시행되었으며 통계적 유의수준은 0.05로 하였다. 결과: 각 군들의 굴곡강도는 NC군은 $1119{\pm}305N$로 나타났고 DP-1군은 $619{\pm}150N$, DT-1군은 $413{\pm}65N$로 측정되었다. SPSS를 사용한 일원배치분산분석법 및 Tukey HSD에서는 NC와 DP-1, NC와 DT-1사이에 유의한 차이를 보였으며(P < 0.05), DP-1과 DT-1사이에는 유의한 차이를 보이지 않았다(P > 0.05). 결론: 디지털 광학 기술 방식으로 3D프린팅을 하여 제작한 3유닛 고정성 보철 형태의 레진 보철물에 있어서 메타크릴산 에스텔 재료가 높은 굴곡강도를 보여주었다.

• 한국미생물·생명공학회지
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• 제44권4호
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• pp.571-576
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• 2016

본 연구에서는 섬바디 나물의 항염증 효과를 알아보기 위하여 LPS로 염증을 유도한 Raw 264.7 세포에 대한 섬바디나물 80% 에탄올 추출물의 효과를 살펴보았다. 섬바디 나물 추출물을 LPS로 유도된 Raw 264.7 대식세포에서 전염증성인자(iNOS, COX-2)들을 생성하여 측정하였다. 섬바디 나물 추출물의 대식세포에서의 세포 독성 측정을 MTT를 수행하였다. 섬바디 나물 추출물의 세포 독성을 측정한 결과, $1,000{\mu}g/ml$의 농도에서 100% 이상의 세포 생존율을 보였다. 섬바디 나물 추출물의 50, 100, $500{\mu}g/ml$ 농도에서 iNOS와 COX-2의 단백질 발현 억제 효과를 측정하기 위해 western blot을 통해 측정하였고, 양성대조군으로는 ${\beta}-actin$을 사용하였다. 그 결과, 섬바디 나물 추출물을 western blot을 통해 측정한 iNOS, COX-2의 단백질 발현 억제 효과는 $500{\mu}g/ml$ 농도에서 각각 56%, 61.6%로 감소하였다. 섬바디 나물 추출물의 50, 100, $500{\mu}g/ml$ 농도에서 iNOS, COX-2의 mRNA의 발현억제 효과를 측정하기 위해 RT-PCR을 통해 측정하였으며, 양성 대조군으로 GAPDH를 사용하였다. 그 결과, 섬바디 나물 추출물을 RT-PCR을 통해 iNOS, COX-2의 mRNA 발현 억제 효과를 측정한 결과는 $500{\mu}g/ml$에서 각각 77.9%, 83.3%로 감소하였다. 이를 통해, 섬바디 나물 추출물은 염증을 억제시켜 주는 가능성이 있는 항염증 물질로써의 효과가 있을 것으로 보여진다.

• Journal of Korean Neurosurgical Society
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• 제55권4호
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• pp.208-211
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• 2014

Recently, the increasing rates of facial nerve preservation after vestibular schwannoma (VS) surgery have been achieved. However, the management of a partially or completely damaged facial nerve remains an important issue. The authors report a patient who was had a good recovery after a facial nerve reconstruction using fibrin glue-coated collagen fleece for a totally transected facial nerve during VS surgery. And, we verifed the anatomical preservation and functional outcome of the facial nerve with postoperative diffusion tensor (DT) imaging facial nerve tractography, electroneurography (ENoG) and House-Brackmann (HB) grade. DT imaging tractography at the 3rd postoperative day revealed preservation of facial nerve. And facial nerve degeneration ratio was 94.1% at 7th postoperative day ENoG. At postoperative 3 months and 1 year follow-up examination with DT imaging facial nerve tractography and ENoG, good results for facial nerve function were observed.

• Physical Therapy Rehabilitation Science
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• 제7권3호
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• pp.95-101
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• 2018

Objective: To determine if the provision of visual biofeedback using real-time rehabilitative ultrasound imaging (RUSI) enhances the acquisition and retention of diaphragm muscle recruitment during exercise. Design: Two group pretest posttest design. Methods: Thirty healthy subjects were randomly assigned to the verbal feedback group (VG, n=15) or the visual and verbal feedback group (VVG, n=15). The VG performed breathing exercises 10 times with verbal feedback, and the VVG also performed breathing exercises 10 times with verbal feedback and visual feedback with the use of RUSI to measure changes in diaphragm thickness (DT). For DT, the mid-axillary lines between ribs 8 and 9 on both sides were measured in standing, and then the chest wall was perpendicularly illuminated using a linear transducer with the patients in supine to observe the region between rib 8 and 9 and to obtain 2-dimensional images. DT was measured as the distance between the two parallel lines that appeared bright in the middle of the pleura and the peritoneum. After one week, three repetitions (follow-up session) were performed to confirm retention effects. Intra- and between- group percent changes in diaphragm muscle thickness were assessed. Results: In the VVG, the intervention value had a medium effect size compared to the baseline value, but the follow-up value decreased to a small effect size. In the between-group comparisons, during the intervention session, the VVG showed no significant effect on percent change of DT but had a medium effect size compared to the VG (p=0.050, Cohen's d=0.764). During the follow-up session, retention effect did not persist (p=0.311, Cohen's d=0.381). Conclusions: RUSI can be used to provide visual biofeedback and improve performance and retention in the ability to activate the diaphragm muscle in healthy subjects. Future research needs to establish a protocol for respiratory intervention to maintain the effect of diaphragmatic breathing training using RUSI with visual feedback.

• 한국식품영양학회지
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• 제11권1호
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• pp.6-10
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• 1998

탈취온도가 옥수수기름의 냉각시험 및 발연점에 미치는 영향을 측정해 보았다. 탈취온도가 상승할수록 투입되는 탈납유 대비 탈취유의 냉각시험 결과는 현저히 하락하였으며, 26$0^{\circ}C$ 이상에서는 그 정도가 극심하여 이는 포화도 증가 및 SU2, S2U, S3형 triglycerides 함량 증가와 상관관계가 있는 것으로 추측되었다. 한편, 발연점은 탈취온도 24$0^{\circ}C$에서 가장 높은 242$^{\circ}C$를 나타내었고, 탈취온도 245~27$0^{\circ}C$의 범위에서는 235~238$^{\circ}C$로 하락하였으며, 이러한 현상은 시료유의 산값과 반비례하는 것으로 나타났다. 따라서 일반 이화학적 특성, 지방산 조성 등과 함께 냉각시험 및 발연점에서도 고온탈취는 악영향을 미치는 것으로 판명되었다.

• 한국학교ㆍ지역보건교육학회지
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• 제12권1호
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• pp.35-44
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• 2011

Objectives: The purpose of this study were to measure the effect of factors analyse the associated by the oral health behaviors and dental health services utilization factors of dental caries in the middle-school student's and then to provide basic material of preventive oral health and oral health education program. Methods: This subject of study consists of 342 middle schools each 1,2,3 grade Daegu city. The data were collected from July 2 to 30, 2009. by way of the self-reported questionnaire. The data materials are analyzed by demographic characteristics, oral health behaviors and dental health services utilization of frequency analysis, demographic characteristics of dental caries and oral health behaviors and dental health services utilization of one-way ANOVA analysis. Results: Brushing twice a day, which was the higher 69.3%, Students were trained received oral health education. Girls than boys dental caries teeth(DT) index (p<0.05), dental filling teeth(FT) index(p<0.00), dental experience caries teeth(DMFT) index(p<0.00) was higher than all three variables was a statistically significant. Oral health behavior of brushing twice a day 'once' dental caries teeth(DT) index was the highest, there was statistically significant difference (p<0.01), oral health education students experience a higher dental caries teeth(DT) index(p=0.36). dental health services utilization of preventive dental visits last one year when they did not have dental caries teeth(DT) index was higher (p=0.076) Conclusions: Oral health promotion is considered to adolescent as part of the oral health clinics school for elementary school students in the focus to middle school students and enhance.

• 천문학논총
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• 제30권2호
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• pp.211-214
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• 2015

We investigated the period variation for 79 eclipsing binary systems using 20 years (1990-2009) of EROS, Macho, and OGLE survey observations. We discovered 9 apsidal motions, 8 mass transfers, 5 period increasing and decreasing systems, 12 light-travel-time effects, 5 eccentric systems and 40 other systems showing no period variations. We select 3 representative eclipsing binary systems; EROS 1052 for apsidal motion, EROS 1056 for mass transfer, and EROS 1037 for the light-travel-time effect. We determine the period variation rate (dP/dt), orbital parameters of the 3rd body (e3, ${\omega}_3$, $f(m_3)$, $P_3$, $T_3$), apsidal motion parameters ($d{\omega}/dt$, U, Ps, Pa, e) and apsidal motion period by analyzing the light curves and O-C diagrams.

• 디지털융복합연구
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• 제12권12호
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• pp.633-641
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• 2014

본 연구는 비만과 치아우식증의 관계를 파악하고자 대한민국 전국단위의 건강 및 영양조사인 국민건강영양조사 제 4기 3차년도(2009) 원시자료를 활용하여 연구하였다. 연구대상은 만 19세 이상 성인 중 비만과 치아우식증 관련 변수의 결측 대상자를 제외하여 최종 7,393명이다. 자료 분석은 SPSS 18.0 프로그램을 이용하였으며, 유의수준 0.05로 분석한 결과 다음과 같은 결과를 얻었다. 1. 저체중(${\beta}$ = 0.21, p=.03)은 정상에 비해 DT 개수가 높게 나타났고, 과체중(${\beta}$ = -0.12, p=.02)은 정상에 비해 DT 개수가 낮게 나타났다. 2. 비만(OR = 0.69, 95% CI: 0.57, 0.84)은 정상에 비해 DMFT를 가질 가능성이 낮게 나타났다. 3. 저체중(${\beta}$ = 1.14, p<.001)은 정상에 비해 DMFT 개수가 높게 나타났고, 과체중(${\beta}$ = -0.39, p = .02)과 비만(${\beta}$ = -0.70, p<.0001)은 정상에 비해 DMFT 개수가 낮게 나타났다. 결론적으로, 비만(체질량지수)과 치아우식증(DT, DMFT)은 음의 상관관계를 갖는 것으로 밝혀졌으며, 혼란변수를 보정한 후에도 유사한 결과가 나타났다.