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Effect of Vehicles and Penetration Enhancers onthe Percutaneous Absorption of Ketorolac Tromethamine across Hairless Mouse Skin

  • Cho, Young-Ah;Gwak, Hye-Sun
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.234.1-234.1
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    • 2003
  • The effects of vehicles and penetration enhancers on the in vitro permeation of ketorolac tromethamine (KT) across excised hairless mouse skins were investigated. Among pure vehicles examined, propylene glycol monolaurate (PGML) showed the highest permeation flux, which was 94.3${\pm}$17.3 mg/cm$^2$/hr. Even though propylene glycol monocaprylate (PGMC) alone did not show high permeation rate, the skin permeability of DT was markedly increased by the addition of diethylene glycol monoethyl ether (DGME); the enhancement factors were 19.0 and 17.1 at 20 and 40% of DGME, respectively. (omitted)

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Soft-Switching PWM Boost Chopper-Fed DC-DC Power Converter with Load Side Auxiliary Passive Resonant Snubber

  • Nakamura, Mantaro;Ogura, Koki;Nakaoka, Mutsuo
    • Journal of Power Electronics
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    • v.4 no.3
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    • pp.161-168
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    • 2004
  • This paper presents a new circuit topology of high-frequency soft switching commutation boost type PWM chopper-fed DC-DC power converter with a loadside auxiliary passive resonant snubber. In the proposed boost type chopper-fed DC-DC power converter circuit operating under a principle of ZCS turn-on and ZVS turn-off commutation, the capacitor and inductor in the auxiliary passive resonant circuit works as the lossless resonant snubber. In addition to this, the voltage and current peak stresses of the power semiconductor devices as well as their di/dt or dv/dt dynamic stress can be effectively reduced by the single passive resonant snubber treated here. Moreover, it is proved that chopper-fed DC-DC power converter circuit topology with an auxiliary passive resonant snubber could solve some problems on the conventional boost type hard switching PWM chopper-fed DC-DC power converter. The simulation results of this converter are illustrated and discussed as compared with the experimental ones. The feasible effectiveness of this soft witching DC-DC power converter with a single passive resonant snubber is verified by the 5kW, 20kHz experimental breadboard set up to be built and tested for new energy utilization such as solar photovoltaic generators and fuel sell generators.

(Real Time Classification System for Lead Pin Images) (실시간 Lead Pin 영상 분류 시스템)

  • 장용훈
    • Journal of the Korea Computer Industry Society
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    • v.3 no.9
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    • pp.1177-1188
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    • 2002
  • To classify real time Lead pin images in this paper, The image acquisition system was composed to C.C.D, image frame grabber(DT3153), P.C(PentiumIII). I proposed image processing algorithms. This algorithms were composed to real time monitoring, Lead Pin image acquisition, image noise deletion, object area detection, point detection and pattern classification algorithm. The raw images were acquired from Lead pin images using the system. The result images were obtained from raw images by image processing algorithms. In implemental result, The right recognition was 97 of 100 acceptable products, 95 of 100 defective products. The recognition rate was 96% for total 200 Lead Pins.

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Two-Stage Logistic Regression for Cancer Classi cation and Prediction from Copy-Numbe Changes in cDNA Microarray-Based Comparative Genomic Hybridization

  • Kim, Mi-Jung
    • The Korean Journal of Applied Statistics
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    • v.24 no.5
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    • pp.847-859
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    • 2011
  • cDNA microarray-based comparative genomic hybridization(CGH) data includes low-intensity spots and thus a statistical strategy is needed to detect subtle differences between different cancer classes. In this study, genes displaying a high frequency of alteration in one of the different classes were selected among the pre-selected genes that show relatively large variations between genes compared to total variations. Utilizing copy-number changes of the selected genes, this study suggests a statistical approach to predict patients' classes with increased performance by pre-classifying patients with similar genetic alteration scores. Two-stage logistic regression model(TLRM) was suggested to pre-classify homogeneous patients and predict patients' classes for cancer prediction; a decision tree(DT) was combined with logistic regression on the set of informative genes. TLRM was constructed in cDNA microarray-based CGH data from the Cancer Metastasis Research Center(CMRC) at Yonsei University; it predicted the patients' clinical diagnoses with perfect matches (except for one patient among the high-risk and low-risk classified patients where the performance of predictions is critical due to the high sensitivity and specificity requirements for clinical treatments. Accuracy validated by leave-one-out cross-validation(LOOCV) was 83.3% while other classification methods of CART and DT performed as comparisons showed worse performances than TLRM.

Phage typing and pulsed-field gel electrophoresis of Salmonella typhimurium and S enteritidis isolated from domestic animals in Gyeongbuk province (경북지역 가축에서 분리된 Salmonella typhimurium과 S enteritidis의 phage typing 및 pulsed-field gel electrophoresis)

  • Kim, Sang-Yun;Lee, Hee-Moo;Kim, Sin;Hong, Hyon-Pyo;Kwon, Heon-Il
    • Korean Journal of Veterinary Service
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    • v.24 no.3
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    • pp.243-253
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    • 2001
  • Forty-five Salmonella typhimurium isolates were encountered 8 phage types in which DT197 and U302 were the predominant types. The DT104 type which was first found from pig in Korea, and was resistant to chloramphenicol, streptomycin, sulfamethoxazole/trimethoprim, tetracycline, gentamicin and nalidixic acid. Twenty-two S enteritidis isolates were encountered 5 phage types in which PT4 were the representative (predominant). S enteritidis isolates were susceptible to all antimicrobial agents. As a result of PFGE analysis for S typhimurium and S enteritidis, PFGE patterns was better than phage typing in discriminating of strains. PFGE patterns were not in accord with phage type even though some strain had the same phage types.

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SPECTRUM WEIGHTED RESPONSES OF SEVERAL DETECTORS IN MIXED FIELDS OF FAST AND THERMAL NEUTRONS

  • Kim, Sang In;Chang, Insu;Kim, Bong Hwan;Kim, Jang Lyul;Lee, Jung Il
    • Nuclear Engineering and Technology
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    • v.46 no.2
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    • pp.273-280
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    • 2014
  • The spectrum weighted responses of various detectors were calculated to provide guidance on the proper selection and use of survey instruments on the basis of their energy response characteristics on the neutron fields. To yield the spectrum weighted response, the detector response functions of 17 neutron-measuring devices were numerically folded with each of the produced calibration neutron spectra through the in-house developed software 'K-SWR'. The detectors' response functions were taken from the IAEA Technical Reports Series No. 403 (TRS-403). The reference neutron fields of 21 kinds with 2 spectra groups with different proportions of thermal and fast neutrons have been produced using neutrons from the $^{241}Am$-Be sources held in a graphite pile, a bare $^{241}Am$-Be source, and a DT neutron generator. Fluence-average energy ($E_{ave}$) varied from 3.8 MeV to 16.9 MeV, and the ambient-dose-equivalent rate [$H^*(10)/h$] varied from 0.99 to 16.5 mSv/h.

Germination Responses of Cassia mimosoides var nomame Seeds to Temperature (온도에 대한 차풀(Cassia mimosoides var nomame)종자의 발아 반응)

  • Lee, Ho-Joon;Ji-Seok Suh;Young-Jin Yoon;Ung-Kyu Lim
    • The Korean Journal of Ecology
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    • v.19 no.3
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    • pp.231-240
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    • 1996
  • The germination responses of Cassia mimosoides var. nomame seeds to temperature were examined under various conditions. The temperature range allowing germination was $20~40^{\circ}C$, and the linear relationship between the germination rate and temperature appeared to exist between $28~38^{\circ}C$ The total thermal time required for germination (10~80%) of C. mimosoides seeds ranged from 259 Kh (degree Kelvin$\times$hours) to 421 Kh and base temperature range was relatively constant, i.e., $23.39~26.68^{\circ}C$. In the increasing temperature (IT) regime, C. mimosoides seeds started to germinate at $16^{\circ}C$ and showed greater germination rate with increasing temperatures. The final germination rate was 64% at $36^{\circ}C$. On the other hand, in the decreasing temperature (DT) regime, the seeds began to germinate at $36^{\circ}C$, and the final germination rate was 52% at $20^{\circ}C$. An induced dormancy occurred at $16^{\circ}C$ in the DT regime.

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The Use of Semi-Adiabatic Calorimetry for Hydration Studies of Cement Paste

  • Chung, Chul-Woo;Kim, Ji-Hyun;Lee, Soo-Yong
    • Journal of the Korea Institute of Building Construction
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    • v.16 no.2
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    • pp.185-192
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    • 2016
  • The semi-adiabatic calorimetry technique is a robust and easy technique that can be used to measure the temperature rise of concrete. This method is often used for investigating the maturity of concrete, as well as to predict maximum temperature rise of mass concrete using various heat loss compensating models. Semi-adiabatic calorimetry can also be used for predicting setting time of concrete. However, it has seldom been used to investigate the hydration characteristics of various cement paste samples. In this research, semi-adiabatic calorimetry and X-ray diffraction methods were used to investigate the hydration characteristics of 3 different ASTM type I Portland cements. First derivative of temperature rise (dT/dt) curve was used to isolate individual peaks. Based on the results of the experiments, a combination of dT/dt curve with XRD could be used to successfully identify hydration at a specific time period, showing its potential to be used as an alternative tool for hydration studies of cement-based materials.

Measurement of the Post-Arc Current in a Vacuum Circuit Breaker (진공차단기에서 아크-후 전류의 측정)

  • Song, Ki-Dong;Chong, Jin-Kyo;Oh, Yeon-Ho;Lee, Woo-Young
    • The Transactions of the Korean Institute of Electrical Engineers B
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    • v.55 no.10
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    • pp.521-527
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    • 2006
  • After various measuring methods and system were investigated, Rogowski colis for the measurement of parameters in current zero region were designed and manufactured. Using the Rogowski coils and a 38kV 40kA VCB (vacuum circuit breaker), at last the post-arc current has been successfully measured firstly. It was found that the Rogowski coils used in this study have good characteristics and propriety to measure the parameters of current zero. We realized that the data processing for evaluating the post-arc current from the experimental results needs much more careful attention than that for building the measuring technique and system. The magnitude of post-arc current and the falling time of it to zero are proportioned to the rate of current di/dt. The magnitude of post-arc currents were around $1{\sim}3A$ to the interruption current of $20{\sim}30kA$ in the model VCB.

High-performance photovoltaics by double-charge transporters using graphenic nanosheets and triisopropylsilylethynyl/naphthothiadiazole moieties

  • Agbolaghi, Samira;Aghapour, Sahar;Charoughchi, Somaiyeh;Abbasi, Farhang;Sarvari, Raana
    • Journal of Industrial and Engineering Chemistry
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    • v.68
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    • pp.293-300
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    • 2018
  • Reduced graphene oxide (rGO) nanosheets were patterned with poly[benzodithiophene-bis(decyltetradecyl-thien) naphthothiadiazole] (PBDT-DTNT) and poly[bis(triiso-propylsilylethynyl) benzodithiophene-bis(decyltetradecyl-thien) naphthobisthiadiazole] (PBDT-TIPS-DTNT-DT) and used in photovoltaics. Conductive patternings changed via surface modification of rGO; because polymers encountered a high hindrance while assembling onto grafted rGO. The best records were detected in indium tin oxide (ITO):poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS):PBDTDTNT/rGO:PBDT-DTNT:LiF:Al devices, i.e., short current density $(J_{sc})=11.18mA/cm^2$, open circuit voltage $(V_{oc})=0.67V$, fill factor (FF) = 62% and power conversion efficiency (PCE) = 4.64%. PCE increased 2.31 folds after incorporation of PBDT-DTNT into thin films. Larger polymer assemblies on bared-rGO nanosheets resulted in greater phase separations.