• Biomolecules & Therapeutics
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• v.4 no.2
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• pp.196-201
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• 1996

The N-methyl-D-aspartate (NMDA) receptor-ion channel complex is activated by the simultaneous presence of L-glutamate and glycine, allowing the binding of MK-801 to the phencyclidine (PCP) site of the receptor. The $[^3H]$MK-801 binding assay system was established for determination of pharmacological functions of test compounds acting at the glycine site of the receptor. The binding in the presence of 0.1 $\mu$M L-glutamate was increased by an agonist (glycine) in a dose-dependent fashion, while decreased by either partial agonist (R-(+)-HA-966) or antagonist (5,7-dichlorokynurenic acid: 5,7-DCKA). To distinguish partial agonism from antagonism, various concentrations of 7-chlorokynurenic acid (7-CKA) were added in the assay to eliminate the interference of the endogenous glycine present in the membrane preparations. The bindings in the presence of L-glutamate (0.1$\muM$) and 7-CKA (1, 5, or 10$\muM$) were increased by R-(+)-HA-966. Being a weak partial agonist, the extent of potentiation was much less than that by the agonist. These binding profiles were clearly distinguishable from those by the antagonist, 5,7-DCKA, which exhibited no intrinsic activity. The binding assays established in the present study are a useful system to classify ligands acting at the glycine site of the NMDA receptor by their pharmacological functions.

• Korean Journal of Agricultural Science
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• v.49 no.3
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• pp.441-450
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• 2022

This study explored the effects of milk flavor (MF) supplementation on growth efficiency, nutrient absorption, fecal score, and blood profiles in weaning piglets. A total of 80 (21 days old) crossbred ([Yorkshire × Duroc] × Landrace) healthy weaned piglets with an initial body weight (BW) of 7.05 ± 1.22 kg were randomly allotted to one of two nutritive treatments with 8 repetitions and five pigs (2 female and 3 male) per pen. The experiment was divided into 2 phases (d 0 - 21, and d 21 - 42), and the dietary treatments consisted of TRT1, basal diet, TRT2 and basal diet + 1.0 g·kg^-1 MF. At days 21 - 42 and the overall period, the average daily gain (ADG) and average daily feed intake (ADFI) increased (p < 0.05) by receiving the MF added feed. However, MF inclusion did not impact (p > 0.05) the feed efficiency (G : F) throughout the entire experiment. Piglets consuming the MF supplemented diet showed that the apparent total tract digestibility of dry matter (DM), nitrogen (N) and energy (E) did not vary significantly (p > 0.05) between the treatments. All through the experiment, the fecal score and blood profile of the piglets fed the flavor diet also remained unaffected (p > 0.05). In conclusion, MF addition to the diet of the piglets increased their body weight and had no adverse effects on nutrient utilization, fecal score, and blood profile. Thus, MF addition could improve the performance outcomes of weaning piglets.

• Tribology and Lubricants
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• v.39 no.3
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• pp.118-122
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• 2023

In our study, we develop a finite element model based on Archard's wear law to predict the cumulative wear and the evolution of the tool profile in friction stir welding (FSW) applications. Our model considers the rotational and translational behaviors of the tool, providing a comprehensive description of the wear process. We validate the accuracy of our model by comparing it against experimental results, examining both the predicted cumulative wear and the resulting changes to the tool profile caused by wear. We perform a detailed comparison between the predictions of the model and experimental data by manipulating non-dimensional coefficients comprising model parameters, such as element sizes and time increments. This comparison facilitates the identification of a specific non-dimensional coefficient condition that best replicates the experimentally observed cumulative wear. We also directly compare the worn tool profiles predicted by the model using this specific non-dimensional coefficient condition with the profiles obtained from wear experiments. Through this process, we identify the model settings that yield a tool wear profile closely aligning with the experimental results. Our research demonstrates that carefully selecting non-dimensional coefficients can significantly enhance the predictive accuracy of finite element models for tool wear in FSW processes. The results from our study hold potential implications for enhancing tool longevity and welding quality in industrial applications.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.379-387
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• 2023

Dog owners seek treatment when their pets develop cancer. IMMUNIES is traditional herbal medicine-based figment made of 10 natural herbs, designed to maintain host immune function. The major component of IMMUNIES is Dendropanax morbiferus. This clinical pilot study monitored the toxicity and efficacy of IMMUNIES. Four senile dogs with spontaneously occurring mammary and liver cancers were enrolled in this study and treated orally daily for 3 months, and their blood/urine biochemical profiles were examined each month. IMMUNIES was well tolerated during the treatment period. Blood urea nitrogen, creatinine, alanine aminotransferase, alkaline phosphatase, and C-reactive protein levels decreased in all four dogs, whereas red blood cells and hematocrit were within the normal range. IMMUNIES also changed the expression of several molecular targets in the anticancer pathway, such as pro-NAG-1, p53, and cyclin D1. Although the tumors did not completely respond to IMMUNIES, the biochemical profiles and clinical examination showed a stabilized cancer status for 3 months. Thus, IMMUNIES was found to be safe and well-tolerated in the dosage range tested and exhibited cancer antiproliferative activity in canine cancer. Future studies should address other potential benefits of IMMUNIES, including correlative assessments of immune function, quality of life, and owner satisfaction.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.41 no.3
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• pp.267-273
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• 1992

An advanced on-resistance model of VDMOS devices in the low voltage regimes is proposed and verified by 2-D device simulations. The model considers the lateral gaussian doping profiles in the channel region and exact current spreading angles in the epitaxial layer for both linear and cellular geometries by employing the conformal mapping, It is found out that the on-resistance of low voltage VDMOS may be overestimated considerably if it is analyzed by the conventional method. The 2-D device simulation results show that the proposed model is valid for the VDMOS devices in the low voltage regimes.

• Journal of Ecology and Environment
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• v.46 no.4
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• pp.304-315
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• 2022

Background: Filter-feeding zooplankton has limited food resources owing to their habitat. Consequently, it is crucial for them to acquire all essential compounds, such as fatty acids (FAs) and amino acids, from confined diets. To elucidate the trophic transfer of FAs to filter feeders, the primary consumers in freshwater ecosystems, we compared the FA accumulation patterns of two species of filter-feeding zooplankton, Daphnia magna and Branchinella kugenumaensis, in a laboratory experiment. Experimental neonates and nauplii preyed on a single phytoplankton species (Selenastrum capricornutum) for three days after hatching prior to diet switching. Five replicates per feeding group in each species were fed on six different types of mixed phytoplankton diet for 10 days after diet switching. Subsequently, the consumers and diets were harvested and FAs were extracted. Results: Principal component analysis showed that the FA profiles of zooplankton were well-grouped by species and diet. Although diet affects the FA profiles of consumers, they exhibit different FA accumulation patterns. D. magna had a higher 18C-ω3 content and ω3/ω6 ratio than did B. kugenumaensis. In contrast, B. kugenumaensis had higher contents of 18:1ω7 and 20:5ω3 (eicosapentaenoic acid), 22:6ω3 (docosahexaenoic acid), and a higher ratio of ∑18C monounsaturated FAs to ∑18C-ω3 polyunsaturated FAs than did D. magna. Conclusions: This study showed that two primary consumers, D. magna and B. kugenumaensis, fed the same diet had different assimilation patterns of FAs under controlled environments. Specific FA accumulation patterns in filter feeders can provide information on the transfer process of various FAs to high-trophic organisms.

• Carbon letters
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• v.25
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• pp.25-32
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• 2018

In this study, a thermal-gradient chemical vapor infiltration (TG-CVI) process was numerically studied in order to enhance the deposition uniformity within the preform. The computational fluid dynamics technique was used to solve the governing equations for heat transfer and gas flow during the TG-CVI process for two- and three-dimensional (2-D and 3-D) models. The temperature profiles in the 2-D and 3-D models showed good agreement with each other and with the experimental results. The densification process was investigated in a 2-D axisymmetric model. Computation results showed the distribution of the SiC deposition rate within the preform. The results also showed that using two-zone heater gave better deposition uniformity.

• Journal of Institute of Control, Robotics and Systems
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• v.22 no.1
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• pp.59-65
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• 2016

As modern electronic devices get smaller and smaller, high-resolution, large Field-Of-View (FOV), fast, and cost-effective 3-dimensional (3-D) measurement is requested more and more. In particular, defect inspection machines using machine-vision technology nowadays require 3-D inspection as well as the conventional 2-D inspection. Phase Measuring Profilometry (PMP) is one of the fast non-contact 3-D shape measuring methods currently being extensively investigated in the electronic component manufacturing industry. The PMP system is well known and is successfully applied to measuring complex surface profiles with varying reflectance properties. However, for highly reflective surfaces, such as Ball Grid Arrays (BGAs), it has difficulty accurately measuring 3-D shapes. In this paper, we propose a new fast optical system that can eliminate the highly reflective saturated regions in BGA ball images. This is achieved by utilizing four Low Intensity Grating (LIG) images together with the conventional High Intensity Grating (HIG) images. Extensive experiments using BGA samples show a repeatability of under ${\pm}20um$ in standard deviation, which is suitable for most 3-D shape measurements of BGAs.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.19 no.3
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• pp.173-178
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• 2019

To analyze the diffraction properties of optical signals by periodic blazed 2D diffraction gratings, Toeplitz dielectric tensor is first defined and formulated by 2D spatial Fourier expansions associated with asymmetric blazed grating profile. The characteristic modes in each layer is then based on eigenvalue problem, and the complete solution is found rigorously in terms of modal transmission-line theory (MTLT) to address the pertinent boundary-value problems. Toeplitz matrix of symmetric and sawtooth profiles is derived from that of asymmetric blazed grating profile, and the diffraction properties for each profile are numerically simulated. The numerical results reveal that the asymmetric and symmetric profiles behave as anti-reflection GMR filter while the sawtooth profile works better as anti-transmission one rather than anti-reflection filter.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.1501-1514
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• 2008

Recently, so as to solve the urban transportation problem the LRT(Light Rail Transit) system has been studied on the essential technology and the engineering know-how, which lead lower construction cost and higher reliability. The localization development of rubber tired AGT(Automatic Guided Trainsit) system has performed from 1999 to 2004, as a national project of the Minister of Land, Transport and Maritime Affairs. For the application of the rubber tired AGT system in Busan Subway 3-2 Line, this study is focused on the reliability of aluminium profiles vehicle carbody and the establishment of the test and evaluation technologies. In this paper, 3D modeling simulation was applied to the load test of aluminium vehicle carbody. The reliability of the vehicle carbody was estimated as the fatigue test of welded aluminium profiles. From the test and simulation results, it could be concluded that the developed rubber tired AGT shows a good structural reliability and integrity.