• Journal of Nutrition and Health
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• v.52 no.3
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• pp.243-249
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• 2019

Purpose: Platycodon grandiflorum (PG) is known to have effective antimicrobial and anticancer activity. The main bioactive components of PG are saponins, and these could contribute to anti-inflammatory activity. However, little is known about the anti-inflammatory effect of PG. In this study, we aim to assess the anti-inflammatory response to Red PG Extract (RPGE) in splenocytes under ex vivo conditions. Methods: The cell viability of isolated splenocytes taken from mice was analyzed by performing a Cell Counting Kit-8 assay. The productions of nitric oxide (NO) and cytokines (specifically interleukin-6 (IL-6) and interleukin-10 (IL-10)) were measured utilizing Griess reagent and ELISA, respectively. Results: We found that co-treatment with RPGE and Lipopolysaccharide (LPS) decreased isolated splenocyte proliferation as compared with that of the LPS-stimulated control. We also observed that RPGE markedly suppressed NO synthesis and IL-6 production that was induced by LPS. There were no significant differences of IL-10 production between co-treatment with RPGE plus LPS and treatment with LPS alone. Conclusion: When taken together, our data has shown that RPGE mitigates LPS-induced inflammation in splenocytes isolated from mice. Further research is surely needed to confirm the anti-inflammation effects of RPGE in an in vivo model.

• Journal of the Korea Convergence Society
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• v.10 no.5
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• pp.385-395
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• 2019

This was a descriptive study to investigate the effect of social support and resilience on sick role behaviors of hemodialysis patients, and aims to provide base data on nursing intervention programs for improving the sick role behaviors of hemodialysis patients. The study subjects was patients with chronic kidney disease undergoing hemodialysis treatment at a general hospital in D city. The final analysis has been made on 131 questionnaires. The average of social support score was $3.93{\pm}0.84$, and resilience score was $2.67{\pm}0.80$. At last sick role behavior score was $3.99{\pm}0.80$. According to the analysis on the correlations among the study subjects' social support, resilience and sick-role behaviors, the social support had statistically and significantly positive correlation. In regression analysis, frequency of dialysis, social support and resilience have appeared to be the variables influencing sick role behavior, and the explanatory power of this model is 44.0%.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.4
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• pp.2160-2169
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• 2014

The purpose of this research was to investigate the relation between social support and the knowledge of drug which affects drug abuse in elderly by using structure equation model(SEM). The samples included 177 elderly who lived in 'D' city was selected. Data were collected and analyzed using questionnaires for 13 days from May 13 to May 25, 2013. 3 factors of research models had a significant model fit and correlation. The key research findings are as follows. First, the more social support they have, the more knowledge of drug they tend to have(${\beta}$=.515, p=.005). Second, direct effect that social support led to drug abuse was significant.(${\beta}$=-.769, p=.002) However the indirect effect was not significant(${\beta}$=.036, p=.671). Third, the indirect effect that social support led to drug abuse was not significant, which means it has no mediating effect. Social support turned out to be very important factor in this research, but other preceding research mentioned that knowledge of drug is an important factor which could reduce drug abuse. Research needs to be analyzed repeatedly for verification of effects.

• Journal of KIISE:Software and Applications
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• v.37 no.2
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• pp.110-119
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• 2010

In this paper, we propose an automatic segmentation of the prostate using intensity distribution and gradient information in MR images. First, active shape model using adaptive intensity profile and multi-resolution technique is used to extract the prostate surface. Second, hole elimination using geometric information is performed to prevent the hole from occurring by converging the surface shape to the local optima. Third, the surface shape with large anatomical variation is corrected by using 2D gradient information. In this case, the corrected surface shape is often represented as rugged shape which is generated by the limited number of vertices. Thus, it is reconstructed by using surface modelling and smoothing. To evaluate our method, we performed the visual inspection, accuracy measures and processing time. For accuracy evaluation, the average distance difference and the overlapping volume ratio between automatic segmentation and manual segmentation by two radiologists are calculated. Experimental results show that the average distance difference was 0.3${\pm}$0.21mm and the overlapping volume ratio was 96.31${\pm}$2.71%. The total processing time of twenty patient data was 16 seconds on average.

• Journal of Korea Water Resources Association
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• v.31 no.6
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• pp.727-739
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• 1998

The main objectives o reservoir optimal operation can be described as follows : maximization of the benefits through optimal allocation of the limited water resources for various purpose; minimization of t도 costs by the flood damage in potential damaging regions and risk of dam failure, etc. through safe drainage of a bulky volume of excessive water by a proper reservoir operation. Reviewing the past research works related to reservoir operation, we can find that the study on the matter of the former has been extensively carried out in last decades rather than the matter of the latter. This study is focused on developing a methodology of optimal reservoir operation for flood control, and a case study is performed on the Chungju multipurpose reservoir in Korea. The final goal of the study is to establish a reservoir optimal operation system which can search optimal policy to compromise two conflicting objectives: downstream flood damage and dam safety-upstream flood damage. In order to reach the final goal of the study, the following items were studied : (1)validation of hydrological data using HYMOS: (2)establishment of a downstream flood routing model coupling a rainfall-runoff model and SOBEK system for 1-D hydrodynamic flood routing; (3)replication of a flood damage estimation model by a neural network; (4)development of an integrated reservoir optimization module for an optimal operation policy.

• Archives of design research
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• v.17 no.3
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• pp.335-342
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• 2004

Recently there have been various research activities regarding Korean traditional aesthetics. However, those researches were mainly conducted individually, partially, and periodically, which resulted in unsystematic and incomprehensive works. Therefore, it is required to orginze all the precedent research works with more systematic and objective framework. Generally speaking, all the human activities including aesthetic activity have ends, procedure and means. In other words, human being needs three key elements for realizing any thought and those three elements include contents, formal, and practical element. Element of contents is ultimate goal to accomplish as value, concept, and meaning of thought with their aims. Formal element includes methods, principles, norms, procedure, formality and style comprising of thought in order to accomplish the goal. Finally, practical element refers to specific means, tool, media, material and techniques to concretize the contents through form. Almost all of thoughts and meaning which human being tries to express consist of language. Major elements in sentence include 'subject (omissible)' , 'objects (aim)', 'predicate (formality)', 'complement (means)' and they are composed systematically and hierarchically with rules in sentence. The study compared human activity model with language structure and analyzed their implication with design (aesthetics), which made it possible to propose analytic frameworks for traditional aesthetics. In addition, the study also systematically organized the way to realize traditional aesthetic value in the present context based on the methods developed in this study.

• Journal of the Korean GEO-environmental Society
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• v.22 no.2
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• pp.35-39
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• 2021

Photogrammetry using drone can produce high-resolution ortho image and acquire high-accuracy 3D information, which is useful. Therefore, this study attempted to determine the possibility of using drone-photogrammetry in park construction by producing a topographic map using drone-photogrammetry and analyzing the problems and accuracy generated during production. For this purpose, we created ortho image and DSM (digital surface model) using drone images and created topographic status map by vectorizing them. Accuracy was compared based on topographic status map by GPS (global positioning system) and TS (total station). The resulting of analyzing mean of the residuals at check points showed that 0.044 m in plane and 0.066 m in elevation, satisfying the tolerance range of 1/1,000 numerical maps, and result of compared lake size showed a difference of about 4.4%. On the other hand, it was difficult to obtain accurate height values for terrain in which existed vegetation when producing the topographic map, and in the case of underground buried objects, it is not possible to confirm it in the image, so direct spatial information acquisition was necessary. Therefore, it is judged that the topographic status map using drone photogrammetry can be efficiently constructed if direct spatial data acquisition is achieved for some terrain.

• Journal of Veterinary Science
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• v.24 no.6
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• pp.83.1-83.12
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• 2023

Background: Ellipticine (Ellip.) was recently reported to have beneficial effects on the differentiation of adipose-derived stem cells into mature chondrocyte-like cells. On the other hand, no practical results have been derived from the transplantation of bone marrow stem cells (BMSCs) in a rabbit osteoarthritis (OA) model. Objectives: This study examined whether autologous BMSCs incubated with ellipticine (Ellip.+BMSCs) could regenerate articular cartilage in rabbit OA, a model similar to degenerative arthritis in human beings. Methods: A portion of rabbit articular cartilage was surgically removed, and Ellip.+BMSCs were transplanted into the lesion area. After two and four weeks of treatment, the serum levels of proinflammatory cytokines, i.e., tumor necrosis factor α (TNF-α) and prostaglandin E2 (PGE2), were analyzed, while macroscopic and micro-computed tomography (CT) evaluations were conducted to determine the intensity of cartilage degeneration. Furthermore, immuno-blotting was performed to evaluate the mitogen-activated protein kinases, PI3K/Akt, and nuclear factor-κB (NF-κB) signaling in rabbit OA models. Histological staining was used to confirm the change in the pattern of collagen and proteoglycan in the articular cartilage matrix. Results: The transplantation of Ellip.+BMSCs elicited a chondroprotective effect by reducing the inflammatory factors (TNF-α, PGE2) in a time-dependent manner. Macroscopic observations, micro-CT, and histological staining revealed articular cartilage regeneration with the downregulation of matrix-metallo proteinases (MMPs), preventing articular cartilage degradation. Furthermore, histological observations confirmed a significant boost in the production of chondrocytes, collagen, and proteoglycan compared to the control group. Western blotting data revealed the downregulation of the p38, PI3K-Akt, and NF-κB inflammatory pathways to attenuate inflammation. Conclusions: The transplantation of Ellip.+BMSCs normalized the OA condition by boosting the recovery of degenerated articular cartilage and inhibiting the catabolic signaling pathway.

• Economic and Environmental Geology
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• v.53 no.1
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• pp.33-43
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• 2020

CO₂ geological storage is currently considered as the most stable and effective technology for greenhouse gas reduction. The saline formations for CO₂ geological storage are generally located at a depth of more than 800 m where CO₂ can be stored in a supercritical state, and an extensive impermeable cap rock that prevents CO₂ leakage to the surface should be distributed above the saline formations. Trough analysis of seismic and well data, we identified the basalt flow structure for potential CO₂ storage where saline formation is overlain by basalt cap rock around PZ-1 exploration well in the Southern Continental Shelf of Korea. To evaluate CO₂ storage capacity of the saline formation, total porosity and CO₂ density are calculated based on well logging data of PZ-1 well. We constructed a 3D geological grid model with a certain size in the x, y and z axis directions for volume estimates of the saline formation, and performed a property modeling to assign total porosity to the geological grid. The estimated average CO₂ geological storage capacity evaluated by the U.S. DOE method for the saline formation covered by the basalt cap rock is 84.17 Mt of CO₂(ranges from 42.07 to 143.79 Mt of CO₂).

• Korean Journal of Construction Engineering and Management
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• v.17 no.5
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• pp.120-129
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• 2016

The user cost is an important analysis item which should be considered together with life-cycle of facility, administrator cost and discount rate in LCCA for efficient asset management of SOC facilities. Especially, a significant delay cost occurs often for users in the road field due to a work zone for cleaning and maintenance, and in such case, the administrator should consider the administrator cost as well as the user cost for more rational decision making. However, the user cost has not been considered in most decision making steps until recently and relevant studies also have not been carried out actively. In this study, the methodology to estimate the user cost and delay cost required in the decision making step using the traffic flow model and the direct benefit estimation model in the traffic facility investment evaluation guideline is suggested. And, the traffic flow model was estimated on 4 national highway sections where maintenance was actually carried out in 2014 using VISSIM and, the user cost and the delay cost were estimated based on the suggested methodology. The analysis result showed that the average user cost of $17,569,000KRW/km{\times}day$ occurred on Section A with approximately 30,000 AADT before a work zone occurred, and in case the first lane was blocked for maintenance, the delay cost of $10,193,000KRW/km{\times}day$ (158%) on average occurred additionally. The delay cost of $1,507,000KRW/km{\times}day$ (115%) and $1,985,000KRW/km{\times}day$ (119%) occurred on Sections B and D with approximately 20,000 AADT respectively and the delay cost of $262,000KRW/km{\times}day$ (105%) occurred on Section C with approximately 10,000 AADT. This result of this study was estimated based on the simulation of traffic flow model so that there is a limitation in its actual application. A study ot develop a highly appropriate model using actual observation data and improve the possibility to apply it through the verification using the simulation will be necessary in future.