• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.60 no.6
• /
• pp.1196-1203
• /
• 2011

The reduced frequency selectivity is a typical phenomenon of sensorineural hearing loss. In this paper, we compared two modeling methods for reduced frequency selectivity of hearing impaired people. The two models of reduced frequency selectivity were made using LPC(linear prediction coding) algorithm and bandwidth control algorithm based on ERB(equivalent rectangular bandwidth) of auditory filter, respectively. To compare the effectiveness of two models, we compared the result of PESQ (perceptual evaluation of speech quality) and LLR(log likelihood ratio) using 36 Korean words of two syllables. To verify the effect on noise condition, we mixed white and babble noise with 0dB and -3dB SNR to speech words. As the result, it is confirmed that the PESQ score of bandwidth control algorithm is higher than the score of LPC algorithm, on the other hands, and the LLR score of LPC algorithm is lower than the score of bandwidth control algorithm. It means that both non-linearity and widen auditory filter characteristics caused by reduced frequency selectivity could be more reflected in bandwidth control algorithm than in LPC algorithm.

• Journal of Information Processing Systems
• /
• v.9 no.1
• /
• pp.53-68
• /
• 2013

We investigate the rate-compatible punctured convolutional (RCPC) codes concatenated with hierarchical QAM for designing a cross-layer unequal error protection scheme for H.264 coded sequences. We first divide the H.264 encoded video slices into three priority classes based on their relative importance. We investigate the system constraints and propose an optimization formulation to compute the optimal parameters of the proposed system for the given source significance information. An upper bound to the significance-weighted bit error rate in the proposed system is derived as a function of system parameters, including the code rate and geometry of the constellation. An example is given with design rules for H.264 video communications and 3.5-4 dB PSNR improvement over existing RCPC based techniques for AWGN wireless channels is shown through simulations.

• Microbiology and Biotechnology Letters
• /
• v.31 no.3
• /
• pp.230-234
• /
• 2003

The Bacillus subtilis YvaE protein, the small multidrug resistance (SMR) family (TC #2.A. 7.1), is shown to catalyze efflux of multiple cationic drugs including many disinfectants, when it was cloned and expressed in Escherichia coli. When the yvaD gene was coexpressed with yvaE gene, the yvaD protein, encoded within a single operon with the yvaE gene, is shown to counteract the action ofYvaE. By ethidium efflux analysis, the cells harvoring a vector with yvaE gene showed a rapid ethidium efflux, compared with the control cells. These results clearly suggest that YvaE mediates drug export from the cell cytoplasm.

• Journal of Microbiology and Biotechnology
• /
• v.16 no.5
• /
• pp.764-770
• /
• 2006

Dihydrochalcomycin (GERI-155), produced by Streptomyces sp. KCTC-0041BP isolated from Korean soil, is a 16-membered macrolide antibiotic consisting of two deoxysugar moieties at C-5 and C-20 positions of a branched lactone ring. The cloning and sequencing of a gene cluster for dihydrochalcomycin biosynthesis revealed a 63-kb nucleotide region containing 25 open reading frames (ORFs). The products of all of these 25 ORFs playa role in dihydrochalcomycin biosynthesis and self-resistance against the compounds synthesized. At the core of this cluster lies a 39.6-kb polyketide synthase (PKS) region encoding eight modules in five giant multifunctional protein-coding genes (gerSI-SV). The genes responsible for the biosynthesis of deoxysugar moieties, D-chalcose and D-mycinose, and their modification and attachment were found on either side of this PKS region. The involvement of this gene cluster in dihydrochalcomycin biosynthesis was confirmed by disruption of the dehydratase (DH) domain in module 3 of the PKS gene and by metabolite analysis.

• Genomics & Informatics
• /
• v.5 no.3
• /
• pp.107-112
• /
• 2007

MicroRNAs (miRNAs) are known to negatively control protein-coding genes by binding to messenger RNA (mRNA) in the cytoplasm. In innate immunity, the role of miRNA gene silencing is largely unknown. In this study, we performed microarray-based experiments using lipopolysaccharide (LPS)-stimulated macrophages derived from wild-type, MyD88 knockout (KO), TRIF KO, and MyD88/TRIF double KO mice. We employed a statistical approach to determine the importance of the commonality and specificity of miRNA binding sites among groups of temporally co-regulated genes. We demonstrate that both commonality and specificity are irrelevant to define a priori groups of co-down regulated genes. In addition, analyzing the various experimental conditions, we suggest that miRNA regulation may not only be a late-phase process (after transcription) but can also occur even early (1h) after stimulation in knockout conditions. This further indicates the existence of dynamic interactions between miRNA and signaling molecules/transcription factor regulation; this is another proof for the need of shifting from a 'hard-wired' paradigm of gene regulation to a dynamical one in which the gene co-regulation is established on a case-by-case basis.

• The Transactions of the Korean Institute of Electrical Engineers D
• /
• v.54 no.2
• /
• pp.124-130
• /
• 2005

In this paper, low-power design and implementation techniques for DWT(Discrete Wavelet Transform) of the JPEG2000 compression are proposed. In DWT block of the JPEG2000, linear phase 9 tap and 7 tap filters are used. For low-power implementation of those filters, processor technique for DA(Distributed Arithmetic) filter and minimization technique for number of addition in CSD(Canonic Signed Digit) filter are utilized. Proposed filter structure consists of 3 blocks. In the first CSD coefficient block, every possible 4 bit CSD coefficients are calculated and stored. In second processor block, multiplication is done by MUX and addition processor in terms of the binary values of filter coefficient. Finally, in third block, multiplied values are output and stored in flip-flop train. For comparison of the implementation area and power dissipation, proposed and conventional structures are implemented by using Verilog-HDL coding. In simulation, it is shown that 53.1% of the implementation area can be reduced comparison with those of the conventional structure.

• Journal of the Korean Institute of Telematics and Electronics S
• /
• v.36S no.1
• /
• pp.70-80
• /
• 1999

In this paper, a new hierarchical image segmentation algorithm based on human visual system(HVS) characteristic is proposed which can efficiently reduce and control transmission information quantity without the degradation of the subjective and objective image quality. It consists of image segmentation based on mathematical morphology and region merging considering HVS characteristic for the pairs of two adjacent regions at each level of the hierarchy. Image segmentation is composed of 3-level hierarchical structure. In the region merging structure of each level, we extract the pairs of two adjacent regions which human vision can't discriminate, and then merge them. The proposed region merging method extracts pairs of two neighbor regions to be merged and performs region merging according to merging priority based on HVS characteristics. The merging priority for each adjacent pair is determined by the proposed merging priority function(MPF). First of all, the highest priority pair is merged. The information control factor is used to regulate the transmission information at each level. The proposed segmentation algorithm can efficiently improve bottleneck problem caused by excessive contour information at region-based very low bit rate coding. And it shows that it is more flexible structure than that of conventional method. In experimental results, though PSNR and the subjective image quality by the proposed algorithm is similar to that of conventional method, the contour information quantity to be transmitted is reduced considerably. Therefore it is an efficient image segmentation algorithm for region-based very low bit rate coding.

• Journal of The Institute of Information and Telecommunication Facilities Engineering
• /
• v.2 no.2
• /
• pp.36-45
• /
• 2003

This paper presents a way to maximize transmission efficiency and reception ability through transmission diversity technology, which can be adapted to wireless multimedia OFDM (orthogonal FDM) system. The presented method gives a comparative analysis between a case where parameter a for time average is 0.3, i with consideration of channel presumption and two types of rms delayed proliferation, which is 50nsec, 150nsec, for the performance analysis of STTC (Space-Time Trellis Code) using time-space code method which is appropriate for MIMO channel, and performance, in the case, where presumed channel value from long training column section is applied to the according frame in a single frame. The result shows that BER brought SNR improvement of 1.0dB in $10^{-3}$ when a was 0.3 than using only the long training column, and shows an increasement of general performance improvement when the time average factor is used.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.8 no.11
• /
• pp.1749-1754
• /
• 2013

Binary sequences of period $2^n-1$ are widely used in many areas of engineering and sciences. Some well-known applications include coding theory, code-division multiple-access (CDMA) communications, and stream cipher systems. In this paper we analyze different solutions to $x^5+bx^3+b^{2^m}x^2+1=0$ over $GF(2^n)$. The number of different solutions determines frequencies of cross-correlations of nonlinear binary sequences generated by $d=3{\cdot}2^m-2$, n=2m, m=4k($k{\geq}2$). Also we give an algorithm for determination of number of different solutions to the equation.

• Korean Journal of Biological Psychiatry
• /
• v.2 no.1
• /
• pp.57-62
• /
• 1995

Objects : Clozapine, prototype of the atypical neuroleptics, was known to have unique antipsychotic effect with a few extrapyramidal effects. While most typical antipsychotic agents mainly block $D_2$ receptors, clozapine has higher affinity for dopamine $D_4$ receptor than for $D_2$ receptor. Many researchers have tried to find out the relationship between schizophrenia and the abnormality of the genes coding dopamine receptors. But no consistent findings were reported. Recently, dopamine $D_4$ receptor was fully sequenced, and the alleles of dopamine $D_4$ receptor gene was found in unusual form on the 48th base pair. Our study was performed to identify the distribution of the dopamine $D_4$ receptor alleles of schizophrenics and normal controls, and whether any difference between the dopamine $D_4$ receptor alleles of schizophrenics and that of normal controls exists. Methods : DNA was extracted from the blood of schizophrenic patients(N=60) and normal controls(N=60). Part of the dopamine $D_4$ receptor gene was amplified by PCR, and amplified DNA was electrophoresed. Authors compared the distribution of the alleles of dopamine $D_4$ receptor gene of normal controls and that of schizophrenic patients. Results : Six kinds of alleles of $D_4$ receptor were observed both groups. The fourth repeat form of alleles was the most common in both schizophrenic patients(75.8%) and normal controls(70.3%), so there was not significant difference between two groups. Conclusion : The Difference in the distribution of the dopamine $D_4$ receptor gene alleles is not thought to be responsible for the pathophysiology of the schizophrenia. However, the difference in the expression of the dopamine $D_4$ receptor gene between normal and schizophrenia is left to be scrutinized.