• IMMUNE NETWORK
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• v.21 no.3
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• pp.23.1-23.16
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• 2021

Chemokines are key factors that influence the migration and maintenance of relevant immune cells into an infected tissue or a tumor microenvironment. Therefore, it is believed that the controlled administration of chemokines in the tumor microenvironment may be an effective immunotherapy against cancer. Previous studies have shown that CCL3, also known as macrophage inflammatory protein 1-alpha, facilitates the recruitment of dendritic cells (DCs) for the presentation of tumor Ags and promotes T cell activation. Here, we investigated the role of CCL3 in regulating the tumor microenvironment using a syngeneic mouse tumor model. We observed that MC38 tumors overexpressing CCL3 (CCL3-OE) showed rapid regression compared with the wild type MC38 tumors. Additionally, these CCL3-OE tumors showed an increase in the proliferative and functional tumor-infiltrating T cells. Furthermore, PD-1 immune checkpoint blockade accelerated tumor regression in the CCL3-OE tumor microenvironment. Next, we generated a modified CCL3 protein for pre-clinical use by fusing recombinant CCL3 (rCCL3) with a non-cytolytic hybrid Fc (HyFc). Administering a controlled dose of rCCL3-HyFc via subcutaneous injections near tumors was effective in tumor regression and improved survival along with activated myeloid cells and augmented T cell responses. Furthermore, combination therapy of rCCL3-HyFc with PD-1 blockade exhibited prominent effect to tumor regression. Collectively, our findings demonstrate that appropriate concentrations of CCL3 in the tumor microenvironment would be an effective adjuvant to promote anti-tumor immune responses, and suggest that administering a long-lasting form of CCL3 in combination with PD-1 blockers can have clinical applications in cancer immunotherapy.

• Trans-
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• v.10
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• pp.73-113
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• 2021

Previous studies show that VR images can influence consumers' attitudes and behaviors by evoking imagination. In this study, we introduce a reality-based closed-loop 3D image (hereafter Virtualgraph). Then we try to see whether such image would increase evocativeness in a mobile commerce environment and whether higher telepresence of the visual image of a product can increase the purchase intention of that product. In order to find the above, we developed a model comprised of constructs containing telepresence, perceived value price, perceived food quality, and vividness of visual imagery questionnaire (VVIQ). We used Virtualgraph application to conduct an experiment, and then conducted an interview as well as a survey. As results of the experiment, survey and interview, we found the followings. First, users evoke imagination better with Virtualgraph than with still images. Second, increased evocativeness affects purchase intention if the perceived quality of fresh food product is satif actory. Third, increased evocativeness makes users value products higher and do even much higher when the perceived quality of fresh food product is good. From the interview, we could find that the experimental group had higher purchase intentions and perceived products as more expensive ones. Also, they perceived images of products clearer and more vivid than did the control group. We also discuss the strategic implications of using Virtualgraph in mobile shopping malls.

• Childhood Kidney Diseases
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• v.13 no.2
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• pp.138-145
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• 2009

Purpose : This study was aimed to evaluate the changes of immunologic parameters during hospitalization, and the relationship between IgG and other laboratory or clinical indices in patients with acute poststreptococcal glomerulonephritis (APSGN). Methods : We reviewed the medical charts of 36 children with APSGN who showed ASO titer>250 Todd U/L and C3<70 mg/dL. We evaluated the levels of IgG and other laboratory parameters including C3 and ASO at admission and at discharge (14 cases). Results : The mean age of APSGN patients was $7.5{\pm}2.6$ year of age, and male-to-female ratio was 2.3:1. At presentation, hypertension (systolic blood pressure>125 mmHg), gross hematuria, and weight gain were observed in 27.8% (10/36), 80.1% (29/36), and 80% (24/30) of the patients, respectively. The mean IgG level was $1,432{\pm}322$ mg/dL ($1,025{\pm}234$ mg/dL in control group, P<0.001), and C3 and ASO levels were $26.1{\pm}16.1$ mg/dL and $1,068{\pm}730$ Todd U, respectively. There were no correlation between IgG level and the levels of any of the parameters analyzed (ASO, C3, BUN, creatinine and white blood cell count), and the severity of the disease assessed by the weight-change during admission. The patients aged<6 years of age (10 cases) had less degree of the weight-change, compared to those of the patients aged>8 years of age (15 cases) (-0.6% vs. -5.7%, P=0.01). The IgG and ASO levels did not change, but C3 (P=0.001) and IgM (P=0.02) levels increased during admission. Conclusion : Increased IgG and ASO levels in APSGN did not change, but C3 level increased during admission. IgG level was not correlated with other laboratory parameters (ASO and C3) and the severity of the disease. Younger children seem to have less severe clinical course compare to older children. With our hypothetic pathogenesis of APSGN, further studies are needed to resolve the pathogenesis of the disease including the increase of IgG.

• Journal of Korean Institute of Industrial Engineers
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• v.37 no.2
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• pp.118-123
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• 2011

This study aims to investigate stereotype and effective cue presentation methods for burner-control relationship of four-stove range for Korean. A total of 381 subjects(male : 262, female : 119) were surveyed using questionnaire, in which eight gas range models drawn by 3-D Max 2010 were presented. The gas range models were labeled by signs(☆#${\triangle}{\square}$) to eliminate suggestive effect of sequential codes such as alphabets and numbers. The results showed that the stereotype was significantly affected by occupation(p < 0.10), but not by subjects' gender and age(p > 0.39). The stereotype of four-burner gas range for Korean was the same as that of Chinese, while the stereotype was different from that of American. The cues with rectangular-shaped arrangements identical or similar to those of burners were effective to relate burners to corresponding controls. The diamond-shaped cues and burner arrangements were not appropriate for representing burner-control relationship of four-stove gas range. These findings would be used as a basic guideline when designing four-burner gas range or similar equipments.

• Steel and Composite Structures
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• v.34 no.5
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• pp.657-670
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• 2020

In this paper, vibration analysis of functionally graded nanoshell is studied based on the sinusoidal higher-order shear and normal deformation theory to account thickness stretching effect. To account size-dependency, Eringen nonlocal elasticity theory is used. For more accurate modeling the problem and corresponding numerical results, sinusoidal higher-order shear and normal deformation theory including out of plane normal strain is employed in this paper. The radial displacement is decomposed into three terms to show variation along the thickness direction. Governing differential equations of motion are derived using Hamilton's principle. It is assumed that the cylindrical shell is made of an arbitrary composition of metal and ceramic in which the local material properties are measured based on power law distribution. To justify trueness and necessity of this work, a comprehensive comparison with some lower order and lower dimension works and also some 3D works is presented. After presentation of comparative study, full numerical results are presented in terms of significant parameters of the problem such as small scale parameter, length to radius ratio, thickness to radius ratio, and number of modes.

• Journal of Adhesion and Interface
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• v.3 no.1
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• pp.37-42
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• 2002

Adhesives are becoming increasingly accepted for advanced engineering/boding tasks. Therefore the understanding of the basic principles and the benefits of elastic bonding and structural bonding respectively is of utmost importance. Structural bonding means adhesive performance in load-bearing environments. Furthermore. the time to achieve handling strength has an impact on the economics of an assembly line. The paper gives briefly a summary about the fundamentals of elastic bonding and discusses different adhesive systems in the context of handling strength. Hereby the focus lies on the Warm Melt Technology, and its potential is compared to standard adhesives (l-part, 2-part and Booster Technology, a special 2-C system). Examples illustrate their economical benefits. Main Points : ${\bullet}$ The basic principles and benefits of elastic bonding ${\bullet}$ Warm-melt Technology in comparison with standard adhesives ${\bullet}$ Handling strength an economic issue ${\bullet}$ Combination with Booster-Technology, a special 2-C PUR system ${\bullet}$ Presentation of real world applications Learning Objectives: ${\bullet}$ Fundamentals of elastic bonding ${\bullet}$ Warm-melt Technology: correlation between chain length and cristallinity ${\bullet}$ Handling strength and curing speed of various systems in comparison ${\bullet}$ Real world applications illustrate the potential of the Warm-melt Technology.

• Journal of the Korean Child Neurology Society
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• v.24 no.3
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• pp.71-83
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• 2016

X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ATP binding cassette subfamily D member 1 (ABCD1), a gene that encodes peroxisomal membrane located on ABC half-transporter named adrenoleukodystrophy protein (ALDP). X-ALD is characterized by a highly variable clinical spectrum, including progressive cerebral type, adrenomyeloneuropathy, and addison-only phenotype. No genotype/phenotype correlation has been established. Thus, unidentified modifier genes and other co-factors are speculated to modulate the phenotypic variation and disease severity. Recent advanced sequencing methods and reprogramming technologies not only offer an affordable and applicable approach to investigate the pathophysiological mechanisms of adrenoleukodystrophy, but also provide means to develop therapy. A causal therapy of X-ALD is lacking. Lorenzo's oil therapy is recommended for asymptomatic boys, but the longest study found that the oil was not beneficial at all to symptomatic X-ALD patients. Hematopoietic stem cell therapy has a relevant chance of success when performed during this early stage of cerebral type X-ALD. Recently, it has been insisted that lentiviral-mediated gene therapy of hematopoietic stem cells can provide clinical benefits in X-ALD. This review describes current knowledge on the clinical presentation, pathogenesis, diagnosis and management of X- ALD.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.29 no.4
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• pp.83-90
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• 2006

It has lately been difficult to share the research outcomes information due to the information system not being compatible with one another. To solve this problem, it is believed that a meta data standard needs to be developed for all the institutions to follow. This paper shows how to make the research outcome of Science and Technology R&D project a standard metadata. We first classified all the research outcome into the following seven groups: Report, Journal article, Presentation material, Book, Dissertation, Industrial rights, and Technology development. We then identified three components that constitute a standard metadata. We employed the Dublin Core Metadata Set and CERIF(Common European Research Information Format) for worldwide interoperability. This Standard can be applied in the following areas: 1) Developing a standard architecture to manage research result within the organization. 2) Designing a conceptual/logical database to measure and evaluate the research outcome. 3) Developing a metadata system for research outcome as a subsystem of an Industrial Technology MDR (Metadata Registry) System.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.2
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• pp.48.1-48.1
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• 2021

The Main-belt asteroid (298) Baptistina (hereafter 'Baptistina') is regarded as an X- (or C-) type asteroid and the largest member of the Baptistina asteroid family. Its basic physical properties play an important role in understanding the rotational evolution and orbital dynamics of the Baptistina family. In this study, we determined the physical characteristics of Baptistina from the optical observations. We conducted BVRI and R band photometric observations from 2017 to 2021 for a total of 47 nights using the 0.5 - 2.0 m-class telescopes. As a result, the color indices of Baptistina were derived as, , and ; this result is consistent with the previous classification of Baptistina as an X- (or C-) type. We also determined absolute magnitude () and slope parameter () by using a simplified version of the IAU H & G function (Bowell et al. 1989) are mag and respectively. We calculated the effective radius of Baptistina of km considering the visual geometric albedo of 0.131 from the NEOWISE data. Using the light-curve inversion method, the sidereal rotation period of 16.224235 h and the 3D shape model with a pole orientation (,) were also determined. In this presentation we will introduce our observations and results, and also discuss about the physical properties of Baptistina asteroid family members such as color indices.

• Clinical and Experimental Pediatrics
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• v.50 no.12
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• pp.1188-1193
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• 2007

Purpose : The prevalence of rickets in the world is on the rise not only in developing but also in developed countries. In Korea, breastfeeding has increased. There have been few studies on the possible association of rickets with breastfeeding. The purpose of this study was to identify the development and the clinical presentation of subclinical rickets in breastfed infants. Methods : We investigated patients who were breastfed and had hypovitaminosis D in the blood from May 2006 to April 2007, and who were diagnosed with vitamin D deficient rickets from May 2003 to April 2006. We evaluated the results of blood tests, x-rays and other relevant information in the medical record. A questionnaire that included questions on the diet of patients, the mothers activity during pregnancy and place of residence was administered. Results : Twelve patients (66%: male, 34%: female) were enrolled in this study. There were eight in the asymptomatic and four in the symptomatic group. The median age for each group was 8 months (range 4-11 month) and 5.5 months (5-8 month). All patients in the symptomatic group were breastfed until diagnosed. In the asymptomatic group, they were breastfed for four to six months, and then weaned with only thin rice soup and vegetables. Nine patients had a vitamin D concentration below 20 ng/mL and three patients had levels between 20 and 29 ng/mL. Alkaline phosphatase (ALP) and parathyroid hormone (PTH) were elevated in both groups. There were statistically significant $25-OHD_3$ levels in the blood in both groups (P=0.008). Ten of the patients (83%) also had iron deficient anemia. Conclusion : Vitamin D deficiency and subclinical rickets has been identified in Korea. However, the prevalence of this disease has not been determined. The main limitation of this study was the small number of patients and the absence of a control group.