• Radiation Oncology Journal
• /
• v.9 no.1
• /
• pp.131-141
• /
• 1991

A comprehensive set of dosimetric measurements has been made on the Varian Clinac 1800 15 MV photon beam. Beam quality, percentage depth dose, dose in the build up region, output, symmetry and flatness, transmission through iead (Cerrobend), tray attenuation, isodose curves for the open and wedged fields were measured using 3 dimensional water phantom dosimetry system (including film densitometer system) and polystyrene phantoms. These dosimetric measurements sufficiently characterized the beam to permit clinical use. The depth dose characteristics of photon beam is $d_{max}$ of 3.0 cm and percentage depth dose of $76.8\%$ at 10 cm,100 cm source-surface distance, field size of $10\times10\;cm^2$ for 15 MV X-ray beam. The Output factors ranged 0.927 for $4\times4\;cm^2$ field to 1,087 for $35\times35\;cm^2$ field. The build-up level of maximum dose was at 3.0 cm and surface dose was approximately $15.5\%$ for a field size $10\times10\;cm^2$ The stability of output is $within\pm1\%$ and flatness and symmetry are $within\pm3\%$. The half value thickness (HVL) of lead is 13 mm, which corresponds to an attenuation coefficient of $0.053\;mm^{-1}$. These figures compare facorably with the manufacturesr`s specifications.

• Journal of the Korean Magnetic Resonance Society
• /
• v.9 no.1
• /
• pp.48-60
• /
• 2005

Purpose: The purpose of this study was to design and build an optimized birdcage resonator configuration with a low pass filter, which would facilitate the acquisition of high-resolution 3D-image of small animals at 3T MRI system. Methods and Materials: The birdcage resonator with 12-element structures was built, in order to ensure B1 homogeneity over the image volume and maximum filling factor, and hence to maximize the signal to noise ratio (SNR) and resolution of the 3-dimensional images. The diameter and length of each element of a birdcage resonator were as follows: (1) diameter 13 cm, length 22 cm, (2) diameter 15 cm, length 22 cm, (3) diameter 17 cm, length 25 cm. Spin echo pulse sequence and fast spin echo pulse sequence were employed in obtaining MR images. The quality of the manufactured birdcage resonators wes evaluated on the basis of the return loss following matching and tuning process. Results: The experimental MR image of phantoms by the various manufactured birdcage resonators were obtained to compare the SNR in accordance with the size of objects. The size of an object to that of coil was identified by parameters that were estimated from the image of a phantom. First, the diameter of the birdcage resonator was 15cm, and the ratio of the tangerine to the birdcage resonator accounted for approximately 27%. The Q factor was 53.2 and the SNR was 150.7. Second, at the same birdcage resonator, the ratio of the orange was approximately 53%. The SNR and the Q parameter was 212.8 and 91.2, respectively. Conclusion: The present study demonstrated that if birdcage resonators have the same forms, SNR could be different depending on the size of an object, especially when the size of an object to that of coil is approximately 40~80%, the former is bigger than the latter. Therefore, when the size of an object to be observed is smaller than that of coil, the coil should be manufactured in accordance with the size of an object in order to obtain much more excellent images.

• Tunnel and Underground Space
• /
• v.8 no.3
• /
• pp.209-225
• /
• 1998

Recently, Umbrella Arch Method(UAM), one of the auxiliary techniques for tunnelling, is used to reinforce the ground and improve stability of tunnel face. Because UAM combines the advantages of a modern forepoling system with the grouting injection method, this technique has been applied in subway, road and utility tunnel sites for the last few years in Korea. Also, several research results are reported on the examination of the roles of inserted pipes and grouted materials in UAM. But, because of its empirical design and construction methodology, more qualitative and systematic design sequences are needed. Therefore, above sequences using numerical analysis are proposed and, the effects of some design parameters were studied in this research. In order to acco,mplish these objects, first, the roles of pipe and grouting materials, steel-rib and the others in ground improving mechanism of UAM are clarified. Second, the effects of design parameters are investigated through parametric studies. Design parameters are as follows; 1) ground condition, 2) overburden, 3) geometrical formulation of pipes, 4) grouting region and 5) characteristics of pipes.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.32 no.5C
• /
• pp.199-210
• /
• 2012

The effects of tunnelling in weak weathered rock on the behaviour of a pre-existing single pile and pile groups ($3{\times}3$ and $5{\times}5$ pile groups) above a tunnel have been studied by carrying out three-dimensional (3D) elasto-plastic numerical analyses. Numerical modelling of such effects considers the response of the single pile and pile groups in terms of tunnelling-induced ground and pile settlement as well as changes of the shear transfer mechanism at the pile-soil interface due to tunnelling. Due to changes in the relative shear displacement between the pile and the soil at the pile-soil interface with tunnel advancement, the shear stresses and axial pile force distributions along the pile change drastically. Based on the computed results, upward shear stresses are induced up to about Z/L=0.775 from the pile top, while downward shear stresses are mobilised below Z/L=0.775, resulting in a reduction in the axial pile force distribution with depth equivalent to a net increase in the tensile force on the pile. A maximum tensile force of about $0.36P_a$ developed on the single pile solely due to tunnelling, where $P_a$ is the service axial pile loading prior to tunnelling. The degree of interface shear strength mobilisation at the pile-soil interface was found to be a key factor governing pile-soil-tunnelling interaction. Overall it has been found that the larger the number of piles, the greater is the effect of tunnelling on the piles in terms of pile settlement, while changes of the axial pile forces for the piles in the groups are smaller than for a single pile due to the shielding effect. The reduction of apparent allowable pile capacity due to tunnelling-induced pile head settlement was significant, in particular for piles inside the groups.

• Journal of Korean Ophthalmic Optics Society
• /
• v.6 no.1
• /
• pp.149-153
• /
• 2001

Three-dimensional thermoluminescence(TL) spectra of LiF: Mg, Cu, Na, Si TL material based on temperature, wavelength and intensity were measured and analyzed. The glow curves were obtained by integration of luminescence intensity for wavelength at each temperature, and various trapping parameters related to the trap formation were determined by analyzing these curves. Computerized glow curve deconvolution(CGCD) method which based on general order kinetics(GOK) model were used for the glow curve analysis. The glow curves of LiF:Mg, Cu, Na, Si TL material were deconvoluted to six isolated glow curves which have peak temperature at 333 K, 374 K, 426 K, 466 K, 483 K and 516 K, respectively. The 466 K main glow peak had an activation energy of 2.06 eV and a kinetic order of 1.05. This TL material was also found to have three recombination centers, 1.80 eV, 2.88 eV and 3.27 eV by TL spectra analysis based on Franck-Condon model. It showed that 2.88 eV is the dominant center, followed by 3.27 eV level, and 1.80 eV center is ascertained as emission center of this material even though its very weak emission intensity.

• Korean Chemical Engineering Research
• /
• v.55 no.2
• /
• pp.201-213
• /
• 2017

Water is removed from crude oil containing water by using oil separator. This study aims to develop a three-dimensional (3D) Eulerian computational fluid dynamics (CFD) model to predict the separation efficiency of air-water-oil separator. In the incompressible, isothermal and unsteady-state CFD model, air is defined as continuous phase, and water and oil are given as dispersed phase. The momentum equation includes the drag force, lift force and resistance force of porous media. The standard k-${\varepsilon}$ model is used for turbulence flow. The exit pressures of water and oil play an important role in determining the liquid level of the oil separator. The exit pressures were identified to be 6.3 kPa and 5.1 kPa for water and oil, respectively, to keep a liquid level of 25 cm at a normal operating condition. The time evolution of volume fractions of air, water and oil was investigated. The settling velocities of water and oil along the longitudinal separator distance were analyzed, when the oil separator reached a steady-state. The oil separation efficiency obtained from the CFD model was 99.85%, which agreed well with experimental data. The relatively simple CFD model can be used for the modification of oil separator structure and finding optimal operating conditions.

• Korean Journal of Applied Biomechanics
• /
• v.15 no.3
• /
• pp.95-104
• /
• 2005

To know the proper setup posture for the various clubs, changes of setup variables according to the change of golf club length was investigated. Swing motions of three male low handicappers including a professional were taken using two high-speed videocameras. Four clubs iron 7, iron 5, iron 3 and driver (wood 1) were selected for this experiment. Three dimensional motion analysis techniques were used to get the kinematical variables. Mathcad and Kwon3D motion analysis program were used to analyze the position, distance and angle data in three dimensions. The variables divided into three categories 1) position and width of anterior-posterior direction 2) position and width of lateral direction 3) angles and evaluated based on the theories of many good golf teachers. Major findings of this study were as follows. 1.The stance (distance between ankle joints) was increased as the length of the club increased but the increasing width was not large. It ranges from 5cm to 10cm and professional player showed small changes. 2. Forward lean angle of trunk was decreased (more erected) as the length of the club increased. It ranges from 30 degrees for iron7 to 25 degrees for driver. 3. Angle between horizontal and right shoulder were increased as the length of the club increased. It ranges from 10 degrees to 20 degrees and professional player showed small changes. 4. Anterior-posterior position of the shoulders were located in front of the foot for all clubs and the difference between the shoulder and knee position was decreased as the length of the club increased. 5. Anterior-posterior position of grip (hand) was located almost beneath the shoulders (2.5cm front) for iron7, but it increased to 10cm for the driver. This grip adjustment makes the height of the posture increased only 5cm from iron7 to driver. 6. Lateral position of grip located at 5cm left for the face of iron7, but it located at the right side (behind) for the face of driver. 7. Lateral position of the ball located at the 40%(15cm) of stance from left ankle for iron7 and located at the 10% (5cm) of stance for driver. 8. Head always located at the right side of the stance and the midpoint of the eyes located at the 37% of stance from the right ankle for all clubs. This means that the axis of swing always maintained consistently for all clubs. 9. Left foot opened to the target for all subject and clubs. The maximum open angle was 25 degrees. Overall result shows that the changes of the setup variables vary only small ranges from iron7 to driver. Paradoxically it could be concluded that the failure of swing result from the excessive changes of setup not from the incorrect changes. These findings will be useful for evaluating the setup motion of golf swing and helpful to most golfers.

• Tunnel and Underground Space
• /
• v.23 no.3
• /
• pp.180-191
• /
• 2013

The purpose of this research was to find an optimal quarrying for marble by analyzing the applicability and the work efficiency of a chain saw machine newly introduced in the underground Baekwoon mine. From the test results of the physical properties of Baekwoon marble, which affects the efficiency of rock cutting, it was found to have similar physical characteristics as the ones which are now being produced in the other areas in Korea. And especially it shows isotropic property, which can be thought to be advantageous as a dimensional stone. To check the long-term quality of the marble as a stone material, several tests such as corrosion resistance test and abrasion test were carried out. It was found to be vulnerable to acid rain with decrease of weight and seismic wave velocity after applying artificial rain at pH 5.6 for 50 times. The percentage of wear from abrasion test was 22.67%. The working time and cutting speed of the chain saw machine were recorded and analyzed during the test-run at the quarry. The overall work cycle was assorted into 9 unit operations and the operating time per each unit was drawn. The operating times for the two cutting patterns, which could be possibly applicable to the work site, were compared. The results indicated that the pattern B, that the cutting sequence was set to minimize the movement of the machine, showed 6% less working hours than the pattern A, which first cuts the outer boundary. With cutting pattern analysis, the ore body in the Baekwoon mine was 3 dimensionally modeled and a quarrying plan considering the existing conditions of the marble was suggested.

• Journal of Microbiology and Biotechnology
• /
• v.31 no.7
• /
• pp.933-941
• /
• 2021

Ginsenoside Rg4 is a rare ginsenoside that is naturally found in ginseng, and exhibits a wide range of biological activities including antioxidant and anti-inflammatory properties in several cell types. The purpose of this study was to use an in vivo model of hair follicle (HF)-mimic based on a human dermal papilla (DP) spheroid system prepared by three-dimensional (3D) culture and to investigate the effect of Rg4 on the hair-inductive properties of DP cells. Treatment of the DP spheroids with Rg4 (20 to 50 ㎍/ml) significantly increased the viability and size of the DP spheres in a dose-dependent manner. Rg4 also increased the mRNA and protein expression of DP signature genes that are related to hair growth including ALP, BMP2, and VCAN in the DP spheres. Analysis of the signaling molecules and luciferase reporter assays further revealed that Rg4 induces the activation of phosphoinositide 3-kinase (PI3K)/AKT and the inhibitory phosphorylation of GSK3β, which activates the WNT/β-catenin signaling pathway. These results correlated with not only the increased nuclear translocation of β-catenin following the treatment of the DP spheres with Rg4 but also the significant elevation of mRNA expression of the downstream target genes of the WNT/β-catenin pathway including WNT5A, β-catenin, and LEF1. In conclusion, these results demonstrated that ginsenoside Rg4 promotes the hair-inductive properties of DP cells by activating the AKT/GSK3β/β-catenin signaling pathway in DP spheres, suggesting that Rg4 could be a potential natural therapy for hair growth.

• Microbiology and Biotechnology Letters
• /
• v.38 no.4
• /
• pp.420-427
• /
• 2010

A process for manufacturing virally-safe bovine amniotic membrane(BAM) has been developed for biological dressing. BAM was harvested from a healthy bovine placenta, and then the epithelium was removed. The remaining stromal layer was consecutively disinfected with 70% ethanol and 0.05% sodium hypochlorite. The stromal layer was incubated in a decellularization solution containing 0.25%(w/v) trypsin to remove the cellular components. The resulting acelluar BAM was lyophilized to preserve its biochemical and structural integrity. The BAM was packed and exposed to 25 kGy of gamma irradiation for sterilization purpose. Histological, electron microscopical, and biochemical observations showed that the acellualr BAM had intact structural integrity of three dimensional collagen fibers and contained several growth factors, accelerating wound healing, such as EGF (Epidermal growth factor), KGF (Keratinocyte growth factor), and FGF (Fibroblast growth factor). Bovine herpes virus (BHV), bovine viral diarrhoea virus (BVDV), bovine parainfluenza virus type 3 (BPIV-3), and bovine parvovirus (BPV) were chosen as the biological indicators for validation of viral safety of the acellular BAM. Samples from relevant stages of the production process were spiked with each virus and subjected to viral inactivation processes. Viruses were recovered from the samples and then titrated immediately. All the viruses tested were completely inactivated to undetectable levels within 1 h of 70% ethanol treatment. Enveloped viruses such as BHV, BVDV, and BPIV-3 were more effectively inactivated than BPV by 0.05% sodium hypochlorite treatment. BHV, BVDV, and BPIV-3 were completely inactivated to undetectable levels by 25 kGy of gamma irradiation. Also BPV was effectively inactivated by 25 kGy of gamma irradiation. The cumulative log reduction factors of BHV, BVDV, BPIV-3, and BPV were ${\geq}$13.30, ${\geq}$14.32, ${\geq}$15.22, and ${\geq}$7.57, respectively. These results indicate that the production process for acelluar BAM has a sufficient virus-reducing capacity to achieve a high margin of the virus safety.