• Journal of the Optical Society of Korea
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• v.19 no.1
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• pp.55-62
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• 2015

In this study we demonstrate ultrahigh-resolution spectral domain optical coherence tomography (UHR SD-OCT) with a linear-wavenumber (k) spectrometer, to accelerate signal processing and to display two-dimensional (2-D) images in real time. First, we performed a numerical simulation to find the optimal parameters for the linear-k spectrometer to achieve ultrahigh axial resolution, such as the number of grooves in a grating, the material for a dispersive prism, and the rotational angle between the grating and the dispersive prism. We found that a grating with 1200 grooves and an F2 equilateral prism at a rotational angle of $26.07^{\circ}$, in combination with a lens of focal length 85.1 mm, are suitable for UHR SD-OCT with the imaging depth range (limited by spectrometer resolution) set at 2.0 mm. As guided by the simulation results, we constructed the linear-k spectrometer needed to implement a UHR SD-OCT. The actual imaging depth range was measured to be approximately 2.1 mm, and axial resolution of $3.8{\mu}m$ in air was achieved, corresponding to $2.8{\mu}m$ in tissue (n = 1.35). The sensitivity was -91 dB with -10 dB roll-off at 1.5 mm depth. We demonstrated a 128.2 fps acquisition rate for OCT images with 800 lines/frame, by taking advantage of NVIDIA's compute unified device architecture (CUDA) technology, which allowed for real-time signal processing compatible with the speed of the spectrometer's data acquisition.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.29 no.9
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• pp.722-730
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• 2018

This paper presents an analysis technique for estimating the properties of a target's power-spill patterns observed in reconstructed SAR images, which in turn depend on the setup squint angle of the FMCW signal-based SAR system. The target responses observed in the reconstructed SAR images were affected by the range-direction and azimuth-direction of a wave projected on the ground, and the obtained results were analyzed by applying three-dimensional squinted SAR geometry. Furthermore, the rotation patterns were verified through simulations based on the FMCW signal model and back-projection algorithm. This paper summarizes the obtained evaluation results as a function of SAR geometry and squint angle.

• The KIPS Transactions:PartD
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• v.10D no.1
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• pp.133-142
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• 2003

The major challenge for post-genomic study is to identify structural similarity and relationships of proteins. SCOP (Structural Classification of Proteins) is a typical database for this purpose, providing a derailed description of the structural and functional relationships of the proteins whose three-dimensional structures have been determined. Unfortunately, since the SCOP data is only available as a plain text format, it is cumbersome and error-prone to develop tools and resources to utilize the data more effectively. To meet these researchers to utilize the data more effectively. To meet these requirements, we have developed an XML representation for the SCOP site, users of the tool, named, SCOPBrowser, for effective search of SCOP database. In addition to the information available from the SCOP site, users of the tool can obtain various information such as viewing the tree hierarchy of structure classification of proteins, searching into whole protein domains, showing XML contents of a specific domain, and some useful statistics about protein structures.

• 한국신재생에너지학회:학술대회논문집
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• 2011.11a
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• pp.47.1-47.1
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• 2011

We report on a direct measurement of two-dimensional chemical and electrical distribution on the surface of photovoltaic Cu(In,Ga)$Se_2$ thin-films using a nano-scale spectroscopic and electrical characterization, respectively. The Raman measurement reveals non-uniformed surface phonon vibration which comes from different compositional distribution and defects in the nature of polycrystalline thin-films. On the other hand, potential analysis by scanning Kelvin probe force microscopy shows a higher surface potential or a small work function on grain boundaries of the thin-films than on the grain surfaces. This demonstrates the grain boundary is positively charged and local built-in potential exist on grain boundary, which improve electron-hole separation on grain boundary. Local electrical transport measurements with scanning probe microscopy on the thin-films indicates that as external bias is increases, local current is started to flow from grain boundary and saturated over 0.3 V external bias. This accounts for carrier behavior in the vicinity of grain boundary with regard to defect states. We suggest that electron-hole separation at the grain boundary as well as chemical and electrical distribution of polycrystalline Cu(In,Ga)$Se_2$ thin-films.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.30 no.6
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• pp.559-566
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• 2017

This paper proposes a new composite deckplate system reinforced with inverted triangular truss girders(called 'D Deck'), which does not require the use of temporary supports at construction stage. The proposed system retains increased stiffness and strength while keeping the absolute floor height change to a minimum level and can be utilized as floor systems of various types beam members such as the conventional wide-flange and U-shaped composite beams. In order to evaluate the performance of the proposed system, five specimens with a span of 5.5 m were fabricated and tested under field loading conditions consisting of several intermediate steps. The load-deflection curves of each specimen were plotted and compared with the nonlinear three-dimensional finite element analysis results. The comparison showed that the effective load sharing between the truss girders and floor deck occurs and the maximum deflection under construction stage loading is well below the limit estimated by the provisions in Korea Building Code.

• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.245-245
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• 2015

In the recent years, due to long-lasting heavy rainfall events, a large number of landslides have been observed in the mountainous area of the world. Such landslides can also form a dam as it blocks the course of a river, which may burst and cause a catastrophic flood. Numerical analysis of landslide dam formation is rarely available, while laboratory experimental studies often use assumed shape to analyze the landslide dam failure and flood hydraulics in downstream. In this study, both experimental and numerical studies have been carried out to investigate the formation of landslide dam. Two case laboratory experiments were conducted in two flumes simultaneously. The first flume (2.0 m 0.6 m 0.5 m) was set at $22^{\circ}$ and $27^{\circ}$ slope to generate the landslide using rainfall intensity of 70.0 mm/hr. On the other hand, the second flume (1.5 m 0.25 m 0.3 m) was set perpendicularly at the downstream end of the first flume to receive the landslide mass forming landslide dam. The formation of landslide dam was observed at $15^{\circ}$ slope of the second flume. The whole processes including the landslide initiation and movement of the landslide mass into the second channel was captured by three digital cameras. In numerical analysis, a two-dimensional (2D) seepage flow model, a 2D slope stability model (Spencer method) and a 2D landslide dam-geometry evaluation model were coupled as a single unit. This developed model can determine the landslide occurrence time, the failure mass and the geometry of landslide dam deposited in the second channel. The data obtained from numerical simulation results has good agreement with the experimental measurements.

• Journal of Korean Society of Disaster and Security
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• v.11 no.2
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• pp.83-89
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• 2018

The significant sedimentation at the estuary in the eastern coast of Korea frequently causes river mouth occlusion where disconnection between the river and sea is observed. River mouth occlusion causing watershed retention raises the environmental risk of the area as it impairs water quality and threatens the area's safety in the event of floods. This study proposes a plan to maintain stability of river channel and flow of flood discharge at the estuary with loss of its function for disaster prevention. To this end, the study tries to change the location and width of stream path, focusing on the center line of stream near the sand bar of river mouth. This allows to identify a shape of stream path that leads the most stable flow. To review the result, this study uses the SRH-2D, a model for two-dimensional hydraulic analysis, and conduct numeric simulation. The simulation result showed that the most effective plan for maintaining the stable flow of running water without having the area sensitive to changes in hydraulic characteristics is to lower the overall river bed height of the sand bar near the center line of stream to a equal level.

• Tissue Engineering and Regenerative Medicine
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• v.15 no.6
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• pp.761-769
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• 2018

BACKGROUND: Bioprinting has recently appeared as a powerful tool for building complex tissue and organ structures. However, the application of bioprinting to regenerative medicine has limitations, due to the restricted choices of bio-ink for cytocompatible cell encapsulation and the integrity of the fabricated structures. METHODS: In this study, we developed hybrid bio-inks based on acrylated hyaluronic acid (HA) for immobilizing bio-active peptides and tyramine-conjugated hyaluronic acids for fast gelation. RESULTS: Conventional acrylated HA-based hydrogels have a gelation time of more than 30 min, whereas hybrid bio-ink has been rapidly gelated within 200 s. Fibroblast cells cultured in this hybrid bio-ink up to 7 days showed >90% viability. As a guidance cue for stem cell differentiation, we immobilized four different bio-active peptides: BMP-7-derived peptides (BMP-7D) and osteopontin for osteogenesis, and substance-P (SP) and Ac-SDKP (SDKP) for angiogenesis. Mesenchymal stem cells cultured in these hybrid bio-inks showed the highest angiogenic and osteogenic activity cultured in bio-ink immobilized with a SP or BMP-7D peptide. This bio-ink was loaded in a three-dimensional (3D) bioprinting device showing reproducible printing features. CONCLUSION: We have developed bio-inks that combine biochemical and mechanical cues. Biochemical cues were able to regulate differentiation of cells, and mechanical cues enabled printing structuring. This multi-functional bio-ink can be used for complex tissue engineering and regenerative medicine.

• Geomechanics and Engineering
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• v.24 no.4
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• pp.323-335
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• 2021

This paper aims to estimate the range of the excavation damaged zone (EDZ) formation caused by the tunnel boring machine (TBM) advancement through dynamic three-dimensional large deformation finite element analysis. Large deformation analysis based on Coupled Eulerian-Lagrangian (CEL) analysis is used to accurately simulate the behavior during TBM excavation. The analysis model is verified based on numerous test results reported in the literature. The range of the formed EDZ will be suggested as a boundary under various conditions - different tunnel diameter, tunnel depth, and rock type. Moreover, evaluation of the integrity of the tunnel structure during excavation has been carried out. Based on the numerical results, the apparent boundary of the EDZ is shown to within the range of 0.7D (D: tunnel diameter) around the excavation surface. Through series of numerical computation, it is clear that for the rock of with higher rock mass rating (RMR) grade (close to 1st grade), the EDZ around the tunnel tends to increase. The size of the EDZ is found to be direct proportional to the tunnel diameter, whereas the depth of the tunnel is inversely proportional to the magnitude of the EDZ. However, the relationship between the formation of the EDZ and the stability of the tunnel was not found to be consistent. In case where the TBM excavation is carried out in hard rock or rock under high confinement (excavation under greater depth), large range of the EDZ may be formed, but less strain occurs along the excavation surface during excavation and is found to be more stable.

• Annals of Clinical Neurophysiology
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• v.1 no.2
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• pp.112-117
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• 1999

Background : Posterior tibial nerve somatosensory evoked potentials (PTSEP) have cortical potentials on primary sensory area of foot around 40 msec. The direct cortical recordings of the cortical potentials shows high voltage positive wave on medial hemisphere, especially on paracentral lobule (PCL). However, it is so difficult to record the potential directly on PCL that the cortical potential of PTSEP is not well understood. We investigated the cortical potential of PTSEP on subdural electrodes. Methods : We recorded cortical potentials to posterior tibial nerve stimulation on subdural electrodes which were on medial hemisphere near PCL in 15 intractable neocortical epilepsy patients. The numbers of subdural electrodes were 8 in 10 subjects ($1{\times}8array$) and 16 in 5 subjects ($2{\times}8arrays$). Seven subjects had three-dimensional imaging fusion (3D-fusion) of MRI and the electrodes using Analyze program. We investigated the amplitude, latency, polarity, and phase of the waves regarding location. Results : The waves had maximal amplitude on PCL in 4 subjects, precuneus in 1, cingulate gyrus nearest to PCL in 2 among 7 subjects with 3D-fusion. Also the electrodes were located on posterior area of PCL (2 out of 2 subjects with more than two electrodes put on PCL in 3D-fusion) and superior area of it (5 out of 5 subjects with $2{\times}8arrays $). All the high (more than 20 uV) amplitude around 40msec had positive polarity in 7 subjects. The phase reversals were detected between the electrodes with the highest amplitude and the just posterior (2 subjects) or anterior (6 subjects) located electrodes. The just posterior located electrodes had sharper phase reversal than the anterior one. Conclusion : PTSEP might have maximal amplitude of cortical potentials on the more superior and posterior area of PCL. The highest amplitude potential has positivity. The wave with maximal amplitude could have phase reversal of cortical potentials with surrounding electrodes, especially shaper with posterior part than with anterior one.