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간암에서 FGFR3 mRNA의 과발현과 FGFR3 유전자의 돌연변이 분석 (Overexpression of FGFR3 mRNA and Mutational Analysis of FGFR3 Gene in Hepatocellular Carcinoma)

  • 장영균;배현진;남석우
    • 약학회지
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    • 제56권6호
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    • pp.352-357
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    • 2012
  • FGFR3 is a member of the fibroblast growth factor receptor family which interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Accumulated evidence suggests that aberrant regulation of FGFR3 and genetic alterations are implicated in the development and progression of various cancers. Despite a high incidence of FGFR3 over-expression, no such investigation has been performed in hepatocellular carcinoma. Thus, we investigated genetic alterations of the FGFR3 gene in 73 cases of hepatocellular carcinoma by single-strand conformational polymorphism (SSCP) and sequencing. One silent mutation (A369A) was found in the extracellular domain of FGFR3, and one genetic alteration in the immunoglobulin-like III domain of FGFR3 appeared to be polymorphism. Taken together, we concluded that over-expression of FGFR3 in hepatocellular carcinoma is not associated with genetic alterations of FGFR3 gene, and we suggest that there could be another underlying mechanism of aberrant FGFR3 expression in hepatocellular carcinoma.

스커트 3D 모델의 기하학적 생성 방법 (A Geometrical Generation Method of the Skirt 3D Models)

  • 최우혁;최창석;김효숙;강인애
    • 한국의류학회지
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    • 제27권7호
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    • pp.770-777
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    • 2003
  • This paper proposes a geometrical method for generating and draping the skirt 3D models. The method constructs a 3D basic skirt model using a truncated elliptical cone and generates the various skirt 3D models by controlling the elliptical cone. The B-Spline approximates the 3D drapes which change variously according to the angles and the textiles of the skirts. The mapping sources consist of the textile textures and the skirt 2D model. The 2D models are obtained by mapping the 3D skirt models to the 2D plane. The mapping sources allow us to map the textiles to the 3D skirts. We make the real skirts for the 6 kinds of angles and textiles. and investigate the data of their drape appearances. The investigated data are applied to the virtual skirts. Appearances of the virtual skirts are similar to those of the real.

Ensemble UNet 3+ for Medical Image Segmentation

  • JongJin, Park
    • International Journal of Internet, Broadcasting and Communication
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    • 제15권1호
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    • pp.269-274
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    • 2023
  • In this paper, we proposed a new UNet 3+ model for medical image segmentation. The proposed ensemble(E) UNet 3+ model consists of UNet 3+s of varying depths into one unified architecture. UNet 3+s of varying depths have same encoder, but have their own decoders. They can bridge semantic gap between encoder and decoder nodes of UNet 3+. Deep supervision was used for learning on a total of 8 nodes of the E-UNet 3+ to improve performance. The proposed E-UNet 3+ model shows better segmentation results than those of the UNet 3+. As a result of the simulation, the E-UNet 3+ model using deep supervision was the best with loss function values of 0.8904 and 0.8562 for training and validation data. For the test data, the UNet 3+ model using deep supervision was the best with a value of 0.7406. Qualitative comparison of the simulation results shows the results of the proposed model are better than those of existing UNet 3+.

$\alpha$,$\beta$-Diphenylsuccinic Acid의 구조 (Structure of $\alpha$,$\beta$-Diphenylsuccinic Acid)

  • 서일환;윤민중
    • 한국결정학회지
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    • 제5권2호
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    • pp.108-112
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    • 1994
  • C19H20O5, Mr=314.337,삼사정계,PI, a=10.291(2)A, b=11.218(3)A, c=3.059(1)A, α=74.54(2)°,β=1148.84(1)°,r=109.84(2)°,V=883.283(2)A3, λ(Mo Kα)=0.71069A, μ=0.47 mm-1, F(000)=324, 296K, Z=2, Dx=1.18Mgm-3. 1637[F>3σ(F)]개 독립 반사면에 대한 최종 R=0.0580이다. α,β-diphenylsuccinic acid,C16H14O4, 분자들은 O(4)-H˙˙˙O(5)수소결합에 의하여 용체인 acetone과 결합되어 있고 중심대칭관계에 있는 dimer는 분자간의 carboxylic 수소결합 O(1)-H˙˙˙O(2)(-x,-y,-z)에 의하여 결합되어 있다. Dimer간의 가장 가까운 거리 3.288A[O(2)˙˙˙O(2)(-x,-y,-z)]은 분자들의 packing이 van der Waals 력으로 이루어졌음을 보인다.

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얼굴 2D 이미지의 3D 모델 변환 알고리즘 (An Algorithim for Converting 2D Face Image into 3D Model)

  • 최태준;이희만
    • 한국컴퓨터정보학회논문지
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    • 제20권4호
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    • pp.41-48
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    • 2015
  • 최근 3D 프린터의 보급과 함께 3D 모델에 대한 수요가 급증하고 있다. 그러나 3D 모델의 생성은 숙달된 전문가가 전문 소프트웨어를 이용하여 작성하여야 한다. 본 연구는 한 장의 2차원 정면 얼굴사진으로 부터 3D 모델링하는 방법에 대한 것으로 일반인들도 쉽게 3D모델을 생성할 수 있도록 한다. 사진으로부터 배경과 전경을 분리하고 분리한 전경 영역에 일정간격으로 2차원 상에 버텍스를 배치하고 배치한 버텍스 위치를 이미지의 계조 값과 눈썹과 코 등의 특성을 고려하여 버텍스를 3차원으로 확장한다. 전경과 배경을 분리하는 방법으로 에지정보를 사용하였으며 눈과 코의 위치를 찾기 위하여 Haar-like feature를 이용하는 AdaBoost 알고리즘을 사용하였다. 알고리즘으로 생성한 3D 모델은 수작업에 의한 후처리가 필요하지만 3D 프린터를 위한 콘텐츠 제공에 매우 유용하게 활용될 것이다.

CLO 3D 아바타 사이징과 실제인체간의 치수 및 형태 차이 비교 분석 (A Comparative Analysis of the Different between CLO 3D Avatar Sizing and Actual Body Measurement Shapes)

  • 이민정;손희순
    • 패션비즈니스
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    • 제16권4호
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    • pp.137-151
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    • 2012
  • This study aims to use the avatar sizing system of the 3D apparel CAD program instead of the existing 3D body scanners, and to commercialize 3D personal avatars. Towards these ends, the study examined a difference between a 3D avatar and actual body was determined to verify the 3D avatar sizing system. For the experiment, three subjects were selected, were measured as they were, and were made to undergo 3D body scanning and photographing. Then, using avatar sizing system on the 3D apparel CAD program, three types of virtual bodies, namely 3D avatars. The 3D avatar and actual body measurements were compared, and 3D avatars and 3D body-scanned shapes were likewise compared. As a result, the three types of actual bodies and their 3D avatars that were created based on the sizing system of the 3D apparel CAD program were overall similar. but, the thin body-YY type and the normal body-A type were different from their avatars. In the case of type B, who had a bulging abdomen, the 3D avatar was bigger than the actual body as measured. Also, in all body shapes, the girths around the chest, waist and abdomen were produced with exaggerated muscular amounts compared to their actual muscular amounts.

인체모델과 3차원 일러스트레이션을 이용한 의복패턴개발 (Direct Clothing Pattern Development from the 3D Illustration on the Personal Human Body Model)

  • 박혜준;홍경희
    • 한국의류학회지
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    • 제32권2호
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    • pp.340-347
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    • 2008
  • A prototype of 3D clothing design system with a direct pattern development function was suggested, reflecting intuitive design functions and design modifications while considering the fit of clothing patterns with the 3D human body in the virtual 3D space. The research method was as follows. Clothing models were created using a 3D design tool, 3ds max on the surface of 3D human body model made by scanning an actual human body. 3D illustrations were completed by revising the fit and sizing of the human body and clothing models. 2D T-shirt pattern was produced 3D illustrations using from a 3D scanning data modeling solution RapidForm 2004, a 2D conversion program for 3D data called 2C-AN, and Yuka CAD. As a result, the following conclusions were made. The fit of the clothing and human body can be adjusted by reflecting individual body figure characteristics and 3D illustrations over the actual 3D body model. Furthermore, intuitive design support functions were intensified overcoming the weak point of existing 3D clothing design system by developing the direct clothing design in the virtual 3D space. 3D illustration design modifications can be directly reflected on clothing patterns from 3D illustrations by 3D clothing design system developed in this study.

Pseudomonas sp. HJ-2를 이용한 고무탄성 Polyhydroxyalkanoate의 생산 (Production of Rubber-Elastic Polyhydroxyalkanoates by Pseudomonas sp. HJ-2)

  • 정정욱;최강욱;김영백;이영하
    • 미생물학회지
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    • 제36권2호
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    • pp.155-160
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    • 2000
  • Pseudomonas sp. HJ-2는 heptanoinc acid를 단일탄소원으로 이용하여 3-hydroxybutyrate (3HB),3-hydroxy-velerate (3HV) 및 3-hydroxybutyrate (3HHp)를 구성 단위체로 하는 고무탄성 polyhydroxyalkanoate (PHA)를 생합성한다. 이 미생물 고분자는 poly(3HB-co-3HV)공중합체와 poly(3HHp) 단일중합체로 이루어진 혼합물임이 밝혀졌다. 본 연구에서는 PHA가 고무탄성체로서의 성질을 유지하는데 필용한 단위체 조성과 HJ-2의 배양조건이 PHA의 생산 및 단위체 조성에 미치는 영향에 대하여 조사하였다. 생합성된 PHA의 탄성률은 poly(3HHp)의 존재로 크게 감소되었으나, 3HV의 함량이 높은 poly(3HB-co-3HV) 자체도 최대변형률 740%로서 고무탄성체로서의 성질을 보였다. HJ-2의 생장 및 PHA 생합성은 탄소원인 heptanoic acid의 초기농도가 40mMdlfEo 가장 높았으나, 50mM의 농도에서는 큰 저해를 받았다. PHA 생합성은 질소와 인이 결핍된 조건에서 크게 증가되었다. 배양액의 pH 및 통기는 HJ-2로부터 생합성되는 PHA의 단위체 조성에 큰 영향을 주는 것으로 나타났다. pH 7.5에서 생합성되는 고분자는 poly(3HB-co-38% 3HV)인 반면에 pH8.0에서의 고분자는 3HHp가 95%를 차지하였다. 발효조의 교반속도를 달리한 실험의 결과 고분자 내 3HHp의 함량은 산소전달 속도가 높아질수록 증가하였다.

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3차원 시뮬레이터의 사용자 인터페이스 개발 도구 구현 (Implementation of an User Interface Developing Tool for 3D Simulator)

  • 윤가림;전준영;김영봉
    • 한국멀티미디어학회논문지
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    • 제19권2호
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    • pp.504-511
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    • 2016
  • 3D simulation programs or games on a smart phone and a personal computer have often employed 3D graphic processing techniques and 3D graphical views. However, the user interfaces in those 3D programs have sticked to take a typical 2D style user interface and thus the combination of a 2D user interface view and a 3D simulation view give us a mismatched sense. Since a 2D user interface has been based on the windows controls, it causes sometime DC conflicts between a simulation view and an interface view. Therefore, we will implement the UI developing tool which can be inserted into the pipeline structure for the development of a 3D simulation software and also follows the view-handler design pattern in Microsoft windows system. It will provide various graphical effects such as the deformation of UI depending on the view direction of simulation view and the sitting pose of user. This developing tool gives the natural user interface which heightens the sense of unity with a given 3D simulation view.

Effectual Method FOR 3D Rebuilding From Diverse Images

  • Leung, Carlos Wai Yin;Hons, B.E.
    • 한국정보컨버전스학회:학술대회논문집
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    • 한국정보컨버전스학회 2008년도 International conference on information convergence
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    • pp.145-150
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    • 2008
  • This thesis explores the problem of reconstructing a three-dimensional(3D) scene given a set of images or image sequences of the scene. It describes efficient methods for the 3D reconstruction of static and dynamic scenes from stereo images, stereo image sequences, and images captured from multiple viewpoints. Novel methods for image-based and volumetric modelling approaches to 3D reconstruction are presented, with an emphasis on the development of efficient algorithm which produce high quality and accurate reconstructions. For image-based 3D reconstruction a novel energy minimisation scheme, Iterated Dynamic Programming, is presented for the efficient computation of strong local minima of discontinuity preserving energyy functions. Coupled with a novel morphological decomposition method and subregioning schemes for the efficient computation of a narrowband matching cost volume. the minimisation framework is applied to solve problems in stereo matching, stereo-temporal reconstruction, motion estimation, 2D image registration and 3D image registration. This thesis establishes Iterated Dynamic Programming as an efficient and effective energy minimisation scheme suitable for computer vision problems which involve finding correspondences across images. For 3D reconstruction from multiple view images with arbitrary camera placement, a novel volumetric modelling technique, Embedded Voxel Colouring, is presented that efficiently embeds all reconstructions of a 3D scene into a single output in a single scan of the volumetric space under exact visibility. An adaptive thresholding framework is also introduced for the computation of the optimal set of thresholds to obtain high quality 3D reconstructions. This thesis establishes the Embedded Voxel Colouring framework as a fast, efficient and effective method for 3D reconstruction from multiple view images.

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