• Korean Journal of Biological Psychiatry
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• v.7 no.1
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• pp.3-13
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• 2000

There is nothing that is harmless ; the dose alone decides that something is no poison(Paracelsus, 1493-1541). So, in a point of view to maximize the therapeutic efficacy of drug therapy in a way that minimize the drug toxicity, the knowledges of the drug-ineractions as well as the pharmacokinetic and pharmacodynamic principles of every therapeutic drug used in the medical clinic cannot be emphasized too much. Many drug interactions can be predicted if the pharmacokinetic properties, pharmacodynamic mechanisms of action of the interacting drugs are known, and most adverse interactions can be avoided. In this paper, the clinical importance, classification, and general principles of clinical drug-interactions are presentated with a few explanatory examples.

• Journal of Magnetics
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• v.2 no.3
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• pp.105-109
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• 1997

The Preisach model neds a density function or Everett function for the hysterisis operator to simulate the hysteresis phenomena. To obtain the function, many experimental data for the first order transition curves are required. However, it needs so much efforts to measure the curves, especially for the hard magnetic materials. By the way, it is well known that the density function has the Gaussian distribution for the interaction axis on the Preisach plane. In this paper, we propose a simple technique to determine the distribution function or Everett function analytically. The initial magnetization curve is used for the distribution of the Everett function for the coercivity axis. A major, minor loop and the initial curve are used to get the Everett function for the interaction axis using the Gaussian distribution function and acceptable results were obtained.

• 한국가시화정보학회:학술대회논문집
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• 2006.12a
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• pp.141-144
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• 2006

In this study, one-way fluid structure interaction analysis(FSI) on wind turbine blade was performed. Both a quantitative fluid analysis on 3-bladed wind turbine and a structural analysis using the surface pressure data resulting from fluid analysis were carried out. Streamlines and angle of attack was easily acquired from analysis results, we showed the inlet velocity that the stall begins to occur. In the structural analysis, structural displacement and maximum stress of the two comparative models was calculated. The location that has maximum stress was found. The pressure difference between back and front part of the blade increases as the inlet velocity increase. The torque and maximum with regard to inlet velocity was also presented.

• The Mathematical Education
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• v.46 no.4
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• pp.423-443
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• 2007

Based on the framework of Huffered-Ackles, Fuson and Sherin(2004), data were analyzed in terms of 3 components: explaining(E), questioning(Q) and justifying(J) of students' mathematical concepts and problem solving in a math classroom. The students used varied presentations to explain and justify their mathematical concepts and ideas. They corrected their mathematical errors or misconceptions through discourses. In addition, they constructed and clarified their concepts and thinking while they were interacted. We were able to recognize there was a special feature in discourses that encouraged the students to construct and develop their mathematical concepts. As they participated in math class and received feedback on their learning, the whole class worked cooperatively in a positive way. Their discourse was improved from the level of the actual development to the level of the potential development and the pattern of interaction moved from ERE(Elicitaion-Response-Elaboration to PD(Proposition Discussion).

• Bulletin of the Korean Mathematical Society
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• v.57 no.3
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• pp.661-676
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• 2020

To understand the interaction of a fluid and a rigid body, we use the concept of B-evolution. Then in a similar way to the usual Navier-Stokes system, we obtain a Helmholtz type decomposition. Using B-evolution theory and the decomposition, we work on the semigroup to analyze the linear part of the system.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.5
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• pp.1463-1476
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• 2014

In order to understand hydrodynamic and morphodynamic characteristics under wave-current interactions in an estuary, a coupled model for two-way analysis between existing 3-d numerical wave tank and newly-developed 3-d morphodynamic model has been suggested. Comparing to existing experimental results it is revealed that computed results of the newly-suggested model are in good agreement with each laboratory test result for wave height distribution, vertical flow profile and topographical change around ocean floor pipeline in wave-current coexisting field. Also the numerical result for suspended sediment concentration is verified in comparison with experimental result in solitary wave field. Finally, it is shown that the 3-D coupled Hydro-Morphodynamic model suggested in this study is applicable to morphological change under wave-current interaction in an estuary.

• Journal of the Korean Society of Costume
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• v.57 no.6 s.115
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• pp.160-171
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• 2007

This research studied men's cosmetics purchasing behavior based on the level of interest one has in one's appearance, the country of origin, and the sales promotion of the cosmetics. The study was conducted by experimental $2{\times}[2{\times}2]$ design by combining the 3 variables mentioned above. The Independent variables in this research were levels of appearance interest(high vs. low), the country of origin(Korean vs. foreign), and types of sales promotion(discount vs. coupon). The dependent variables were the purchase behaviors including favor to cosmetics and purchase intent. Two hundred male consumers participated for the study. Data analysis conducted were factor analysis, cluster analysis and ANOVA. The results were as follows. 1. Male consumers' cosmetics favorness: 3-way significant interaction, in appearance interest, the country of origin, and types of sales promotion, was found for favor to male cosmetics. When male subjects were provided with price discounts and skin care coupons for the Korean cosmetics, they didn't reveal significant differences in favor, regardless of the level of appearance interest. However, for the imported cosmetics, male subjects with high appearance interest showed more favor to the cosmetics than the ones with low appearance interest. 2. Male consumers' purchase intent: 3-way significant interaction, in appearance interest, the country of origin, and types of sales promotion was found for the purchase intent. When male subjects were provided with price discounts and skin care coupons for the Korean cosmetics, they didn't show significant difference in purchase intent, regardless of their appearance interest. However, for the imported cosmetics, male consumers with high appearance interest reported more purchase intent than the ones with low appearance interest.

• Earthquakes and Structures
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• v.12 no.2
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• pp.251-262
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• 2017

The present research intends to study the effects of the seismic soil-foundation-structure interaction (SFSI) on the dynamic response of various buildings. Two methods including direct and Cone model were studied through 3D finite element method using ABAQUS software. Cone model as an approximate method to consider the SFSI phenomenon was developed and evaluated for both high and low rise buildings. Effect of soil nonlinearity, foundation rigidity and embedment as well as friction coefficient between soil-foundation interfaces during seismic excitation are investigated. Validity and performance of both approaches are evaluated as reference graphs for Cone model and infinite boundary condition, soil nonlinearity and amplification factor for direct method. A series of calculations by DeepSoil for inverse earthquake record modification was conducted. A comparison of the two methods was carried out by root-mean-square-deviation (RMSD) tool for maximum lateral displacement and story shear forces which verifies that Cone model results have good agreement with direct method. It was concluded that Cone method is a convenient, fast and rather accurate method as an approximate way to count for soil media.

• Genomics & Informatics
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• v.21 no.1
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• pp.6.1-6.8
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• 2023

Glaucoma is the second leading cause of irreversible blindness, and primary open-angle glaucoma (POAG) is the most common type. Due to inadequate diagnosis, treatment is often not administered until symptoms occur. Hence, approaches enabling earlier prediction or diagnosis of POAG are necessary. We aimed to identify novel drugs for glaucoma through bioinformatics and network analysis. Data from 36 samples, obtained from the trabecular meshwork of healthy individuals and patients with POAG, were acquired from a dataset. Next, differentially expressed genes (DEGs) were identified to construct a protein-protein interaction (PPI) network. In both stages, the genes were enriched by studying the critical biological processes and pathways related to POAG. Finally, a drug-gene network was constructed, and novel drugs for POAG treatment were proposed. Genes with p < 0.01 and |log fold change| > 0.3 (1,350 genes) were considered DEGs and utilized to construct a PPI network. Enrichment analysis yielded several key pathways that were upregulated or downregulated. For example, extracellular matrix organization, the immune system, neutrophil degranulation, and cytokine signaling were upregulated among immune pathways, while signal transduction, the immune system, extracellular matrix organization, and receptor tyrosine kinase signaling were downregulated. Finally, novel drugs including metformin hydrochloride, ixazomib citrate, and cisplatin warrant further analysis of their potential roles in POAG treatment. The candidate drugs identified in this computational analysis require in vitro and in vivo validation to confirm their effectiveness in POAG treatment. This may pave the way for understanding life-threatening disorders such as cancer.

• Korean Journal of Child Studies
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• v.21 no.3
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• pp.25-40
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• 2000

This study investigated the development of infant behaviors and maternal scaffolding in mother-infant games. Subjects were 60 mothers and their 9-, 12-, 15- and 18-month infants, 15 dyads in each age group. Mother-infant interaction was videotaped in the laboratory as they played peek-a-boo and a ball game in 2 sessions. Infant game behaviors were classified by the Rome-Flanders, Cossette, Ricard and $D{\acute{e}}carie$(1995) list, and maternal game behaviors were classified by the Hodapp, Goldfield & Boyatzis(1984) list. Data were analyzed by one-way ANOVA, two-way ANOVA with repeated measures, sequential analysis and Z test as well as qualitative analysis. Results showed that infants played an increasingly active role with age. Infants mastered the ball game at earlier age than peek-a-boo. Mothers scaffolded infant behaviors in various ways. The amount of maternal game behavior varied by type of game.