• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.3
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• pp.261-264
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• 2009

We present a three-dimensional (3D) particle focusing channel using the positive dielectrophoresis (pDEP) guided by a dielectric structure between two planar electrodes. The dielectric structure between two planar electrodes induces the maximum electric field at the center of the microchannel, and particles are focused to the center of the microchannel by pDEP as they flow from the single sample injection port. Compared to the previous 3D particle focusing methods, the present device achieves the simple and effective particle focusing function without any additional fluidic ports and top electrodes. In the experimental study, approximately 90 % focusing efficiency were achieved within the focusing length of 2mm, on both x-z plane (top-view) and y-z plane (side-view) for $2{\mu}m$-diameter polystyrene (PS) bead at the applied voltage over 15 Vp-p (square wave) and at the flow rate below 0.01 ${\mu}l$/min. The present 3D particle focusing channel results in a simple particle focusing method suitable for use in integrated microbiochemical analysis system.

• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.581-584
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• 2008

A generation of a particle beam is the key technique in a flow cytometry that measures the fluorescence and light scattering of individual cell and other particulate or molecular analytes in biomedical research. Recent methods performing this function require a laborious and time-consuming assembly. In the present work, we propose a novel device for the generation of an axisymmetrical focusing beam of microparticles (3-D focusing) in a single capillary without sheath flows. This work uses the concept that the particles migrate toward the centerline of the channel when they lag behind the parabolic velocity profile. Particle focusing of spherical particles was successfully made with a beam diameter of about 10 ${\mu}$m. Proposed device provides crucial solutions for simple and innovative 3-D particle focusing method for the applications to the MEMS-based micro-flow cytometry. We believe that this device can be utilized in a wide variety of applications, such as biomedical/ biochemical engineering.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.25 no.3
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• pp.315-321
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• 2001

Aerodynamic lenses are widely used in generating particle beams of high density and small diameter, but analytical or modeling studies are limited only in the free molecular regime. In this study, it is shown that generating particle beam is also possible in atmospheric pressure range, and the mechanism of generating particle beam using an orifice is analysed into three different parts : fluid dynamic contraction, diffusional defocusing, and inertial focusing. In laminar flow conditions, the diffusional defocusing effect can be neglected, and the effects of inertial focusing can be expressed in terms of the orifice size and Stokes number. Numerical experiments are done for two different orifices, d/D=1/5 and 1/10 and particle diameter d(sub)p=1-10 ㎛. The results for two different orifices can be made into a single curve when a modified Stokes number is used. The inertial focusing effect diminishes when the modified Stokes number becomes smaller than 10(sup)-2.

• Journal of ILASS-Korea
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• v.10 no.3
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• pp.17-28
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• 2005

The Holographic Particle Velocimetry system can be a promising optical tool for the measurements of three dimensional particle velocities. In this study, diffused illumination holographic system to measure the sizes and 3D velocities of moving particles based on automatic image processing was developed. First of all basic optical systems for pulse laser recording, continuous laser reconstruction, and image acquisition, were constructed. To determine the position of particles in the optical axis, new three auto-focusing parameters(AEP), namely, Correlation Coefficient, Sharpness Index, and Depth Intensity were introduced and verified. The developed system was applied to spray droplets to validate the capability of the system. Three dimensional positions of particles viewed from two sides were decided using AFP and then 3D velocities of Particles were extracted by particle tracking algorithm. Comparison of measurement results of sizes and 3D velocities of particles with those obtained by laser instrument, PDPA, showed good consistency of the developed holographic system.

• Transactions of the Korean Society of Automotive Engineers
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• v.15 no.6
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• pp.144-150
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• 2007

In recent years, the particle number emissions rather than particulate mass emissions in automotive engine have become the subject of controversial discussions. Recent results from the health effects studies imply that it is possible that particulate mass does not properly correlated with the variety of health effects attributed to diesel exhaust. So, the concern is instead now focusing on nano-sized particles emitted from I. C. engine. This study has been performed for the better understanding about the engine nano-particle for 3-measurement systems with different measuring principle. Firstly, EEPS is a newly introduced instrument for size distribution measurement of engine exhaust particles. It can measure nano-particles with an adequate resolution and in real time. In this study, the characteristics of EEPS were compared with ELPI and SMPS. As a research results, EEPS showed a same effect of engine load on the size distribution with ELPI and SMPS. But the quantitative results of EEPS were more similar to SMPS than ELPI, because the EEPS and SMPS use a same principle for classifying particles by size. The capability for transient measurement of EEPS was equivalent to that of ELPI.

• Journal of the Optical Society of Korea
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• v.15 no.2
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• pp.187-195
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• 2011

We have designed two photonic crystal waveguide (PCW) structures with output focused beams in order to achieve more coupling between photonic devices and decrease the mismatch losses in photonic integrated circuits. PCW with coupled resonator optical waveguide (CROW) termination has been optimized by both one dimensional (1D) and seven dimensional (7D) particle swarm optimization (PSO) algorithms by evaluating the fitness function by the finite difference time domain (FDTD) method. The 1D and 7D-optimizations caused the factors of 2.79 and 3.875 improvements in intensity of the main lobe compared to the non-optimized structure, whereas the FWHM in 7D-optimized structure was increased, unlike the 1D case. It has also been shown that the increment of focusing causes decrement of the bandwidth.

• Biomedical Science Letters
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• v.12 no.3
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• pp.177-183
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• 2006

To demonstrate the effect of formulation conditions and evaluations of structural integrity from ovalbumin containing poly lactide glycolide copolymer (PLGA) microspheres for Vaccine delivery, OVA microspheres were prepared by a W/O/W multiple emulsion solvent extraction technique. Dichloromethan (DCM) and Ethyl acetate (EA) were applied as an organic phase and poly vinyl alcohol (PVA) as a secondary emulsion stabilizer. Microspheres were characterized for particle size, morphology (optical microscopy and Scanning Electron Microscope (SEM)). Protein denaturation was evaluated by size exclusion chromatography (SEC), SDS-PAGE and isoelectric focusing (IEF). Residual organic solvent was estimated by gas chromatography (GC) and differential scanning calorimetry (DSC). Optical photomicrograph and SEM revealed that micro spheres were typically spherical but various morphologies were observed. Mean particle size $(d_{vs})$ of microspheres were in the range of $3{\sim}50{\mu}m$. Also, The protein stability was not affected by the fonnulation process and residual organic solvent was beyond the detection below 0.1ppm. These results demonstrated that micro spheres might be a good candidate for the parenteral vaccine delivery system.

• Journal of Environmental Science International
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• v.33 no.2
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• pp.121-129
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• 2024

The study investigated the effect of thermo-alkaline pretreatment on the solubilization of polyhydroxybutyrate (PHB) and its potential to enhance of thermophilic anaerobic digestion, focusing on biochemical methane potential (BMP) and methane production rate, using two different particle sizes of PHB (1500 ㎛ and 400 ㎛). Thermo-alkaline pretreatment tests were conducted at 90 ℃ for 24 hours with varying NaOH dosages from 0-80% (w/w). BMP tests with untreated PHB exhibited methane production ranging from 150.4~225.4 mL CH₄/g COD and 21.5~24.2 mL CH₄/g VSS/d, indicating higher methane production for smaller particle sizes of PHB, 400 ㎛. Thermo-alkaline pretreatment tests achieved a 95.3% PHB solubilization efficiency when 400 ㎛ PHB particles were treated with 80% NaOH dosage at 90 ℃ for 24 hours. BMP tests with pretreated PHB showed substantial improvement in thermophilic anaerobic digestion, with an increase of up to 112% in BMP and up to 168% in methane production rate. The results suggest that a combined pretreatment process, including physical (400 ㎛ PHB particles) and thermo-alkaline (90 ℃, 40-80% NaOH dosage, and 24 hours reaction time), is required for high-rate thermophilic anaerobic digestion of PHB with enhanced methane production.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2017.11a
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• pp.1533-1549
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• 2017

정부 R&D성과의 질적 수준을 제고하고 중장기 국가 재정사업의 효율성을 높이기 위한 각 연구 기관의 시도들이 있어 왔다. 연구사업의 발굴, 기획 및 수행에 있어 효과적인 정부 R&D 예산의 배분, 우선순위를 도출, 기술개발 전략 수립을 하는 것이 매우 중요해지고 있다. 정부 재정사업인 국가 R&D사업은 국가 기간산업을 활성화하고 경제발전을 수반할 수 있는 중요한 모멘텀으로서의 역할을 하고 있다. 또한, 국가 R&D사업의 한 축인 거대과학은 최첨단 기술의 개발과 미래성장동력의 발굴이라는 대명제로 그 중요성이 강조되고 있다. 거대과학 연구는 그 분야의 특수성으로 인해 대학의 과학자, 공공 연구기관의 연구원, 기업의 엔지니어가 함께 참여하여야 하고 대규모 국가 예산을 동원하는 과학 연구 사업이다. 이는 대규모 예산을 기반으로 하고 있기에 집중적 투자가 수반된다면 단기적으로 기초과학의 발전을 이뤄낼 수 있다. 이것은 산업발전에 밑거름이 되어 그 분야 자체로 하나의 산업생태계를 구성하고 요소 기술들의 응용으로 파생기술이 전파된다면 새로운 신산업 창출 등 국가산업에 많은 혜택을 줄 수 있다. 하지만 많은 인력과 대규모 투자 그리고 중장기 프로젝트라는 특성으로 인해 실패 가능성도 높아 전략적 선택 및 추진이 필요하다. 따라서 본 논문에서는 거대과학의 기술개발전략의 수립을 위하여 중이온 입자가속기 핵심부품 국산화 전략수립 사례를 중심으로 효율적인 R&D추진 방안을 도출해보고자 한다. 또한, 논문, 특허를 기반으로 한 3P분석을 통하여 중이온 가속기 핵심부품의 국산화 전략을 제안하고, 추진 우선순위 및 전략을 제시하고자 한다.

• Journal of the Korean Wood Science and Technology
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• v.28 no.3
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• pp.1-8
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• 2000

To develop the technology of producing structural board from low grade materials, an attempt was made to produce strand/particle composites from split wood strand(S) and particle(P) of (Cryptomeria japonica D. Don), which changed the layer construction and the ratio of S/P. The influence of layer construction on board properties was determined, focusing on the number and alignment of the S layers. The effect of weight ratio of S/P (3:7, 1:1, 7:3) on mechanical properties was also discussed on seven layered panel. Mechanical properties were determined from static bending tests to give parallel and perpendicular modulus of rupture (MOR) and modulus of elasticity (MOE), and the internal bond (IB) strength. In general, the surface strand layers contributed to the MOR and MOE. The parallel MOR and MOE values were the largest for the single layered S panel (only Slayers: S1), but the perpendicular MOR and MOE was the smallest. Perpendicular MOR and MOE were the largest for seven layered composite that had two cross oriented strand layers (SPSPSPS: SP7). Specimens retained more than half of their MOE and MOR after two hours in boiling water and one hour soaking. IB was the largest for the panel having only P layers, however, differences in IB strength were not identified among the other multi-layered composite panels thus the effect of layer construction on IB strength was small. Thickness swelling (TS) and surface roughness were smaller for the composite having P layers on the surface than for those having S layers. The addition of strands did not enhance the mechanical properties (MOR, MOE, IB). TS values for the panels, with which the S/P ratio was over than 1:1, was the similar to the value for the single layered S panels.