• Korean Journal of Veterinary Research
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• v.37 no.2
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• pp.321-330
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• 1997

Enrofloxacin is one of the second-generation quinolones which have been widely used to treat bacterial infections in various species including chicken, pig, horse and cattle. The objective of the present study was to describe the serum bactericidal activity(SBA) of enrofloxacin, its pharmacokinetic behaviors after intramuscular or intravenous administration to Korean native goats in the dose rate of 5mg/kg b.w. The results obtained through this study were as follows : 1. Sera collected from both sexes of Korean native goats administered 5mg/kg i.v. or i.m. showed potent antibacterial activities up to the 12 hours by way of the serum bactericidal activity. 2. Concentrations of enrofloxacin in the biological samples were measured by high-performance liquid chromatography(HPLC) so as to study pharmacokinetic characteristics. For detection of enrofloxacin, 10% TCA was optimal for protein precipitation and the mobile phase was 0.01M citric acid/methanol/acetonitrile(7/2/1, pH 3.5) with solid phase being the $C_{18}$ reversephase column and detection wavelength being 278nm. The limit of detection of enrofloxacin on HPLC was $0.05{\mu}g/ml$. 3. Pharmacokinetic profile of enrofloxacin administered 5mg/kg i.v. in Korean native goats was best described by two-compartment open model and that administered i.m. the same rate by one-compartment model. There were no sex differences in pharmacokineticl parameters. In conclusion, enrofloxacin showed potent in vivo antibacterial activity and excellent pharmacokinetic properties in Korean native goats, hence it may be used as a potential antibacterial in the veterinary clinical settings.

• Journal of Pharmaceutical Investigation
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• v.39 no.5
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• pp.373-379
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• 2009

This study was conducted to develop a pharmacokinetic-pharmacodynamic (PK/PD) model of a direct thrombin inhibitor, argatroban to predict the concentration-effect profiles in rats. Argatroban was i.v. injected to rats at 0. 2, 0.8 and 3.2 mg/kg doses (n = 4-5 per dose), and plasma drug levels were determined by a validated LC/MS/MS assay. The pharmacokinetics of argatroban was linear over the i.v. dose range studied. The thrombin time (TT) and the activated partial thromboplastin time (aPTT) were measured in rat plasma and they were found to linearly increase with increasing the dose. A 2-compartment pharmacokinetic model linked with an indirect response pharmacodynamic model was successfully utilized to evaluate the drug concentration-response relationship.

• Journal of Korean Society for Atmospheric Environment
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• v.17 no.3
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• pp.241-249
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• 2001

A report by the National Research Council in the United States suggested that many lung cancer deaths each year are associated with breathing radon in indoor air. Most of the indoor radon comes directly from soil beneath the basement of foundation. Recently, radon released from groundwater is found to contribute to the total inhalation risk from indoor air. This study presents the assessment of a exposure to radon released from the groundwater into indoor air. At first, a 3-compartment model is describe the transfer and distribution if radon released from groundwater in a house through showering, washing clothes, and flushing toilets. The model is used to estimate a daily human exposure through inhalation of such radon for adults based on two sets of exposure scenarios, Finally, a sensitivity analysis is used to identify important parameters. The results obtained from the study would help to increase the understanding of risk assessment issues associated with the indoor radon released from groundwater.

• International Journal of Vascular Biomedical Engineering
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• v.2 no.2
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• pp.16-26
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• 2004

The object of this study is to develop a mathematical model of the hemodialysis system including the mechanism of solute kinetics, water exchange and also cardiovascular dynamics. The cardiovascular system model used in this study simulates the short-term transient and steady-state hemodynamic responses such as hypotension and disequilibrium syndrome (which are main complications to hemodialysis patients) during hemodialysis. It consists of a 12 lumped-parameter representation of the cardiovascular circulation connected to set-point models of the arterial baroreflexes, a kinetic model (hemodialysis system model) with 3 compartmental body fluids and 2 compartmental solutes. We formulate mathematically this model in terms of an electric analog model. All resistors and most capacitors are assumed to be linear. The control mechanisms are mediated by the information detected from arterial pressoreceptors, and they work on systemic arterial resistance, heart rate, and systemic venous unstressed volume. The hemodialysis model includes the dynamics of urea, creatinine, sodium and potassium in the intracellular and extracellular pools as well as fluid balance equations for the intracellular, interstitial, and plasma volumes. Model parameters are largely based on literature values. We have presented the results on the simulations performed by changing some model parameters with respect to their basal values. In each case, the percentage changes of each compartmental pressure, heart rate (HR), total systemic resistance (TSR), ventricular compliance, zero pressure filling volume and solute concentration profiles are represented during hemodialysis.

• Journal of Radiation Protection and Research
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• v.8 no.2
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• pp.8-14
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• 1983

The doses to Korean adult by a single and chronic intake of tritiated water are determined using a three compartment model, which describes the retention of tritium radionuclide in body water and in bound organic form in the body. The results show that the total dose of a single intake, using retention half-time for the three-compartment of 9, 30, and 450 days, is 17.64 mrads ($176.4{\mu}Gy$) per 1mCi/kg ($3.7{\times}10^7Bq/kg$) intake, 97% of which is due to tritium in body water and 3% to bound tritium in tissue. In the chronic intake of 1mCi/day($3.7{\times}10^7Bq/day$) tritiated water, the total dose is 85.5 mrad/day(0.855mGy/day). Furthermore, in this study (MPC) a and (MPC)w values of tritium for Korean man are calculated by using the modified formula originated from ICRP Publication-2. From the results, we found that the (MPC) a, w values of ICRP underestimated approximately 50%, the (MPC)a, w values of Korean man must be elevated as high as approximately 50% than that of ICRP.

• Korean Journal of Clinical Pharmacy
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• v.26 no.4
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• pp.312-317
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• 2016

Objective: Midazolam is mainly metabolized by cytochrome P450 (CYP) 3A. Inhibition or induction of CYP3A can affect the pharmacological activity of midazolam. The aims of this study were to develop a population pharmacokinetic (PK) model and evaluate the effect of CYP3A-mediated interactions among ketoconazole, rifampicin, and midazolam. Methods: Three-treatment, three-period, crossover study was conducted in 24 healthy male subjects. Each subject received 1 mg midazolam (control), 1 mg midazolam after pretreatment with 400 mg ketoconazole once daily for 4 days (CYP3A inhibition phase), and 2.5 mg midazolam after pretreatment with 600 mg rifampicin once daily for 10 days (CYP3A induction phase). The population PK analysis was performed using a nonlinear mixed effect model ($NONMEM^{(R)}$ 7.2) based on plasma midazolam concentrations. The PK model was developed, and the first-order conditional estimation with interaction was applied for the model run. A three-compartment model with first-order elimination described the PK. The influence of ketoconazole and rifampicin, CYP3A5 genotype, and demographic characteristics on PK parameters was examined. Goodness-of-fit (GOF) diagnostics and visual predictive checks, as well as bootstrap were used to evaluate the adequacy of the model fit and predictions. Results: Twenty-four subjects contributed to 900 midazolam concentrations. The final parameter estimates (% relative standard error, RSE) were as follows; clearance (CL), 31.8 L/h (6.0%); inter-compartmental clearance (Q) 2, 36.4 L/h (9.7%); Q3, 7.37 L/h (12.0%), volume of distribution (V) 1, 70.7 L (3.6%), V2, 32.9 L (8.8%); and V3, 44.4 L (6.7%). The midazolam CL decreased and increased to 32.5 and 199.9% in the inhibition and induction phases, respectively, compared to that in control phase. Conclusion: A PK model for midazolam co-treatment with ketoconazole and rifampicin was developed using data of healthy volunteers, and the subject's CYP3A status influenced the midazolam PK parameters. Therefore, a population PK model with enzyme-mediated drug interactions may be useful for quantitatively predicting PK alterations.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.19 no.3
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• pp.235-244
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• 2007

In the case of the fire outburst within a partitioned space, it can disappear inside it through smoldering process if the fire cannot obtain sufficient imflammability. On the contrary, if it obtains it, the fire is not restricted within the room, spreading to the higher levels beyond outside windows and the compartment room. The method to prevent the fire spread through windows is considered to build a balcony or equip with sprinkler facilities. This case study is to identify which effects and controlibility a balcony brings about on the spread of fire through a full scale model experiment. In order to understand the effects of fire spread on the upper levels of the room on fire by changing the length of balcony, the temperature was measured, radiant heat was investigated, and products of combustion were analyzed. The result showed that when fire occured, longer length of the balcony, which linked to the outside wall of the apartments, led to the blocking of the fire spread, lower level of radiant heat, and significantly less transfer of toxic gases, and the driving force of the outburst of flame was identified as the attractive force due to the turbulence of uncombusted gases, which exist on the upper level of the outbursting flame.

• Archives of Pharmacal Research
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• v.13 no.3
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• pp.227-232
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• 1990

A Physiologically based pharmacokinetic model was used to describe the distribition and elimination of cefriazone in the rat. To validate the practical application of the model, the effect of cffeine on the model was also examined. The model consisted of eleven compartments representing the major sites for ceftriaxone distribution including carcass which served as a residual compartment. Elimination was represented by renal and hepatic (metabolic biliary )excretion with GI secretion and re-absorption. The drug concentrations in most of the tissues were simulated using flow limited equations while brain levels were simulated using membrane limited passive diffusion distribution. The experimental data were obtained by averaging the concentration of drug in the plasma and tissues of five rats after i. v. injection of cefriazone 100 mg/kg without and with caffeine 20 mg/kg. The data for the amount of ceftriazone excreted in urine and gut contents were used to apportion total body clearance. HPLC with UV detection was used for the assay with 0.1-0.2 $\mu$g/ml sensitivity. The great majority of drug concentrations with and without caffeine show reasonably good agreements to the simulation results within 20%. The effect of caffeine on renal and hepatic clearances was apparent with 18.8% and 18.6% increase in the model values, respectively.

• Transactions of the Korean Society of Automotive Engineers
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• v.5 no.3
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• pp.66-75
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• 1997

Sound transmission from the luggage comparment into the car cabin is important in the viewpoint if exhaust and road noises of passenger cars. In this paper, acoustic modal coupling between passenger and luggage compartments through loudspeaker holes at parcel shelf is dealt with for a sedan type passenger car with rigid rear seat. For these purposes, a half-scaled model car is tested and computed by the indirect BEM. Predicted acoustic transfer functions are compared with experimental ones and they agree reasonably well. It is found that the fore-aft resonance frequencies of the passenger cavity in the absence of coupling holes are tend to shift to higher frequencies when the luggage compartment is coupled to the passenger cavity.

• ALGAE
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• v.17 no.3
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• pp.187-194
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• 2002

A seaweed biofilter/production system of being developed to reduce the environmental impact of marine fish farm effluent in coastal ecosystems as a part of an integrated aquaculture system. Several known seaweed taxa and their cultivars have been considered as candidate biofilter organisms based on their species-specific physiological properties such as nutrient uptake kinetics and their economic value. Porphyra is an excellent cadidate and shows efficient nutrient extraction properties. Rates of ammonium uptake were maintained at around 3 ${\mu}moles{\cdot}g{\cdot}dw^{-1}{\cdot}min^{-1}$ at 150 ${\mu}M$ inorganic nitrogen at $10^{\circ}C$. Ulva is another possible biofilter candidate with an uptake rate of 1.9 ${\mu}moles{\cdot}g{\cdot}dw^{-1}{\cdot}min^{-1}$ under same conditions. A simple uptake/growth and harvest model was applied to estimate the efficiency of the biofilter/production system. The model was deterministic and used a compartment model structure based on difference equations. The efficiency of Porpyra filter was estimated over 17% of ${NH_4}^+$ removal from the contimuous supply of 100 ${\mu}mole{\cdot}l^{-1}\;{NH_4}^+\;at\;100l{\cdot}sec^{-1}$ flow rate.