• Journal of Yeungnam Medical Science
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• v.22 no.2
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• pp.166-182
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• 2005

Background: Cyclin-dependent kinase (CDK) inhibitors are family of molecules that regulate the cell cycle. The CDKN2, a CDK4 inhibitor, also called p16, has been implicated in human tumorigenesis. The CDKN2 inhibits the cyclin/CDK complexes which regulate the transition from G1 to S phase of cell cycle. There is a previous report that homozygous deletion of CDKN2 region on chromosome 9p21 was detected frequently in astrocytoma, glioma and osteosarcoma, less frequently in lung cancer, leukemia and ovarian cancer, but not detected in colon cancer and neuroblastoma. However, little is known about the relationship between CDKN2 and laryngeal cancer. Therefore this study was initiated to investigate the role of CDKN2 in human laryngeal squamous cell carcinoma development.1) Materials and methods: We used 5 human laryngeal carcinoma cell lines whether they have deletions or losses of CDKN2 gene expression by DNA-PCR or RT-PCR, respectively. We examined 8 fresh frozen human laryngeal cancer tissues to detect the loss of heterozygosity (LOH) of CDKN2. PCR was performed by using microsatellite markers of short arm of human chromosome 9 (D9S126, D9S144, D9S156, D9S161, D9S162, D9S166, D9S171, D9S200 and D9SIFNA). For informative cases, allelic loss was scored if the signal of one allele was significantly decreased in tumor DNA when compared to the same allele in normal DNA. Results: The CDKN2 DNA deletion was observed in 3 cell lines. The CDKN2 mRNA expression was observed in only one cell line, which was very weak. LOH was detected in 7 cases (87.5%). Conclusion: These results suggest that CDKN2 plays a role in the carcinogenesis of human laryngeal squamous cell carcinoma.

• Journal of the Korean Child Neurology Society
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• v.26 no.4
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• pp.227-232
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• 2018

Purpose: Febrile seizure (FS) is the most common type of seizure in children between 6 months to 5 years of age. A family history of febrile seizures can increase the risk a child will have a FS. Yet, prevalence of FS regarding external environment has not been clearly proved. This study attempts to determine the association between prevalence of FS and weather. Methods: This study included medical records from the Korea National Health Insurance Review and Assessment Service. Data were collected from 29,240 children, born after 2004, diagnosed with FS who were admitted to one of the hospitals in Seoul, Korea, between January 2009 and December 2013. During the corresponding time period, data from the Korea Meteorological Administration on daily monitoring of four meteorological factors (sea-level pressure, amount of precipitation, humidity and temperature) were collected. The relationships of FS prevalence and each meteorological factor will be designed using Poisson generalized additive model (GAM). Also, the contributory effect of viral infections on FS prevalence and weather will be discussed. Results: The amount of precipitation was divided into two groups for comparison: one with less than 5 mm and the other with equal to or more than 5 mm. As a result of Poisson GAM, higher prevalence of FS showed a correlation with smaller amount of precipitation. Smoothing function was used to classify the relationships between three variables (sea-level pressure, humidity, and temperature) and prevalence of FS. FS prevalence was correlated with lower sea-level pressure and lower humidity. FS prevalence was high in two temperature ranges (-7 to $-1^{\circ}C$ and $18-21^{\circ}C$). Conclusion: Low sea-level pressure, small amount of precipitation, and low relative air humidity may increase FS prevalence risk.

• Journal of agriculture & life science
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• v.44 no.4
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• pp.45-55
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• 2010

In this study, the acetylcholinesterase (AChE) inhibition and neuronal cell protective effects of water, 100% methanol and dichlromethane extracts from garlic were investigated. We found that dichloromethane extract of garlic resulted in a dose-dependent manner on AChE inhibition ($IC_{50}$: $36.1{\mu}g/mL$). In cell viability assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide (MTT), cell viabilities of water, 100% methanol and dichlromethane extracts were lower (almost under 40%) than amyloid ${\beta}$ protein ($A{\beta}$)-induced neurotoxicity. Because $A{\beta}$ is also known to increase neuronal cell membrane breakdown, neuronal apoptosis was further confirmed by lactate dehydrogenase (LDH) and neutral red uptake (NRU) assay. Water extract presented relative protection against $A{\beta}$-induced membrane damage in LDH assay. However all garlic extracts showed significant problem with decrease of cell viability in NRU assay, especially at dichloromethan extract. To determine active compounds in column fractions (98:2 fraction) from dichloromethane extract which showed significant AChE inhibitory effect, we performed HPLC and LC-MS analysis. It was supposed that garlic may contain allyl methyl disulfide, diallyl monosulfide, and diallyl disulfide as active compounds.

• Journal of Korean Philosophical Society
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• v.117
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• pp.275-301
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• 2011

Die Einzelwissenschaften, zum Beispiel, die Biologie, die Psychologie, Soziologie behandeln heuzutage den Menschen. Aber sie alle behandeln den Menschen nach ihren eigenen Gesichtpunkten. Infolgedessen $k{\ddot{o}}nnen$ die Einzelwissenschaften den ganzen Menschen als den Menschen nicht $ber{\ddot{u}}ksichtigen$. Jhre Anthropologien $m{\ddot{u}}{\ss}en$ daher weitgehend $beschr{\ddot{a}}nkt$ bleiben. Dagegen entwickelte Max Scheler im letzten Jahrhundert eine neue philosophische Anthropologie. Seine Anthropologie ist wirklich neu und grundgehend. Diese Anthropologie bestimmt den Menschen als Geist, Freiheit, Person. Aber Max Scheler betont allzusehr "den Geist" in seiner philosophischen Anthropologie und infolgedessen distanzierter sich vom "Leben" in seinem $Menschenverst{\ddot{a}}ndnis$. Die Verfasserin sieht hier in dieser philosophischen Anthropologie einen Dualismus zwischen den Geist und das leben. Und Verfasserin findet eine Integration von Geist und Leben in der ontologischen Anthropologie bei Edith Stein. Diese ontologische Anthropologie charakterisiert sich $folgenderma{\ss}en$. 1. Es ist eine Anthropologie des "$Ge{\ddot{o}}ffnet$-Seins." 2. Es ist eine Anthropologie des "$Gef{\ddot{u}}hlt$-Seins." 3. Es ist eine Anthropologie des "Einheits-Seins." Die Verfasserin behauptet infolgedessen die ontologische Anthropologie bei Edith Stein sei eine geeignete und $sachm{\ddot{a}}{\ss}ige$ Anthropologie.

• Korean Journal of Soil Science and Fertilizer
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• v.39 no.6
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• pp.329-333
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• 2006

Most of volcanic ash soils in South Korea are distributed in Jeju province which is an island placed on southern part of Korea and has steep slope mountain area. There are many soils containing high contents of organic matter (OM) derived from volcanic ash in Jejudo, also. Therefore, irrigation and drainage in volcanic ash soil different with general soil which has low OM content have to be applied with another management way, but studies searching appropriate methods for them are set on insufficient situation because the area of volcanic ash soil in South Korea is only 1.3% (130,000ha). This study was conducted for analysis of soil water content and irrigation quantity appropriate for crops cultivated in volcanic ash soil with high OM content. Although soils with different soil color have the same soil texture, soil water characteristics curve by soil color showed the difference of water retention capability by OM content. But, this characteristics classified with soil color could be unified by scaling technique with similitude analysis method which get dimensionless water content using a present water content, a residual water content and saturated water content (or water content at 10kPa). A relation of gravimetric soil water content (GSWC) and dimensionless water content by the results showed a form of power function. The dimensionless water content (DWC) express a relative saturation degree of present water content. This was also expressed by van Genuchten model which describe the relation between relative saturation degrees and matric potentials. These results on soil water characteristics curve (SWCC) of volcanic ash soil will be the basic of irrigation plan in area having high organic contents into soil.

• Korean Journal of Soil Science and Fertilizer
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• v.44 no.5
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• pp.779-787
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• 2011

This study was conducted to evaluate the usefulness of ground-based remote sensing for the estimation of rice yield and application rate of N-fertilizer during growing season. Dongjin-1, Korean cultivar of rice was planted on May 30, 2006 and harvested on October 9, 2006. Chlorophyll content and LAI (leaf area index) were measured using Minolta SPAD-502 and AccuPAR model LP-80, respectively. Reflectance indices were determined with passive sensors using sunlight and four types of active sensors using modulated light, respectively. Reflectance indices and growth rate were measured three times from 29 days to 87 days after rice plating and at harvesting day. The result showed that values of growing characteristics and reflectance indices were highly correlated. Growing characteristics to show significant correlation with reflectance indices were in order of followings: fresh weight > N uptake > dry weight > height > No. of tiller > N content. Chlorophyll contents measured by chlorophyll meter (SPAD 502) showed high correlation with nitrogen concentration (r=$0.743^{**}$), although the correlation coefficients between remote sensing data and nitrogen concentration were higher. LAI was highly correlated with dry weight (r=$0.931^{**}$), but relationship between LAI and nitrogen concentration (r=$0.505^*$) was relatively low. The data of CC-passive sensor were negatively correlated with those of the near-infrared. NDVI correlation coefficients found more useful to identify the growth characteristics rather than data from single wavelength. Both passive sensor and active sensor were highly significantly correlated with growth characteristics. Consequently, quantifying the growth characteristics using reflectance indices of ground-based remote sensing could be a useful tool to determine the application rate of N fertilizer non-destructively and in real-time.

• The Journal of Korean Academy of Sensory Integration
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• v.19 no.2
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• pp.12-25
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• 2021

Objective : This study explored the effects of family-centered coaching using a sensory integration-based approach on the levels of performance and satisfaction for children with autism spectrum disorder (ASD). Methods : From April 16, 2020 to August 6, 2020, participants included 10 children with ASD, between the ages of three to six who met the inclusion criteria, and their guardians. I used the Canadian Occupational Performance Measure (COPM) to evaluate the children's levels of performance and satisfaction and the Goal Attainment Scaling (GAS) to evaluate their occupational performance. The experimental group (n=5) continued the sensory integration therapy while receiving their personalized family-centered coaching training for 60 minutes per week. This continued for four weeks via home visits and video calls. The control group (n=5) also continued to receive the sensory integration therapy while receiving sensory integration-based general counseling in relation to activity objectives. Results : Statistically significant differences were found in the scores of COPM performance and satisfaction and the GAS scores between the experimental group and the control group, before and after the intervention (p<.05). Statistically significant differences were found in score changes in COPM and GAS, between the two groups (p<.05). Cohen's d also showed a big effect size on the scores of COPM satisfaction (d=2.768) and the GAS scores (d=2.786). Conclusion : This study demonstrated that the sensory integration-based, family-centered coaching had more positive effects on the level of performance and satisfaction of children with ASD, than general counseling.

• Korean Journal of Food Science and Technology
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• v.53 no.6
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• pp.669-681
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• 2021

The content of major constituents and antioxidant activities of two lavers (Pyropia seriata, Pyropia dentata) selected through breeding at different regions (Jangsan-do, Amtae-do, Dali-do, Jin-do, Muan) were compared in this study. The mineral contents of both cultivars were in the following order: K>Na>Mg>Ca>Fe>Zn>Mn>Cu. The content of major fatty acids was as follows: eicosapentaenoic acid>palmitic acid>arachidonic acid>dihomo-ɣ-linolenic acid. Main constituents of total and free amino acids were as follows: alanine>glutamic acid>aspartic acid. In particular, the total amino acid content in P. dentata was higher than that in P. seriata and was the highest in the sample from Jangsan-do in January. In addition, in terms of total phenolic content, reducing power, and DPPH radical-scavenging activity of both samples collected in January and February, P. dentata showed better characteristics than P. seriata. This study may provide useful information for the selection of laver in high quality.

• Journal of the Korean Applied Science and Technology
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• v.38 no.4
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• pp.951-962
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• 2021

The purpose of this study was to analyze the effects of smart machine circulation exercise on body composition, lung function, blood lipid and insulin resistance in obesity middle-aged women among 40-60 years by dividing them into a smart machine circulation exercise group(n=8), and control group(n=6). The smart machine circulation exercise program included 55-minutes sessions thrice each week at the following intensities: The strength of aerobic exercise is applied to smart machines by linking the smart machine with the POLAR T31; the 1-4 week is 40-50%HRR, 5-8 week is 50-60%HRR, and 9-10 week is 60-70%HRR. The strength of the resistance exercise was tested using a smart machine based on the constant velocity motion, and then, using the 1-RM data value, applied 40% 1-RM for 1-4 weeks, 60% 1-RM for 5-8 weeks, and 80% 1-RM for 9-10 week. As a results, body composition indicated that weight, BMI, %BF, WHR had a significant interaction effect. Lung function indicated that FVC levels significantly changes in the exercise group and the between groups difference in changes at 10week was significant. Also, FVC and FEV₁ significantly showed interaction effect. TC, TG and HDL-C levels significantly changes in smart machine circulation exercise group and the between-group difference in changes after 10 weeks was significant. TC, TG and HDL-C significantly showed interaction effect. Insulin resistance demonstrated that Insulin, Glucose and HOMA-IR levels significantly showed difference over 10 weeks between group. Therefore, the 10 weeks smart machine circulation exercise positively effects on the body composition, lung function, blood lipids, and insulin resistance in obesity middle-aged women and this smart machine circulation exercise can improve their obesity and prevent obesity.

• Journal of Korea Port Economic Association
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• v.36 no.4
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• pp.17-30
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• 2020

In the shipping industry, it is essential to engage in the preemptive prediction of freight rate volatility through market monitoring. Considering that freight rates have already started to fall, the loss of shipping companies will soon be uncontrollable. Therefore, in this study, factors affecting the freight rates of bulk carriers, which have relatively large freight rate volatility as compared to container freight rates, were quantified and analyzed. In doing so, we intended to contribute to future shipping market monitoring. We performed an analysis using a vector error correction model and estimated the influence of six independent variables on the charter rates of bulk carriers by Handy Size, Supramax, Panamax, and Cape Size. The six independent variables included the bulk carrier fleet volume, iron ore traffic volume, ribo interest rate, bunker oil price, and Euro-Dollar exchange rate. The dependent variables were handy size (32,000 DWT) spot charter rates, Supramax 6 T/C average charter rates, Pana Max (75,000 DWT) spot charter, and Cape Size (170,000 DWT) spot charter. The study examined charter rates by size of bulk carriers, which was different from studies on existing specific types of ships or fares in oil tankers and chemical carriers other than bulk carriers. Findings revealed that influencing factors differed for each ship size. The Libo interest rate had a significant effect on all four ship types, and the iron ore traffic volume had a significant effect on three ship types. The Ribo rate showed a negative (-) relationship with Handy Size, Supramax, Panamax, and Cape Size. Iron ore traffic influenced three types of linearity, except for Panamax. The size of shipping companies differed depending on their characteristics. These findings are expected to contribute to the establishment of a management strategy for shipping companies by analyzing the factors influencing changes in the freight rates of charterers, which have a profound effect on the management performance of shipping companies.