• Journal of architectural history
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• v.5 no.2 s.10
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• pp.25-39
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• 1996

Architectural researches on the traditional houses of Korea have been studied mainly based on the data collected in the field survey. From explosively incresed real mesurements and drawings in the field, plenty of data have been collected. Those have been the basic data for verifing and developing the theories on the traditional house. But after Korean war the researchers in South-Korea were not able to approach to the field in North Korea, so the new data of North Korea were not added any more. The poverty of real data have caused regional unbalance in the researches. This paper aims at collecting new data of traditional house in North Korea. But still being prohibited for the researchers of South Korea to approach to the field, I had to depend on the memories and experiences of the immigrants from North Korea who are now living in Kyon-Nam and Pusan Province. Through the questionnaire and drawings, they described vivid memory of their old houses. I was able to collect the data of 71 cases, which are significant and valuable as much as those of the real field are. The data include the address and site condition, family structure, economic condition, construction period of each house, The drawings by themselves show the building forms and plans, the plans of each building, and the included spaces. Although the quantity of those data is not enough for statistical analysis, it shows general tendency for analizing regional charateristics, the differnces among economical classes, and the periodical change. It opens the way for verfying the existing theory. Analizing the data, I have some conclusions as followings: a. Most of researchers have classified the dominant housing type of Hamkyong-Do as 'the double fold' type. In this study, all cases of Hamkyongbuk-do also show 'the double fold plan with Chongju-kan'. But in Hamkyongnam-do some cases show 'the double fold plan without Chongju-kan, or projecting the stable into the yard, which seem to be different type from 'the double fold plan with Chongju-kan' b. Existing theories classified the dominant housing type of Pyongahn-do as 'two buildings with pararell arrangement'. This classification is verified with the plentiful cases in this study. Futhermore, I found new tendency, that is, getting higher econnomic condition, they construct annex buildings between the main buildings. Finally their houses show 'scattered ㅁ shape'. The houses included in this two types has narrow and closed inner yard, which is different from the houses of the same shape in the south region of Korea. c. Existing theories classified the dominant housing type of Hwanghae-do as 'ㅁ sape with Daechong' type. I found many cases of 'ㅁ shape', but only two cases show 'Daechong'. 'The doble fold' type was also founded. Unfortunately very few cases were sent from Hwanghae-do, it is not enough for finding general tendency.

• Journal of Life Science
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• v.30 no.6
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• pp.513-521
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• 2020

B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) is a polycomb group protein and a core component of polycomb repressive complex 1. Initial research into Bmi1 has focused on its role in tumorigenesis, and it is generally accepted that it is important for the proliferation and survival of cancer cells. However, more recent studies have revealed that Bmi1 is downregulated in brains with neurodegenerative disease and that it regulates the function of mitochondria and reactive oxygen species levels. In this study, we tested the therapeutic potential of Bmi1 in pilocarpine-induced seizures in Bmi1-knockout mice. Bmi1 expression transiently increased in the hippocampal CA1 and CA3 and the dentate gyrus following pilocarpine-induced status epilepticus (SE). In terms of seizure behavior, SE induction was 43.14% and 53.57% for Bmi1^+/+ and Bmi1^+/- mice, respectively. However, there was no significant difference in mortality or hippocampal damage between the two groups. Two months after SE induction, the frequency of epileptic seizures in the Bmi1^+/- mice was 50% lower than in the control group, although the difference was not statistically significant. In addition, mossy fiber outgrowth in the Bmi1^+/- mice was significantly higher than in their wild-type littermates. Taken together, these data indicate that reduced Bmi1 activity increases pilocarpine-induced seizure probability and mossy fiber outgrowth.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7207-7211
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• 2014

Background: The aim of this study was to assess the epidemiological and clinicopathological characteristics of primary extranodal non-Hodgkin's lymphoma (pENL) patients, focusing on treatment and survival outcome. Materials and Methods: Between October 2003 and March 2012, 802 patients with non-Hodgkin's lymphoma (NHL) were diagnosed and treated in two different cancer centers of Southern Turkey. Results: pENL, constituted 12.4% (100/802) of all NHL studied during this period. Median age of the patients was 56 years (range 17-87 years) and the male: female distribution was 3:2. Eighty-five of 100 patients (85%) were in stage I/II, 9/100 (9%) in stage III, whereas 6/100 (6%) were in stage IV. Head and neck constituted the most common site (51/100, 51%), followed by gastrointestinal tract (GIL) (37/100, 37%), and cerebrum (CL) (5/100, 5%). Diffuse large B cell lymphoma (DLBCL) was the most common histological type, observed in 53% of patients, followed by marginal zone extranodal lymphoma (13%). Most of patients (76%) received a CHOP containing regimen. Complete remission (CR) were achieved in 71% of patients. The median follow-up duration of all patients was reported as 37.6 months (range, 0.8-165 months). This period was reported as 137.5 months (range, 117.5-1578.6 months) in gastrointestinal lymphoma (GIL) patients, 119.0 months (range, 91.8-146.1 months) in head and neck lymphoma (HNL) patients, and 18.4 months (range, 12.6-24.1 months) in cerebral lymphoma (CL) patients. Conclusions: Head and neck, and the gastrointestinal tract were the two most common extranodal sites observed. Histologically DLBC accounted for the majority of cases. Most patients were on earlier stages, had low-low intermediate IPI scores and had a favorable prognosis.

• Journal of Radiation Protection and Research
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• v.24 no.2
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• pp.109-120
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• 1999

Residual radiation and radioactivity level in TRIGA Mark-II, III research reactors and facilities at the KAERI Seoul site, which are to be decommissioned, have been measured, analyzed and evaluated to know the current status of radiation and radioactivity level and to establish and to provide the technical requirements for the safe decommissioning of the facilities which shall be applied in minimizing the radiation exposure for workers and in preventing the release of the radioactive materials to the environment. Radiation dose rate and surface radioactivity contamination level on the experimental equipments, floors, walls of the facilities, and the surface of the activated materials within the reactor pool structure were measured and evaluated. Radioactivity and radionuclides in the pool and cooling water were also analyzed. In case of the activated reactor pool structures which are very difficult to measure the radiation and radioactivity level, a computer code Fispin was additionally used for estimation of the residual radioactivity and radionuclides. The radiation and radioactivity data obtained in this study were effectively used as basic data for decontamination and dismantling plan for safe decommissioning of TRIGA Mark-II, III facilities.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.3151-3156
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• 2014

Background: Sorafenib is a promising drug for advanced hepatocellular carcinoma (HCC); however, treatment may be discontinued for multiple reasons, such as progressive disease, adverse events, or the cost of treatment. The consequences of sorafenib discontinuation and continuation are uncertain. Materials and Methods: We retrospectively analyzed 88 HCC patients treated with sorafenib from July 2007 to January 2013. Overall survival (OS), post-disease progression overall survival (pOS), and time to disease progression (TTP) were compared for survival analysis. Cox proportional hazard regression was performed to assess the effect of important factors on OS in the overall patient population and on pOS in patients who continued sorafenib treatment. Results: Sorafenib was discontinued and continued in 24 and 64 patients, respectively. The median OS (355 vs 517 days respectively; p=0.015) and median post-PD OS (260 vs 317 days, respectively; p=0.020) were statistically different between the discontinuation and continuation groups. Neither the median time to first PD nor the time to second PD were significantly different between the 2 groups. In the discontinuation group, 3 of the 24 patients (12.5%) suffered disease outbreaks. In Cox proportional hazard regression analysis after correction for confounding factors, BCLC stage (p=0.002) and PD site (p=0.024) were significantly correlated with pOS in patients who continued sorafenib treatment. Conclusions: Sorafenib discontinuation may cause HCC flares or outbreaks. It is advisable to continue sorafenib treatment after first PD, particularly in patients with Barcelona Clinic Liver Cancer stage B disease or only intrahepatic PD.

• Proceedings of the KSEE Conference
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• 2006.10a
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• pp.167-184
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• 2006

There is cattle shed and house structure of a country village in the vicinity of the construction site. that is why the environmental effect evaluation on blasting had been done in advance to prevent any harm to those from the work. As the result, it is impossible to apply to the blasting method, and the Super wedge method, a kind of a rock-splitting method which there is no secondary breaking by a breaker of the methods breaking &excavating rock according to the classification of the blasting method by the ministry of construction & transpotation, applied to decrease noise and vibration, and to the work classification, the extent of noise and vibration measured with the instrument only for noise(SC-310c) and with the instrument only for vibration(BLASTMATE) respectively. A drilling, splitting, collecting, loading works at the closest point(about 10m) is barely possible on the consideration of vibration to the result of measurement, but carefulness needs on moving of equipment. On the case of noise, even drilling, collecting, loading work except splitting at the comparatively close point(about 20m) is difficult. So, the method breaking &excavating rock according to the classification of the blasting method by the ministry of construction & transpotation has to apply in consideration of noise level in accordance with the work processing.

• Journal of Information Management
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• v.40 no.4
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• pp.109-133
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• 2009

Among biological information, GenBank, provided by the National Center for Biotechnology Information (NCBI)of the United States, is a representative database on genetic information and is the most widely used by researchers around the world. Korea Institute of Science and Technology Information (KISTI) visits NCBI on a regular basis and downloads the latest version of GenBank to reorganize the information gathered there into a database. This database is provided for Korean researchers of science and technology through the Bio-KRISTAL search engine, developed by KISTI. This study aims to design a service model that links information on papers, patents, and biodiversity and other contents of NDSL, an integrated service on scientific and technological information run by KISTI, with GenBank's reference and organism fields and to develop a prototype system. For this purpose, this paper explores the possibility of a linkage and convergence service between heterogeneous content by: (a) collecting GenBank data from NCBI's FTP site; (b) dividing GenBank text files into basic and reference genetic information and restructuring them into a database; (c) extracting article and patent information from the GenBank reference fields to generate new tables; and (d) leveraging data mapping technology to implement a prototype system where GenBank and NDSL data are interlinked and provided.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.32 no.1
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• pp.69-75
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• 2006

Head and neck squamous cell carcinoma(HNSCC) is the sixth most common cancer among men in the developed world affecting the tongue, pharynx, larynx and oral cavity. HNSCC is thought to represent a multistep process whereby carcinogen exposure leads to genetic instability in the tissue and accumulation of specific genetic events, which result in dysregulation of proliferation, differentiation, and cell loss and the acquisition of invasive capacity. Despite therapeutic and diagnostic progress in oncology during the past decades, the prognosis of HNSCC remains poor. Thus it seems that finding a biological tumor markers which will increase the early diagnosis and treatment monitoring rates, is of paramount importance in respect to improving prognosis. In an effort to identify gene expression signatures that may serve as biomarkers, this study several genes were selected, such as H3,3A, S100A7, UCHL1, GSTP1, PAI-2, PLK, TGF${\beta}$1 and bFGF, and used 7 HNSCC cell lines that were established various anatomical sites, and also 17 other cancer cell lines were used for control group using real-time quantitative RT-PCR and immunocytochemical analysis with a monoclonal antibody. In this study, S100A7 showed a clearly restricted occurrence in tongue originated cell line, and GSTP1 expression level in the pharynx originated cell line was very increased, relative to corresponding other cell lines. These results suggest that S100A7 and GSTP1 genes' expression can occur during tongue and pharynx originated head and neck tumorigenesis and that genetic change is an important driving force in the carcinogenesis process. This data indicate that S100A7 and GSTP1 expression pattern in HNSCC reflect both diagnostic clue and biological marker. And this is provides a foundation for the development of site-specific diagnostic strategies and treatments for HNSCC.

• Geotechnical Engineering
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• v.3 no.4
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• pp.41-54
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• 1987

A stochastic numerical analysis for predicting the groundswater fluctuations in hillside slopes is performed in this paper to account for the uncertainties associated with the rainfall and site characteristics. The effect of spatial variabilities of aquifer parameters and the effect of temporal variability of recharge on the groundwater fluctuations are studied in depth. The Kriging is used to account for the spatial tariabilities of aquifer parameters. This technique prolevides the best linear unbiased estimator of a parameter and its minimum variance from a litsitem number of measured data. A stochastic one-dimensional numerical model is delreloped b) combining the groundwater flow model, the Kriging, and the first-order second-moment analysis. In addition, a two dimensional detelministic groundwater model is developed to study the change of ground water surfas in the transverse direction as well as in the downslope direction. It is revealed that the undulations of the impervious bedrock in addition to the permeability and the specific yield have an important influence on the fluctuations of the groundwater surface. It is also found that th'e groundwater changes significantly in the transverse direction as well as in the downslope direction. The results obtained in this analysis may be used for evaluation of landslide risks due to high porewater pressure.

• Information Systems Review
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• v.25 no.1
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• pp.233-255
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• 2023

The development of information technology(IT) has brought so-called "online experience" to satisfy our daily needs. The market for online experiences grew more during the COVID-19 pandemic. Therefore, this study attempted to analyze how the features of online experience services affect customer satisfaction by crawling structured and unstructured data from the online experience web site newly launched by Airbnb after COVID-19. As a result of the analysis, it was found that the structured data generated by service users on a C2C online sharing platform had a positive effect on the satisfaction of other users. In addition, unstructured text data such as experience introductions and host introductions generated by service providers turned out to have different subjectivity scores depending on the purpose of its text. It was confirmed that the subjective host introduction and the objective experience introduction affect customer satisfaction positively. The results of this study are to provide various implications to stakeholders of the online sharing economy platform and researchers interested in online experience knowledge management.