• Tunnel and Underground Space
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• v.17 no.5
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• pp.411-427
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• 2007

Reliability in tunnel analysis is necessary to accomplish technically sound design and economical construction. For this, a thorough understanding of the construction procedure including the ground-support interaction has to be obtained. This paper describes a proper modelling technique to simulate the behavior of the steel fiber reinforced shotcrete (SFRS) which maintain the supporting capability in post-failure regime. The additional supporting effect of the steel support was also verified by 3-D analyses and a new load distribution factor were proposed. The use of the plastic moment limit (PML) alone can eliminate the occurrence of the awkwardly high tensile stress in the shotcrete and can successfully model the post-peak ductile behavior of the SFRS. But with this method, moment is limited whenever the stress caused by moment reaches tensile strength of the shotcrete irrespective of the stress by axial force. Therefore, it was necessary to find a more comprehensive method which can reflect the influence of the moment and axial force. This can be accomplished by the proper use of "liner element" which is the built-in model in FLAC. In this model, the peak and residual strength as well as the uniaxial compressive strength of the SFRS can be specified. Analyses were conducted with these two models on the 2-lane road tunnels excavated in class IV and V rock mass and results were compared with the conventional elastic beam model. Results showed that both models can reflect the fracture toughness of the SFRS which could not be accomplished by the elastic beam model.

• Journal of dental hygiene science
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• v.9 no.1
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• pp.99-108
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• 2009

The purpose of this study was to investigate the effect of oral health education practice and schoolteacher's self-efficacy on oral health attitude. The data of 217 dental hygienists was subjected to path analysis using AMOS 16.0. Oral health knowledge, attitude, self-efficacy and oral health education practice of schoolteacher were measurement variables of three path models. The goodness of fitness of Knowledge-Attitude-Practice model and Knowledge-Attitude-Self efficacy -Practice model were acceptable. The regression weights of two models were statistically significant. Oral health education practice of schoolteacher gave impact on oral health attitude by mediation of self-efficacy of schoolteacher. Self-efficacy of schoolteacher was a important determinant of oral health education practice. Oral health attitude and practice were supposed to be mutual determinants of health behavior models.

• Journal of the Korean Society for Precision Engineering
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• v.29 no.3
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• pp.279-288
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• 2012

The material removal mechanism in machining is significantly affected by the cutting edge geometry. Its effect becomes even more substantial when the depth of cut is relatively small as compared to the characteristic length which represents the shape and size of the cutting edge. Conventionally, radius or focal length has been employed as the characteristic length with the assumption that the shape of cutting edge is round or parabolic. However, in reality, there could be various ways to determine the radius or focal length even for the same tool edge profile, depending on the region to be considered as cutting edge in the measured profile and the constraints to be set in constructing the best fitted circle or parabola. In this regard, the present study proposes various models to determine the characteristic length in terms of radius or focal length. Their physical compatibility are validated by carrying out 2D orthogonal cutting experiments using inserts with a wide range of characteristic length ($30{\sim}180\;{\mu}m$ in terms of radius) and then by investigating the correlation between the characteristic length and the cutting forces. Such validation is based on the common belief that the larger the characteristic length is, the blunter the cutting edge is and the higher the cutting forces are. Interestingly, the results showed that the correlation is higher for the radius or focal length obtained with a constraint that the center of best fitted circle or the focus of the best fitted parabola should be on the bisectional line of the wedge angle of tool.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.42.2-42.2
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• 2020

We report on multi-wavelength observations of AA Ori, a Young Stellar Object in Orion-A star-forming region. AA Ori is known to have a pre-transitional disk based on infrared observations including Spitzer/IRS data. We construct its broadband spectral energy distribution (SED) by not only taking data in the optical and IR region but also including Herschel/PACS, JCMT/SCUBA, and SMA observational data. We use the Monte Carlo radiative transfer code (RADMC-3D) to reconstruct the SED with a viscous accretion disk model initialized by a radially continuous disk and finally having an inner and outer dusty disk separated by a dust-depleted radial gap. By comparing the model SEDs with different configurations of disk parameters, we discuss the limits to find a single solution of model parameters to fit the data. We suggest that some models with a modified inner disk surface density gradient and some degree of dust depletion in the inner disk can explain the AA Ori's SED, from which we infer that the inner disk of AA Ori has evolved. We present that model configurations of a pre-transitional disk with a large gap extended to 60-80 AU in a settled dusty disk of a few hundred AU size with a high inclination angle (~60°) also create model SEDs close to the observed one. To distinguish whether the disk has a just-opened narrow gap or a large gap, with an altered surface density of the inner disk extended to 10 AU, we suggest a further investigation of AA Ori with high angular resolution observations.

• Journal of Embryo Transfer
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• v.19 no.3
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• pp.291-299
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• 2004

Characterization of quantitative trait loci (QTL) was investigated in the experimental cross population between Berkshire and Yorkshire breed. A total of 512 F$_2$ offspring from 65 matting of F$_1$ parents were phenotyped the carcass traits included average daily gain (ADG), average backfat thickness (ABF), tenth rip backfat thickness (TRF), loin eye area (LEA), and last rip backfat thickness (LRF). All animals were genotyped for 125 markers across the genome. Marker linkage maps were derived and used in QTL analysis based on line cross least squares regression interval mapping. A decision tree to identify QTL with imprinting effects was developed based on tests against the Mendelian mode of QTL expression. To set the evidence of QTL presence, empirical significance thresholds were derived at chromosome-wise and genome-wise levels using specialized permutation strategies. Significance thresholds derived by the permutation test were validated in the data set based on simulation of a pedigree and data structure similar to the Berkshire-Yorkshire population. Genome scan revealed significant evidences for 13 imprinted QTLs affecting growth and body compositions of which nine were identified to be QTL with paternally expressed inheritance mode. Four of QTLs in the loin eye area (LEA), and tenth rip backfat thickness (TRF), a maternally expressed QTL were found on chromosome 10 and 12. These results support the useful statistical models to analyse the imprinting far the QTLs related carcass trait.

• The Journal of Korean Society of Virology
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• v.29 no.3
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• pp.165-174
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• 1999

To investigate viral pathogenesis and in vivo efficacy of acyclovir (ACV) in mouse HSV-1 encephalitis models, female BALB/c mice aged 5 weeks were inoculated with strain F either intranasally (IN) or intracerebrally (IC). ACV-treatment by intraperitomeal injection with 0, 5, 10 and 25 mg/kg b.i.d. for 6 days was commenced 1 h after infection. Body weight and signs of clinical disease were noted daily up to 2 weeks. $ED_{50}$ of ACV in IN infection was <5 mg/kg and 14.1 mg/kg in IC infection. Tissues of central nervous system were collected from 2 mice per group everyday up to 5 day p.i. and the virus titers were measured. In IN infection model, high titers in eyes and trigeminal nerves were observed. ACV-treatment showed significant reduction of the titers in all the isolated. In IC infection model, cerebrum, cerebellum and brain stem showed high virus titers. ACV-treatment showed less significant reduction of virus titers than that in IN infection model. Reactivation of explanted trigeminal nerves from mice 30 day p.i. was monitored. In all of ACV treated mice reactivation was observed, i.e. even the highest dose of ACV did not inhibit the establishment of viral latency.

• Journal of Nutrition and Health
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• v.38 no.9
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• pp.750-755
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• 2005

Hepcidin, a peptide hormone synthesized mainly by the liver, has been implicated as a key regulator of iron homeostasis. Results from studies with experimental animal models suggested that hepcidin levels are related with body iron status, but little data is available in human subjects. This study was conducted to determine the relationship between serum pro-hepcidin levels, blood indexes of anemia, and dietary iron intake in female college students. Serum pro-hepcidin concentrations were measured by enzyme-linked immunosorbent assay in eighty-two women with $22.1\pm0.2$ years old. Dietary intake data were collected by using the 24-hour recall method for 3 days. Mean concentrations of serum pro-hepcidin were 85.1 ng/ml$\pm$6.1(s.d.) with the range of 13.6-295.7 ng/ml. The median value of serum pro-hepcidin in the study subjects was 70.3 ng/ml. Serum pro-hepcidin concentrations were positively correlated with hemoglobin concentrations (r=0.273, p=0.013), and also with hematocrit (r=0.291, p=0.008). To examine whether the level of dietary iron intake affects serum pro-hepcidin levels, study subjects were divided into two groups according to the amounts of daily iron intake. Serum pro-hepcidin concentrations were $22\%$ lower in groups with low iron intake (${\leq}10.1$ mg/day), compared to high-iron intake group (>10.1 mg/day) . In conclusion, these data, as in agreement with findings in mice, suggest that hepcidin plays an important role in regulating iron metabolism in the human body.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.39 no.6
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• pp.691-702
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• 2019

Flood inundation map has various important roles in terms of municipal planning, timely dam operation, economic levee design, and building flood forecasting systems. Considering that the riparian areas adjacent to national rivers with high potential flood vulnerability conventionally imposed special cares to justify applications of recently available two- or three-dimensional flood inundation numerical models on top of digital elevation models of dense spatial resolution such as LiDAR irrespective of their high costs. On the contrary, local streams usually could not have benefits from recent technological advances, instead they inevitably have relied upon time-consuming manual drawings or have accepted DEMs with poor resolutions or inaccurate 1D numerical models for producing inundation maps due mainly to limited budgets and suitable techniques. In order to efficiently and cost-effectively provide a series of flood inundation maps dedicatedly for the local streams, this study proposed an OpenGIS-based flood mapping tool named Open Flood Mapper (OFM). The spatial accuracy of flood inundation map derived from the OFM was validated throughout comparison with an inundation trace map acquired after typhoon Nari in Hancheon basin located in Jeju Island. Also, a series of inundation maps from the OFM were comprehensively investigated to track the burst of flood in the extreme flood events.

• Tunnel and Underground Space
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• v.28 no.5
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• pp.400-425
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• 2018

This study presents the research results and current status of the DECOVALEX-2019 project Task B. Task B named 'Fault slip modelling' is aiming at developing a numerical method to simulate the coupled hydro-mechanical behavior of fault, including slip or reactivation, induced by water injection. The first research step of Task B is a benchmark simulation which is designed for the modelling teams to familiarize themselves with the problem and to set up their own codes to reproduce the hydro-mechanical coupling between the fault hydraulic transmissivity and the mechanically-induced displacement. We reproduced the coupled hydro-mechanical process of fault slip using TOUGH-FLAC simulator. The fluid flow along a fault was modelled with solid elements and governed by Darcy's law with the cubic law in TOUGH2, whereas the mechanical behavior of a single fault was represented by creating interface elements between two separating rock blocks in FLAC3D. A methodology to formulate the hydro-mechanical coupling relations of two different hydraulic aperture models and link the solid element of TOUGH2 and the interface element of FLAC3D was suggested. In addition, we developed a coupling module to update the changes in geometric features (mesh) and hydrological properties of fault caused by water injection at every calculation step for TOUGH-FLAC simulator. Then, the transient responses of the fault, including elastic deformation, reactivation, progressive evolutions of pathway, pressure distribution and water injection rate, to stepwise pressurization were examined during the simulations. The results of the simulations suggest that the developed model can provide a reasonable prediction of the hydro-mechanical behavior related to fault reactivation. The numerical model will be enhanced by continuing collaboration and interaction with other research teams of DECOLVAEX-2019 Task B and validated using the field data from fault activation experiments in a further study.

• Geophysics and Geophysical Exploration
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• v.12 no.1
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• pp.33-40
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• 2009

In field surveys using the dipole-dipole electrical resistivity method, we often encounter negative apparent resistivity. The term 'negative apparent resistivity' refers to apparent resistivity values with the opposite sign to surrounding data in a pseudosection. Because these negative apparent resistivity values have been regarded as measurement errors, we have discarded the negative apparent resistivity data. Some people have even used negative apparent resistivity data in an inversion process, by taking absolute values of the data. Our field experiments lead us to believe that the main cause for negative apparent resistivity is neither measurement errors nor the influence of self potentials. Furthermore, we also believe that it is not caused by the effects of induced polarization. One possible cause for negative apparent resistivity is the subsurface geological structure. In this study, we provide some numerical examples showing that negative apparent resistivity can arise from geological structures. In numerical examples, we simulate field data using a 3D numerical modelling algorithm, and then extract 2D sections. Our numerical experiments demonstrate that the negative apparent resistivity can be caused by geological structures modelled by U-shaped and crescent-shaped conductive models. Negative apparent resistivity usually occurs when potentials increase with distance from the current electrodes. By plotting the voltage-electrode position curves, we could confirm that when the voltage curves intersect each other, negative apparent resistivity appears. These numerical examples suggest that when we observe negative apparent resistivity in field surveys, we should consider the possibility that the negative apparent resistivity has been caused by geological structure.