• 한국의학물리학회지:의학물리
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• 제26권1호
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• pp.18-27
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• 2015

컴프턴 산란 현상을 이용하여 전자적 집속 방법으로 영상화하는 컴프턴카메라는 고민감도 및 고에너지 해상도의 장점을 이용하여 핵의학 응용분야에 대한 잠재력이 큰 영상 시스템이다. 본 논문에서는 컴프턴카메라를 이용한 다중 추적자 영상의 효용성 평가와 정확한 3차원 단면영상 촬영을 위한 Orlov 조건을 만족하는 회전하는 컴프턴카메라의 구조를 조사하였다. 140/511 keV의 방사선원의 소프트웨어 모형을 구성하고 이에 대한 몬테카를로 전산모사 시뮬레이션을 수행하여 리스트모드 배열된 부분집합 기댓값 최대화 방법으로 재구성된 다중 추적자 영상으로 컴프턴카메라의 효용성을 검증하였다. 산란부와 흡수부를 평행하게 위치시킨 고정된 컴프턴카메라와 촬영대상 주위 $360^{\circ}$를 회전하는 컴프턴카메라를 구성하여 검출된 투사선의 구좌표계 각도에 대한 히스토그램을 비교 평가하였다. 140/511 keV의 동시 계측된 몬테카를로 전산모사 데이터의 다중 추적자 영상이 2차원 및 3차원 재구성 시 잘 구분되는 것을 확인하였으며, 회전된 컴프턴카메라의 경우, 회전각도에 반비례하여 3차원 영상재구성에 필요한 유효 투사선이 증가하였다. 26분의 계산 시간 및 5백만개의 적절한 유효 투사선의 개수를 고려할 때 컴프턴카메라의 회전각은 $30^{\circ}$가 현실적으로 적절할 것이며 증가한 검출 시간은 다중 컴프턴카메라를 구성하여 해결할 수 있다. 본 논문에서 고찰한 고민감도 및 고에너지 해상도를 가진 컴프턴 카메라는 다중추적자 영상화를 위해 적합한 시스템이며 생화학 및 생리학적 상태 변화에 대한 임상 정보를 제공하며 각종 질병 진단 및 치료 방법 개발 등에 기여할 수 있는 잠재력이 있는 영상 시스템이다.

• 대한소아치과학회지
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• 제47권1호
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• pp.17-24
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• 2020

이 연구의 목적은 소아 얼굴 연조직의 선형 길이를 비교하여 삼차원 입체영상의 정확성과 재현성을 평가하는 것이다. 연구는 7 - 12세 아동 15명을 대상으로 하였다. 환자의 안모에 23개의 계측 점을 표시하고, 전자 캘리퍼를 이용하여 16 개의 선형길이를 직접 2번 계측하였다. 3차원(3D) 스캐너를 이용하여 2개의3D 얼굴 영상을 만들었으며, 직접계측과 동일한 16개의 선형 길이를 계측하였다. 연구결과 정확성 평가에서 전체 평균 차이 값은 0.9 mm였다. 3D 영상의 재현성은 직접계측의 재현성과 거의 유사한 정도로 나타났다. 이에 따라 이 3D 영상장비는 소아에서 임상적으로 충분한 정확성과 재현성을 가지고 있었다. 3D 영상 시스템은 정확한 이미지를 위하여 대상의 협조가 필요하다. 소아의 정확한 3D영상을 얻기 위한 구체적인 지시사항을 바탕으로 촬영을 한다면, 이 3D 영상 장비는 향후 소아의 성장과 발달을 조사하고, 소아교정치료에서 결과를 평가하는데 유용하게 사용될 수 있을 것이다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.85-85
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• 2013

Label-free, sensitive and selective detection methods with high spatial resolution are critically required for future applications in chemical sensor, biological sensor, and nanospectroscopic imaging. Here I describe the development of Plasmon Resonance Energy Transfer (PRET)-based molecular imaging in living cells as the first demonstration of intracellular imaging with PRET-based nanospectroscopy. In-vivo PRET imaging relied on the overlap between plasmon resonance frequency of gold nanoplasmonic probe (GNP) and absorption peak frequencies of conjugated molecules, which leads to create 'quantized quenching dips' in Rayleigh scattering spectrum of GNP. The position of these dips exactly matched with the absorption peaks of target molecules. As another innovative application of PRET, I present a highly selective and sensitive detection of metal ions by creating conjugated metal-ligand complexes on a single GNP. In addition to conferring high spatial resolution due to the small size of the metal ion probes (50 nm in diameter), this method is 100 to 1,000 folds more sensitive than organic reporter-based methods. Moreover, this technique achieves high selectivity due to the selective formation of Cu2+complexes and selective resonant quenching of GNP by the conjugated complexes. Since many metal ion ligand complexes generate new absorption peak due to the d-d transition in the metal ligand complex when a specific metal ion is inserted into the complex, we can match with the scattering frequency of nanoplasmonic metal ligand systems and the new absorption peak.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.555-558
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• 1997

A new approach to silent MR imaging using a rotating DC gradient has been explored and experimentally studied. As is known, acoustic or sound noise has been one of the major problems in handling patients, mainly due to the fast gradient pulsings in interaction with the main magnetic field. The sound noise is also proportionally louder as the magnetic field strength becomes larger. In this article, we have described a new imaging technique using a mechanically rotating DC gradient coil as an approach toward silent MR imaging, i.e., a mechanically rotated DC gradient effectively replaces both the phase encoding as well as the readout gradient pulsings and data obtained in this manner provides a set of project ion data which later can be used or the projection reconstructionorwithsomeinterpolation techniques one can also perform conventional 2-D FFT (Fast Fourier Transform) image reconstruction. We found, with this new technique, that the sound noise intensity compared with the conventional imaging technique, such as spin echo sequence, is reduced down to -20.7 dB or about 117.5 times. The experimental pulse sequence and its principle are described and images obtained by the new silent MR imaging technique are reported.

• Imaging Science in Dentistry
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• 제53권4호
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• pp.283-289
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• 2023

The apnea-hypopnea index is widely regarded as a measure of the severity of obstructive sleep apnea (OSA), a condition characterized by recurrent episodes of apnea or hypopnea during sleep that induce airway collapse. OSA is a catastrophic problem due to the wide range of health issues it can cause, including cardiovascular disease and memory loss. This review was conducted to clarify the roles of various imaging modalities, particularly cone-beam computed tomography (CBCT), in the diagnosis of and preoperative planning for OSA. Unfortunately, 2-dimensional imaging techniques yield insufficient data for a comprehensive diagnosis, given the complex anatomy of the airway. Three-dimensional (3D) imaging is favored as it more accurately represents the patient's airway structure. Although computed tomography and magnetic resonance imaging can depict the actual 3D airway architecture, their use is limited by factors such as high radiation dose and noise associated with the scans. This review indicates that CBCT is a low-radiation imaging technique that can be used to incidentally identify patients with OSA, thereby facilitating early referral and ultimately enhancing the accuracy of surgical outcome predictions.

• 인포메이션 디스플레이
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• 제5권2호
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• pp.27-32
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• 2004

• Journal of Information Display
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• 제13권2호
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• pp.83-89
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• 2012

The crosstalk evaluation of multiview autostereoscopic three-dimensional (3D) displays is discussed, with both the human and technical factors investigated via image quality assessment. In the imaging performance measurements and analysis for a multiview autostereoscopic display prototype equipment, it was inferred that crosstalk would have both a positive and a negative effect on the imaging performance of the equipment. The importance of the attached diaphragm in the crosstalk evaluation was proposed and then experimentally verified, using the developed prototype equipment. The luminance distribution and crosstalk situation were given, with two different diaphragm arrays applied. The analysis results showed that the imaging performance of this 3D display system can be improved with minimum changes to the system structure.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2010년도 하계학술대회 논문집
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• pp.66-66
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• 2010

잉크젯용 저온 Cu ink의 소성 특성을 향상 시키기 위해 소성 분위기롤 조절 하였다. 일반적으로 Cu는 산화가 잘되는 물질로 환원 분위기에서 소성이 이루어져야만 하기 때문에 acid, alcohol, aldehyde, ether와 같은 환원제를 소성시 사용하였다. 또한 1종의 환원제가 아닌 2종의 환원제롤 일정 비율로 섞음으로써 환원력를 조절하여 소성 품질을 향상 시킬 수 있었으며, 이러한 환원 분위기 조절을 통하여 300도 이하 저온에서 소성이 가능하였다. 또한 optical microscopy와 field emission scanning electron microscopy를 통해 막 품질과 미세조직의 치밀도를 확인하였고 배선 재료로써의 적용을 위해 resistance를 측정 비교하였다.

• Investigative Magnetic Resonance Imaging
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• 제20권2호
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• pp.81-87
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• 2016

Purpose: To analyze the feasibility of three-dimensional (3D) diffusion-weighted (DW) PSIF (reversed FISP [fast imaging with steady-state free precession]) sequence in order to evaluate peripheral nerves in the elbow. Materials and Methods: Ten normal, asymptomatic volunteers were enrolled (6 men, 4 women, mean age 27.9 years). The following sequences of magnetic resonance images (MRI) of the elbow were obtained using a 3.0-T machine: 3D DW PSIF, 3D T2 SPACE (sampling perfection with application optimized contrasts using different flip angle evolution) with SPAIR (spectral adiabatic inversion recovery) and 2D T2 TSE (turbo spin echo) with modified Dixon (m-Dixon) sequence. Two observers used a 5-point grading system to analyze the image quality of the ulnar, median, and radial nerves. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of each nerve were measured. We compared 3D DW PSIF images with other sequences using the Wilcoxon-signed rank test and Friedman test. Inter-observer agreement was measured using intraclass correlation coefficient (ICC) analysis. Results: The mean 5-point scores of radial, median, and ulnar nerves in 3D DW PSIF (3.9/4.2/4.5, respectively) were higher than those in 3D T2 SPACE SPAIR (1.9/2.8/2.8) and 2D T2 TSE m-Dixon (1.7/2.8/2.9) sequences (P < 0.05). The mean SNR in 3D DW PSIF was lower than 3D T2 SPACE SPAIR, but there was no difference between 3D DW PSIF and 2D T2 TSE m-Dixon in all of the three nerves. The mean CNR in 3D DW PSIF was lower than 3D T2 SPACE SPAIR and 2D T2 TSE m-Dixon in the median and ulnar nerves, but no difference among the three sequences in the radial nerve. Conclusion: The three-dimensional DW PSIF sequence may be feasible to evaluate the peripheral nerves around the elbow in MR imaging. However, further optimization of the image quality (SNR, CNR) is required.

• Journal of Electrical Engineering and Technology
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• 제13권1호
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• pp.468-475
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• 2018

In medical ultrasound imaging, frequency-dependent attenuation downshifts and reduces a center frequency and a frequency bandwidth of received echo signals, respectively. This causes considerable errors in quadrature demodulation (QDM), result in lowering signal-to-noise ratio (SNR) and contrast resolution (CR). To address this problem, adaptive dynamic QDM (ADQDM) that estimates center frequencies along depth was introduced. However, the ADQDM often fails when imaging regions contain hypoechoic regions. In this paper, we introduce a valid region-based ADQDM (VR-ADQDM) method to reject the misestimated center frequencies to further improve SNR and CR. The valid regions are regions where the center frequency decreases monotonically along depth. In addition, as a low-pass filter of QDM, Gaussian wavelet based dynamic filtering was adopted. From the phantom experiments, average SNR improvements of the ADQDM and the VR-ADQDM over the traditional QDM were 1.22 and 5.27 dB, respectively, and the corresponding maximum SNR improvements were 2.56 and 10.58 dB. The contrast resolution of the VR-ADQDM was also improved by 0.68 compared to that of the ADQDM. Similar results were obtained from in vivo experiments. These results indicate that the proposed method would offer promises for imaging technically-difficult patients due to its capability in improving SNR and CR.