• Structural Engineering and Mechanics
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• v.85 no.6
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• pp.765-780
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• 2023

In this work, a novel combined logarithmic, secant and tangential 2D and quasi-3D refined higher order shear deformation theory is proposed to examine the buckling analysis of simply supported uniform functionally graded plates under uniaxial and biaxial loading. The proposed formulations contain a reduced number of variables compared to others similar solutions. The combined function employed in this study ensures automatically the zero-transverse shear stresses at the free surfaces of the structure. Various models of the material distributions are considered (linear, quadratic, cubic inverse quadratic and power-law). The differentials stability equations are derived via virtual work principle with including the stretching effect. The Navier's approach is applied to solve the governing equations which satisfying the boundary conditions. Several comparative and parametric studies are performed to illustrates the validity and efficacity of the proposed model and the various factors influencing the critical buckling load of thick FG plate.

• Nutrition Research and Practice
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• v.13 no.6
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• pp.498-508
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• 2019

BACKGROUND/OBJECTIVES: Lower circulating 25-hydroxyvitamin D [25(OH)D] levels are associated with a higher risk of hypertension (HTN); however, it remains unclear whether the relationship is causal. We aimed to evaluate the causal effects of circulating 25(OH)D levels on the prevalence of HTN in the Korean population using the Mendelian randomization (MR) approach. SUBJECTS/METHODS: Epidemiological data, serum 25(OH)D data, and genomic DNA biospecimens were obtained from 2,591 participants, a subset of the study population in the Korea National Health and Nutrition Survey 2011-2012. Five 25(OH)D-related single nucleotide polymorphisms (SNPs; DHCR7 rs12785878, CYP2R1 rs10741657, CYP2R1 rs12794714, CYP24A1 rs6013897, and GC rs2282679), identified a priori from genome-wide association studies, were used as instrument variables (IVs) for serum 25(OH)D levels. In the MR analysis, we performed IV analyses using the two-stage least squares method. RESULTS: In the observational analysis, circulating 25(OH)D levels were found to be inversely associated with the HTN prevalence in ordinary least squares models (odds ratio: 0.97, 95% confidence interval: 0.96, 0.99) after adjusting for the potential confounders. There were differences in the circulating 25(OH)D levels across genotypes of individual SNPs. In the MR analysis, using individual SNPs as IVs, 25(OH)D levels were not associated with the HTN prevalence. CONCLUSIONS: We found no association between genetically determined circulating 25(OH)D levels and HTN in Korean adults. Our results are listed owing to the relatively small sample size and possible weak instrument bias; therefore, further studies are needed to confirm these results.

• Journal of the Korea Convergence Society
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• v.11 no.5
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• pp.399-412
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• 2020

This study aimed to evaluate the effectiveness of smartphone addiction interventions among university students. Selection criteria included university students, smartphone addiction interventions, smartphone addiction, depression, anxiety, self-control and time of smartphone usage. A total of 915 articles were retrieved. From those, 15 studies from 13 articles fulfilled the inclusion criteria. A meta-analysis showed that smartphone addiction interventions undergone by university students had statistical significance in alleviating smartphone addiction (d=-1.57, 95% CI:-2.84, -0.30), depression (d=-3.73, 95% CI:-4.97, -2.48), and self-control (d=7.28, 95% CI:2.76, 11.79); but were not significantly effective in improving anxiety and reducing time of smartphone usage. The systematic review and meta-analysis suggested that smartphone addiction interventions boost the alleviation of smartphone addiction. However, it remains necessary to conduct well-designed randomized controlled trials, including the consideration of various cultural characteristics.

• Proceedings of the Korean Information Science Society Conference
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• 2012.06d
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• pp.372-374
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• 2012

급속도로 증가하는 모바일 데이터 트래픽으로 인해 현재 이동통신 기술에서 모바일 트래픽 감소와 네트워크 효율 증대가 가능한 기술이 필요시 되고 있다. D2D 통신은 인접한 기기간의 직접 통신을 지원함으로써 기지국에서의 트래픽 과부하를 분산시키고 기기 간 인접함을 이용해 놓은 전송속도, 낮은 전송시간, 낮은 전력소모의 이득을 얻을 수 있으며 기지국을 이용한 통신과의 주파수 재사용으로 인한 자원 재활용 이득을 얻을 수 있다. 이러한 이점으로 인해 D2D는 차세대 이동통신 기술의 중요한 요소로 여겨지고 있으며 표준화 단체와 여러 기업에서 D2D를 활용한 차세대 이동통신 기술을 개발하는데 많은 투자를 하고 있다. 본 논문에서는 D2D에 대한 설명과 Qualcomm 사의 D2D 기술인 FlashLinQ, Nokia 사의 D2D 통신기술에 대하여 알아보고 미래 이동통신 환경에서 D2D 기술을 활용한 다양한 서비스 시나리오를 분류하고 이에 대한 요구사항을 정리해 봄으로써 D2D를 활용한 이동통신기술 개발의 초석을 마련한다.

• Preventive Nutrition and Food Science
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• v.3 no.1
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• pp.36-42
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• 1998

Ion-selective eleltrodes(ISEs) are simple electrodechemical devices for the direct measurement of ions in the samples. A novel potentiometric biosensor for the determination of L-Malate or D-isocitrate has been developed by using CO2-3 -ISE-FIA system was composed of a pump, an injector, a malic enzyme or isocitric dehydrogenase enzyme reactor, a CO2-3 -ISE, a pH/mV meter, and an integrater. The various factors, such as buffer capacity types of plstericizer and polymer, were optimized for the CO2-3 selectivity. In this novel CO2-3 --ISE-FIA system, the potential difference due to the amount of CO2-3 produced from each enzyme reaction was proportional to the amount of L-malate or D-isocitrate.

• Archives of Pharmacal Research
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• v.21 no.5
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• pp.555-558
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• 1998

chondroitin sulfates were isolated from the mud snail. For the quantitative analysis of enzymatic digestion products of isolated chondroitin sulfates, strong anion exchange-high performance liquid chromatography (SAX-HPLC) was performed. by the action of chondroitinase ABC, three unsaturated disaccharides$ 2-acetamide-2-deoxy-3-O-({\beta}-D-gluco-4-enepyranosyluronic acid)-D-galactose $$({\Delta}Di-OS), $2-acetamide-2-deoxy-3-O-({\beta}-D-gluco-4-enepyranosyluronic acid)-6-O-sulfo-D-galactose ({\Delta}Di-6S) and 2-acetamide-2-deoxy-3-O-({\beta}-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose ({\Delta}Di-4S)$ were produced from the mud snail chondroitin sulfates. The analysis showed that relative proportion of ${\Delta}Di-OS/{\Delta}Di-6S/{\Delta}Di-4S$ was 58.7/3.1/38.2. The immunomodulating activity of chondroitin sulfate was examined by cell proliferation assay and these results suggest that it might be a immunosuppressant.

• Health Policy and Management
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• v.20 no.1
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• pp.183-203
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• 2010

The purpose of this study is to analyze the effect of the R&D subsidies by the government on the private firms' R&D investments in the Korean pharmaceutical industry, which are supposed to have positive effects on their economic performance. We also estimate the relationship between the private firms' R&D investments and firms' economic outcome. Empirical analysis is done by Error Component 2 Stage Least Squares(EC2SLS) estimation using 43 pharmaceutical firms' 8 years' panel data. The elasticity of the government R&D subsidies on the private R&D investments is 0.021%, which we cannot say 'efficient'. Also R&D investments have positive effects on the economic outcome of the pharmaceutical firms, as we expected. We propose several suggestions in the conclusion for the efficient way of government R&D subsidies to induce more private R&D investments.

• Journal of Korean Institute of Industrial Engineers
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• v.40 no.3
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• pp.342-357
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• 2014

The present study analyzes the relationship between research and development (R&D) inputs and performance of a national technology innovation R&D program using successive binary Logistic regression models based on a typical R&D logic model. In particular, this study focuses on to answer the following three main questions; (1) "To what extent, do the R&D inputs have an effect on the performance creation?"; (2) "Is an obvious relationship verified between the immediate predecessor and its successor performance?"; and (3) "Is there a difference in the performance creation between R&D government subsidy recipient types and between R&D collaboration types?" Methodologically, binary Logistic regression models are established successively considering the "Success-Failure" binary data characteristic regarding the performance creation. An empirical analysis is presented analyzing the sample n = 2,178 R&D projects completed. This study's major findings are as follows. First, the R&D inputs have a statistically significant relationship only with the short-term, technical output, "Patent Registration." Second, strong dependencies are identified between the immediate predecessor and its successor performance. Third, the success probability of the performance creation is statistically significantly different between the R&D types aforementioned. Specifically, compared with "Large Company", "Small and Medium-Sized Enterprise (SMS)" shows a greater success probability of "Sales" and "New Employment." Meanwhile, "R&D Collaboration" achieves a larger success probability of "Patent Registration" and "Sales."

• Journal of the Institute of Convergence Signal Processing
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• v.2 no.2
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• pp.68-74
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• 2001

A design and implementation method for the UHF-band(800MHz) variable attenuator using the 3dB coupler is proposed. The 90 degree, 3-dB Coupler is used for the variable attenuator. The principal theory for the 3-dB coupler is introduced. The 3-dB Coupler is designed by the mathematical analysis and a computer simulation tool. A PIN diode is used for the variable resistor at UHF-band. The variable attenuator using the 3-dB coupler and the PIN diode is designed and implemented. The measured results for the variable attenuator by a network analyzer show that the insertion loss is below -l0dB, and the continuous variable attenuation range is about 10dB.

• Transactions of the Korean Society of Mechanical Engineers
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• v.10 no.1
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• pp.102-109
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• 1986

Based on the Hartenberg-Denavit symbolic equation, which is one of equations for the kinematic analysis of three dimensional (3-D) linkage, a generalized kinematic motion equation is derived utilizing Euler angles and employing the coordinates transformation. The derived equation can feasibly be used for the motion analysis of any type of 3-D linkages as well as 2-D ones. In order to simulate the general motion of 3-D linkgages on digital computer, the generalized equation is programmed through the process of numerical analysis after converting the equation to the type of Newton-Raphson formula and denoting it in matrix form. The feasibility of theoretically derived equation is experimentally proved by comparing the results from the computer with those from experimental setup of three differrent but generally empolyed 3-D linkages.