• Title/Summary/Keyword: 2 order system

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Development of Controlled Release Oral Drug Delivery System by Membrane-Coating Method-I - Preparation and pharmaceutical evaluation of controlled release acetaminophen tablets-

  • Shim, Chang-Koo;Kim, Ki-Man;Kim, Young-Il;Kim, Chong-Kook
    • Archives of Pharmacal Research
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    • v.13 no.2
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    • pp.151-160
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    • 1990
  • In order to develop a controlled-release oral drug delivery system (DDS) which sustains the plasma acetaminophen (AAP) concentration for a certain period of time, microporous membrane-coated tablets were prepared and evaluated in vitro. Firstly, highly water-soluble core tablet of AAP were prepared with various formulations by wet granulation and compression technique. Then the core tablets were coated with polyvinychloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of core tablets and coating suspensions on the pharmaceutical characteristics such as drug release kinetics and membrane stability of the coated tablets was investigated in vitro. AAP was released from the coated tablets as a zero-order rate in a pH-independent manner. This independency of AAP release to pH change from 1.2 to 7.2 is favorable for the controlled oral drug delivery, since it will produce a constant drug release in the stomach and intestine regardless of the pH change in the GI tract. Drug release could be extended upto 10 h according to the coating condition. The release rate could be controlled by changing the formula compositions of the core tablets and coating suspensions, coat weight per each tablet, and especially PVC/sucrose ratio and particle size of the sucrose in the coating suspension. The coated tablets prepared in this study had a fairly good pharmaceutical characteristics in vitro, however, overall evaluation of the coated tablet should await in vivo absorption study in man.

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A Study on Mechanism of Consumed Water in tne Farm Land (밭에의 토양수분 소비기구에 관한 연구)

  • 류능환;민병섭
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.16 no.4
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    • pp.3555-3571
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    • 1974
  • This experiment of which aim contribute to plan irrigation system so as to increase forage crop yields, was conducted to estimate evapotranspiration amount of forage crops and to find out system of consumed water in a pasture-ground. The results obtained by this study are as follows: 1. The general weather conditions which, were closely related to the evapotrannpiration of forage crops were nearly same as those of the average year with the exception that temperature of May and June were slightly low. 2. According to the investigation of potential evapotranspirations (P.E) or forage crops and its changes during growing periods, changes of tenday P.E. were high significant according to the harvesting period. P.E of Alfalfa of which yield was the largest was the biggest. Althrough the correlations between P.E. and meteorological factors were irregular oming to three-time harvesting, correlation between ten-day evapotraspiration amount and copper plated pan evaporation or solar radiation was high positive significant. 4. Predicting formulas of P.E. were led by weather factors, and also relatione between P.E. and weather factors were showed as figure. from the these formulas, P.E. may be calculated by weather factors. 5. Predicting formulas of P.E. were led by mean temperature and copper plated pan evaporation, and by mean temperature and solar radiation. As computed values and measured values showed in figure, these formulas were high signiflent. 6. In the total consumed soil water duration of 10 days which, was non-rain period from 12th to 21th of August, Alfalfa was the largest 48.1mm, second, Orchard grass 40.1mm and Fescue 37.6mm, and Ladino clover was the smallest 37.1mm, also, order of each forage crop yield amound. was same to the abov. Order of soil moisture extraction rate of soil layer of all the for forage crops dulation of ten-day was soil layer 1 which was largest, soil layer 2, 3, and 4 Reviewing the the first five-day and the second five day, in the first five-day, order of that of all the forage crops was same to the above, but in the second five-day, that of soil layer 2 or 3 was more than the of soil layer 1.

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Containment Control for Second-order Multi-agent Systems with Input Saturations (입력 포화를 고려한 2차 다중 에이전트 시스템을 위한 봉쇄제어)

  • Young-Hun, Lim
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.27 no.1
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    • pp.109-116
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    • 2023
  • In this paper, we study the containment control problem for second-order multi-agent systems, which consists of multiple leaders and followers. The goal is to drive the followers toward the convex hull spanned by the leaders. Thus, the swarm behavior can be obtained by controlling the entire group by the leaders. This paper considers the leaders move at a constant speed and the followers have input saturations. Moreover, we assume that the followers can exchange information with neighbors, and only relative state information is available. Under these assumptions, we propose the Proportional-Integral based distributed control algorithm to solve the containment control problem with moving leaders. Moreover, based on Lasalle's invariance principle, the conditions for the control gains that guarantee the convergence of the followers to the convex hull spanned by the leaders are investigated, and it was shown that it can be designed only using the system parameter. Finally, the simulations are conducted to validate the theoretical result.

Improvement of a Context-aware Recommender System through User's Emotional State Prediction (사용자 감정 예측을 통한 상황인지 추천시스템의 개선)

  • Ahn, Hyunchul
    • Journal of Information Technology Applications and Management
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    • v.21 no.4
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    • pp.203-223
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    • 2014
  • This study proposes a novel context-aware recommender system, which is designed to recommend the items according to the customer's responses to the previously recommended item. In specific, our proposed system predicts the user's emotional state from his or her responses (such as facial expressions and movements) to the previous recommended item, and then it recommends the items that are similar to the previous one when his or her emotional state is estimated as positive. If the customer's emotional state on the previously recommended item is regarded as negative, the system recommends the items that have characteristics opposite to the previous item. Our proposed system consists of two sub modules-(1) emotion prediction module, and (2) responsive recommendation module. Emotion prediction module contains the emotion prediction model that predicts a customer's arousal level-a physiological and psychological state of being awake or reactive to stimuli-using the customer's reaction data including facial expressions and body movements, which can be measured using Microsoft's Kinect Sensor. Responsive recommendation module generates a recommendation list by using the results from the first module-emotion prediction module. If a customer shows a high level of arousal on the previously recommended item, the module recommends the items that are most similar to the previous item. Otherwise, it recommends the items that are most dissimilar to the previous one. In order to validate the performance and usefulness of the proposed recommender system, we conducted empirical validation. In total, 30 undergraduate students participated in the experiment. We used 100 trailers of Korean movies that had been released from 2009 to 2012 as the items for recommendation. For the experiment, we manually constructed Korean movie trailer DB which contains the fields such as release date, genre, director, writer, and actors. In order to check if the recommendation using customers' responses outperforms the recommendation using their demographic information, we compared them. The performance of the recommendation was measured using two metrics-satisfaction and arousal levels. Experimental results showed that the recommendation using customers' responses (i.e. our proposed system) outperformed the recommendation using their demographic information with statistical significance.

The Development of Integration Electronic Block System for Maintenance Efficiency on Railway Wayside Signalling System (철도 선로변 신호설비 유지보수 효율화를 위한 집중형 전자폐색제어장치 개발)

  • Baek, Jong-Hyen;Jo, Hyun-Jeong;Kim, Yong-Kyu
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.9
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    • pp.4171-4176
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    • 2012
  • The conventional block systems for railway signaling currently in operation in Korea have not been electrified or integrated and therefore there have been difficulties in terms of construction and maintenance. Two independent systems have been installed for ABS and LEU of ATP system (for speeded-up lines), although they deal with the same signaling information at the same location in order to control the trains. In these conventional ABS and LEU, a number of duplicate modules are installed in each device including lamp detection units and power supply units and it results increased manufacturing costs and maintenance efforts. This paper deals with the prototype development of integrated electronic block system with CPU-based digital control methods in order to overcome the limitations of the conventional ABS. The suggested system is the integration of the conventional ABS with LEU of ATP and it is also applicable for the non-ATP sections as well.

An Example-Based Natural Language Dialogue System for EPG Information Access (EPG 정보 검색을 위한 예제 기반 자연어 대화 시스템)

  • Kim, Seok-Hwan;Lee, Cheong-Jae;Jung, Sang-Keun;Lee, GaryGeun-Bae
    • Journal of KIISE:Software and Applications
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    • v.34 no.2
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    • pp.123-130
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    • 2007
  • In this paper, we present an example-based natural language dialogue system for Electronic Program Guide Information Access. We introduce an effective and practical dialogue management technique incorporating dialogue examples and situation-based rules. In order to generate cooperative responses to smoothly lead the dialogue with users, our natural language dialogue system consists of natural language understanding, dialogue manager, system utterance generator. and EPG database manager. Each module is designed and implemented to make an effective and practical natural language dialogue system. In particular, in order to reflect the up-to-date EPG information which is updated frequently and periodically, we applied a web-mining technology to the EPG database manager, which builds the content database based on automatically extracted information from popular EPG websites. The automatically generated content database is used by other modules in the system for building their own resources. Evaluations show that our system performs EPG access task in high performance and can be managed with low cost.

THREE DIMENSIONAL FINITE ELEMENT STRESS ANALYSIS OF FIVE DIFFERENT TAPER DESIGN IMPLANT SYSTEMS (3차원 유한요소법적 분석을 이용한 5종의첨형 임플랜트에 발생하는 응력의 비교연구)

  • Byun, Sang-Ki;Park, Won-Hee;Lee, Young-Soo
    • The Journal of Korean Academy of Prosthodontics
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    • v.44 no.5
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    • pp.584-593
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    • 2006
  • Statement of problem : Dental implant which has been developed gradually through many experiments and clinical applications is presently used to various dental prosthetic treatments. To conduct a successful function of implant prosthesis in oral cavity for a long time, it is important that not only structure materials must have the biocompatibility, but also the prosthesis must be designed for the stress, which is occurred in occlusion, to scatter adequately of load support. Therefore, it is essential to give the consideration about the stress analysis of supporting tissues for higher successful rates. Purpose : Recently, many implant manufacturing company produce various taper design of root form implant, the fixture is often selected. However, the stress analysis of taper form fixture still requires more studies. Material and method : This study we make the element models that five implant fixture; Branemark system(Nobel Biocare, Gothenberg, Sweden), Camlog system(Altatec, Germany), Astra system(Astra Tech, Sweden), 3i system(Implant Innovations Inc, USA), Avana system(Osstem, Korea) were placed in the area of mandibular first premolar and prosthesis fabricated, which we compared with stress distribution using the three-dimension finite element analysis under two loading condition. Results : This study compares the aspect of stress distribution of each system with the standard of Von mises stress, among many resulted from finite element analysis so that this research gets the following results. 1. In all implant system, oblique loading of maximum Von mises stress of implant, alveolar bone and crown is higher than vertical loading of those. 2. Regardless of loading conditions and type of system, cortical bone which contacts with implant fixture top area has high stress, and cancellous bone has a little stress. under the vertical loading, maximum Von mises stress is more higher in order of Branemark, Camlog, Astra, 3i, Avana. under the horizontal loading, maximum Von mises is more higher in order of Camlog, Branemark, Astra, 3i, Avana.

A Study of Lorentz-Meutzner's Two Evaporator Refrigeration System Using Alternative Refrigerant Mixtures (대체혼합냉매를 사용하는 Lorentz-Meutzner의 이중 증발기 냉동 시스템의 성능에 관한 연구)

  • Park, Y.M.
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.4 no.2
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    • pp.123-136
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    • 1992
  • A preliminary thermodynamic design model of two-evaporator refrigerator/freezer system is constructed. This system is based on Lorentz-Meutzner cycle using refrigerant mixtures. This model screens alternative refrigerant (R32, R125, R143a, R22, R134a, R152a, R124, R142b, R123) mixtures to select the best performance-giving refrigerant mixtures and its composition for the system. Also, it estimates the effects of cooling temperatures of intercoolers, evaporator's area ratio, cooling load ratio on the performance of the system. The COP of the system ranges from 1.4 to 1.6, which is superior to that of the single evaporator system charged with R12 by 13% to 29%. Among 15 mixtures, R22/R123, R143a/R123, R32/R142b, and R32/R124 (in the order of high COP) are most recommendable. For the case of R22/R123, R22 mass fraction more than 0.5(Load Ratio=1.0) or 0.7(Load Ratio=0.33) is recomended in order to replace R12 without reduction in volumetric capacity when keeping the compressor as the same one. COP has the highest value with X(R22)=0.7 and 0.8, respectively. For the case of R143a/R123, in the similar manner, mass fraction of R143a is more than 0.5 or 0.6 while best performance occurs at X(R143a)=0.8. Higher temperature intercooler is more important for the performance of the system than lower temperature intercooler. The area ratio of evaporators is roughly proportional to load ratio of the evaporators.

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Tracking Control System Design for the Transfer Crane : Design of Full-order Observer with Weighted $H_{\infty}$ Error Bound (트랜스퍼 크레인의 이송위치제어를 위한 서보계 설계 : 가중 $H_{\infty}$ 오차사양을 만족하는 동일차원 관측기 설계)

  • Kim, Y.B.;Jeong, H.H.;Yang, J.H.
    • Journal of Power System Engineering
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    • v.12 no.6
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    • pp.42-49
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    • 2008
  • The most important job in the container terminal area is to handle the cargo effectively in the limited time. To achieve this object, many strategies have been introduced and applied to. If we consider the automated container terminal, it is necessary that the cargo handling equipments are equipped with more intelligent control systems. From the middle of the 1990's, an automated rail-mounted gantry crane(RMGC) and rubber-tired gantry crane(RTG) have been developed and widely used to handle containers in the yards. Recently, in these cranes, the many equipments like CCD cameras and sensors are mounted to cope with the automated terminal environment. In this paper, we try to support the development of more intelligent automated cranes which make the cargo handling be performed effectively in the yards. For this plant, the modelling, tracking control, anti-sway system design, skew motion suppressing and complicated motion control and suppressing problems must be considered. Especially, in this paper, the system modelling and tracking control approach are discussed. And, we design the tracking control system incorporating an observer based on the 2DOF servo system design approach to obtain the desired state informations. In the case of observer design, a weighted $H_{\infty}$ error bound approach for a state estimator is considered. Based on an algebraic Riccati equation(inequality) approach, a necessary and sufficient condition for the existence of a full-order estimator which satisfies the weighted $H_{\infty}$ error bound is introduced. Where, the condition for existence of the estimator is denoted by a Linear Matrix Inequality(LMI) which gives an optimized solution and observer gain. Based on this result, we apply it to the tracking control system design for the transfer crane.

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Performance Analysis of Water-Water Heat Pump System of 100 kW Scale for Cooling Agricultural Facilities

  • Kang, Youn Ku;Ryou, Young Sun;Jang, Jae Kyung;Kim, Young Hwa;Kim, Jong Goo;Kang, Geum Chun
    • Journal of Biosystems Engineering
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    • v.39 no.1
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    • pp.34-38
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    • 2014
  • Purpose: In this study, the performance of cooling system with the water-water heat pump system of 100kW scale made for cooling agricultural facilities, especially for horticultural facilities, was analyzed. It was intended to suggest performance criteria and performance improvement for the effective cooling system. Methods: The measuring instruments consisted of two flow meters, a power meter and thermocouples. An ultrasonic and a magnetic flow meter measured the flow rate of the water, which was equivalent to heat transfer fluid. The power meter measured electric power in kW consumed by the heat pump system. T-type thermocouples measured the temperature of each part of the heat pump system. All of measuring instruments were connected to the recorder to store all the data. Results: When the water temperature supplied into the evaporator of the heat pump system was over $20^{\circ}C$, the cooling Coefficient Of Performance(COP) of the system was higher than 3.0. As the water temperature supplied into the evaporator, gradually, lowered, the cooling COP, also, decreased, linearly. Especially, when the water temperature supplied into the evaporator was lower than $15^{\circ}C$, the cooling COP was lower below 2.5. Conclusions: In order to maintain the cooling COP higher than 3.0, we suggest that the water temperature supplied into evaporator from the thermal storage tank should be maintained above $20^{\circ}C$. Also, stratification in the thermal storage tank should be formed well and the circulating pumps and the pipe lines should be arranged in order for the relative low-temperature water to be stored in the lower part of the thermal storage tank.