• Title/Summary/Keyword: 1p/19q

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Chromosome Imbalances and Alterations of AURKA and MYCN Genes in Children with Neuroblastoma

  • Inandiklioglu, Nihal;Yilmaz, Sema;Demirhan, Osman;Erdogan, seyda;Tanyeli, Atila
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.11
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    • pp.5391-5397
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    • 2012
  • Background: Neuroblastoma (NB), like most human cancers, is characterized by genomic instability, manifested at the chromosomal level as allelic gain, loss or rearrangement. Genetics methods, as well as conventional and molecular cytogenetics may provide valuable clues for the identification of target loci and successful search for major genes in neuroblastoma. We aimed to investigate AURKA and MYCN gene rearrangements and the chromosomal aberrations (CAs) to determine the prognosis of neuroblastoma. Methods: We performed cytogenetic analysis by G-banding in 25 cases [11 girls (44%) and 14 boys (66%)] and in 25 controls. Fluorescence in situ hybridization (FISH) with AURKA and MYCN gene probes was also used on interphase nuclei to screen for alterations. Results: Some 18.4% of patient cells exhibited CAs., with a significant difference between patient and control groups in the frequencies (P<0.0001). Some 72% of the cells had structural aberrations, and only 28% had numerical chnages in patients. Structural aberrations consisted of deletions, translocations, breaks and fragility in various chromosomes, 84% and 52% of the patients having deletions and translocations, respectively. Among these expressed CAs, there was a higher frequency at 1q21, 1q32, 2q21, 2q31, 2p24, 4q31, 9q11, 9q22, 13q14, 14q11.2, 14q24, and 15q22 in patients. 32% of the patients had chromosome breaks, most frequently in chromosomes 1, 2, 3, 4, 5, 8, 9, 11, 12, 19 and X. The number of cells with breaks and the genomic damage frequencies were higher in patients (p<0.001). Aneuploidies in chromosomes X, 22, 3, 17 and 18 were most frequently observed. Numerical chromosome abnormalities were distinctive in 10.7% of sex chromosomes. Fragile sites were observed in 16% of our patients. Conclusion: Our data confirmed that there is a close correlation between amplification of the two genes, amplification of MYCN possibly contributing significantly to the oncogenic properties of AURKA. The high frequencies of chromosomal aberrations and amplifications of AURKA and MYCN genes indicate prognostic value in children with neuroblastomas and may point to contributing factors in their development.

Unbalanced Power Sharing for Islanded Droop-Controlled Microgrids

  • Jia, Yaoqin;Li, Daoyang;Chen, Zhen
    • Journal of Power Electronics
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    • v.19 no.1
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    • pp.234-243
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    • 2019
  • Studying the control strategy of a microgrid under the load unbalanced state helps to improve the stability of the system. The magnitude of the power fluctuation, which occurs between the power supply and the load, is generated in a microgrid under the load unbalanced state is called negative sequence reactive power $Q^-$. Traditional power distribution methods such as P-f, Q-E droop control can only distribute power with positive sequence current information. However, they have no effect on $Q^-$ with negative sequence current information. In this paper, a stationary-frame control method for power sharing and voltage unbalance compensation in islanded microgrids is proposed. This method is based on the proper output impedance control of distributed generation unit (DG unit) interface converters. The control system of a DG unit mainly consists of an active-power-frequency and reactive-power-voltage droop controller, an output impedance controller, and voltage and current controllers. The proposed method allows for the sharing of imbalance current among the DG unit and it can compensate voltage unbalance at the same time. The design approach of the control system is discussed in detail. Simulation and experimental results are presented. These results demonstrate that the proposed method is effective in the compensation of voltage unbalance and the power distribution.

Growth and Physiological Responses of Indeciduous Quercus L. in Container by Fertilizing Treatment (시비 처리에 따른 상록 참나무속 수목의 용기 내 생장 및 생리적 반응)

  • Kim, Jong Jin;Lee, Seung Hak;Song, Ki Seon;Jeon, Kwon Seok;Choi, Jin Young;Choi, Kyu Seong;Lee, Seok Noh;Sung, Hwan In
    • Korean Journal of Environmental Agriculture
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    • v.33 no.4
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    • pp.372-380
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    • 2014
  • BACKGROUND: This study was carried out in order to closely examine the influence of fertilization upon growth in container of seedling in indeciduous Quercus species (Q. mysinaefolia, Q. acuta and Q. glauca). METHODS AND RESULTS: Fertilizer level was made by adjusting water soluble compound fertilizer (N:P:K=19: 19:19, v/v) to 1000, 2000, $3000mg{\cdot}L^{-1}$ level along with non-fertilizing plot. Fertilization increased height, root collar diameter growth, and dry weight in these three species of trees. The more increase in fertilizer level led to the more rise even in growth of these species. H/D ratio and T/R ratio also showed tendency of getting bigger in the more rise in fertilizer level. Photosynthetic rate was shown to get higher in the higher fertilizer level according to fertilization in all the three species. In the analysis of root morphological traits, the total root length was surveyed to be longer in the more rise in fertilizer concentration. As even a case of root project area, surface area, and root volume is the similar tendency to characteristics in the total root length, a rise depending on fertilization was observed. CONCLUSION: In light of the results in this experiment, the fertilizer level is judged to be $2000mg{\cdot}L^{-1}$ level that is proper for production of 1-year-old container seedling in indeciduous Quercus species with excellent root development and high seedling quality index.

Effects of Light, Temperature, and Water Stress on the Photosynthesis and Respiration Rates of Leaves in Four Oak Species (4종(種)의 참나무엽(葉)의 광합성속도(光合成速度)와 호흡속도(呼吸速度)에 미치는 광(光), 온도(溫度), 수분(水分)의 영향(影響))

  • Han, Sang Sup;Kim, Ha Sun
    • Journal of Korean Society of Forest Science
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    • v.78 no.2
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    • pp.151-159
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    • 1989
  • The present study has been designed to define the effects of photosynthetically active radiation, leaf temperature, and water stress on photosynthesis and respiration of leaves of four oak species (Quercus mongolica, Quercus aliens, Quercus variabilis, and Quercus serrate). The results obtained are as follows : 1. The estimated light compensation points at which Pn approached zero were 38, 24, 20, and $18{\mu}Em^{-2}s^{-1}$ for Q. aliens, Q. variabilis, Q, mongolica, and Q. serrate, respectively. The light saturation points occurred at $500{\mu}Em^{-2}s^{-1}$ in three oak species except Q, aliens. 2. The maximum rates of Pn were 19.7, 15.2, 11.2, and 11.0 mg $CO_2$ $dm^{-2}h^{-1}$ for Q. variabilis, Q. serrate, Q. monglica, and Q. aliens leaves, respectively. 3. The transpiration rates of Q. variabilis and Q. serrate leaves were slightly higher than those of Q. mongolica and Q. aliens leaves at various photosynthetically active radiations(PAR), but cuticular transpiration rates at dark were similar in four oak species. 4. The optimum photosynthesis occurred at $25^{\circ}C$ in Q. aliens, Q. variabilis, and Q. serrate leaves, but $20^{\circ}C$ in Q. mongolica leaves. In four oak species, the net photosynthesis approached zero at about $40^{\circ}C$. 5. The dark respiration rates of leaves exhibited the following ranking of species : Q, variabilis > Q. mongolica > Q. aliens > Q. serrate. 6. The maximum productive efficiency (Pg/Rd) of leaves occurred highest in Q, serrate at $20^{\circ}C$, then in Q. mongolica at $20^{\circ}C$, then in Q, aliens at $25^{\circ}C$, and finally in Q. variabilis at $15^{\circ}C$. 7. The decrease of net photosynthesis in Q. serrate began at about -1.2 MPa, and then approached zero at -2.9 MPa of leaf water potential. The decrease of net photosynthesis began at 3% of water loss, and then approached zero at 17.5% of water loss. 8. As indicated by tissue-water relations parameters, it may be suggested that Q. aliens and Q. variabilis are more tolerant and favored on xeric forest soils than Q. mongolica and Q. serrate.

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Exponent Study of the p($2{\times}1$) Phase on an O/W(110) Surface (O/W(110) 표면의 p($2{\times}1$) 구조의 임계지수 연구)

  • 백두현;정석민;정진욱
    • Journal of the Korean Vacuum Society
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    • v.1 no.1
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    • pp.88-95
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    • 1992
  • Abstract-Using a high resolution low energy electron diffraction(HRLEED), we report an exponent study of 2d continuous phase transition from an ordered ~ ( 2 x 1 )ox ygen overlayer on a W(110) surface. Temperature dependence of a (% 0) superlattice diffraction spot, characteristic of the p(2X 1) structure, shows power-law like divergence of the susceptibility and the fluctuation correlation length at T,=708.765 K. By fitting the intensities as well as the line-shapes, we obtained exponents P=0.19* 0.05, y=1.48+ 0.34, v= 1.23i 0.27 and q=0.38+ 0.12. The non-universal character of the exponents are understood in terms of a 2d XY model with cubic anisotropy as suggested previously.

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Phosphorus and Suspended Solid Loading in Lake Yongdam (용담호 소유역별 인 및 부유물질 유입부하량 산정)

  • Kwon, Sang-Yong;Kim, Young-Geel;Yih, Won-Ho;Kim, Bom-Chul;Heo, Woo-Myung
    • Korean Journal of Ecology and Environment
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    • v.38 no.3 s.113
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    • pp.322-333
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    • 2005
  • Total phosphorus (TP) and suspended solids (SS) were measured in the discharge waters from 5 drainage basins of Lake Yongdam, from April, 2002 till March, 2004. The responses of SS and TP to rainfall were analyzed and their loadings into Lake Yongdam were calculated. The inflowing rivers into Lake Yongdam were the Juja River, the Jeongja River, the Jinan River, the Geum River and the Guryang River. Among these rivers Jinan River showed the highest TP that fluctuated very much according to the flow rate. TP and the flow rates (Q) of each river showed positive correlations with empirical relationsip of $TP\;=\;6.32Q^{0.30}$ for the Juia River, $TP\;=\;8.58Q^{0.49}$ for the Jeongia River, $TP\;=\;307.92Q^{0.10}$, for the Jinan River, $TP\;=\;17.91Q^{0.47}$, for the Geum River, $TP\;=\;20.11Q^{0.53}$ for Guryang River. In April 2002 ${\sim}$ March 2003, phosphorus loadings from the Juja River, the Jeongja River, the Jinan River, the Geum River and the Guryang River were calculated to be 3,677, 11,430, 36,412, 89,651, and 42,226 kgP ${\cdot}$ $yr^{-1}$ respectively. And the specific loadings from the Juja River, the Jeongia River, the Jinan River, the Geum River and the Guryang River were calculated to be 0.3, 2.9, 13.6, 9.3, and 13.0 kgP ${\cdot}$ $km^{-2}$ ${\cdot}$ $yr^{-1}$ respectively. In April 2002 ${\sim}$ March 2004, the suspended particles loading from the Juja River, the Jeongia River, the Jinan River, the Geum River and the Guryang River were 673, 1,232, 4,232, 30,902, 80,202 ton ${\cdot}$ $yr^{-1}$ respectively. The Guryang River showed the largest contribution of SS loading.

Prognostic Factors Influencing Clinical Outcomes of Malignant Glioblastoma Multiforme: Clinical, Immunophenotypic, and Fluorescence in Situ Hybridization Findings for 1p19q in 816 Chinese Cases

  • Qin, Jun-Jie;Liu, Zhao-Xia;Wang, Jun-Mei;Du, Jiang;Xu, Li;Zeng, Chun;Han, Wu;Li, Zhi-Dong;Xie, Jian;Li, Gui-Lin
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.3
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    • pp.971-977
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    • 2015
  • Malignant glioblastoma multiforme (GBM) is the most malignant brain tumor and despite recent advances in diagnostics and treatment prognosis remains poor. In this retrospective study, we assessed the clinical and radiological parameters, as well as fluorescence in situ hybridization (FISH) of 1p19q deletion, in a series of cases. A total of 816 patients with GBM who received surgery and radiation between January 2010 and May 2014 were included in this study. Kaplan-Meier survival analysis and Cox regression analysis were used to find the factors independently influencing patient progression free survival (PFS) and overall survival (OS). Age at diagnosis, preoperative Karnofsky Performance Scale (KPS) score, KPS score change at 2 weeks after operation, neurological deficit symptoms, tumor resection extent, maximal tumor diameter, involvement of eloquent cortex or deep structure, involvement of brain lobe, Ki-67 and MMP9 expression level and adjuvant chemotherapy were statistically significant factors (p<0.05) for both PFS and OS in the univariate analysis. Cox proportional hazards modeling revealed that age ${\leq}50$ years, preoperative KPS score ${\geq}80$, KPS score change after operation ${\geq}0$, involvement of single frontal lobe, deep structure involvement, low Ki-67 and MMP9 expression and adjuvant chemotherapy were independent favorable factors (p<0.05) for patient clinical outcomes.

User Types of Shared Mobility Services and UX Design Strategies: an application of Q Methodology (Q방법론을 적용한 공유 모빌리티 서비스의 이용자 유형 연구 및 모빌리티 서비스 UX 디자인 전략)

  • Hong, Seung-Hye;Byun, Young-Si;Lee, Jeong-Myeong
    • The Journal of the Korea Contents Association
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    • v.19 no.10
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    • pp.568-580
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    • 2019
  • With mobility-as-a-service(MaaS) drawing attention to its influence and ripple effect around the world, the mobility service market is currently growing rapidly mainly focusing on mobility sharing. In order to preemptively dominate the mobility service market following the full-scale spread of MaaS, it is important to first identify the recognition and experience of users in personal mobility sharing services, which are currently in the early stages of diffusion, and through which to understand the characteristics of potential consumers of the extended mobility service market. Therefore, the study aims to classify the user types of mobility service and establish a future user experience-oriented mobility service strategy using a subjectivity study method, Q methodology.

Perception toward Happiness and Department Satisfaction in Nursing Students (간호대학생의 행복 인식과 학과만족도)

  • Kwon, Hyuk-Mi;Han, Hye-Sook
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.1
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    • pp.527-536
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    • 2018
  • This study was conducted to classify the factors influencing nursing students' subjectivity toward happiness and to identify differences in department satisfaction according to happiness factors. Q-methodology, which is effective at studying human subjectivity, was employed. Sixty-four students were asked to sort the 34 Q-statements along a 9-point scale ranging from most disagree (-4) to most agree (+4). The Q-sorts were analyzed using pc-QUNAL program, which subjects the data to principle component factor analysis, followed by varimax rotation. Moreover, the data were collected using a questionnaire that consisted of 27 questions pertaining to department satisfaction and analyzed using the SPSS 21.0 program. The result was classified into four factors that explained 58.0% of the total variance. Factor 1 was a progressive self-realization type, factor 2 an isolated flow type, factor 3 an optimistic friendly type, and factor 4 a self-centered relationship seeking type. Moreover, there was a significant difference in department satisfaction according to happiness factors (F=4.53, p=.006). To enhance department satisfaction and nursing professionalism, education and counseling in consideration of these types are needed.

Effect of Mulligan Taping and Flossing Bands on Q-angle and Functional Movement in with Chronic Ankle Instability (멀리건 테이핑과 플로싱 밴드가 만성 발목 불안정성 환자의 한 다리 점프와 Q-각에 미치는 효과)

  • Jeong, Hyo-chang;Park, Se-jin;Kim, Seung-hwan;Kim, Wan-ki;Park, Sung-doo;Yu, Seung-hun
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.28 no.1
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    • pp.19-27
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    • 2022
  • Background: This study investigated the effects of a single-leg hopping test and Q-angle when applying Mulligan taping, flossing bands, and a combination of Mulligan taping and flossing bands to chronic ankle instability (CAI) patients. Methods: The subjects of the study were 68 patients with chronic ankle instability, randomly divided into three groups receiving the following treatments: Mulligan taping (n=22), flossing bands (n=23), and a combination of Mulligan taping and flossing bands (n=23). The immediate effects of the treatments were evaluated using the single-leg hopping test and Q-angle measurement for functional movement before and after the intervention. Results: All three groups showed significant improvements in the single-leg hopping test after the intervention, and there was a significant difference between the performance of the simultaneous application group and the Mulligan taping group (p<.01). As a result of the post-hoc test, there was a significant difference in the simultaneous application group than in the mulligan taping group (p<.01). When measuring the Q-angle change during the activity of descending stairs, there was also a significant effect in all three groups, with no significant differences when comparing the changes between groups (p>.05). Conclusions: In conclusion, Mulligan taping and flossing bands were confirmed as effective interventions for the functional movement of the lower extremities in patients with CAI. This study can provide basic data on the effectiveness of interventions in patients with CAI.