• JSTS:Journal of Semiconductor Technology and Science
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• v.16 no.1
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• pp.70-79
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• 2016

This paper proposes a low-power range-scaled 14b 30 MS/s pipeline-SAR composite ADC for high-performance CIS applications. The SAR ADC is employed in the first stage to alleviate a sampling-time mismatch as observed in the conventional SHA-free architecture. A range-scaling technique processes a wide input range of 3.0VP-P without thick-gate-oxide transistors under a 1.8 V supply voltage. The first- and second-stage MDACs share a single amplifier to reduce power consumption and chip area. Moreover, two separate reference voltage drivers for the first-stage SAR ADC and the remaining pipeline stages reduce a reference voltage disturbance caused by the high-speed switching noise from the SAR ADC. The measured DNL and INL of the prototype ADC in a $0.18{\mu}m$ CMOS are within 0.88 LSB and 3.28 LSB, respectively. The ADC shows a maximum SNDR of 65.4 dB and SFDR of 78.9 dB at 30 MS/s, respectively. The ADC with an active die area of $1.43mm^2$ consumes 20.5 mW at a 1.8 V supply voltage and 30 MS/s, which corresponds to a figure-of-merit (FOM) of 0.45 pJ/conversion-step.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2002.05a
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• pp.151-156
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• 2002

중의적인 단어를 처리하는 방법에 대한 선행연구로, 첫째 문맥에 맞는 의미가 먼저 활성화된다는 가설과 둘째, 여러 뜻 중에 상대적인 빈도에 따라 많이 쓰이는 의미가 먼저 활성화되고, 그것이 문맥과 일치하지 않는다면, 다른 관련된 의미를 찾는다는 가설이 제기되었다. 마지막으로 문맥에 상관없이 모든 의미가 활성화 된 후 문맥을 고려하여 문맥에 적절한 의미를 선택한다는 가설이 있다. 본 연구에서는 '먹을', '감을' 등과 같이 2가지 의미의 품사가 다른 중의 어절과 '쥐어', '감어' 등과 같이 어절 문맥('어')이 주어진 어절의 의미 활성화가 어떻게 다른지를 조사하였다. 본 연구의 목적을 위해 점화어휘 판단 과제를 사용하였다. 실험 1의 결과는 SOA 150ms 조건에서 점화자극어절과 관련된 의미가 품사와 관련 없이 모두 활성화되었다. SOA 1000ms 조건에서는 상대적으로 많이 쓰이는 체언의 의미는 계속 활성화 되어 있는 반면, 용언의 의미 점화량은 감소하였다. 명칭성 실어증 환자인 SDK의 경우 SOA 150ms 조건에서는 일반인과 같은 형태소 처리특성을 보였으나 1000ms 조건에서는 달랐다. 다른 명칭성 실어증 환자인 BIS과 전반성 실어증 환자인 PSB는 SOA 150ms 조건과 1000ms 조건에서 일반인과 아주 다른 양상을 보였다. 이것은 실어증 환자의 타잎에 따라 형태소의 처리나 중의적인 의미 활성화가 일반인과는 다르다는 것을 보여준다. 실험 2에서는 어절 문맥이 있는 '먹어', '쥐어', '감어' 등과 같은 어절을 사용하였다. 실험 2의 결과는 SOA 150ms 조건일 때 어절문맥의 영향으로 용언의 의미만 촉진적 점화효과가 있었고, 체언의 의미는 활성화되지 않았다. 그러나 SOA 1000ms로 지연시켰을 때는 용언뿐만 아니라 체언의 의미도 촉진적 점화효과가 있었다. 실험 1과 2의 결과는 중의적인 한국어 어절의 경우에도 모든 의미가 활성화되나 어절 문맥이 존재할 때는 어절 문맥의 제약으로 어절 문맥에 맞는 한 가지 의미만 활성화된다는 것을 암시한다. 또한 이러한 결과는 한국어 어절이 분석된 형태가 아닌 어절 형태로 심성 어휘집에 저장되어 있다는 것을 암시한다. 실어증 환자의 경우 실험 1과 마찬가지로 환자의 수준이나 종류에 따라 다양한 반응을 보여주었다.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.7
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• pp.122-130
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• 2013

This work proposes a 12b 100MS/s 45nm CMOS four-step pipeline ADC for high-speed digital communication systems requiring high resolution, low power, and small size. The input SHA employs a gate-bootstrapping circuit to sample wide-band input signals with an accuracy of 12 bits or more. The input SHA and MDACs adopt two-stage op-amps with a gain-boosting technique to achieve the required DC gain and high signal swing range. In addition, cascode and Miller frequency-compensation techniques are selectively used for wide bandwidth and stable signal settling. The cascode current mirror minimizes current mismatch by channel length modulation and supply variation. The finger width of current mirrors and amplifiers is laid out in the same size to reduce device mismatch. The proposed supply- and temperature-insensitive current and voltage references are implemented on chip with optional off-chip reference voltages for various system applications. The prototype ADC in a 45nm CMOS demonstrates the measured DNL and INL within 0.88LSB and 1.46LSB, respectively. The ADC shows a maximum SNDR of 61.0dB and a maximum SFDR of 74.9dB at 100MS/s, respectively. The ADC with an active die area of $0.43mm^2$ consumes 29.8mW at 100MS/s and a 1.1V supply.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.3
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• pp.75-85
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• 2009

This work proposes a 13b 100MS/s 0.13um CMOS ADC for 3G communication systems such as two-carrier W-CDMA applications simultaneously requiring high resolution, low power, and small size at high speed. The proposed ADC employs a four-step pipeline architecture to optimize power consumption and chip area at the target resolution and sampling rate. Area-efficient high-speed high-resolution gate-bootstrapping circuits are implemented at the sampling switches of the input SHA to maintain signal linearity over the Nyquist rate even at a 1.0V supply operation. The cascode compensation technique on a low-impedance path implemented in the two-stage amplifiers of the SHA and MDAC simultaneously achieves the required operation speed and phase margin with more reduced power consumption than the Miller compensation technique. Low-glitch dynamic latches in sub-ranging flash ADCs reduce kickback-noise referred to the differential input stage of the comparator by isolating the input stage from output nodes to improve system accuracy. The proposed low-noise current and voltage references based on triple negative T.C. circuits are employed on chip with optional off-chip reference voltages. The prototype ADC in a 0.13um 1P8M CMOS technology demonstrates the measured DNL and INL within 0.70LSB and 1.79LSB, respectively. The ADC shows a maximum SNDR of 64.5dB and a maximum SFDR of 78.0dB at 100MS/s, respectively. The ABC with an active die area of $1.22mm^2$ consumes 42.0mW at 100MS/s and a 1.2V supply, corresponding to a FOM of 0.31pJ/conv-step.

• YAKHAK HOEJI
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• v.51 no.2
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• pp.96-102
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• 2007

Measurement of globotriaosylceramide (Gb3, ceramide trihexoside) in urine has clinical importance for monitoring after enzyme replacement therapy in Fabry disease patients. The disease is an X-linked lipid storage disorder that results from a deficiency of the enzyme ${\alpha}$-galactosidase A (${\alpha}$-Gal A). The lack of ${\alpha}$-Gal A causes an intracellular accumulation of glycosphingolipids, mainly Gb3. A simple, rapid, and highly sensitive analytical method for Gb3 in urine was developed without labor-extensive pre-treatment by electrospray ionization MS/MS (ESI-MS/MS). Only simple 5-fold dilution of urine is necessary for the extraction and isolation of Gb3 in urine. Gb3 in diluted urine was dissolved in dioxane containing C17:0 Gb3 as an internal standard. After centrifugation it was directly injected and analyzed through guard column by in combination with multiple reaction monitoring mode of ESI-MS/MS. Eight isoforms of Gb3 were completely resolved from urine matrix. C24:0 Gb3 occupied 50% of total Gb3 as a major component in urine. Linear relationship for Gb3 isoforms was found in the range of 0.005${\sim}$5.0 ${\mu}$g/ml. The limit of detection (S/N=5) was 0.005 ${\mu}$g/ml and limit of quantification was 0.05 ${\mu}$g/ml for C24:0 Gb3 with acceptable precision and accuracy. Correlation coefficient of calibration curves for 8 Gb3 isoforms ranged from 0.9598 to 0.9975. This method could be useful for rapid and sensitive 1st line Fabry disease screening, monitoring and/or diagnostic tool for Fabry disease.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.07b
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• pp.902-905
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• 2004

A heart diagnosis system adopts Superconducting Quantum Interface Device(SQUID) sensors for precision MCG signal acquisitions. Such system is composed of hundreds of sensors, requiring fast signal sampling and precise analog-digital conversions(ADC). Our development of hardware board, processing 64-channel 12-bit 1ks/s, is built by using 8-channel ADC chips, 8-bit microprocessors, SPI interfaces, and parallel data transfers between microprocessors to meet the 1ks/s, i.e. 1 ms speed. The test result shows that the signal acquisition is done in 168 usuc which is much shorter than the required 1 ms period. This hardware will be extended to 256 channel data acquisition to be used for the diagnosis system.

• The Korean Journal of Applied Statistics
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• v.26 no.1
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• pp.111-118
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• 2013

In this paper we study the effect of failure detection equipment(FDE)s on system availability. A new repair scheme is considered for the step of repairing FDE which becomes out of order in the course of repairing the main system(MS). We compute and compare the availability of MS.

• Korean Journal of Clinical Laboratory Science
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• v.41 no.1
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• pp.31-36
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• 2009

The exposure of human beings to toxic trace metals (Cu, Zn) continues to be an important public health issue and concern. This study was conducted to assess the exposure to trace metals (Cu, Zn) in the general Korean population by inductively coupled plasma mass spectrometry (ICP-MS) and Atomic absorption spectrometry (AAS). Serum samples were obtained from 40 healthy volunteers. Specimens were collected in special container and we applied sample processing to minimize contamination. We used ICP-MS and AAS to analyze simultaneously the concentration of metals including copper, zinc. Distribution of trace metal levels in the general healthy population showed lower values. The results in this study can provide background data for clinical studies associated with trace metal exposure in the korean population.

• Journal of radiological science and technology
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• v.41 no.4
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• pp.313-319
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• 2018

The purpose of this study was to investigate the influence of metabolic syndrome (MS) on the lower urinary tract symptoms (LUTS), prostate specific antigen (PSA), and prostate volume in Korean men. We analyzed the data from 2654 men over the age of 40 who visited our health promotion center for regular health checkups. Of the total 2654 men, mean age, PSA level, International Prostate Symptom Score (IPSS), and prostate volume were 54.6 years, 1.21ng/ml, 6.2 points, and 27.8ml, respectively. All examinees were divided into MS group (46.5%, 1235 men) and non-MS group (53.5%, 1419). Age and prostate volume were significantly higher in the MS group. The patients were divided into three groups according to their ages: 40's, 50's, and over 60 years old. Prostate volume of the MS group in the younger age groups (40-49 years and 50-59 years) was significantly larger than that of the non-MS group. However, no difference was revealed in the age group of 60-69 years. No significant differences were found in the PSA level and LUTS between the MS and non-MS groups. In the multivariate regression analysis, central obesity was the strongest risk factor for the enlargement of prostate over 30ml among the metabolic components.

• YAKHAK HOEJI
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• v.52 no.2
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• pp.93-100
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• 2008

A liquid chromatographic method with tandom spectrometric detection (LC/MS/MS) for the simultaneous determination of doxifluridine and its active metabolite, 5-fluorouracil (5-FU) was developed over the concentration range of $5{\sim}2000$ ng/ml, respectively. Doxifluridine, 5-FU and internal standard, 5-chlorouracil (5-CU), were extracted from liver and intestine tissue via protein precipitation. Acetonitrile was used as the extraction solvent and the supernatant was evaporated and reconstructed in mobile phase. Optimum chromatographic separation was achieved on a Agilent Zorbax $C_{18}$ ($100\;mm{\times}2.1\;mm$, $3.5\;{\mu}m$) column with mobile phase run in isocratic with methanol : water (20 : 80, v/v). The flow rate was 0.2 ml/min with total cycle time of 5 min. The lower limit of quantification was validated at 5.0 ng/ml of liver and intestine tissue, for both doxifluridine and 5-FU, respectively. The intra-day and inter-day precision and accuracy of quality control (QC) samples were <11% coefficient of variation and <7% relative error from theoretical concentration for both analytes. In addition, the special designed stability study was performed, because the metabolism of doxifluridine occurs spontaneously even in ice bath for monkey liver. The stability of doxifluridine in liver and intestine of monkey and beagle dog was compared. It was found that bioanalytical validation could not be performed for the monkey liver; however, beagle dog's liver has relatively low speed of metabolism compared to monkey liver and instead of monkey liver, beagle dog's liver could be used for the validation. Bioanalytical validation could be performed in monkey intestine. Eventually, this developed method for liver and intestine will be useful in support of the toxicokinetic and pharmacokinetic studies of doxifluridine and 5-FU.