• Tuberculosis and Respiratory Diseases
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• v.47 no.3
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• pp.347-355
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• 1999

Background: Phospholipase C(PLC) plays a central role in cellular signal transduction and is important in cellular growth, differentiation and transformation. There are currently ten known mammalian isozymes of PLC reported to this date. Hydrolysis of phosphatidylinositol 4,5-bisphosphate($PIP_2$) by PLC produces two important second messengers, inositol 1,4,5-trisphosphate($IP_3$) and diacylglycerol. PLC-${\gamma}1$, previously, was known to be activated mainly through growth factor receptor tyrosine kinase. Other mechanisms of activating PLC-yl have been reported such as activation through tau protein in the presence of arachidonic acid in bovine brain and activation by $IP_3$, phosphatidic acid, etc. Very recently, another PLC-${\gamma}1$ activator protein such as tau has been found in bovine lung tissue, which now is considered to be AHNAK protein. But there has been no report concerning AHNAK and its associated disease to this date. In this study, we examined the expression of the PLC-${\gamma}1$ activator, AHNAK, in lung cancer specimens and their paired normal. Methods: From surgically resected human lung cancer tissues taken from twenty-eight patients and their paired normal counterparts, we evaluated expression level of AHNAK protein using immunoblot analysis of total tissue extract Immunohistochemical stain was performed with primary antibody against AHNAK protein. Results: Twenty-two among twenty-eight lung cancer tissues showed overexpression of AHNAK protein (eight of fourteen squamous cell lung cancers, all of fourteen adenocarcinomas). The resulting bands were multiple ranging from 70 to 200 kDa in molecular weight and each band was indistinct and formed a smear, reflecting mobility shift mainly due to proteolysis during extraction process. On immunohistochemistry, lung cancer tissues showed a very heavy, dense staining with anti-AHNAK protein antibody as compared to the surrounding normal lung tissue, coresponding well with the results of the western blot Conclusion: The overexpression of PLC-${\gamma}1$ activator protein, AHNAK in lung cancer may provide evidence that the AHNAK protein and PLC-${\gamma}1$ act in concerted manner in carcinogenesis.

• Geophysics and Geophysical Exploration
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• v.18 no.3
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• pp.154-161
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• 2015

For efficiently designing neutron induced gamma spectroscopy sonde, Monte Carlo simulation is employed to understand a dominant location of thermal neutron and classify the formation elements from the energy peak of capture gamma spectrum. A pulsed neutron generator emitting 14 MeV neutron particles was used as a source, and flux of thermal neutron was calculated from the twelve detectors arranged at each 10 cm intervals from the source. Design for reducing borehole effects using shielding materials was also applied to numerical sonde model. Moreover, principal elements and quantities of numerical earth models were verified through the energy spectrum analysis of capture gamma detected from a gamma detector. These results can help to enhance the signal-to-noise ratio, and determine an optimal placement of capture gamma detectors of neutron induced gamma spectroscopy sonde.

• Journal of Korean Academy of Nursing
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• v.29 no.1
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• pp.161-173
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• 1999

The purpose of this study was to develope and test the structural model for quality of life in women having hysterectomies. A hypothetical model was constructed on the basis of previous studies and a review of literature. The conceptual framework was built around eight constructs. Exogenous variables included in this model were marital intimacy, importance of uterus, professional support, positive coping behavior and pre-operative symptoms. Endogenous variables were spouse's support, sense of loss and quality of life. Empirical data for testing the hypothetical model was collected using a self-report questionnare from 203 women having hysterectomies at the outpatient clinics of four general hospitals and a mail survey in Pusan City. The Data was collected from December, 1997 to January, 1998. Reliability of the eight instruments was tested with Cronbach's alpha which ranged from 0.639-0.915. For the data analysis, SPSS 7.5 WIN Program and LISREL 8.12 WIN Program were used for descriptive statistics and covariance structural analysis. The results of covariance structure analysis were as follows : 1. Hypothetical model showed a good fit with the empirical data. ［$\chi$$^2$＝6.93(df＝5, P＝.23), GFI＝.99, AGFI＝.94, RMSR＝.019, NNFI＝.97, NFI＝.98, CN＝440, standardized residuals(-2.14-2.10)］ 2. For the parsimony of model, a modified model was constructed by deleting 3 paths and adding 1 path according to the criteria of statistical significance and meaning. 3. The modified model also showed a good fit with the data. ［$\chi$$^2$＝5.26(df＝7, P＝.63), GFI＝.99, AGFI＝.97, RMSR＝.014, NNFI＝1.02, NFI＝.99, CN＝710, standardized residuals(-1.46-1.70)］ Results of the testing of the hypothesis were as follows : 1. Marital intimacy(${\gamma}$11＝.78, t＝14.37) and professional support(${\gamma}$13＝.12, t＝2.12) had a significant direct effect on the spouse's support. 2. Pre-operative symptoms(${\gamma}$25＝.32, t＝3.12), importance of uterus(${\gamma}$22＝.20, t＝2.61) and spouse's support($\beta$2l＝-.19, t＝-2.43) had a significant direct effect on the sense of loss. 3. Sense of loss($\beta$32＝-.66, t＝-9.83) had a direct effect on the quality of life. Marital intimacy had a direct(${\gamma}$31＝.19, t＝3.33), indirect(${\gamma}$31＝.14, t＝2.52) and total effect(${\gamma}$31＝.25, t＝4.41) on the quality of life. Professional support had a direct effect(${\gamma}$33＝.11, t＝2.07) and total effect(${\gamma}$33＝.13, t＝2.31) on the quality of life. The direct effect of pre-operative symptoms(${\gamma}$35＝-.36, t＝4.02) and positive coping behavior(${\gamma}$34＝.15, t＝2.06) had the insignificant effect on the quality of life while, due to the idirect effect these variables had overall significant effect on the quality of life. The results of this study showed that the sense of loss had the most significant direct effect on the quality of life. Marital intimacy, pre -operative symptoms and spouse's support had a significant direct effect on this sense of loss. These four variables, the sense of loss, marital intimacy, pre-operative symptoms and spouse's support, were identified as relatively important variables. The results of this study suggested that there is needed to determine if nursing intervention would alleviate this sense of loss and promote a greater quality of life in women who have had hysterectomies.

• Journal of the Korean Applied Science and Technology
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• v.33 no.2
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• pp.401-410
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• 2016

The $Pt-Sn/Al_2O_3$ catalysts mixed with metal oxides for propane dehydrogenation were studied. $Cu-Mn/{\gamma}-Al_2O_3$, $Ni-Mn/{\gamma}-Al_2O_3$, $Cu/{\alpha}-Al_2O_3$ was prepared and mixed with $Pt-Sn/Al_2O_3$ to measure the activity for propane dehydrogenation. As standard sample, $Pt-Sn/Al_2O_3$ catalyst mixed with glassbead was adopted. In the case of catalytic activity test after non-reductive pretreatment of catalyst and metal oxide, $Pt-Sn/Al_2O_3$ mixed with $Cu-Mn/{\gamma}-Al_2O_3$ showed higher conversion of 15% and similar selectivity at $576.5^{\circ}C$, compared to conversion of 8% in standard sample. In the case of catalytic activity test after reductive pretreatment of catalyst and metal oxde, $Cu/{\alpha}-Al_2O_3$ showed higer yield than standard sample. But, increase of yield of most of samples after reductive pretreatment was not significant, so it was found that lattice oxygen of $Cu-Mn/{\gamma}-Al_2O_3$ is effective to propane dehydrogenation.

• Journal of the Korean Chemical Society
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• v.14 no.3
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• pp.237-242
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• 1970

Effect of Added 1-hexene on the yield of hydrogen produced from Co-60 gamma radiolysis of methanol was investigated at room temperature. The results indicated that the yield of hydrogen decreased rapidly with increasing 1-hexene concentrations. Effect of added methyl borate on the radiolysis of methanol was also studied in the presence of oxygen. The results revealved that methyl borate acted as a less effective scavenger than oxygen towards the precursors of the radiolysis products. Experimental data previously obtained on the systems with oxygen added were treated more quantitatively to re-examine mechanism of the radiolysis of methanol in detail.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.180-180
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• 2003

Peroxisome proliferator-activated receptor gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, is involved in the suppression of growth of several types of tumors such as liposarcoma, cancers of breast, prostate, and colon, possibly through induction of cell cycle arrest and/or apoptosis.(omitted)

• Journal of Radiation Protection and Research
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• v.30 no.4
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• pp.167-174
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• 2005

The concentrations of natural and artificial radionuclides in soil and gamma ray dose rate in air at 233 locations in Korea have been determined. The national mean concentrations of $^{232}Th,\;^{226}Ra,\;^{40}K,\;^{137}Cs\;and\;^{90}Sr$ in soil were $60{\pm}31,\;33{\pm}14,\;673{\pm}238,\;35{\pm}9.3\;and\;5.0{\pm}3.4\;Bq\;kg^{-1}$, respectively. The mean gamma-ray dose rate at 1 m above the ground was $7918\;nGy\;h^{-1}$. $^{137}Cs$ concentration had highly significant correlation with organic matter content and cation exchange capacity. $^{90}Sr$ concentration had slightly coherent with pH. The results have been compared with other global radioactivity and radiation measurements.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.74.2-74.2
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• 2014

Magnetohydrodynamics(MHD) dynamo depends on many factors such as viscosity ${\gamma}$, magnetic diffusivity ${\eta}$, magnetic Reynolds number $Re_M$, external driving source, or magnetic Prandtl number $Pr_M$. $Pr_M$, the ratio of ${\gamma}$ to ${\eta}$ (for example, galaxy ${\sim}10^{14}$), plays an important role in small scale dynamo. With the high PrM, conductivity effect becomes very important in small scale regime between the viscous scale ($k_{\gamma}{\sim}Re^{3/4}k_fk_f$:forcing scale) and resistivity scale ($k_{\eta}{\sim}PrM^{1/2}k_{\gamma}$). Since ${\eta}$ is very small, the balance of local energy transport due to the advection term and nonlocal energy transfer decides the magnetic energy spectra. Beyond the viscous scale, the stretched magnetic field (magnetic tension in Lorentz force) transfers the magnetic energy, which is originally from the kinetic energy, back to the kinetic eddies leading to the extension of the viscous scale. This repeated process eventually decides the energy spectrum of the coupled momentum and magnetic induction equation. However, the evolving profile does not follow Kolmogorov's -3/5 law. The spectra of EV (${\sim}k^{-4}$) and EM (${\sim}k^0$ or $k^{-1}$) in high $Pr_M$ have been reported, but our recent simulation results show a little different scaling law ($E_V{\sim}k^{-3}-k^{-4}$, $EM{\sim}k^{-1/2}-k^{-1}$). We show the results and explain the reason.

• Nuclear Engineering and Technology
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• v.55 no.7
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• pp.2613-2620
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• 2023

Excellent thermal neutron absorption performance of boron expands the potential use of boron rich slag to prepare epoxy resin matrix nuclear shielding composites. However, shielding attenuation behaviors and mechanism of the composites against gamma rays are unclear. Based on the radiation protection theory, Phy-X/PSD, XCOM, and ⁶⁰Co gamma ray source were integrated to obtain the shielding parameters of boron rich slag/epoxy resin composites at 0.015-15 MeV, which include mass attenuation coefficient (µ_t), linear attenuation coefficient (µ), half value thickness layer (HVL), electron density (N_eff), effective atomic number (Z_eff), exposure buildup factor (EBF) and exposure absorption buildup factor (EABF).µ_t, µ, HVL, N_eff, Z_eff, EBF and EABF are 0.02-7 cm²/g, 0.04-17 cm^-1, 0.045-20 cm, 5-14, 3 × 10²³-8 × 10²³ electron/g, 0-2000, and 0-3500. Shielding performance is BS4, BS3, BS3, BS1 in descending order, but worse than ordinary concrete. µ and HVL of BS1-BS4 for ⁶⁰Co gamma ray is 0.095-0.110 cm^-1 and 6.3-7.2 cm. Shielding mechanism is main interactions for attenuation gamma ray by BS1-BS4 are elements with higher content or higher atomic number via Photoelectric Absorption at low energy range, and elements with higher content via Compton Scattering and Pair Production in Nuclear Field at middle and higher energy range.

• Journal of Korean Society for Atmospheric Environment
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• v.10 no.E
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• pp.311-324
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• 1994

The quantitative knowledge of N $O_{\gamma}$ (＝N $O_{x}$ ＋HN $O_3$＋/PAN＋N $O_3$ ＋$N_2$ $O_{5}$ ＋HN $O_2$＋N $O_3$$^{-10}$ ＋organic nitrates＋......)distribution is essential in tropospheric chemistry, especially, especially that related to understanding the processes leading to ozone production. Ambient concentrations of NO, N $O_2$, HN $O_3$ and PAN as well as total N $O_{\gamma}$ were measured during June and early July 1992 at a rural site(Candor, NC), in the central Piedmont region of NC. The measurements of N $O_{\gamma}$ species were made in an effort to provide a comprehensive understanding of nitrogen chemistry and to investigate the total nitrogen budget at the site. N $O_{\gamma}$, N $O_2$, and NO showed diurnal variations with maxima in the morning. The maximum N $O_{\gamma}$ concentration reached was 14.5 ppbv, and the maximum concentrations of NO and N $O_2$ were 5.4 and 7.8 PPbv, respectively. The mean N $O_{\gamma}$ concentration as found to be 2.88$\pm$1.58 ppbv(n=743). The mean concentrations of NO and N $O_2$, were found to be 0.15 $\pm$ 0.29 ppbv(n＝785) and 1.31 $\pm$ 0.99 ppbv(n＝769). Products of photochemical oxidants, (N <$O_{\gamma}$-N $O_{x}$ ), such as HN $O_3$ and PAN, as well as ozone showed diurnal variation with maxima in the afternoon and minima at night The fractions of individual reactive nitrogen species to total N $O_{\gamma}$ were investigated and contrasted to the results from remote marine site and rural continental sites. N $O_{x}$ was the major species to total N $O_{\gamma}$(45%). NO concentrations appeared to be nearly constant whether the Prevailing winds were from continental areas or from oceanic areas. Linear regression of $O_3$ with (N $O_{\gamma}$- N $O_{x}$ )/N $O_{\gamma}$ (i.e. percent N $O_{x}$ converted to the photochemical products of N $O_{\gamma}$) yielded ( $O_3$) ＝25.8 〔 N $O_{\gamma}$-N $O_{x}$ 〕/(N $O_{\gamma}$) ＋27, ( $r^{2}$＝0.58). The regression intercept is interpreted as the ozone back ground (intercept=27ppbv) and the slope suggests that 8.6 molecules of ozone are formed per molecule of N $O_{x}$ oxidized products (when the average N $O_{\gamma}$ concentration, about 3 ppbv at the site, is used). The N $O_{x}$ N $O_{\gamma}$ ratio was used as an indicator of the chemical age of airmasses and the ratio showed strong positive correlations with HN $O_3$( $r^{2}$=0.58), PAN ( $r^{2}$=0.46) and $O_3$( $r^{2}$=0.62). Larger N $O_{\gamma}$ and N $O_{x}$ N $O_{\gamma}$ ratio were found when winds came from continental sides. It may suggest that synoptic meteorological conditions and transport of N $O_{x}$ are important in the distribution of N $O_{\gamma}$ and its relationship with photochemical oxidants at the site.