• 제목/요약/키워드: 12 Jung-kyung

검색결과 2,193건 처리시간 0.038초

Effects of Cigarette Smoke Condensate on the Activities of Xenobiotic Metabolizing Enzymes in Primary Cultured Rat Hepatocytes

  • Park, Mi-Jung;Song, Yeon-Jung;Seo, Kyung-Won
    • Biomolecules & Therapeutics
    • /
    • 제12권3호
    • /
    • pp.185-188
    • /
    • 2004
  • The purpose of this study is to evaluate the effect of cigarette smoke condensate (CSC) on toxification/detoxification metabolic pathway in primary cultured rat hepatocytes. We measured the activities of cytochrome P450 monooxygenases (CYP450s) and UDP-glucuronyltransferase, sulfotransferase and glutathione-S-transferase in CSC-treated rat hepatocytes. CSC significantly increased the activities of hepatic CYP4501A1 and CYP4501A2 to 7.5 fold and 1.6 fold respectively, compared with control level. However, CSC did not affect the activities of conjugation enzymes. We a1so examined if treatment of CSC could change thc cytotoxicity of acetaminophen (AA) through modulation of metabolizing enzymes. In rat hepatocytes, pretreatment with CSC potentiated the cytotoxicity of AA. This result indicates that potentiation of AA toxicity by CSC pretreatment may be related to induction of CYP4501A1 and CYP4501A2.

고속 전철 견인용 영구자석 전동기의 고조파 철손해석 (Harmonic Iron Loss Analysis of Permanent Magnet Motor for High-Speed Train)

  • 서장호;정태경;정상용;이철균;정현교
    • 한국철도학회논문집
    • /
    • 제12권3호
    • /
    • pp.335-341
    • /
    • 2009
  • 차세대 고속 전철용 매입형 영구자석 전동기의 효율 및 매입된 자석의 감자를 방지하기 위해서 정확한 철손해석과 철손특성을 이해하는 것은 전동기 설계단계에서 매우 중요하다. 본 논문에서는 견인전동기의 약계자 제어 및 최대토크 제어와 같은 구동상황을 고려하여 운전영역별 철손해석을 수행하고 특성을 분석하고자 한다.

Amitraz 중독 후 혼수 상태를 보인 환자 1례 (A Case of a Patient with Stuporous Mentality and Hypotension after Amitraz Ingestion)

  • 정시영;정진희;어은경
    • 대한임상독성학회지
    • /
    • 제5권2호
    • /
    • pp.123-125
    • /
    • 2007
  • Amitraz is a formamidine-derived insecticide and acaricide which is commonly used throughout the world. Amitraz intoxication is mediated through ${\alpha}_2$ adrenergic receptor agonist effects, similar to those of the ${\alpha}_2$ agonist clonidine. We report a case of a patient who experienced coma and hypotension after amitraz ingestion. A 37-year-old woman visited the ER with symptoms of vomiting and altered mental state. She had ingested a mouthful of liquid amitraz concentrate (12.5%), which rapidly led to vomiting, hypotension, bradycardia, hyperglycemia, and mental stupor. Supportive treatment, including mechanical ventilation and administration of inotropics, resulted in full recovery within four days.

  • PDF

PECVD에 의해 증착된 비정질 탄소층 구조 (Structures of Amorphous Carbon Layer Deposited by PECVD)

  • 박소연;배근학;김경수;노형욱;김호식;박성호;정주희;정일현
    • 한국전기전자재료학회:학술대회논문집
    • /
    • 한국전기전자재료학회 2007년도 하계학술대회 논문집 Vol.8
    • /
    • pp.129-130
    • /
    • 2007
  • 3,3-Dimethyl-1-butene ($C_6H_{12}$) monomer를 이용하여 RF power와 압력에 따라 막을 증착하였다. Power/pressure (W/Torr)가 증가할수록 증착된 비정질 탄소막은 FT-IR 스펙트럼에서 $CH_x$ (at around $2900cm^{-1}$)는 감소하였지 만 elastic modulus는 증가하는 것으로 나타났다.

  • PDF

PECVD에 의해 증착된 비정질 탄소층의 광학적 특성 (Optical Properties of Amorphous Carbon Layer Deposited by PECVD)

  • 배근학;김경수;노형욱;박소연;김호식;박성호;정주희;정일현
    • 한국전기전자재료학회:학술대회논문집
    • /
    • 한국전기전자재료학회 2007년도 하계학술대회 논문집 Vol.8
    • /
    • pp.185-186
    • /
    • 2007
  • 3,3-Dimethyl-1-butene ($C_6H_{12}$) monomer를 이용하여 RF power와 압력에 따라 막을 증착하였다. 증착된 막은 power/pressure (W/Torr)가 증가할수록 비정질 탄소막은 FT-IR 스펙트럼에서 $CH_x$ (at around $2900cm^{-1}$)는 감소하였고, n과 k값은 증가하는 것으로 나타났다.

  • PDF

PECVD에 의해 증착된 비정질 탄소층에서 아르곤 가스의 효과 (Effects of Argon Gas on Amorphous Carbon Layer Deposited by PECVD)

  • 김경수;배근학;노형욱;박소연;김호식;박성호;정주희;정일현
    • 한국전기전자재료학회:학술대회논문집
    • /
    • 한국전기전자재료학회 2007년도 하계학술대회 논문집 Vol.8
    • /
    • pp.104-105
    • /
    • 2007
  • 3,3-Dimethyl-1-butene($C_6H_{12}$) monomer를 이용하여 RF power와 압력에 따라 증착된 막의 refractive index와 extinction coefficient를 알아보았다. 증착된 막의 n & k는 power/pressure가 증가할수록 증가하였으며, Ar으로 증착된 막이 더 낮은 값을 갖는 것으로 나타났다.

  • PDF

Simultaneous Analysis of Benzophenone and its Analogs by gas chromatography/mass spectrometry in rat bloods

  • Jeon, Hee-Kyung;Kim, Youn-Jung;Yun, Hye-Jung;Kim, En-Young;Yong Chung
    • 한국독성학회:학술대회논문집
    • /
    • 한국독성학회 2003년도 추계학술대회
    • /
    • pp.131-131
    • /
    • 2003
  • Benzophenone is an UV-absorbing agent that has been used in industry and medicine for more than 30 years. Its twelve derivatives, designated benzophenone-1 through benzophenone-12, are widely used today in cosmetic products as a photostabilizer, a sunscreen in lotions, and hair sprays to protect the skin and hair from UV irradiation.(omitted)

  • PDF

염좌로 유발된 좌측 거골 골연골 병변 1례에 대한 한방 복합치료 증례 보고 (A Case Report of Osteochondral Lesions of the Left Talus after Ankle Sprain Treated with Complex Traditional Korean Medical Care)

  • 박준형;김성윤;안재현;조정재;김용석;김지혜;이상훈
    • Journal of Acupuncture Research
    • /
    • 제33권2호
    • /
    • pp.181-187
    • /
    • 2016
  • Objectives : The purpose of this report is to introduce a case of osteochondral lesions of the left talus caused by ankle sprain and suggest complex traditional Korean medical care with warm needling therapy as a possible method of conservative treatment. Methods : A 20-year-old male with osteochondral lesions of the left talus complaining of ankle pain and restricted range of movement was treated mainly with warm needling therapy and other combined Korean medicine therapy from January 5, 2015 to January 12, 2015. Improvements of symptoms were measured by American Orthopaedic Foot & Ankle Society Score (AOFAS Score), Visual Analog Scale (VAS) and Range of movement (ROM). Results : During 8 days of treatment, the patient showed gradual improvement in AOFAS score, VAS at rest and at weight bearing position, as well as ROM of the ankle. Conclusion : According to the result, warm needling therapy is a possible conservative treatment for osteochondral lesions of the talus. Further studies are needed regarding possible longterm effects.

무월경 환자의 DITI와 HRV, 체성분 분석을 통한 특성 연구 (A Study on Characters of DITI, HRV and Body Composition Analysis in Amenorrhea)

  • 정재혁;이진무;이창훈;조정훈;장준복;이경섭
    • 대한한방체열의학회지
    • /
    • 제7권1호
    • /
    • pp.30-36
    • /
    • 2009
  • Purpose : The purpose of this study is investigate the characters of DITI, HRV and Body composition analysis in Amenorrhea. Methods : We studied 47 patients visiting OO hospital from 1st October 2007 to 19st September 2009. The subjects were categorized in two groups, amenorrhea group(26) and normal group(21). We studied the difference of DITI, HRV and Body composition analysis between two groups by Mann-whitney test using SPSS for windows(version 12.0). Results : there is not statistically significant difference of DITI, HRV and BMI between amenorrhea group and normal group. But there is statistically significant difference of percent body fat and waist-hip ratio between amenorrhea group and normal group. Conclusion : Percent body fat and Waist-Hip ratio of amenorrhea groups is lower than normal groups. Percent body fat and Waist-Hip ratio can be diagnosis index.

  • PDF