• 미생물학회지
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• 제35권4호
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• pp.253-257
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• 1999

Cadaverine, putrescine, spermidine과 spermine이 spectinomycin에 의한 T4 파지 thymidylate synthase 유전자(td) intron의 splicing 억제에 미치는 영향을 조사하였다. Polyamine이 존재하지 않는 상태에서 7mM spectinomycin은 splicing rate를 약 40% 감소시켰다. 사용한 농도 범위(0.1~5mM)에서 cadaverine은 splicing rate를 감소시켰으나, putrescine은 0.5mM 농도에서 약 13% 정도의 splicing rate를 증가시켰다. Spermidine은 0.5mM 농도에서 약 11% 정도의 splicing rate를 증가시켰으며, sperimine은 0.01mM 농도에서 약 16% 정도의 splicing rate을 증가시켰다. 시험한 polyamine 중에서 특히 sperimine은 가장 낮은 농도에서 spectinomycin에 의한 억제반응을 극복하는 최고의 활성효과를 나타냈다. 이와 같은 억제 회복 효과는 polyamine에 의한 td intron 리보자임의 구조적 안정성에 기인하는 것으로 추정된다.

• 한국전자파학회논문지
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• 제21권11호
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• pp.1235-1239
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• 2010

본 논문에서는 혼합기의 IF 대역폭을 향상시키는 방법을 제안하며, 이를 적용하여 설계 제작된 0.13-${\mu}m$ RFCMOS 공정 기반 24 GHz 하향 변환 혼합기의 결과를 보인다. 측정 결과, 본 혼합기는 24 GHz의 LO 주파수에 대해 DC부터 5.25 GHz까지의 IF 주파수에서 $2.7{\pm}1.5$ dB의 변환 이득을 보이며, P-1dB와 LO-RF isolation은 각각 -8.7 dBm과 21 dB로 나타났다. 본 혼합기는 1.3 V의 전원으로부터 10.6 mA의 DC 전류를 소모한다.

• Korean Chemical Engineering Research
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• 제56권3호
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• pp.430-434
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• 2018

본 연구에서는 잔류 메틸렌 클로라이드 제거를 위한 마이크로웨이브를 이용한 파클리탁셀 건조에서 유효확산계수 및 물질전달계수를 조사하였다. 모든 온도(35, 45, $55^{\circ}C$)에서 건조 초기에 많은 양의 잔류 메틸렌 클로라이드가 제거되었으며 건조 온도가 증가할수록 건조 효율은 증가하였다. 건조 온도가 증가할수록 파클리탁셀의 유효확산계수($1.299{\times}10^{-13}{\sim}2.571{\times}10^{-13}m^2/s$)와 물질전달계수($1.625{\times}10^{-11}{\sim}4.857{\times}10^{-11}m/s$)는 증가하였다. 또한 낮은 Biot 수(0.0100~0.0151)로부터 건조의 진행이 주로 파클리탁셀의 외부확산에 의해 조절됨을 알 수 있었다.

• Archives of Pharmacal Research
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• 제13권2호
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• pp.142-146
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• 1990

Reaction of ethyl 4-chloro-2-phenylpyrimidine-4-carboxylate (4) with 5-chloro-2-methylthiophenol or 3-aryl-4-phenyl-1, 2, 4-triazole-5 thiol yielded the corresponding thioethers (5) and (8a, b), respectively. Careful alkaline hydrolysis of (5) yielded the corresponding carboxylic acid (6). Reaction of (4) with p-aminoacetophenone yielded compound (10) which was reacted with certain aromatic aldehyde to afford the$\alpha,\beta$-unsaturated ketones (11a-d). Condensation of (11a-d) with malononitrile or phenylhydrazine yielded the 2-amino-3-cyanopyridines (12a-f) or the 2-pyrazolines (13a, b) respectively. Seven representative compounds were tested for their in vitro antimicrobial activity against some pathogenic micro-organisms, some of them were proved to be active.

• 한국항해학회지
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• 제20권4호
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• pp.81-98
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• 1996

The purpose of this study was analysis of the muscle action in physical exercise in the rolling machine. The rolling machine moved by eletric power-driven was made to keep the constant cycle and size of rolling. The subjects of this study consist of 4 seaman(SM) and 4 landman (LM). The experiment analyzed the muscle power of lower and upper limbs by Intergrated Electromyogram(IEMG). The measurement was made on the ground, and 6 and 8 degrees of rolling separately. This study concludes as follows ; including analysis of IEMG of heavy exercise in two hands curl, a standstill walking and just standing. 1. IEMG of the lower limbs when standing. 1) In 6 degrees of rolling, for the landman(LM), vastus medialis m.(9.73), vastus lateralis m.(9.55), and rectus femores m.(8.73) acted more. As for the seaman(SM), tibialis anterior m.(5.38), biceps femores m.(5.05), and gastrocnemius m.(4.47) acted more. 2) In 8 degrees of rolling, in common, for both LM and SM, it were vastus medialis m.(11.20 and 8.97), vastus lateralis m.(16.20 and 4.63), and tibialis anterior m.(5.13 and 4.47). 3) It was showed that IEMG of LM was larger than that of SM. 2. IEMG of the lower limbs when walking. 1) On the ground, for the LM, gastrocnemius m.(7.08), vastus medialis m.(6.65), and vastus latralis m.(6.60) acted more. As for the SM, vastus lateralis m.(7.08), vastus medialis m.(6.58) and restus femores m.(5.10) acted more. 2) In both 8 and 6 degrees of rolling, vastus medials m.(14.50 and 11.98), vastus lateralis m.(10.10 and 14.10), and gastrocnemius m.(11.75 and 7.10) acted more in two groups. 3) It was showed that IEMG of LM was larger than that of SM. 3. IEMG of the lower limbs when heavy exercise(two hands curl). 1) On the ground, for the LM, vastus lateralis m.(21.68), vastus medialis m.(16.08), and rectus femores m.(14.08) acted more. As for the SM, tibialis anterior m.(16.08), vastus medialis m.(14.58), and vastus lateralis m.(8.78) acted more. 2) In 8 and 6 dgrees of rolling, it were vastus medialis m.(17.05 and 12.45), vastus lateralis m.(37.98 and 17.08), and tibialis anterior m.(19.83 and 13.20). 3) It was showed that IEMG of LM was larger than that of SM. 4. IEMG of the upper limbs when heavy exercise. 1) On the ground, the brachialis m.(44.30 and 17.80), and biceps brachii m.(13.40 and 25.10) acted more in two groups. 2) In both 6 and 8 degrees of rolling, the brachialis m.(37.60 and 24.35), and biceps brachii m.(11.38 and 7.97) acted more in two groups. 3) It was showed that IEMG of SM was larger than that of LM.

• 한국환경생태학회지
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• 제5권1호
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• pp.9-24
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• 1991

지리산 국립공원중 반야봉을 중심으로 피아골과 심원계곡을 포함하는 자연생태계보전구역의 현존식생을 파악하기 위하여 총 43개 조사지의 종조성 및 식생상관에 의하여 삼림군집을 구분하였으며 이를 토대로 현존식생도를 작성하였다. 지리산 자연생태계보전구역의 식생은 냉온대남부에서 아한대에 이르기까지 13개의 삼림군집이 형성되었으며 확인된 삼림군집은 다음과 같다. 1. 졸참나무군집 2. 서어나무군집 3. 졸참나무-서어나무군집 4. 노각나무군집 5. 고로쇠나무군집 6. 까치박달나무군집 7. 들메나무군집 8. 개서나무군집 9. 소나무군집 10. 신갈나무군집 1) 신갈나무-철쭉 하위군집 2) 신갈나무-조록싸리 하위군집 11. 분비나무군집 12. 구상나무군집 1) 구상나무-신갈나무 하위군집 2) 구상나무-잣나무 하위군집 13. 철쭉군집 확인된 삼림식생중에서 졸참나무군집은 해발 700m에서 1,000m에 분포하였으며 서어나무군집, 개서나무군집은 동지역의 계곡부에 분포하였다. 해발 1,000m에서 1,400m에는 신갈나무군집이 그 이상 1,700m까지에는 구상나무군집, 분비나무군집등 아고산대림이 발달하였다.

• Environmental Engineering Research
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• 제13권4호
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• pp.216-223
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• 2008

An efficient method for the simultaneous determination of eleven phenolic endocrine-disrupting chemicals (EDCs) present in wastewater influent samples was described. The 11 phenolic EDCs including alkylphenols, chlorophenols, and bisphenol A were determined by gas chromatography/mass spectrometry-selected ion monitoring (GC/MS-SIM) following two work-up methods for comparison; isobutoxycarbonyl (isoBOC) derivatization and tert-butyldimethylsilyl (TBDMS) derivatization. The wastewater influent samples containing the 11 EDCs were adjusted to pH 2 with $H_2SO_4$ and then cleaned up with n-hexane. Next, they were subjected to solid-phase extraction (SPE) with XAD-4 resin and subsequently converted to isoBOC or TBDMS derivatives for sensitivity analysis with gas chromatography/mass spectrometry-selected ion monitoring (GC/MSSIM). Following isoBOC derivatization and TBDMS derivatization, the recoveries were 86.6-105.2% and 97.6-142.7%, the limits of quantitation (LOQ) for the 11 phenolic EDCs for SIM was 0.001-0.050 ng/mL and 0.003-0.050 ng/mL, and the SIM responses were linear with the correlation coefficient varying by 0.9717-0.9995 and 0.9842-0.9980, respectively. When these methods were applied to five selected wastewater influent samples, for isoBOC derivatization and TBDMS derivatization the ranges of concentration detected were 0.2-99.6 ng/mL and 0.4-147.4 ng/mL, respectively.

• 전기화학회지
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• 제7권1호
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• pp.16-20
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• 2004

플러렌 이온$(full^-)$으로 수식된 피를 고분자 피막을 전기화학법으로 중합하기 위하여 사용된 전지는 Au/5mM pyrrole, 1mM fullerene, 0.1M $TBABF_4,\; CH_2C1_2/Pt$이었으며 이 전지로 $electrode/ppy(full^-)ppy(full^-){\ldots}$와 같은 웨이퍼형의 전극을 제작하였다. 이 전극을 사용한 Au(quartz crystal analyzer; QCA)/ppy$(full^-)$, 0.01M metal ion(aq.)/Pt형의 전지로 알카리 금속이온을 포집하였다. $Li^+,\;Na^+,\;K^+,\;Rb^+$ 및 $Cs^+$이온의 포집에 대한 속도상수는 일차반응 속도식으로 계산한 결과 그 값이 각각 $1.60\times10^{-8},\;3.13\times10^{-11},\;1.38\times10^{-9},\;2.71\times10^{-11}$ 및 $2.98\times10^{-12}mo1.s^{-1}$이였다. 이 전극을 수정판 미량저울(QCM)을 적용하여 결정한 각 이온의 화학양론은 $Li_7C_{60},\;Na_4C_{60},\;K_3C_{60},\;Rb_1C_{60}$ 및 $Cs_1C_{60}$이었다.

• 미생물과산업
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• 제11권1호
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• pp.13-20
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• 1985

특이 단백질(gene II protein)의 정성적 또는 정량적 변화에 의해 DNA 복제에 필요한 replication orgin sequence의 일부분이었단 replication enhancer를 불필요하게 함으로써 minimum replication origin을 core region만으로 국한 되게 함이었다.

• 생약학회지
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• 제47권1호
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• pp.62-72
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• 2016

Banhasasim-tang is a well-known traditional Korean herbal formula and has been used clinically for the treatment of gastric disease, including acute and chronic gastritis, diarrhea and gastric ulcers in Korea. In this study, an ultra-performance liquid chromatography-electrospray ionization-mass spectrometer method was developed for the quantitative determination of the 13 marker constituents, homogentisic acid (1), 3,4-dihydroxybenzaldehyde (2), spinosin (3), liquiritin (4), baicalin (5), ginsenoside Rg1 (6), liquiritigenin (7), wogonoside (8), ginsenoside Rb1 (9), baicalein (10), glycyrrhizin (11), wogonin (12), and 6-gingerol (13) in Banhasasim-tang decoction. Separation of the compounds 1-13 was using an UPLC BEH $C_{18}$ ($100{\times}2.1mm$, $1.7{\mu}m$) column and column oven temperature was maintained at $45^{\circ}C$. The mobile phase consisted of 0.1% (v/v) formic acid in water (A) and acetonitrile (B) by gradient elution. The injection volume and flow rate were $2.0{\mu}L$ and 0.3 mL/min, respectively. Calibration curves of the compounds 1-13 were showed with $r^2$ values ${\geq}0.9908$. The limit of detection and limit of quantification values of the compounds 1-13 were 0.04-1.11 ng/mL and 0.13-3.33 ng/mL, respectively. Among the these compounds, the compounds 1-3 were not detected, while the compounds 4-13 were detected in the ranges of $3.20-107,062.98{\mu}g/g$ in Banhasasim-tang sample.