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MT-2007, Protein Kinase C Inhibitor from Aetinomycetes Isolate No. 2007-18 (방선균 분리주 No 2007-18이 생산하는 Protein Kinase C 저해물질, MT-2007)

  • 안종석;박문수;박찬선;윤병대;민태익;안순철;오원근;이현선;윤병대
    • Microbiology and Biotechnology Letters
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    • v.21 no.1
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    • pp.54-58
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    • 1993
  • During the screening of inhibitors against protein kinase CCPKC) and the bleb formation of K562 cell induced by phorbol ester from microbial secondary metabolites, MT-2007 was purified by solvent extraction, and chromatographic techniques from Actinomycetes isolate No. 2007-18. It showed completely suppression of bleb formation of K562 cell surface induced by phorbol 12.13dibutylate at the concentration of 503.9 11M and ICso on PKC was 31.4 11M. Its structure was postulated as lasalocid A sodium salt by physico-chemical properties and UV, IR. MS, IH-NMR.

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Changes of physico-chemical properties of the activated sludges with anaerobic storage time (혐기화 시간에 따른 활성슬러지의 물리ㆍ화학적 특성변화)

  • 이창한;나영수;김도한;이송우;송승구
    • Journal of Environmental Science International
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    • v.11 no.4
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    • pp.339-346
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    • 2002
  • Physico-chemical properties of the activated sludges(Suyoung and Changlim treatment plant), such as SVI(sludge volume index), absorbance, specific surface area, and specific resistance using Buchener funnel test were investigated with changing anaerobic storage time. This experimental condition was found that it was possible to estimate a linear relationship between their parameters such as specific surface area specific resistance, and sludge volume index(SVI). The specific surface area and the specific resistance to filtration of the activated sludges of Suyoung and Changlim treatment plant were found as 123.6~136.6$m^2$/gDS and 41.5~44.9$m^2$/gDS(dry solid), and 1.09$\times$10$^{14}$ ~5.48$\times$10$_{14}$ m/kg and 1.05$\times$10$^{14}$ ~2.48$\times$10$^{14}$ m/kg, respectively. The results gave a good linear relationship between the specific surface area and the specific resistance, r=2.25$\times$10$^{12}$ s-8.10$\times$10$^{13}$ ($R^2$=0.8885) at Suyoung treatment plant and r=1.26$\times$10$^{13}$ s-4.75$\times$10$^{14}$ ($R^2$=0.8756) at Changlim treatment plant.

A Step-by-Step Primality Test (단계적 소수 판별법)

  • Lee, Sang-Un
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.13 no.3
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    • pp.103-109
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    • 2013
  • Miller-Rabin method is the most prevalently used primality test. However, this method mistakenly reports a Carmichael number or semi-prime number as prime (strong lier) although they are composite numbers. To eradicate this problem, it selects k number of m, whose value satisfies the following : m=[2,n-1], (m,n)=1. The Miller-Rabin method determines that a given number is prime, given that after the computation of $n-1=2^sd$, $0{\leq}r{\leq}s-1$, the outcome satisfies $m^d{\equiv}1$(mod n) or $m^{2^rd}{\equiv}-1$(mod n). This paper proposes a step-by-step primality testing algorithm that restricts m=2, hence achieving 98.8% probability. The proposed method, as a first step, rejects composite numbers that do not satisfy the equation, $n=6k{\pm}1$, $n_1{\neq}5$. Next, it determines prime by computing $2^{2^{s-1}d}{\equiv}{\beta}_{s-1}$(mod n) and $2^d{\equiv}{\beta}_0$(mod n). In the third step, it tests ${\beta}_r{\equiv}-1$ in the range of $1{\leq}r{\leq}s-2$ for ${\beta}_0$ > 1. In the case of ${\beta}_0$ = 1, it retests m=3,5,7,11,13,17 sequentially. When applied to n=[101,1000], the proposed algorithm determined 96.55% of prime in the initial stage. The remaining 3% was performed for ${\beta}_0$ >1 and 0.55% for ${\beta}_0$ = 1.

A Study on Growth Acceleration in Korean as Indirected by the Maximum Growth Age in Body Height (한국인(韓國人) 신장(身長)의 최대발육연령(最大發育年齡)으로 본 발육촉진현상(發育促進現象)의 추이(推移)에 관(關)한 연구(硏究))

  • Shin, Hyung-Gyun;Park, Soon-Young;Park, Yang-Won
    • Journal of Preventive Medicine and Public Health
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    • v.17 no.1
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    • pp.173-192
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    • 1984
  • On the basis of the study intended to research by crosssectional study keeps pace with semilongitudinal study the growthaccelerating phenomena that Maximum Growth age in teenager's body-height. By the random sampling method, the subject of study are 12659 persons(male; 6355, female; 6304) that they are from 7 ages to 17 ages in the whole country including the rural community. The measurement period passed three month days, the statistical data became electronic data processing system with computer. The other side, body-height and MGA of Koreans who had been for during the period from 1925 to 1966 proved transition of the growth-accelerating phenomena by research data reported between 1913 and 1983. The results are as follows; 1. The Growth and Development-Value of Body-height An age bracket the growth and development-value of body-height were, respectively, male is $123.88{\pm}5.05cm$ and female is $123.29{\pm}5.54cm$ for 7 ages group. these indices increased with age. the top-value reach, respectively. $169.08{\pm}5.62cm$ and $157.57{\pm}6.13cm$. The intersecting ages of male and female were the age $8.5{\sim}12.5$, during these periods, female excelled male but after these periods, male excelled female again. In case of body-height, MGA's are 7.0cm for male between 12 and 13 ages, and 7.01cm for female between 8 and 9 ages. As a rule, body-height of male excelled female but intersection phenomena of male and female appeared between 8.5 and 12.5 ages. By reginal groups, it is most prevailing is Seoul, and medium size cities and rural community rome in order. By regional groups, intersection phenomena of male and female are. a region of Seoul; $$8.5{\sim}11.5$$ ages a region of Daejeon; $$7.5{\sim}9.5$$ ages rural community; $$11.5{\sim}14.5$$ ages the whole country's average; $$8.5{\sim}12.5$$ ages By regional groups, the rate of maximum increase in a year are a region of Seoul; male is 7.23cm as 13 ages female is 7.65cm as 9 ages. a region of Daejeon; male is 7.85cm as 11 ages. female is 8.39cm as 9 ages. rural community; male is 7.65cm as 14 ages. female is 6.25cm as 12 ages. the whole country's average; male is 7.0cm as 13 ages. female is 7.01 as 9 ages. 2. Maximum Growth Age (M.G.A.) By reginal groups, maximum Growth Age's are as below in a region of Seoul, MGA's are 12.63 for male and 9.01 for female, which shows that MGA for female appears about 3.5 years earlier than that for male. In a region of Daejeon, MGA's are 9.20 for male and 8.93 for female, which. show that they are all much the same in M.G.A. In rural community, MGA's are 14.00 for male and 11.89 for female, which shows that MGA for female apperars about 2 years earlier than that for male. In the whole average, MGA's are 13.01 for male and 8.97 for femal, which shows that for female appears about 4 years earlier than that for male. For boy, M.G.A. shows fastest-growing in Daejeon, and Seoul and rural commonly come in order. For girl, It shows equal growth in Seoul and Daejeon, rural community comes later. 3. The M.G.A's in body height of male are respectively the age 15.02 in 1913, 14.23 in 1956, 13.86 in 1967, 13.62 in 1975, and 12.82 in 1981, while those of female are the age 12.0 in 1940, 11.52 in 1965, 9.53 in 1975, and 11.16 in 1980; these data show that the MGA of the Koreans has been getting younger. 4. The equation of linear regression of all the MGA's in body height are as follow; Male: Y(M.G.A)=$-0.020{\times}$ (the year)+15.19: female:Y(MGA)=$-0.028{\times}$(the year)+13.2549. 5. The corelation of all the MGA's in body height are as below; male; r=-0.329 female;r=-0.252 6. From the transition of the growth-accelating phenomena in 1980 we can capture the fact that the MGA's has been getting younger by 0.2 year per 10 years. 7. The MGA's in bodyheight are shown in table 4... 8. The future growth-accelating phenomena in body height are expected to show the similar tendency like that of the past, in 1910's but it should by more precisely reviewed after investigating the phenomena of the years directly ahead.

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Indicating the Problem of Shielding Design and the Way of Estimating Radiation Leakage for CT Rooms located through Survey of Radiation Leakage : in the case of Busan and Gyung-nam Area (방사선 누설선량 조사를 통한 방어시설과 누설선량 평가방법에 대한 문제점 연구 : 부산, 경남 지역 CT실을 중심으로)

  • Yang, Won Seok;Choi, Jun-Hyeok;Shin, Woon-Jae;Min, Byung-In
    • The Journal of the Korea Contents Association
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    • v.13 no.11
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    • pp.768-777
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    • 2013
  • The purpose of this study is to minimize radiation exposure to the workers and public members during CT examination. The objects are seven of the CT rooms in university hospitals and four of the CT rooms in clinics located in Busan and Gyung-nam area. The places of measurement for radiation leakage are 1) 3 m above the ground of shielding wall in the control room 2) particular space in the control room 3) worker's gate in the control room 4) the patient gate. Its values were calculated maximum leakage radiation per week(MLRW). As a result, the worker's gate of M clinic displayed the highest dose. When it was calculated by MLRW in classic method, it showed 1) $5.97{\pm}0.23$, 2) $0.50{\pm}0.02$, 3) $10.00{\pm}0.11$, 4) $2.37{\pm}0.47$ mR/week. All of them did not exceed limit for maximum permissible dose per week(MPDW). However, When MLRW of M clinic was calculated by empirical method, its value displayed $118.31{\pm}17.72$ mR/week.(MPDW>100 mR/week). Radiation leakage influenced in the control room(p<0.05). Therefore, The way of calculating MLRW must be developed and shielding wall in control room is designed 3 m above the ground for reducing dangerous of leakage radiation.

Preliminary Data on the Ratio of D(-)-Lactate and L(+)-Lactate Levels in Various Lactic Acid Bacteria as Evaluated using an Enzymatic Method

  • Song, Kwang-Young
    • Journal of Dairy Science and Biotechnology
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    • v.40 no.1
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    • pp.15-22
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    • 2022
  • This study evaluated the levels of D(-)-lactate and L(+)-lactate, and the ratio of D(-)-lactate to total lactate (D(-)-lactate + L(+)-lactate) of 15 lactic acid bacteria (LAB) using an enzymatic method. D(-)-lactate and L(+)-lactate levels in the LAB ranged from 0.31 to 13.9 mM and 0.76 to 39.3 mM, respectively, in Bifidobacterium sp.; 1.08 to 11.7 mM and 0.69-13.0 mM in Lactobacillus sp.; 0.72 to 20.3 mM and 0.98 to 32.3 mM in Leuconostoc sp., and 33.0 mM and 39.2 mM in Pediococcus acidilacti KCCM 11747. The ratio of the range of D(-)-lactic acid to total lactic acid was 28.98%-45.76% in Bifidobacterium sp., 41.18%-61.02% in Lactobacillus sp., 29.85%-42.36% in Leuconostoc sp., and 45.71% in P. acidilacti KCCM 11747. In the future, there is a need to test for D(-)-lactate in various fermented products to which different LAB have been added and study the screening of LAB used as probiotics that produce various concentrations of D(-)-lactate.