• 한국어병학회지
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• 제34권1호
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• pp.23-29
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• 2021

Interferon regulatory factors (IRFs) are a family of transcription factors essential to the control of antiviral immune response, cell growth, differentiation and apoptosis. IRF10 of zebrafish (Danio rerio) was negative regulation of the interferonΦ1 and 3 response in vitro. In this study, we analyze the induction of in vivo immune response activation from the IRF10 gene of zebrafish and the protective effect against VHSV. As the results, the group inoculated with IRF10 expression vectors, there was no expression of IFNΦ1, suggestion that IRF10 may function as a negative regulator of IRF3, which binds to the IFNΦ1 promoter. And other types of interferon genes (IFNΦ2-4) are thought to have been activated, inducing to the expression of pro-inflammatory cytokine and Mx genes. As the results of challenge test performed at 14 days after inoculation of the expression vectors, the maximum survival rate [50% (1㎍ DNA) and 42.5% (10㎍ DNA)] for IRF10 group were recorded. Meanwhile, the survival rates of pcDNA3.1 and PBS as the control groups were 10% and 15%, respectively. This study suggests that the possibility that activation of IRF10 molecule could be exploited as a VHS control method.

• 대한암한의학회지
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• 제23권1호
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• pp.33-43
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• 2018

Objectives: To observe the mitigating effects of a Traditional Korean Medicine(TKM) treatment program especially including pharmacopuncture, with Cyclophosphamide and doxorubicin chemotherapy on a both sides breast cancer patient. Methods: AA 74 year-old female patient diagnosed with both sides breast cancer (Right) pT1bpN0M0, (Left) pT1cpN1Mx was admitted to hospital of Dong-eui university in May of 2017. She received Cyclophosphamide and Doxorubicin from May $31^{st}$ to August $2^{nd}$, 2017 followed by TKM treatment consisting of herbal medicine, acupuncture, moxibustion and pharmacopuncture (Trionycis Carapax, Non-toxic Bee Venom, and Cultivated Wild Ginseng Extract) for a period of almost 4 months, from May $13^{th}$ to August $19^{th}$, 2017. Symptoms were evaluated by the grade of chief complaints refer to Common Terminology Criteria for Adverse Events (CTCAE) and Eastern Cooperative Oncology Group (ECOG). Results: TKM including pharmacopuncture alleviated chemotherapy-induced nausea, fatigue, joint pain, diarrhea, insomnia. Conclusions: This case study potentiates TKM with pharmacopuncture's significant efficacy in aiding breast cancer patients suffering from Cyclophosphamide plus Doxorubicin induced adverse effects. Further research should take place for clear understanding of the exact amount of dosage and safety. Moreover it must be accompanied by long-term follow up researches.

• Current Optics and Photonics
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• 제5권2호
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• pp.186-190
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• 2021

In this study, a compact, picosecond, mid-infrared 3.8 ㎛ MgO:PPLN optical parametric oscillator (OPO) laser output with high peak power is realized using a master oscillator power amplifier (MOPA) 1 ㎛ solid-state laser seeded by a picosecond fiber laser as the pump source. The pump source was a 50 MHz and 10 ps fiber seed source. After AOM pulse selection and two-stage solid-state amplification, a 1,064 nm laser output with a repetition frequency of 1-2 MHz, pulse width of 9.5 ps, and a maximum average power of 20 W was achieved. Furthermore, a compact short cavity with a unsynchronized pump is adopted through the design of an OPO cavity structure. When the injection pump power was 15 W and the repetition frequency was 1 MHz, the average output power of idler light was 1.19 W, and the corresponding peak power was 119 kW. The optical conversion efficiency was 7.93%. When the repetition frequency was increased to 2 MHz, the average output power of idler light was 1.63 W, the corresponding peak power was 81.5 kW, and the optical conversion efficiency was 10.87%. At the same time, the output wavelength was measured at 3,806 nm, and the beam quality was MX2 = 3.21 and MY2 = 3.34.

• 천문학회지
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• 제36권spc1호
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• pp.37-44
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• 2003

In this paper, we review recent studies on the magnetic helicity changes of solar active regions by photospheric horizontal motions. Recently, Chae(200l) developed a methodology to determine the magnetic helicity change rate via photospheric horizontal motions. We have applied this methodology to four cases: (1) NOAA AR 8100 which has a series of homologous X-ray flares, (2) three active regions which have four eruptive major X-ray flares, (3) NOAA AR 9236 which has three eruptive X-class flares, and (4) NOAA AR 8668 in which a large filament was under formation. As a result, we have found several interesting results. First, the rate of magnetic helicity injection strongly depends on an active region and its evolution. Its mean rate ranges from 4 to $17 {\times} 10^{40}\;Mx^2\;h^{-1}$. Especially when the homologous flares occurred and when the filament was formed, significant rates of magnetic helicity were continuously deposited in the corona via photospheric shear flows. Second, there is a strong positive correlation between the magnetic helicity accumulated during the flaring time interval of the homologous flares in AR 8100 and the GOES X-ray flux integrated over the flaring time. This indicates that the occurrence of a series of homologous flares is physically related to the accumulation of magnetic helicity in the corona by photospheric shearing motions. Third, impulsive helicity variations took place near the flaring times of some strong flares. These impulsive variations whose time scales are less than one hour are attributed to localized velocity kernels around the polarity inversion line. Fourth, considering the filament eruption associated with an X1.8 flare started about 10 minutes before the impulsive variation of the helicity change rate, we suggest that the impulsive helicity variation is not a cause of the eruptive solar flare but its result. Finally, we discuss the physical implications on these results and our future plans.

• Restorative Dentistry and Endodontics
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• 제26권5호
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• pp.393-398
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• 2001

Polymerization of light-activated restorations results in temperature increase caused by both the exothermic reaction process and the energy absorbed during irradiation. Within composite resin, temperature increases up to 2$0^{\circ}C$ or more during polymerization. But, insulation of hard tissue of tooth lowers this temperature increase in pulp. However, many clinicians are concerned about intrapulpal temperature injury. The purpose of this study was to evaluate temperature changes in the pulp according to various restorative materials and bases during curing procedure. Caries and restoration-free mandibular molars extracted within three months were prepared Class I cavity of 3$\times$6mm with high speed handpiece fissure bur. 1mm depth of dentin was evaluated with micrometer in mesial and distal pulp horns. Pulp chambers were filled with 37.0$\pm$0.1$^{\circ}C$ water to CEJ. Chromium-alumina thermocouple was placed in pulp horn below restorative materials for evaluating of temperature changes. This thermocouple was connected to temperature-recording device(Multiplication analyzer MX, 6.000, JAPAN). Temperature changes was evaluated from initial 37.$0^{\circ}C$ after temperature changes to 37.$0^{\circ}C$. Tip of curing unit was placed in the center of prepared cavity separated 1mm from restorative materials. Curing time was 40s. The restorative materials were used with Z 100, Fuji II LC, Compoglass flow and bases were used with Vitrebond, Dycal. Resrorative materials were placed in 2mm. The depth of bases were formed in 1mm and in this upper portion, resin of 2mm depth was placed. This procedure was performed 10 times. The results were as follows. 1. All the groups showed that the temperature in pulp increased as curing time increased 2. The temperature increase of glass ionomer was significantly higher than that of Resin and Compomer during curing procedure (P<0.05). 3. The temperature increase in glass ionomer base was significantly higher than that of Calcium hydroxide base during Resin curing procedure (P<0.05).

• 한국운동역학회지
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• 제28권1호
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• pp.1-8
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• 2018

Objective: The purpose of this study is to investigate the differences in biomechanical variables of golf driving motion according to gender. Method: A total of 21 healthy golfers (11 men and 10 women) who have more than 5 years of professional experience and have been registered in the Korea Golf Association was recruited. A 250-Hz 8-camera motion capture system (MX-T20, Vicon, LA, USA) was used to capture the motion trajectories of a total of 42 reflective markers attached to the golfer's body and club. Moreover, two 1,000-Hz AMTI force plates (AMTI OR6-7-400, AMTI, MA, USA) were used to measure the ground reaction force. The mean and standard deviation for each parameter were then calculated for both groups of 21 subjects. SPSS Windows version 23.0 was used for statistical analysis. The independent t-test was used to determine the differences between groups. An alpha level of .05 was utilized in all tests. Results: There were differences in joint angles according to gender during golf driver swing. Men showed a statistically significantly higher peak joint angle and maximum range of angle in sagittal and frontal axis of the pelvis, hip, and knee. Moreover, women's swing of the pelvis and hips was found to have a pattern using the peak joint angle and range of angle in the vertical axis of the pelvis and hip. There were the differences in peak joint moment according to gender during golf driver swing. Men used higher joint moment in the downswing phase than women in the extensor, abductor, and external rotator muscles of the right hip; flexor and adductor muscles of left hip joint; and flexor and extensor muscles of the right knee. Conclusion: This result reveals that male golfers conducted driver swing using stronger force of the lower body and ground reaction force based on strength of hip and thigh than female golfers.

• Journal of Animal Science and Technology
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• 제65권4호
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• pp.838-855
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• 2023

The highly pathogenic avian influenza (HPAI) virus triggers infectious diseases, resulting in pulmonary damage and high mortality in domestic poultry worldwide. This study aimed to analyze miRNA expression profiles after infection with the HPAI H5N1 virus in resistant and susceptible lines of Ri chickens.For this purpose, resistant and susceptible lines of Vietnamese Ri chicken were used based on the A/G allele of Mx and BF2 genes. These genes are responsible for innate antiviral activity and were selected to determine differentially expressed (DE) miRNAs in HPAI-infected chicken lines using small RNA sequencing. A total of 44 miRNAs were DE after 3 days of infection with the H5N1 virus. Computational program analysis indicated the candidate target genes for DE miRNAs to possess significant functions related to cytokines, chemokines, MAPK signaling pathway, ErBb signaling pathway, and Wnt signaling pathway. Several DE miRNA-mRNA matches were suggested to play crucial roles in mediating immune functions against viral evasion. These results revealed the potential regulatory roles of miRNAs in the immune response of the two Ri chicken lines against HPAI H5N1 virus infection in the lungs.

• Animal Bioscience
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• 제37권8호
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• pp.1377-1386
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• 2024

Objective: Embryonic interferon-tau (IFNT) and progesterone affect expression of interferon-stimulated genes (ISGs), progesterone receptor (PGR) and progesterone-induced blocking factor (PIBF) in the ovine thyroid. Methods: Thyroids of ewes were sampled at day 16 of nonpregnancy, days 13, 16, and 25 of pregnancy, and real-time quantitative polymerase chain reaction assay, western blot and immunohistochemistry were used to detect expression of ISGs, PGR, and PIBF. Results: Free ISG15 protein was undetected, but ISG15 conjugated proteins upregulated at day 16 of pregnancy, and expression levels of ISG15 conjugated proteins, PGR isoform (70 kDa), PIBF, interferon-gamma-inducible protein 10 and myxovirusresistance protein 1 peaked, but expression level of signal transducer and activator of transcription 1 was the lowest at day 16 of pregnancy. In addition, the expression levels of PGR isoform (70 kDa) and signal transducer and activator of transcription 1 (STAT1) decreased, but levels of PGR isoform (43 kDa), 2',5'-oligoadenylate synthetase, IP-10 and MX1 increased at day 25 of pregnancy comparing with day 16 of the estrous cycle. Conclusion: Early pregnancy affects expression of ISGs, PGR, and PIBF in maternal thyroid through IFNT and progesterone, which may regulate thyroid autoimmunity and thyroid hormone secretion in ewes.

• 대한치과교정학회지
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• 제26권4호
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• pp.401-413
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• 1996

안모의 수직적 부조화는 안면의 전방 고경 요소와 후방 고경 요소 사이의 상관 관계에 따라 결정되는 것이므로, 전 하안면 고경에 대한 후하안면 고경의 비인 FHI에 따라 수직적 control이 치료 성공의 관건인 2급 1류 부정 교합을 분류하고 FHI에 영향을 미치는 요소를 파악하여 치료의 지침으로 삼고자 본 연구를 시행하였다. 단국대학교 치과대학 교정과에 내원한 혼합치열기의 2급 1류 부정 교합자를 대조군의 FHI(평균 0.6999)의 1 S.D (0.25)를 기준으로 수직적으로 분류하였다. 임상적으로 수직적 부조화에 영향을 미칠 것으로 사료되었던 상악 제 1 대 구치 치조 고경, 구치간 각도, 구개평면 기울기, 하악지 기울기 등의 영향을 검증하고, 만약 영향을 미치지 않는다면 어느 요소가 FHI에 영향을 미치는가 알아보고자 하였으며, 각 군간에 골격적 양상을 알아보고자 하여 다음의 결론을 얻었다. 2급 1류 부정 교합자의 FHI에 주로 기여하는 요소는 구개 평면과 하악 평면 사이의 경사도이고, RH, ID의 순으로 나타났으며, 구개 및 하악 평면의 독립적인 경사도 보다는 상호 경사도가 중요하게 나타났다. 2급 1류 부정 교합의 양상은 FHI에 따라보면, Low group은 상악이 전돌되고 하악지의 발육이 아주 강하며 하악체의 길이 및 전후방 위치는 정상이다. Normo group은 상악은 약간 전돌되고 하악지의 발육이 정상보다 약하고 하악이 다소 후방에 위치하고, High group은 상악은 정상위치이고 하악지 및 하악체의 발육이 제일 약하며 하악이 후방에 위치하는 것으로 나타났다. 2급 1류 부정 교합자의 각 군간 FHI를 결정짓는 요소를 보면 Low group은 MP-PP각이 아주 작고, ID는 정상군과 유사하나 RH가 아주 커서 FHI가 크게 된다. Normo-group은 PP-MP각이 정상이고, ID는 정상군보다 약간 작고 RH 가 정상군보다 작아 FHI가 정상비를 유지하였다. High group은 PP-MP각이 아주 크고 ID는 정상군과 유사하나 RH가 정상군보다 작아 FHI가 작았던 것으로 나타났다.

• 대한화학회지
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• 제28권2호
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• pp.121-129
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• 1984

원료가 서로 다른 세종류의 국산활성탄을 사용하여 니켈 및 아연이온에 관한 할로겐과 시안이온의 활성탄 흡착에 대한 공존효과를 살펴보았다. 수용액중에서 니켈 및 아연이온은 할로겐이나 시안이온의 공존으로 착음이온 형태로 활성탄에 용이하게 흡착됨을 알 수 있었으며 니켈이온은 pH $6.0{\sim}7.0$에서, 아연이온은 pH $6.5{\sim}7.0$의 범위가 가장 적합함을 알았다. 또한 니켈이온과의 착음이온을 만들기 위한 음이온은$ 1{\times}10^{-2}mol/l$에서 그 최대치를 나타내었다. 실온에서 구한 이들의 흡착등온선은 거의 직선으로 Freundlich의 흡착등온식게 따랐으며, 시안이온 공존시의 기울기는 활성탄 A, B, C에 대해 각각 1.7, 5.4, 7.1로서 활성탄 A가 흡착제로서 매우 양호한 것을 알 수 있다.