• 제목/요약/키워드: 1/f process

검색결과 1,713건 처리시간 0.025초

Automated radiosynthesis for the routine production of [18F]FPEB for imaging metabotropic glutamate receptor 5 (mGluRS)

  • Kyung Rok Nam;Sang Jin Han;Kyo Chul Lee;Jae Yong Choi
    • 대한방사성의약품학회지
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    • 제8권1호
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    • pp.3-8
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    • 2022
  • Alteration of the mGluR5 density is closely related to various brain diseases including schizophrenia, depression, Parkinson's disease, and Alzheimer's disease. Therefore, mGluR5 is considered as a valuable imaging biomarker for brain disease and many radiopharmaceuticals have been developed so far. Among them, [18F]FPEB has favorable pharmacokinetic characteristics, and this is the most frequently used radiopharmaceutical for preclinical and clinical studies. In the present study, we want to introduce the optimized radiosynthetic method for the routine production of [18F]FPEB using a GE TRACERlabTM FXFN pro module. In addition, the entire process was monitored with a webcam to solve the problems arising from the synthetic process. As a result, [18F]FPEB was prepared by nucleophilic substitution from its nitro- precursor at 120℃ for 20 min in dimethyl sulfoxide. Radiochemical yield was 13.7 ± 5.1% (decay-corrected, n = 91) with the molar activity of 84 ± 17 GBq/µmol at the end of synthesis. The radiochemical purity was determined to be above 96%. The manufactured [18F]FPEB injection for quality controls were carried out in accordance with an KIRAMS approved protocol, as per ICH and USP guidelines.

도재용착주조관용 비귀금속 합금의 사전 열처리가 도재-금속의 결합 강도에 미치는 효과 (The Effect of Oxidation Heat Treatment on Porcelain to Metal Bond Strength)

  • 김치영;남상용
    • 대한치과기공학회지
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    • 제19권1호
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    • pp.37-42
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    • 1997
  • The interfacial bond strengh and microstructural analysis of pre-heat treated porcelain-fusedmetal(PFM) were investigated using a mechanical three-point bending tester and scanning electron microscope(SEM). Four kinds of heat treated samples were prepared as follows ; A: Heating $1200^{\circ}F{\to}1600^{\circ}F$, holding 1min, reheating ${\to}1850^{\circ}F$, hold 3min under vacuum, B: heating $1200^{\circ}F{\to}1600^{\circ}F$, holding 1min, reheating${\to}1850^{\circ}F$ under vacuum conditon, C: heating $1200^{\circ}F{\to}1600^{\circ}F$, holding 1min, reheating${\to}1850^{\circ}F$, holding 3min in the air, repeat same heat treatment process under vacuum condition, D: heating $1200^{\circ}F{\to}1600^{\circ}F$, holding 1min, reheating${\to}1850^{\circ}F$, holding 1min in the air. The three-point bening test result shows that the interfacial bond strength of specimen B and C were higher than that of A and D. The SEM study indicate that Specimen C shows the highest surface density.

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SOME NECESSARY CONDITIONS FOR ERGODICITY OF NONLINEAR FIRST ORDER AUTOREGRESSIVE MODELS

  • Lee, Chan-Ho
    • 대한수학회지
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    • 제33권2호
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    • pp.227-234
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    • 1996
  • Consider nonlinear autoregressive processes of order 1 defined by the random iteration $$ (1) X_{n + 1} = f(X_n) + \epsilon_{n + 1} (n \geq 0) $$ where f is real-valued Borel measurable functin on $R^1, {\epsilon_n : n \geq 1}$ is an i.i.d.sequence whose common distribution F has a non-zero absolutely continuous component with a positive density, $E$\mid$\epsilon_n$\mid$ < \infty$, and the initial $X_0$ is independent of ${\epsilon_n : n > \geq 1}$.

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전면 유기발광 다이오드 제작시 Mg:Ag 캐소드 최적화 및 LiF 전자주입층 유무에 따른 소자 특성에 관한 연구 (Optimization of Mg:Ag Cathodes and Effect of LiF Electron Injection Layer on the Characteristics of Top Emission Organic Light Emitting Diodes)

  • 송민석;권상직;조의식
    • 반도체디스플레이기술학회지
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    • 제21권1호
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    • pp.71-74
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    • 2022
  • For the process simplification in the fabrication of organic light emitting diode(OLED), top emission OLED (TEOLED) was fabricated without lithium fluoride(LiF) used as an electron injection layer (EIL). After co-deposition of Mg and Ag with a different process conditions, a cathode material adjacent to EIL was optimized when Mg and Ag have a ratio of 1:9 considering sheet resistance and transmittance. From the energy band diagram of TEOLED, band gap difference between Trisaluminium (Alq3) and Mg:Ag cathode show the difference of 0.4 eV according to the usage of LiF The fabricated TEOLED without LiF showed the improvement of 5.2 % and 2.7 % in the luminance and the current density comparing that with LiF. The results show there is no significant difference in OLED characteristics regardless of LIF layer in the TEOLED structures.

일부 근로자의 운동행위 변화단계에 영향을 미치는 요인 (Factors Effecting to the Stage of Change for Exercise on the Workers)

  • 서기순;이동배
    • 보건교육건강증진학회지
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    • 제23권1호
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    • pp.63-75
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    • 2006
  • Objective: This study was performed to identify the related factors of change affecting the stage of change, on the assumption that there are various stages of change in the exercise behavior of workers. Method: The subjects of the study consisted of 138 workers of 10 workplaces located in Daejeon City, and data collected by using questionnaires were analyzed with SPSS/WIN 11.5 program. Results: The subjects were distributed in the stage of exercise behavior change as follows: precontemplation stage(10.9%), contemplation stage(22.5%), preparation stage(41.3%), action stage(8.7%), and maintenance stage(16.7%). Of the process of change depending on the stage of exercise behavior change, the consciousness raising(F=11.50, p=.00), dramatic relief(F=2.82, p=.02) showed significant difference in the cognitive process, and the counter conditioning(F=4.56, p=.00), reinforcement management(F=4.64, p=.00), self-liberation(F=9.46, p=.00), and stimulus control(F=13.28, p=.00) showed significant difference in the behavioral process. For decision-making depending on the stage of exercise behavior change, both the pros of decision-making(F=9.23, p=.00) and the cons of decision-making(F=2.45, p=.04) showed significant difference. Self-efficacy depending on the stage of exercise behavior change showed significant difference as F=11.50, p=.00. The related factors of change affecting the stage of exercise behavior change were the pros of decision-making, the cons of decision-making, and self-efficacy including 34.1% R-square. Conclusion: In order to change the exercise behavior of workers positively, they need to be stimulated to use the cognitive and behavioral process in the process of change properly, and to be induced to make a decision positively. And also exercise programs suitable to various characteristics of each worker as well as those of workplaces to enhance self-efficacy need to be applied after being devised. Through the further longitudinal research, it is necessary to analyze the various aspects, such as groups to select, to maintain, to stop or give up the exercise, and to avoid the change, and to study how the related factors of change affect diversity like the above.

도재용착주조관용 비귀금속 합금의 사전 열처리가 도재-금속의 결합 강도에 미치는 효과 (The effect of oxidation heat treatment on porcelain to metal bond strength)

  • 김치영;남상용
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1997년도 춘계학술대회
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    • pp.43-46
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    • 1997
  • The interfacial bond strength and microstructural analysis of pre-heat treated porcelain-fused-metal (PFM) were investigated using a mechanical three-point bending tester and scanning electron microscope(SEM). Four kinds of heat treated samples were prepared as follows; A: heating $1200^{\circ}F\rightarrow1600^{\circ}F$, holding 1min, reheating $\rightarrow1850^{\circ}F$, hold 3min under vacuum, B: heating $1200^{\circ}F\rightarrow1600^{\circ}F$ holding 1min, reheating $\rightarrow1850^{\circ}F$ under vacuum condition, C: heating $1200^{\circ}F\rightarrow1600^{\circ}F$, holding 1min, reheating $\rightarrow1850^{\circ}F$, holding 3min in the air, repeat same heat treatment process under vacuum condition, D: heating $1200^{\circ}F\rightarrow1600^{\circ}F$, holding 1min, reheating $\rightarrow1850^{\circ}F$, holding 1min in the air. The three-point bending test results shows that the interfacial bond strength of specimen B and C were higher than that of A and B. The SEM study reveals that Specimen C shows the highest surface density.

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THE SEQUENTIAL UNIFORM LAW OF LARGE NUMBERS

  • Bae, Jong-Sig;Kim, Sung-Yeun
    • 대한수학회보
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    • 제43권3호
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    • pp.479-486
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    • 2006
  • Let $Z_n(s,\;f)=n^{-1}\;{\sum}^{ns}_{i=1}(f(X_i)-Pf)$ be the sequential empirical process based on the independent and identically distributed random variables. We prove that convergence problems of $sup_{(s,\;f)}|Z_n(s,\;f)|$ to zero boil down to those of $sup_f|Z_n(1,\;f)|$. We employ Ottaviani's inequality and the complete convergence to establish, under bracketing entropy with the second moment, the almost sure convergence of $sup_{(s,\;f)}|Z_n(s,\;f)|$ to zero.

누에고치층의 형광색에 따른 Sericin의 용해성 (Dissolution Behaviors of Sericin in Cocoon Shell on the Fluorescence Colors)

  • 손승종;남중희
    • 한국잠사곤충학회지
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    • 제30권1호
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    • pp.33-39
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    • 1988
  • 본 시험은 자외선에 의해 구분된 황형광색견(Y.F.C)와 자형광색견(V.F.C)의 견층 sericin이 열수에 대한 성질과 견층 sericin 수용액의 물리적 성질 차이를 조사하고 제사성적에 미치는 영향을 검토한 결과를 요약하면 다음과 같다. 1. 용해온도에 따른 sericin의 용해성은 낮은 온도에서보다 높은 온도에서 Y.F.C와 V.F.C간의 차가 켰다. 2. 용해시간에 따른 sericin의 용해성은 Y.F.C 및 V.F.C 모두 비슷한 경향을 나타냈으나 Y.F.C가 V.F.C. 보다 용해성이 좋았다. 3. 초기 sericin 용해성을 도시하면 용해도가 다른 4개 부분으로 구분할 수 있었고 Y.F.C 및 V.F.C 모두 같은 형태였으나 각 용해속도에 있어서는 차이가 있었다. 4. Sericin 수용액의 표면장력 측정결과 처리후 방치 시간에 따른 변화 속도는 45분 이내에서 V.F.C가 빠르기 때문에 sericin의 용해성을 저하시킬 것으로 사료된다. 5. Sericin 입자의 비용적에 있어서 Y.F.C가 V.F.C 보다 크기 때문에 Y.F.C의 용해성이 좋은 것으로 추정된다. 6. 제사가공 중 견층 sericin 용해량은 Y.F.C가 V.F.C 보다 초기용해속도가 빠르기 때문에 전공정 sericin 유실량이 많았고 이 때문에 실켜기 공정에서 고치실의 풀림새를 향상시킨 것으로 사료된다.

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생산 방식별 재생 잔골재의 품질에 대한 기초적 연구 (A Study on the Quality Improvement of Recycled Fine Aggregates with Production Methods)

  • 심종우;이세현;유명열;이문환;송태협
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 2004년도 춘계 학술발표회 제16권1호
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    • pp.368-371
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    • 2004
  • It analyzes the quality of the fine aggregate which is reproduced through a dry production process with cyclone and a wet production process. The conclusions of the study are as follows. 1. The recycled fine aggregate through the dry production process with cyclone shows the low rate of absorption and impurity content after the cyclone process. It shows that its density is 2.37, absorption rate is 4.8 and stability is $5.1\%$ and less. Therefore, it satisfies the standards of KS F 2573(recycled aggregate for concrete) as the first grade. 2. The recycled fine aggregate through the wet production process shows the low rate of absorption and foreign substance content after the process of wash and dehydration. It shows that its density is 2.40, absorption rate is 3.12 and stability is $3.2\%$ and less. Therefore, it satisfies the standards of KS F 2573(recycled aggregate for concrete) as the first grade.

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최소비용(最小費用) 연속생산형(連續生産型) 샘플링검사(檢査)의 탐색(探索) (An Approach to select the lowest cost CSP-1 sampling plan(i, f))

  • 장경;신현재
    • 품질경영학회지
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    • 제11권1호
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    • pp.18-23
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    • 1983
  • Continuous sampling plans CSP-1(i,f)'s with which AOQL is guaranteed, can be applied to the cases in need of effective sampling without stopping the process or dividing batches during production. But the plans that can guarantee the same AOQL value are too many. Therefore we have to select one plan among them. There may be a lot of ways to choose it. This paper connects with various sampling costs, the concept to try to detect the shift of process average under fractional inspection in CSP-1,to find a minimum cost sampling plan among several CSP-1 sampling plan alternatives (i, f)'s with the same AOQL value.

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