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Validation of chrysophanol and cordycepin as marker compounds for standardization of a new herbal mixture AST2017-01

  • Jang, Jae-Bum;Kim, Tae-Young;Jeong, Hyun-Ja;Kim, Hyung-Min
    • CELLMED
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    • v.7 no.3
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    • pp.14.1-14.4
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    • 2017
  • Rumex crispus (RC) or Cordyceps militaris (CM) has been used traditionally to treat various diseases and has been also consumed as a functional food made by humanitas medicine concept. We prepared a new herbal mixture, AST2017-01 which is mainly composed of processed (Beopje)-RC (P-RC) and -CM (P-CM). This study aims to validate marker compounds (chrysophanol and cordycepin) in P-RC and P-CM and water extracted-RC and -CM using liquid chromatography-tandem mass spectrometry. In addition, we analyzed contents of chrysophanol and cordycepin in AST2017-01. The linarites of chrysophanol and cordycepin were obtained in calibration curve with a coefficient of correlation of 0.999. The results showed that the concentrations of chrysophanol and cordycepin in P-RC and P-CM were almost 1.70 and 1.23 fold higher than that in RC and CM, respectively. Furthermore, contents of chrysophanol and cordycepin in the AST2017-01 are approximately 0.13% and 0.028%, respectively. In conclusion, these results indicate that chrysophanol and cordycepin were validated as marker compounds in the AST2017-01.

RADIOLOGICAL STUDY OF THE CONDYLAR HEADS IN TEMPOROMANDIBULAR JOINT ARTHROSIS (악관절증에서의 하악과두의 방사선학적 소견)

  • You Dong Soo
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.15 no.1
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    • pp.13-20
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    • 1985
  • The author obtained the oblique lateral trans cranial radiograms from 376 patients (114 of male, and 262 of female) with temporomandibular joint arthrosis. After tracing each film, the author analyzed the dimensional changes of the condylar heads with pain, clicking, mouth opening limitation, and masticatory difficulty respectively, which were the chief complaints of the TMJ arthrosis and compared these data with control group. The results were as follows; 1. There was a great predilection for occurrence of the TMJ arthrosis in female (262 cases) over male (114 cases). But there was no significant difference in ratio between the sexes on each symptom. In male, 60 patients (52.6%) had pain, 28 patients (24.6%) had clicking, 21 patients (18.4%) had mouth opening limitation, and 5 patients (4.4%) had masticatory difficulty. In female, 148 parients (56.5%) had pain, 57 patients (21.8%) had clicking, 47 patients (17.9%) had mouth opening limitation, and 10 patients (3.8%) had masticatory difficulty. 2. Examined controlled group, the author analyzed the dimension of W-W', 0-H, 0-A, 0-B on the right side first, and left side second. In male, the dimension of W-W' was 14.52㎜, 14.13㎜; 0-H was 13.92㎜, 13. 71㎜' 0-A was 8.91㎜, 9.0㎜ and 0-B was 8.67㎜, 8.78㎜. In female, W-W' was 13.77㎜, 13.51㎜; 0-H was 13.42㎜, 13.35㎜; 0-A was 8.92㎜, 9.01㎜; and 0-B was 8.59㎜, 8.80㎜. 3. W-W' and 0-H of the experimental group were distinctly lesser than the controlled group. Male with mouth opening limitation show the least (12.70㎜, 13.00㎜) on W-W', but both sexes with pain show the least on 0-H. There was no significant difference between experimental group with Clicking and controlled group on 0-H, 0-A, and 0-B. And also there was no difference on 0-B in patients with every symptom except masticatory difficulty. The dimensional changes of the condylar heads with those symptoms were as follows; a) In male patients, complaing of pain, W-W' of the right and left was 13.80㎜, 12.80㎜; 0-H was 13.10㎜, 12.90㎜; 0-A was 8.69㎜, 8.18㎜; 0-B was 8.33㎜, 8.42㎜. In female, W-W' was 13.01㎜, 12.90㎜; 0-H was 12.48㎜, 12.80㎜; 0-A was 8.60㎜, 8.49㎜; 0-B was 8.48㎜, 8.50㎜. b) In male patients with clicking, W-W' was 13.70㎜, 13.10㎜; 0-H was 13.90㎜, 13.10㎜; 0-A was 8.81㎜, 8.16㎜ 0-B was 8.34㎜, 8.25㎜. In female, W-W' was 13.10㎜, 13.50㎜; 0-H was 13.30㎜, 12.91㎜; 0-A was 8.95㎜, 8.49㎜; 0-B was 8.23㎜, 8.70㎜. c) In male patients with mouth opening limitation, W-W' was 12.70㎜, 13.00㎜; 0-H was 13.40㎜, 13.40㎜; 0-A was 8.37㎜, 8.48㎜; 0-B was 8.33㎜, 8.62㎜. In female, W-W' was 13.00㎜, 12.50㎜ 0-H was 12.90㎜, 13.10㎜; 0-A was 8.49㎜, 8.09㎜; 0-B was 8.77㎜, 8.01㎜. d) In male patients with masticatory difficulty, W-W' was 13.30㎜, 13.20㎜; 0-H was 13.40㎜, 12.60㎜; 0-A was 8.26㎜, 8.32㎜; 0-B was 7.80㎜, 8.20㎜. In female, W-W' was 12.30㎜, 12.00㎜; 0-H was 13.10㎜, 13.20㎜; 0-A was 8.68㎜, 7.95㎜; 0-B was 7.46㎜, 7.87㎜.

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Comparison of physical fitness according to body mass index of Chinese college students (중국 대학생의 체질량지수에 따른 체력 비교)

  • Chen, Fu;Kim, Jung-Hyun;Kim, Ok-ja
    • Journal of Korean Physical Therapy Science
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    • v.28 no.3
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    • pp.53-65
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    • 2021
  • Background: The purpose of this study was to a comparison of physical fitness according to the body mass index (BMI) of Chinese college students. Design: Cross-sectional study. Methods: According to the BMI, the research objects are divided into four types: underweight, normal weight, overweight, and obesity. This research took 26,976 college students who participated in Jiujiang College. It examines BMI, 50m, vital capacity, standing long jump, sitting forward bend, sit-up (female), pull-up (male), 800m (female), 1000m (male) which is to research the correlation between different BMI and other indicators. Results: The physical qualities of students with normal weight are significantly better than those with other BMI groups. Pearson correlation analysis showed that male BMI was positively correlated with vital capacity (r=0.07, p<0.01), 50m (r=0.15, p<0.01) and 1000m (r=0.14, p<0.01), and negatively correlated with standing long jump (r=-0.12, p<0.01), sitting forward bend (r=-0.06, p<0.01) and pull-up (r=-0.13, p<0.01); Female BMI was positively correlated with vital capacity (r=0.03, p<0.01), 50m (r=0.21, p<0.01) and 800m (r=0.18, p<0.01), and negatively correlated with standing long jump (r=-0.07, p<0.01), sitting forward bend (r=-0.11, p<0.01) and sit-up (r=-0.10, p<0.01). Conclusion: Overweight and underweight will affect the physical quality of college students. Students should keep their BMI within the normal range for their health.

A study of postoperative pulmonary arterial pressure change in the acquired heart disease with pulmonary hypertension (폐동맥 고혈압을 동반한 후천성 심질환의 술후 폐동맥압의 변화에 대한 연구)

  • 류삼렬
    • Journal of Chest Surgery
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    • v.23 no.2
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    • pp.245-252
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    • 1990
  • To see the change of pulmonary arterial pressure after mitral valve replacement, postoperative cardiac catheterization and echocardiographies were performed in 12 patients of mitral valvular disease with pulmonary hypertension[systolic pulmonary arterial pressure>50 mm Hg]. The mean follow-up duration was 35.4[range: 15-47] months per patient. The following results were obtained. 1] Preoperative systolic pulmonary arterial pressure value of 66.17\ulcorner10.73mmHg decreased significantly to 29.17\ulcorner6.86mmHg postoperatively[p<0.01]. 2] Preoperative Pp/Ps value of 0.67\ulcorner0.13 decreased significantly to 0.28\ulcorner0.06 postoperatively[p<0.01]. 3] Preoperative PAWP value of 29.00\ulcorner4.02mmHg decreased significantly to 9.92\ulcorner4.27 mmHg postoperatively[p<0.01]. 4] Preoperative LAD value of 5.58\ulcorner1.20cm decreased significantly to 4.37\ulcorner0.67cm postoperatively [p<0.01]. In conclusion, pulmonary arterial hypertension secondary to mitral valvular disease could be reduced to normal range after successful mitral valve replacement.

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2002년도 축산물등급판정 결산

  • 박종운
    • KAPE Magazine
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    • no.77
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    • pp.4-9
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    • 2003
  • [ $\blacksquare$ ] 등급판정 현황 - 소도체는 사육두수의 감소로 인해 전년대비 13.3$\%$ 감소하였으나, 등급판정대상 두수 전량(100$\%$) 판정 - 돼지도체는 사육두수의 증가와 등급거래지역의 확대로 전년대비 8.4$\%$가 증가하였고, 도축두수대비 98$\%$ 판정 - 계란등급판정 시범사업은 집하장 3개소가 늘어나 모두 4개소에서 실시 $\blacksquare$ 고급육 출하 - 한우 1등급이상 : (`01) 29.9$\%$ $\rightarrow$ (`02) 35.2$\%$ (5.3$\%$포인트 증가) - 돼지 A$\cdot$B등급 : (`01) 67.3$\%$ $\rightarrow$ (`02) 68.5$\%$ (1.2$\%$포인트 증가) $\blacksquare$ 한우 성별 출하 - 암소 : (`01) 52.8$\%$ $\rightarrow$ (`02) 48.3$\%$ (4.5$\%$포인트 감소) - 거세율 : (`01) 20.6$\%$ $\rightarrow$ (`02) 38.2$\%$ (17.6$\%$포인트 증가)

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Organic Chemical Characteristics and Its Paleoceanographic Implications of the Holocene Sediments on the Continental Shelves Off the Southern Coast of Korea (남해 대륙붕 홀로세 퇴적물의 유기지화학적 특성과 고해양학적 의미)

  • Kong, Gee-Soo;Han, Hyun-Chul;Kim, Seong-Pil;Kim, Ji-Hun;Stott, Lowell
    • Economic and Environmental Geology
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    • v.42 no.2
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    • pp.107-120
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    • 2009
  • Spacial variation in organic components and temporal variation in the origin was examined through the organic geochemical (TC, TN, TS, $CaCO_3$, TOC, C/N, and $\delta^{13}C$) and pyrolysis analysis (HI, OI, and Tmax) in the core sediments which were acquired in the continental shelf of the South Sea close to Seomjin River. Levels of TC, TN, and TS show relatively low and constant in the core SJ03 located close to the Seomjin River mouth, while those are increased a little with being varied with low amplitude in the core SJ02 and SJ04 acquired at the middle of inner shelf area. They fluctuated with high amplitude in the core SJ01 and SJ05 near to the outer boundary of inner shelf. The vertical characteristics of organic components in the core SJ01 acquired at the outer boundary show that the area has undergone distinctly the environmental change at 9.0 kyr B.P. After 9.0 kyr B.P., Levels of TC, TOC, TN, $CaCO_3$, $\delta^{13}C$, HI, and Tmax are rapidly increased, while C/N and or are significantly decreased. Even though the contents of organic components are not high, such a changes reflect that the terrigenous organic matters were predominant before 9.0 kyr B.P due to the influence of Seomjin River, but after then, the marine organic matters have dominated due to the inflow of the Tshusima current.

Sleep Fragementation Decreases during the nCPAP Titration Night in Obstructive Sleep Apnea Syndrome (폐쇄성 수면무호흡증에서 지속적 상기도 양압술 압력 처방 검사 시 나타나는 수면분절의 감소)

  • Lee, Jin-Seong;Jeong, Do-Un
    • Sleep Medicine and Psychophysiology
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    • v.15 no.2
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    • pp.82-86
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    • 2008
  • Objectives: Obstructive sleep apnea syndrome (OSAS) not only causes respiratory disturbances during sleep but also decreases the quality of nocturnal sleep through sleep fragmentation and sleep structure change. We aimed at comparing the changes in sleep fragmentation and structure between baseline (diagnostic) nocturnal polysomnography (NPSG) and nCPAP (nasal continuous positive airway pressure) titration trial. Methods: One hundred and three patients with a baseline night of respiratory disturbance index (RDI) of 5 or greater and reduced RDI score during nCPAP titration night were retrospectively selected for the study. Sleep fragementation and sleep structure between baseline NPSG and the NPSG during nCPAP titration were compared. Sleep fragmentation index (SFI) was defined as the total number of awakenings and shifts to stage 1 sleep divided by the total sleep time in hour. SFI and other polysomnographic parameters were statistically compared between the two nights. Results: SFI during baseline NPSG and nCPAP titration nights were $29.0{\pm}13.8$ and $15.2{\pm}8.8$, respectively, indicating a significant SFI decrease during nCPAP titration (t=9.7, p<0.01). SFI showed significant negative correlations with sleep efficiency (r=-0.60, p<0.01) and total sleep time (r=-0.45, p<0.01) and a positive correlation with RDI (r=0.28, p<0.01). Conclusion: Use of nCPAP, even during the titration, significantly decreases sleep fragmentation and improves sleep structure in OSAS patients. We suggest that SFI may be utilized as a measure of assessing OSAS severity and nCPAP efficacy.

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A Study on the Oral Health Care and Oral Health Awareness of Some Laborers (일부 근로자들의 구강건강관리행태 및 인식 조사)

  • Hong, Min-hee;Kim, Yoon-shin;Jeong, Mi-Ae
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.10 no.9
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    • pp.2545-2550
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    • 2009
  • The purpose of this study was to examine the oral health care and oral health awareness of some laborers. Out of them, 220 workers were selected from K motor company in Hwaseong, and the other 180 workers were selected from D automobile company in Bupyeong. The findings of the study were as follows: As for daily toothbrushing frequency, the largest number of the laborers investigated(44.0%) brushed their teeth three times a day. Smoking made a significant difference to that($x^2$=19.00, p<.01). Concerning the use of oral hygiene supplies, 41.3 percent put oral hygiene supplies to use. There was a significant difference in that aspect according to gender($x^2$=9.20, p<.01). Regarding scaling experience, the largest group(37.3%) had their teeth scaled twice or more, and their scaling experience significantly varied with gender($x^2$=8.60, p<.05), age($x^2$=20.07, p<.01), academic credential($x^2$=11.88, p<.01) and the presence or absence of systemic diseases($x^2$=8.19, p<.05). In relation to oral diseases, the greatest group(27.8%) had dental caries. By gender, the female workers had more dental caries or the more swollen gums than the males, and the gap between the two was significant($x^2$=13.65, p<.05).

Correlations Among Objective Measurements of Spasticity in Patients With Brain Lesions

  • Kim, Yong-Wook
    • Physical Therapy Korea
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    • v.14 no.4
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    • pp.7-13
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    • 2007
  • The purpose of this study was to investigate correlations among objective measurements of spasticity in patients with brain lesions. Thirty-two stroke and traumatic brain injury subjects participated in the study. Spasticity was quantified using the knee first flexion angle, relaxation index obtained from a pendulum drop test, and the amplitude of a knee tendon reflex test. Pearson's product correlation coefficient was used to examine relationships among these measurements of spasticity. There was a significant positive correlation between the relaxation index and knee first flexion angle in patients with brain lesions (r=.895, p<.01). There was also significant negative correlation between the amplitude of knee tendon reflex and relaxation index (r=-.612, p<.01), and between amplitude and knee first flexion angle (r=-.537, p<.01). Thus, it is possible to use the knee first flexion angle as an objective measure of spasticity, rather than relaxation index, which is more complicated to obtain. Further studies are needed to explore the effects of functional improvement and long-lasting carryover effects of spasticity using a simple objective measure such as the knee first flexion angle from a pendulum test.

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