• The Korean Journal of Emergency Medical Services
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• v.27 no.3
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• pp.59-70
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• 2023

Purpose: This study attempted to provide basic data to improve the maturation of career attitudes of emergency medical services students by identifying the effects of clinical practice satisfaction and career undecided level on the maturation of career attitudes of emergency medical services students who had experienced clinical practice. Methods: From May 1 to July 31, 2023, data were collected using a structured questionnaire from third and fourth year students who were enrolled in the department of paramedicine a university in City D and had experienced clinical practice. Results: The results showed that clinical practice satisfaction was significantly positively correlated with career attitude maturity (r=.382, p<.001) and negatively correlated with career indecision (r=.241, p=.002). The influencing factor of career attitude maturity was clinical practice satisfaction (β=.314, p<.001), with an explanatory power of 16%. Conclusion: It was confirmed that the influencing factor of career attitude maturity was clinical practice satisfaction, and the need to find ways to improve clinical practice satisfaction and develop customized education and practice programs for each institution to improve career attitude maturity of emergency rescue students was confirmed. Therefore, it is necessary to find specific ways to improve clinical practice satisfaction and develop customized educational practice programs for each institution.

• Journal of the Korea Society of Computer and Information
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• v.28 no.10
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• pp.103-111
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• 2023

Mountains area, especially walking in open space is important for special active field which is based on mountain terrain. Recent research on pedestrian-path includes elements about pedestrian and various environment by analyzing network, but it is mainly focusing on limited space except for data-poor terrain like a mountain terrain. This paper proposes an architecture to generate walking path considering the slope for mountain terrain open space through virtual network made of mesh. This architecture shows that it reflects real terrain more effective when measuring distance using slope and is possible to generate mountain walking path using open space unlike other existing services, and is verified through the test. The proposed architecture is expected to utilize for pedestrian-path generation way considering mountain terrain open space in case of distress, mountain rescue and tactical training and so on.

• Journal of Aerospace System Engineering
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• v.17 no.6
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• pp.9-15
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• 2023

In order to effectively prevent and respond to disasters, several techniques have been developed in which the pilot wearing a see-through Head Mounted Display (HMD) performs disaster-related rescue activities using images transmitted from an Unmanned Aerial Vehicle (UAV). However, these techniques have limitations in quickly determining and executing tasks appropriate to the on-site situation because the pilot cannot recognize the entire field in an integrated manner. In order to overcome these problems, we propose an AR based-interface technique that allows the rescuer wearing a see-through HMD to operate a UAV efficiently. Simulation results show that the proposed interface technique allows the rescuer wearing a see-through HMD to control the gimbal and flight of the UAV at a high speed based on finger gestures in a visibility situation.

• Journal of Ecology and Environment
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• v.47 no.3
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• pp.146-156
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• 2023

Background: Endemic species are important components in the flora of most world regions. Most of these species have become threatened and exposed to extinction within the last few years. The present study aims to evaluate the ecosystem services offered by the endemic plant taxa in Egypt and the threats that affect them. Twenty-five field visits were conducted during summer 2018 to spring 2022 to several locations all over Egypt. In each location, the main habitats, national distribution, abundance, goods and threats were recorded. Results: Egypt has 41 endemic taxa belonging to 36 genera and 20 families inhabiting 10 main habitats. Rocky surfaces and sandy formations have the highest number of endemic species. The relation between the number of endemic taxa and the abundance categories indicated that 2 taxa are rare (4.9% of the total taxa), while the remaining were very rare (95%). The most represented offered good was the medicinal uses (32 taxa = 78%), while fuel plants were only represented by 2 taxa (2 taxa = 4.9%). Besides, 14 taxa (34.1% of the total studied taxa) have at least 1 environmental service. Soil fertility (7 taxa = 50%) was the most represented, followed by sand accumulations (6 taxa out of 14 taxa = 43%), while shading plant was the least (1 taxon = 7.1%) (Rosa arabica). The most represented threat is over-cutting and over-collecting (38 taxa = 92.7%), while mining and quarrying is the least represented (4 taxa = 9.8%). Conclusions: The potential and actual goods, services and threats of the endemic taxa were assessed as follows; field observation, information collected from local inhabitants and herbalists, and a literature review. The present study recommended planning a strategy about the importance, threats and conservation of endemic taxa in Egypt that would help in the protection and rescue of these plants and increase awareness about the importance of these plants.

• Journal of the Korea Society of Computer and Information
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• v.29 no.1
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• pp.211-218
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• 2024

This study attempted to derive a new policy paradigm of life-span sport of disabled children. For that purpose, collecting and analyzing related preceding researches and literatures from 2008 to present (2022), this study firstly found out past life-span sport policy paradigms for disabled children and the causes of their changes, and secondly found out social problems which present policies could not deal with. Through those study process, this study suggested life-span sport in response to the demands and needs of children with disabilities which could include life-span sport centered on disabled children, life-span sport with family members, the realization of the essential value of life-span sport for the human rights of children with disabilities, and the development of new methodologies using smart technologies.

• Journal of the Korea Society of Computer and Information
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• v.29 no.1
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• pp.219-229
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• 2024

This study attempted to analyze the possibility of sports cooperatives for the disabled as a way to improve sports welfare and revitalize sports for the disabled. For this purpose, investigating the possibility as a review of the literature and a survey of 25 sports instructors for the disabled and 20 operators of cooperatives for the disabled, The results of analyzing the possibility with Excel and SPSS V26 programs were verified by the advisory committee to confirm the validity of the following conclusions. First, it found out the recognition, advantage, possibility of development about disabled sports cooperatives disabled sports, instructors' economic factors, social and environmental factors and institutional factors. Second, obvious planning, continuous business model, unity of members and professionalism of operators are important. If you know well about disabled, It will be possible to improve sports welfare and revitalize sports for the disabled through sports cooperatives for the disabled.

• Journal of Ginseng Research
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• v.48 no.2
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• pp.220-228
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• 2024

Background: Panax ginseng, one of the valuable perennial medicinal plants, stores numerous pharmacological substrates in its storage roots. Given its perennial growth habit, organ regeneration occurs each year, and cambium stem cell activity is necessary for secondary growth and storage root formation. Cytokinin (CK) is a phytohormone involved in the maintenance of meristematic cells for the development of storage organs; however, its physiological role in storage-root secondary growth remains unknown. Methods: Exogenous CK was repeatedly applied to P. ginseng, and morphological and histological changes were observed. RNA-seq analysis was used to elucidate the transcriptional network of CK that regulates P. ginseng growth and development. The HISTIDINE KINASE 3 (PgHK3) and RESPONSE REGULATOR 2 (PgRR2) genes were cloned in P. ginseng and functionally analyzed in Arabidopsis as a two-component system involved in CK signaling. Results: Phenotypic and histological analyses showed that CK increased cambium activity and dormant axillary bud formation in P. ginseng, thus promoting storage-root secondary growth and bud formation. The evolutionarily conserved two-component signaling pathways in P. ginseng were sufficient to restore CK signaling in the Arabidopsis ahk2/3 double mutant and rescue its growth defects. Finally, RNA-seq analysis of CK-treated P. ginseng roots revealed that plant-type cell wall biogenesis-related genes are tightly connected with mitotic cell division, cytokinesis, and auxin signaling to regulate CK-mediated P. ginseng development. Conclusion: Overall, we identified the CK signaling-related two-component systems and their physiological role in P. ginseng. This scientific information has the potential to significantly improve the field-cultivation and biotechnology-based breeding of ginseng.

• IMMUNE NETWORK
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• v.20 no.3
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• pp.26.1-26.9
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• 2020

Cereblon (CRBN), a negative modulator of AMP-activated protein kinase (AMPK), is highly expressed in the retina. We confirmed the expression of CRBN in ARPE-19 human retinal cells by Western blotting. We also demonstrated that CRBN knock-down (KD) could effectively downregulate IL-6 and MCP-1 protein and gene expression in LPS-stimulated ARPE-19 cells. Additionally, CRBN KD increased the phosphorylation of AMPK/acetylcoenzyme A carboxylase (ACC) and the expression of heme oxygenase-1 (HO-1) in ARPE-19 cells. Furthermore, CRBN KD significantly reduced LPS-induced nuclear translocation of NF-κB p65 and activation of NF-κB promoter activity. However, these processes could be inactivated by compound C (inhibitor of AMPK) and zinc protoporphyrin-1 (ZnPP-1; inhibitor of HO-1). In conclusion, compound C and ZnPP-1 can rescue LPS-induced levels of proinflammatory cytokines (IL-6 and MCP-1) in CRBN KD ARPE-19 cells. Our data demonstrate that CRBN deficiency negatively regulates proinflammatory cytokines via the activation of AMPK/HO-1 in the retina.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.1
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• pp.21-30
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• 2024

The challenging clinical outcomes associated with advanced cervical cancer underscore the need for a novel therapeutic approach. Monensin, a polyether antibiotic, has recently emerged as a promising candidate with anti-cancer properties. In line with these ongoing efforts, our study presents compelling evidence of monensin's potent efficacy in cervical cancer. Monensin exerts a pronounced inhibitory impact on proliferation and anchorage-independent growth. Additionally, monensin significantly inhibited cervical cancer growth in vivo without causing any discernible toxicity in mice. Mechanism studies show that monensin's anti-cervical cancer activity can be attributed to its capacity to inhibit the Wnt/β-catenin pathway, rather than inducing oxidative stress. Monensin effectively reduces both the levels and activity of β-catenin, and we identify Akt, rather than CK1, as the key player involved in monensin-mediated Wnt/β-catenin inhibition. Rescue studies using Wnt activator and β-catenin-overexpressing cells confirmed that β-catenin inhibition is the mechanism of monensin's action. As expected, cervical cancer cells exhibiting heightened Wnt/β-catenin activity display increased sensitivity to monensin treatment. In conclusion, our findings provide pre-clinical evidence that supports further exploration of monensin's potential for repurposing in cervical cancer therapy, particularly for patients exhibiting aberrant Wnt/β-catenin activation.

• Journal of Preventive Medicine and Public Health
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• v.57 no.1
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• pp.83-90
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• 2024

Objectives: Professional firefighters face various health hazards and are required to maintain both physical and mental fitness to effectively mitigate crises and respond to emergencies. Moreover, the long working hours and shift work of this profession impact sleep quality. This study investigated the quality of sleep and its associated factors among firefighters in Bangkok, Thailand. Methods: This was a cross-sectional study of firefighters affiliated with the Bangkok Fire and Rescue Department, Bangkok Metropolitan Administration, Thailand between January 2023 and March 2023. A cluster random sampling technique was utilized to distribute 600 questionnaires to firefighters in 15 fire stations. The questionnaire addressed demographic, work-related, and environmental factors. Sleep quality was assessed using the Thai version of the Pittsburgh Sleep Quality Index (PSQI). Data analysis involved both descriptive and inferential statistics. Bivariate and multiple logistic regressions were performed. Results: The response rate was 78.7% (n=472), and 44.1% of the firefighters reported poor sleep quality (PSQI score >5). Sleep quality was statistically associated with conflicting family relationships (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1 to 2.9), additional part-time jobs (daytime, OR, 2.4; 95% CI, 1.3 to 4.4; or nighttime, OR, 4.3; 95% CI, 1.1 to 16.7), noisy sleeping areas (OR, 1.7; 95% CI, 1.1 to 2.8), and the availability of adequate bedding (OR, 3.0; 95% CI, 1.8 to 4.9). Conclusions: Poor sleep quality among firefighters was associated with various personal, work-related, and environmental factors. Organizations should promote policies that improve sleep quality through good sleep hygiene practices and facilities.