• 한국안전학회지
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• 제34권5호
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• pp.15-21
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• 2019

A rack-type warehouse has the advantage of storing a large amount in a small area by loading goods vertically. But in terms of fire risk, the fire load is very high, which can cause massive damage in the event of a fire. In the United States, research has been actively conducted to minimize the spread of vertical fires, and relevant standards have been established and operated. In Korea, research and related standards are insufficient to prevent the vertical spread of rack-type warehouse fires. In this study, an experimental study was conducted to prevent the vertical spread of a rack-type warehouse fire using a horizontal barrier and in-rack sprinklers. As a result of the test, the horizontal barrier considering the continuous flame prevented the vertical spread of the flame for a certain time. However, the horizontal barrier with continuous flame did not show the effect of preventing continuous flame. The combination of the horizontal barrier and the in-rack sprinkler prevented the vertical spread of fire effectively. In addition, the heat collecting effect through the horizontal barrier was shown and helped the early operation of the in-rack sprinklers.

• Journal of Veterinary Science
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• 제22권4호
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• pp.52.1-52.8
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• 2021

Background: The normal vertebral anatomy of Korean raccoon dogs and their variants require research attention as a prerequisite for identifying pathologies and anomalies. Objectives: This retrospective study aimed at describing the vertebral formula and congenital vertebral anomalies in Korean raccoon dogs (Nyctereutes procyonoides koreensis). Methods: Radiographs of 82 raccoon dogs (42 males, 40 females) acquired from May 2013 to June 2020 in the Gangwon Wildlife Medical Rescue Center were reviewed to evaluate the cervical, thoracic, and lumbar vertebrae of the spine. Results: Normal morphology of all vertebrae was observed in 50 of the 82 raccoon dogs, and the vertebral formula was cervical 7, thoracic 13, and lumbar 7. Congenital vertebral anomalies were found in 32 raccoon dogs: transitional vertebrae (TV) in 31 and block vertebrae in 2. Two raccoon dogs had 2 types of vertebral anomalies: one had TV and block vertebra, and the other had 2 types of TV. Twenty-nine raccoon dogs had thoracolumbar TV (TTV) and 3 had lumbosacral TV. TTV was morphologically classified into 4 different types: unilateral extra-rib in 5 raccoon dogs, bilateral extra-ribs in 14, bilateral elongated transverse processes in 4, and an asymmetric mixed formation of extra-rib with elongated transverse process in 6. Conclusions: This study showed that TTV is common in Korean raccoon dogs, and that the vertebral formula is relatively diverse. The bilateral extra-ribs type TTV is the most common variant, which is almost similar to normal rib to be confused the radiographic evaluation.

• Journal of Microbiology and Biotechnology
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• 제31권10호
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• pp.1358-1365
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• 2021

To clarify the role of long intergenic nonprotein-coding RNA 1232 (LINC01232) in the progression of gastric cancer and the potential mechanism, we analyzed the expression of LINC01232 in TCGA database using the GEPIA online tool, and the LINC01232 level in gastric cancer cell lines was detected by quantitative real time-polymerase chain reaction (qRT-PCR) as well. Cell proliferation assay, colony formation assay, transwell assay and tumor formation experiment in nude mice were conducted to observe the biological behavior changes of gastric cancer cells through the influence of LINC01232 knockdown. LncATLAS database and subcellular isolation assay were used for subcellular distribution of LINC01232 in gastric cancer cells. The interaction among LINC01232, zeste homolog 2 (EZH2) and kruppel-like factor 2 (KLF2) was clarified by RNA-protein interaction prediction (RPISeq), RNA immunoprecipitation (RIP), qRT-PCR and chromatin immunoprecipitation (ChIP) assay. Rescue experiments were further conducted to elucidate the biological function of LINC01232/KLF2 axis in the progression of gastric cancer. LINC01232 was upregulated in stomach adenocarcinoma (STAD) tissues and gastric cancer lines. LINC01232 knockdown inhibited the proliferative capacities of gastric cancer cells in vitro, and impaired in vivo tumorigenicity. LINC01232 was mainly distributed in the cell nucleus where it epigenetically repressed KLF2 expression via binding to the enhancer of EZH2, which was capable of binding to promoter regions of KLF2 to induce histone H3 lysine 27 trimethylation (H3K27me3). LINC01232 exerts oncogenic activities in gastric cancer via inhibition of KLF2, and therefore, the knockdown of KLF2 could reverse the regulatory effect of LINC01232 in the proliferative ability of gastric cancer cells.

• 한국의류산업학회지
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• 제23권4호
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• pp.515-526
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• 2021

This study aimed to investigate the evaluation of firefighting gloves and the behavior regarding their usage, of firefighting officials in Seoul, using a questionnaire. Responses from a total of 270 firefighters who are responsible for putting out fires or undertaking rescue works in Seoul were analyzed. As per the findings, the firefighters considered ease of hand operation and fire/flame protection as the most important performance factors for firefighting gloves, and they were satisfied with the supply status of the gloves. The average number of firefighting gloves currently owned by the firefighters was 2.6 ± 0.8 pairs. Thirty-nine percent of the respondents said that their firefighting gloves lasted, with maintained performance, for more than six months and less than a year, and when asked how they handled the gloves with degraded performance, 46% of them said that they would discard them. Sixty-eight percent of the respondents said that they used the most recently developed and supplied gloves, which they considered as the most satisfying gloves and which they mainly used these days. Respondents were highly satisfied with the fire/flame protection performance of their firefighting gloves, but were less satisfied, however, with the glove fit. These results suggest that there has been a significant improvement in the overall performance level and supply status of the firefighting gloves. Given the current situation, careful considerations with flexible approaches are needed on the current firefighting gloves size system as well as on the personal protective equipment maintenance and management scheme.

• 한국융합학회논문지
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• 제12권9호
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• pp.179-183
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• 2021

본 연구는 다양한 항암성분을 함유한 Celeriac Extract의 암세포 증식에 미치는 영향을 살펴보기 위하여 실시되었다. 실험에 사용한 암 세포주는 5종으로 폐암세포 A549, 전립샘암세포 DU-145, 자궁암세포 HeLa, 유방암세포 MCF-7, 간암세포 SNU-182 로 모두 인체 유래 암 세포주를 사용하였으며 Celeriac Extract 10ug/mL, 100ug/mL, 1000ug/mL 에 대한 암세포의 증식 억제는 CCK-8 방법을 이용하여 측정하였다. 암세포 증식 억제를 살펴본 결과 Celeriac Extract 1000ug/mL는 폐암세포 A549, 전립샘암세포 DU-145, 자궁암세포 HeLa, 간암세포 SNU-182에서 유의한 증식 억제를 보였으며 농도 의존성을 나타냈다. 그러나 유방암세포 MCF-7 에서는 농도 의존적인 감소만 보였다. 결론적으로, 다양한 인간유래 암 세포주를 이용한 Celeriac Extract의 세포 증식 억제기전들은 암 예방효과 및 치료제 개발의 잠재력을 제공한다고 볼 수 있다.

• Journal of Veterinary Science
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• 제22권6호
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• pp.78.1-78.10
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• 2021

Background: Recurrent subclinical mastitis (RScM) due to resistant bacteria has low clinical and bacteriological cure rates, often requiring the culling of cows. The sequential intramammary administration of enrofloxacin hydrochloride-dihydrate (enro-C) followed by ceftiofur HCl may be useful for treating these cases. Objectives: This study assessed the bacteriological and clinical cure-efficacies of the sequentially intramammary administration of enro-C, followed by ceftiofur HCl to treat RScM in Holstein/Friesian cows. Methods: This trial was conducted in a herd with a high prevalence of RScM, and 20 Holstein/Friesian cows were included: 45% suffering subclinical mastitis and 38.9% of the mammary quarters affected. Twenty-nine bacterial isolates in vitro resistant to enro-C were obtained (coagulase-negative Staphylococcus spp, 55.2%; Staphylococcus aureus, 27.6%; Escherichia coli, 6.9%; Streptococcus uberis, 6.9%; Corynebacterium bovis, 3.4%). Polymerase chain reaction-isolated the following genes linked to enro-C resistance: chromosomal (gyrA) and plasmid (aac(6')-lb-cr). The treatments were as follows: twice-daily intramammary infusions of enro-C (300 mg/10 mL) for 5 days. Cows clinically considered treatment failures were also treated with intramammary ceftiofur (125 mg/10 mL, twice daily for 5 days. The clinical and bacteriological cure rates were carried out when completing each treatment phase and at 14 and 21 days, aided by a California mastitis test, somatic cell count, and failure to identify the initially causative bacteria. Results: Enro-C achieved 65% clinical and bacteriological cure rates, and 100% cure rates were obtained after the rescue treatment with ceftiofur HCl. Conclusions: Outstanding clinical and bacteriological cure rates in cows affected by RScM were achieved with the consecutive intramammary infusions of enro-C, followed by ceftiofur HCl.

• 한국응급구조학회지
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• 제25권3호
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• pp.145-162
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• 2021

Purpose: The 2018 General survey of emergency assistance was conducted to examine the working conditions and welfare, including educational direction, interests, and awareness of work, of the fire department emergency medical technicians (EMT). This would be used as basic data for future policy directions. Methods: Among the fire-fighting officers in 16 cities nationwide, emergency rescue workers engaged in first-aid activities were targeted. With prior consent, a survey was conducted through electronic documents. Of the total 1,227 people, responses from 1,151 were finally analyzed, excluding 76 who did not respond appropriately. Results: The working conditions and welfare of 119 firefighters were moderate, but in the fields of education and interest, the learning according to the regulations was high. In particular, satisfaction with the scope of work was found to be below average. However, it was positive that it will play a role as a social safety net in the future and will converge with cutting-edge science. Conclusion: Although this study was a total investigation of the EMT survey, conducting an EMT survey on all fire fighters in Korea is difficult. Further research is needed, particularly on first-class emergency medical personnel who play a major role in 119 paramedics.

• Journal of Korean Neurosurgical Society
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• 제62권2호
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• pp.243-255
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• 2019

Objective : Although traumatic brain injury (TBI) occurs in people of all age groups, the elderly population is at a particular risk. The proportion of elderly population in the society is markedly increasing and Korea is one of the most rapidly aging societies. Here, we analyzed the data from 904 patients older over 65 years who were registered in the Korean Neuro-Trauma Data Bank System (KNTDBS). Methods : The Korean Society of Neurotraumatology recorded data from 20 institutions between September 2010 and March 2014. This retrospective study examined the clinical epidemiology, sex difference, outcome epidemiology, sociodemographic variables, and outcomes in the geriatric population related to TBI based on data from the KNTDBS. Results : The study included 540 men and 364 women. The age distributions in the male and female groups were statistically significantly different. The most common cause of trauma was a fall and diagnosis was acute subdural hematoma. The incidence was the highest in men aged 80-84 years and in women aged 75-79 years. The most common time of arrival to hospital after TBI was within 1 hour and 119 rescue team provided first aid earliest to patients with TBI. The mortality rate stratified according to the cause of trauma was significantly different, with mortality rates of 3.77% in fall and 11.65% in traffic accident. The mortality rates according the severity of brain injury, Glasgow Coma Scale score, and treatment were statistically significant. Conclusion : To our knowledge, this study is the first to focus on elderly patients with TBI in Korea and particularly investigate mortality and characteristics related to TBI-related death based on data from the KNTDBS. Although the study has some limitations, our results may be used to obtain useful information to study targeted prevention and more effective treatment options for older TBI patients and establish novel treatment guidelines and health polish for the geriatric population.

• 한국전자통신학회논문지
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• 제13권6호
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• pp.1365-1372
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• 2018

최근 농업 사회의 고령화로 인해 농기계로 인한 안전사고가 급증하고 있다. 어떤 경우에는 부상자가 사고를 주위에 알리지 못한 채 홀로 방치되어 심각한 상황에 이를 수 있다. 경운기, 이앙기, 트랙터, 콤바인 등 농기계를 대상으로 작업 및 이동 중에 전복, 충돌, 기타 사고 등의 안전사고 발생 시 ICT 기술을 이용하여 신속하게 사고 상황을 외부에서 감지하고 전달함으로써 인명 피해를 최소화 할 수 있는 시스템이 요구되고 있다. 본 연구에서는 농기계의 충돌 및 전복 사고를 감지하고, 위험상황을 전송하는 ICT 기반의 농기계 안전사고 자동상황전파시스템을 제안한다. 제안된 시스템은 농기계 사고 발생 시 자동으로 가족, 지인, 병원 및 119로 문자 메시지를 보냄으로써 빠른 사후 조치를 통한 인명구조를 가능하게 한다.

• 디지털융복합연구
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• 제17권2호
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• pp.447-451
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• 2019

본 연구는 건강식품으로 많이 사용되는 32종의 약용식물에 대한 헬리코박터 파이로리 항균효과를 살펴보기 위해서 디자인되었다. 연구에 사용된 약용식물은 모든 사람들이 매일 먹을 수 있는 것으로 H.pylori 활성에 대한 디스크 확산법을 이용하여 32종의 약용식물 추출물을 사용하였고 Amoxicillin sodium (150mg/ml,일동제약)과 메트로니다졸 (Metronidazol, 50mg/ml)을 대조군으로 사용하였다. 투명한 영역의 면적을 측정하고 그 면적이 더 큰 크기가 H. pylori에 많은 효과가 있다고 평가했다. 이 연구의 결과, 고련피 억제 값은 $372.90mm^2$로 가장 높았고, 둘째, 오배자 $358.30mm^2$, 그리고 청호 $348.32mm^2$이었다. 양성 대조군인 Metronidazole (50mg / ml CJ) 값은 $503,29mm^2$이었다. 향후 H. pylori 억제를 위해 다양한 약용식물의 항균소재개발이 가치가 있을 것으로 사료된다.