Journal of Digital Convergence (디지털융복합연구)

The Society of Digital Policy and Management (한국디지털정책학회)
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Antibacterial effect of medicinal plants against Helicobacter pylori

헬리코박터 파이로리균에 대한 약용식물의 항균 효과

  • Received : 2018.12.27
  • Accepted : 2019.02.20
  • Published : 2019.02.28
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Abstract

The study was designed to investigate the antibacterial effect of Helicobacter pylori against 32 medicinal plants commonly used as health foods. The medicinal plants used in this study were 32 kinds of medicinal plant extracts using the disk diffusion method for H. pylori activity, which can be eaten every day by everyone. Amoxicillin sodium (150 mg / ml, Ildong Pharmaceutical) and Metronidazole 50 mg / ml) was used as a control group. We measured the area of the transparent area and evaluated that the larger the area, the more effective it is for H. pylori. As a result of this study, the clear zone of inhibition was highest at $372.90mm^2$, second was $358.30mm^2$, and Chungho was $348.32mm^2$. The positive control group, Metronidazole (50 mg / ml CJ), was $503,29mm^2$. In the future, the development of antimicrobial materials of various medicinal plants is expected to be effective for the inhibition of H. pylori.

본 연구는 건강식품으로 많이 사용되는 32종의 약용식물에 대한 헬리코박터 파이로리 항균효과를 살펴보기 위해서 디자인되었다. 연구에 사용된 약용식물은 모든 사람들이 매일 먹을 수 있는 것으로 H.pylori 활성에 대한 디스크 확산법을 이용하여 32종의 약용식물 추출물을 사용하였고 Amoxicillin sodium (150mg/ml,일동제약)과 메트로니다졸 (Metronidazol, 50mg/ml)을 대조군으로 사용하였다. 투명한 영역의 면적을 측정하고 그 면적이 더 큰 크기가 H. pylori에 많은 효과가 있다고 평가했다. 이 연구의 결과, 고련피 억제 값은 $372.90mm^2$로 가장 높았고, 둘째, 오배자 $358.30mm^2$, 그리고 청호 $348.32mm^2$이었다. 양성 대조군인 Metronidazole (50mg / ml CJ) 값은 $503,29mm^2$이었다. 향후 H. pylori 억제를 위해 다양한 약용식물의 항균소재개발이 가치가 있을 것으로 사료된다.

Keywords

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Fig. 1. Antibacterial effect of 32 medicinal plantsextracts as clear zone of inhibition (mm2)against H. pylori by paper disk diffusionmethods for 48h.

DJTJBT_2019_v17n2_447_f0002.png 이미지

Fig. 2. Antibacterial effect of 32 Antibiotics as clear zone of inhibition (mm2) against H. pylori by paper disk diffusion methods for 48h.

Table 1. Antibacterial effect of 32 medicinal plants extracts as clear zone of inhibition (mm2) against H. pylori by paper disk diffusion methods for 48h

DJTJBT_2019_v17n2_447_t0001.png 이미지

Table 2. Antibacterial effect of Antibiotics as clear zone of inhibition (mm2) against H. pylori by paper disk diffusion methods for 48h.

DJTJBT_2019_v17n2_447_t0002.png 이미지

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