• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1995.04a
• /
• pp.112-112
• /
• 1995

간장 손상시에는 여러 혈청의 효소 활성과 함께 혈청 $\beta$-glucuronidase의 활성도 증가한다는 것이 보고되었으나 심한 간부전이나 간암의 경우 이들의 활성은 오히려 정상치보다 감소하는 것으로 나타났다. Silymarin은 간장 보호효과로 이미 임상에 널리 사용되고 있는 약물로서 김 등에 의해 silymarin이 장내세균의 $\beta$-glucuronidase와 간장의 $\beta$-glucuronidase의 활성을 억제한다는 것이 보고되었다. 이에 연자 둥은 $\beta$-glucuronidase의 저해 효과가 관찰된 영지버섯온 유기용매로 분획하여 간장 보호효과를 검색하였다. 영지버섯의 70% MeOH 추출물(GT)과 그 ether 분획(GE)에 대해 생쥐 1군을 6마리로 하여 20% $CCl_4$0.1$m\ell$/10g(olive oil로 희석)을 경구투여 하였다. 검액 GE는 50mg/kg과 250mg/kg, GT는 100mg/kg과 500mg/kg을 각각 사염화탄소 투여 30분 전에 경구투여 하였으며 사염화탄소를 투여하고 24시간 후에 심장 채혈하고 혈청을 분리하여 혈청성분 및 혈청효소의 활성을 측정하였다. 대조군에는 생리식염수를 투여하였고 양성 비교약물로는 silymarln 100mg/kg을 경구투여 하여 비교 관찰하였다. 실험 결과, 영지버섯의 ether 분획에서는 혈청중 GOT, GPT의 활성과 triglyceride의 함량에 대해 silymarin보다 우수한 효과를 보였으며, 70% MeOH 추출물은 silymarin에 미치지 못했다.

• Composites Research
• /
• v.16 no.2
• /
• pp.18-25
• /
• 2003

The tensile properties of short nylon6 fiber reinforced NR and SBR have been investigated as functions of fiber aspect ratio(AR), diameter ratio(DR), interphase condition, and fiber content. The tensile strength increased with increasing fiber AR(20 min.) and good interphase conditions. The short-fiber(DR=3 and AR=20 min.) reinforced SBR did not show the dilution effect for all interrhase conditions. And the short-fiber(DR=3 and AR=20min.) reinforced NR did not show the dilution effect except for the no-coating. The tensile moduli were significantly improved due to fiber AR. fiber content, and good interphase at same DR. The better interphase condition showed the higher pull-out force at same DR. Also, the stress analysis near the fiber end carried out using axisymmetric FEA to be convinced of the reinforcing mechanism. It is found that the fiber AR, interphase and DR have an important effect on tensile properties.

• Korean Journal of Food Science and Technology
• /
• v.27 no.1
• /
• pp.74-79
• /
• 1995

Autoclaved juices of common vegetables including cabbage were growth inhibitory to various microorganisms. Sensitivity of microorganisms to antimicrobial action of autoclaved vegetable juices was different depending on microbial strains. Lactic acid bacteria and Gram negative bacteria were less sensitive while non-lactic Gram positive bacteria and yeasts were very much sensitive to antimicrobial action of autoclaved cabbage juice(ACJ). Staphylococcus aureus and Candida utilis whose growth were completely inhibited in ACJ could grow in ACJ diluted with distilled water. This suggests that microorganisms were not able to grow in ACJ because of growth inhibitory compounds produced during heating but not because of the lack of nutrients. Cabbage juice heated at $100^{\circ}C$ for up to 30 min was not inhibitory while that heated at $121^{\circ}C$ for 5 min was. Heating temperature was an important parameter in generating growth inhibitory compound in heated cabbage juice.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.22 no.3
• /
• pp.37-50
• /
• 2019

In this study, we analyzed the soil salinity of Saemangeum agricultural land using GIS spatial interpolation method. Dominant soils series of experimental sites were Munpo (coarseloamy, mixed, non-acid, mesic, typically fluvaquents), which was based on the fluvio-marine deposit. Soil samples were periodically collected at 0~20cm and 20~40cm layer from each site. First, the distribution characteristics of EC, ESP, and SAR according to spatial interpolation were analyzed using 142 sample points. Through the error analysis of 143 validation points, the IDW method for EC and SAR, and the Kriging interpolation method for ESP were selected as the optimal interpolation method. Using the optimal interpolation method, the characteristics of EC, ESP, and SAR were analyzed for the change of soil salinity from 2014 to 2016. As a result, EC, ESP and SAR were decreased by 0.26mg/L, 5.97mg/L and 0.73mg/L respectively due to the dilution effect caused by rainfall.

• Journal of the Korean Applied Science and Technology
• /
• v.41 no.2
• /
• pp.386-392
• /
• 2024

Due to COVID-19, modern people have come to prefer natural substances as anxiety due to harmful environments and various stimuli has increased. Therefore, in order to find out the appropriateness of hibiscus, which is recognized as a non-toxic plant in traditional medicine, as a natural cosmetic material, the antioxidant effects (polyphenol, flavonoid, DPPH, ABTS) of hibiscus extract were studied, and the following results were obtained. First, the total polyphenol of hibiscus was found to be 433 ㎍/mL when the HSE was 100%. Second, the total flavonoids showed high antioxidant capacity at 488 ㎍/mL in 100% of the HSE. Third, the DPPH radical scavenging ability was found to be 94.04% in the undiluted HES and 89.54% in the diluted HSE 20%. Fourth, the ABTS radical scavenging ability was 98.95% in 100% of the HSE stock solution and 94.84% in the diluted HSE 20%, respectively, showing a high scavenging ability of more than 90%. As a result of these studies, it is thought that the hibiscus extract can be used as an antioxidant raw material for natural cosmetics in the future.

• Korean Journal of Food Science and Technology
• /
• v.30 no.6
• /
• pp.1470-1475
• /
• 1998

Two kinds of Korean rice-wine (Yakju) with different process and ingredients, and Japanese rice-wine (Sake) were chosen for this study, and throughly dried and solubilized in water or cell culture medium. In vitro cytotoxicity assays of the solubilized wine solids exhibited that maximum dilution factors for inhibition of B 16BL6 mouse melanoma cell growth were 16X for herbal medicine-added rice-wine (Korean rice-wine I) and typical Korean rice-wine (Korean rice-wine II), and 8X for Japanese rice-wine. Their cytotoxic effects on HRT18 human colon adenocarcinoma cells were even lower than those on B16BL6 cells. The morphology of the tumor cells were changed by addition of the solubilized wine solids. Inhibitory effect of the rice-wine on in vivo tumor growth and metastasis were monitored after implantation of B16BL6 cells into C57BL/6 mice with daily feeding the solubilized wine solids. Compared to non-fed control groups, B16BL6 tumor growth and metastasis to lung were clearly inhibited by feeding the wine solids, in order of Korean rice-wine I > Korean rice-wine II > Japanese rice-wine. The data of in vitro cytotoxicity and the cell shape changes indicate that the inhibitory effect of tumor progression may be attributed to tumor cell differentiation or immune stimulation induced by certain components in the rice-wine, rather than direct cytotoxicity of the components.

• Journal of radiological science and technology
• /
• v.38 no.3
• /
• pp.253-259
• /
• 2015

The information of contrast media concentration on target organ is very important to get reduce the side effect and high contrast imaging. We investigated alternation of signal intensity as a function of the modality of Gd-based contrast media on spin echo and ultra short time echo (UTE) of T1 effective pulse sequence at 3T MRI unit. Gadoxetic acid, which is a MRI T1 contrast medium, was used to manufacture an agarose phantom diluted in various molarities, and sterile water and agarose 2% were used as the buffer solution for the dilution. The gold standard T1 calculation was based on coronal single section imaging of the phantom mid-point with 2D Inversion recovery spine-echo pulse sequence MR imaging for testing of phantom accuracy. The 1-2mmol/L and 7mmol/L was shown the maximum signal intensity on spin echo and UTE respectively. We confirm the difference of contrast media concentration which was shown the maximum signal intensity depending on the T1 effective pulse sequence.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
• /
• v.16 no.4
• /
• pp.169-179
• /
• 2011

To investigate the controlling factor and accumulation of trace metal concentrations in Chun-su Bay sediments, grain-size, specific surface area, organic carbon content, calcium carbonate content, and concentration of Al, Fe, Na, K, Mg, Ca, Ti, Mn, P, S, Ba, Sr, Li, Co, Cr, Ni, Cu, Zn, As, Cd, Cs, Sc, V, Sn were analyzed. Controlling factors of metals were quartz-dilution, calcium carbonate and coarse sand or K-feldspar. Although the distribution of V, Co, Cr, Ni, Cu, Zn, Sn, and Cd concentration was explained by grain-size effiect, Mn and As showed the similar importance of grain-size effect and coarse sand or K-feldspar factors. By virtue of enrichment factor and 1 M HCl experiment, there were little enrichment in all the trace metals in bay sediments, which were explained well by geochemical properties of sediments. Since the concentration levels of As in coarse sand were high as much as those in fine-grained sediments and it was combined with Mn oxide (1 M HCl leached) and K-feldspar (residual), it was suggested that when the enrichment of As in sediments would be assessed, it is necessary to separate the coarse sand from bulk sediments or to use only sediments with higher than 10% in < $16{\mu}m$ fraction.

• Journal of the East Asian Society of Dietary Life
• /
• v.9 no.4
• /
• pp.421-426
• /
• 1999

This study was performed to evaluate the effect of persimmon vinegar on serum lipid components in the hypercholesterolemic Sprague-Dawley male rats. Forty rats were divided into four groups and fed diets containing l% cholesterol for 4 weeks. Experimental diets added to distilled water, 1.5%, 3%, and 7% persimmon vinegar(PV) as drinking water. Concentration of total cholesterol, LDL and HDL cholesterol, triglyceride in serum and activity of AST, ALT in serum were assayed. Average food intake, weight gain and FER of experimental rats were not significantly different by contents of persimmon vinegar. Concentration of total cholesterol and LDL cholesterol in serum were lowest in 7% persimmon vinegar group. However concentration of HDL cholesterol in serum was highest in 3% persimmon vinegar group. Concentration of triglyceride in serum was significantly lower in persimmon vinegar group than control group. Activities of AST and ALT in serum were lowest in 7% persimmon vinegar group. The results in this study suggest that persimmon vinegar is effective in lowering serum triglyceride level.

• Korean Journal of Food Science and Technology
• /
• v.36 no.2
• /
• pp.226-232
• /
• 2004

Dilution concentration of watermelon juice, concentrations of added sugar, citric acid, and vitamin C, sterilization temperature and time, and natural color extracts were evaluated to determine optimum conditions for watermelon beverage production. Optimum dilution concentration of watermelon juice and optimum content of soluble solid were 40% and $12^{\circ}Brix$, respectively. Addition of 0.5 and 0.3 g/L or 1.0 and 0.3 g/L citric acid and vitamin C gave optimum sensory quality. Sterilization of watermelon beverage at above $70^{\circ}C$ decreased redness. Sterilization at $60^{\circ}C$ for 10 to 30 min or at $70^{\circ}C$ for 10 min achieved best sensory quality. Addition of 20 g/L raspberries gave best sensory quality among raspberries, omija, and borage. Hot water was better than alcohol for extraction of natural color. Ratio of extracts for optimum sensory quality was 7 : 3 for extract of 20 g raspberries/L : extract of 30 g omija/L.