• Tuberculosis and Respiratory Diseases
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• v.60 no.3
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• pp.321-329
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• 2006

Background : To evaluate the clinical characteristics of lung cancer patients in Korea, where there is a higher number of smokers than in Western countries. Methods : A retrospective study was performed on 1655 lung cancer patients, who were diagnosed at a university hospital between September 1996 and August 2005. Age, gender, cell types and clinical stage were analysed. Of 941 patients, who responded to a questionnaire at the time of diagnosis, the smoking habits, occupational history, family history of lung cancer in the first-degree relatives, coexisting diseases (diabetes mellitus and cardiovascular disease), body weight loss, ECOG performance status and presenting symptoms, were examined prospectively. In addition, coexisting diseases including chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and active pulmonary tuberculosis were evaluated. Results : Of the 1655 patients, the male to females ratio was 3.6. Squamous cell carcinoma was the most common cancer whereas adenocarcinoma was more common in lifetime nonsmokers or women. 19.9% of the patients were non smokers and 80.1% ever smokers. Since 2000, there was an increase in the incidence of adenocarcinoma with a corresponding decrease in the incidence of squamous cell carcinoma. 6.2% of patients were asymptomatic. A coincident diagnosis of chronic obstructive pulmonary disease, cardiovascular disease, diabetes mellitus, active pulmonary tuberculosis, and idiopathic pulmonary fibrosis was made in: 44.1%, 22.2%, 10.7%, 3.9%, and 1.6% of patients, respectively. A positive family history of lung cancer in the first-degree relatives was identified in 4.4% of patients. An occupational history relevant to lung cancer was identified in 12.2% of patients. Conclusion : There is a high proportion of cigarette smokers in Korean lung cancer patients. The most common cell type was squamous cell carcinoma. However, a more detailed, prospective study of the clinical characteristics will be needed to better characterize lung cancer in Korea.

• The Korean Journal of Nuclear Medicine
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• v.28 no.3
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• pp.391-396
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• 1994

Carcinoembryonic Antigen is one of most frequently checked tumor markers in cancer management. We performed statistical analysis with serum CEA data of 2626 persons who received regular health examination and were thought to be free of active disease to determine the cutoff values of serum CEA level in normal Korean adults and to study the factors influencing serum CEA levels in normal subjects. 1) The cutoff values of serum CEA in normal Korean adults in general were 9.28ng/ml for men, 5.90 ng/ml for women. 2) Serum CEA level was influenced by age, present smoking history, sex, and abnormal findings in chest X ray. 3) Serum CEA level had no correlation with the history of amount of alcohol consumption or obesity. 4) Cutoff values of serum CEA in normal Korean adults were tabulated according to age, sex, and smoking history. Serum CEA level was influenced by age, sex, present smoking history and abnormal findings in chest X ray and cutoff values of serum CEA were tabulated according to age, sex, and smoking history.

• Journal of Digital Convergence
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• v.11 no.2
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• pp.365-374
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• 2013

This study was performed to find out the knowledge and attitude of smoking, and smoking cessation recommendation among nursing students. The data were collected from 529 nursing students being at three colleges in Gwangju city through structured questionnaire from 1 to 30 October 2012. In results, the smoking cessation recommendation showed statistically significant differences in grading, residence, subjective health perception, recognition about smoking, present smoking, assessment experience of smoking history, experience of smoking cessation recommendations, and participation intention of smoking cessation intervention education. The smoking cessation recommendation had correlated with smoking knowledge and smoking attitude. In multiple regression analysis, the participation intention of smoking cessation intervention education, the attitude and knowledge of smoking, and experience of smoking cessation recommendation were significant factors of the smoking cessation recommendation explaining 15.5% of the variables. To enhance recommendations of smoking cessation for patients, there are necessary to enforce smoking cessation intervention program for nursing students and increase the experience of smoking cessation intervention recommendation of nursing students in clinical practice.

• Journal of the Korean Society of Food Culture
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• v.17 no.3
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• pp.329-336
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• 2002

The purpose of this study was to investigate of attitudinal beliefs regarding smoking, and antioxidant vitamins status between smokers and non-smokers in college male students. Attitudinal beliefs regarding smoking and antioxidant vitamins intake were investigated by a questionnaire. The result obtained were as follows: Anthropometric measurements were no significant differences between smokers and non-smokers. The attitudinal beliefs regarding smoking of smokers were different from those of non-smokers(p<0.001). Compared with non-smokers, smokers responded more positively on advantage of smoking, while they felt less negatively on disadvantage of smoking. Systolic blood pressure(SBP) and diatolic blood pressure(DBP) of smokers were significantly higher than those of non-smokers(p<0.05). Although antioxidant vitamins intake was not significantly different between smokers and non-smokers, plasma level of vitamin C of smokers was significantly lower than that of non-smokers(p<0.05). However, plasma level of vitamin E was not significantly different between smokers and non-smokers.

• Tuberculosis and Respiratory Diseases
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• v.61 no.3
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• pp.207-213
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• 2006

기존의 폐암 발생의 고위험군(나이. 흡연력, $FEV_1$, 가족력, 직업적 발암물질의 노출력, 기존의 폐암 및 두경부 종양)에 대한 저선량 나선식 CT와 기관지 내시경 검사로 선별 검사 시 폐암의 유병률은 높아야 2%내외이고 대부분 그보다 낮은 것으로 알려져 있다. 특이도는 49-90%, 양성예측률은 10%이하로 선별검사 시 불필요한 검사를 초래하고 그에 따른 이환률과 사망률을 증가시키며 비용적인 문제를 야기하는 것으로 알려져 있다. 이에 기존의 고위험군에 대해 대상 환자를 더욱 더 좁힐 필요가 있으며, 이는 실제 임상적으로 이용 가능한 생물학적 표지자의 개발의 필요성이 있다고 하겠다. 그러나 현재까지 알려진 폐암조기검진에 대한 각종 진단 수기 중애서 상기의 3가지 방법(저선량 MDCT, 자가형광기관지경 및 객담내 MAGE)을 한꺼번에 시행하는 program은 비용적인 문제는 있지만 시도해 볼 만한 방법이라고 생각된다.

• Tuberculosis and Respiratory Diseases
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• v.53 no.2
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• pp.113-126
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• 2002

Background : DNA repair plays a crucial role in protection from cancer-causing agents. Therefore, a reduced DNA repair capacity can increase the susceptibility to lung cancer. The XPC gene contains 15 exons and encodes a 940 amino acid protein that plays a central role in DNA damage recognition of the nucleotide excision repair pathway, which is a major DNA repair mechanisim removing the bulky-helix distorting DNA lesions caused by smoking. Recently several polymorphisms in the XPC gene were identified. In addition, it is possible that these polymorphisms may affect the DNA repair capacity, which modulate cancer susceptibility. The relationship between codon 499 and 939 polymorphisms, and a poly(AT) insertion/deletion polymorphism in the XPC gene, and the lung cancer risk were investigated. Materials and Methods : The genotypes were determined using either PCR or PCR-RFLP analysis in 219 male lung cancer patients and 150 healthy males controls. Results : The frequencies of the genotypes (Val499Ala, PAT and Lys939Gln) among the cases were not significantly different from those of the controls. There was no significant associantion between these polymorphi는 and the lung cancer risk when the analyses were stratified according to age, smoking status and the pack-years of smoking. Moreover, the genotypes had no apparent relationship with any of the histological types of lung cancer. There was a linkage disequilibrium among the Val499Ala, PAT and Lys939Gln polymorphisms. The PAT polymorphism had a strong linkage disequilibrium with the Lys939Gln polymorphism (kappa value=0.87). The XPC haplotypes showed no significant association with the lung cancer risk. Conclusion : These results suggest that XPC Val499Ala, PAT and Lys939Gln polymorphisms are not major contributors to the individual lung cancer susceptibility in Koreans.

• Korea journal of population studies
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• v.13 no.1
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• pp.51-80
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• 1990

한국의 사망력은 높은 수준의 성별 사망력 차이와 중년 남성의 급격한 사망력 상승을 그 구조적 특성으로 하고 있는데, 이러한 한국인 사망력 구조의 특이성은 직접적으로는 사망원인의 성별, 년령별 차별적 역활에 기인하며 간접적으로는 이들 원인의 차별성을 초래하는것으로 추정되는 경제개발기간동안의 사회, 경제 및 공공정책상의 변화 및 생활습관의 차이에서 기인된다고 보아진다. 본 연구에서는 이들 차이를 결과짓는 여러 요인들을 중심으로 한국인의 사망력 구조상에서 나타난 년령별 및 성별특성을 분석하는데 그 주요점을 두었다. 1985년 경제기획원 조사통계과에 의해 집계된 사망원인통계자료는를 활용하여 한국인의 사망력 구조의 특성을 사망원인과 관련시켜 연구분석한 결과는 다음과 같이 종합될수 있다. 첫째, 40대 이후 남성의 높은 사망력에 의거한 요인들은 뇌혈관질환, 고혈압성질환, 암질환 및 기지 심질환 및 간의 악성신생물 순으로 중요하게 나타났다. 둘째, 0세에서의 남녀간의 기득개념의 차이는 차이는 초년 또는 청년층에서의 남녀간의 사망력 차이에서 보다는 40대 이상의 중장년층에서의 남녀간의 사망력 차이에서 비롯되었으며, 뇌혈관 질환, 악성간질환 및 고혈압성 질환, 간의 악성 신생물,및 기타 심질환 및 간의 악성 신생물 질환들이 중장년층에서의 남녀간의 사망력 차이를 결정하는데 주역활을 하고 있는 것으로 나타났다. 세째, 위의 년령간의 및 남녀간의 사망력 수준의 차이를 결정짓는 주요한 사회적 간접요인들로는 첫째, 사회.경제개발과 함께 이어 병행되어온 보건정책들이 즈로 어린이 또는 여성에 편향된 결과 였으며, 둘째,환경적 요소로서 중년 남성들의 Social stress, 운동부족과 관련된 질병들과 공해, 먼지, 유해화학물 가스 등 산업재회와 관련된 질병들에 의한 사망률이 높으며, 세째, 행위적 요소로서 음주와 흡연과 관련된 질병들에 의한 중년 남성의 사망률이 높은것들로 요약될수 있다. 중년 남성의 높은 사망률은 기술적,사회적 경험이 축적된 노동력의 상실로서 국가적 손실이 크며, 고 년령층 인구의 구조적 측면에서도 성의 불균등을 초래하여 미혼 여성의 증가등 사회적인 기반문제의 주요한 요인이 되므로서 그 중요성은 지대하다고 할수 있겠다. 그러므로 이 문제는 국가적 사회적 차원에서 해결이 시급하며 그 해결책으로는 지금 까지 도외시 되어 왔던 중년 남성의 건강을 위한 프로젝트의 실지와 함께 이들에게 노출되어 왔던 운동 부족, 사회적 스트레스 및 산업재회의 해소 내지 제거에 대한 방안들이 연구 되어야 하겠다. 한편 음주 및 흡연등의 개인행위적 습관의 개선을 위한 사회 계몽활동의 추진 및 건전한 스트레스 해결책의 개발이 중요하다고 하겠다.

• Tuberculosis and Respiratory Diseases
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• v.41 no.5
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• pp.521-530
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• 1994

Background : The past studies on prediction formulas of pulmonary function parameters in healthy nonsmoking Korean adults have been performed in relatively small number of subjects and the reported results were restricted on a few parameters. Also there was no systematic investigation into the effect of smoking on pulmonary function parameters in smokers who have no respiratory symptoms. Therefore we attempted to establish prediction formulas of pulmonary function parameters and examined the effect of smoking on pulmonary function parameters. Methods We analyzed the result of parameters derived from the forced expiratory spirogram in 1,067 nonsmoking subjects from June in 1990 to December in 1991. They consisted of 306 males and 761 females and had neither respitatory symptoms nor history of respiratory disease. We derived prediction formulas by multiple linear regression method from their age, heights, and weights in each sex. To examine the effect of smoking on pulmonary function parameters, we classified 383 smoking men into three groups according to the past amount of smoking as follows : i.e. group of smokers who have smoked below 10 pack-years, 10-20 pack-years and above 20 pack-years. Regarding each group of past smoking as an independent dummy variable, we analyzed pulmonary function parameters including nonsmoking men as a baseline by multiple linear regression. We evaluated the smoking effect on pulmonary function parameters according to estimated p-value. Result : 1) Prediction formulas for pulmonary function parameters in each sex were derived. 2) The past smoking less than 10 pack-years does not give any effect on pulmonary function parameters. The past smoking of 10~20 pack-years showed significant negative correlation with $FEV_1$/FVC and FEF 25~75%, and the smoking above 20 pack years showed negative correlation with $FEV_1$ and $FEV_1$/FVC. Conclusion : We have got prediction formulas of pulmonary function parameters which is driven from forced expiratory spirogram in nonsmoking Korean adults by multiple linear regression from age, heights and weights of subjects. The past smoking more than 10 pack-years showed negative correlation with some pulmonary function parameters of airflow obstruction.

• Journal of dental hygiene science
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• v.9 no.5
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• pp.513-518
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• 2009

The purpose of this study was to examine correlation between smoking and gingivitis in boy students targeting 281 students in the 2nd grade for vocational boys' high schools where are located in Cheongju city. As a result of carrying out questionnaire research and oral examination, the following conclusions were obtained. 1. The smoking-experience rate in subjects of this study accounted for 59.4%. The current smoking rate was indicated to be 41.3%. Students' average gingivitis prevalence accounted for 61.5%. Out of those students, the students with experience of smoking accounted for 44.8%. The average gingivitis index was $0.20{\pm}0.27$. Out of those students, the students with experience of smoking were indicated to be $0.29{\pm}0.31$. 2. In case of having experience of smoking, the probability of having gingivitis was high(p = 0.000). The more drinking experience led to the higher gingivitis prevalence(p = 0.010). 3. In the multi-variate analysis, a case of gingivitis prevalence was higher in the group with experience of smoking by 5.5 times(p = 0.000) compared to the non-smoking group. A case that the smoking volume for a day is over 6 pieces was higher by 8.4 times(p = 0.000) compared to the non-smoking group. A case of being over 25 months in the smoking period was higher 13.2 times(p = 0.000) compared to the non-smoking group.

• Tuberculosis and Respiratory Diseases
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• v.46 no.2
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• pp.165-174
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• 1999

Background: Coal-worker's pneumoconiosis(CWP) is radiologically divided into two major groups: simple pneumoconiosis (SP), in which small, rounded or irregular opacities smaller than 1cm are observed, and progressive massive fibrosis(PMF), which is characterized by opacities larger than 1cm. SP has a life expectancy equivalent to miners with no radiographic evidence of CWP, but PMF is associated with more obvious impairments of ventilatory capacity and premature death. But only minority of workers develop PMF when exposed to dust concentrations similar to those experienced by workers who develop only SP. In this study, immune status in patients with CWP were evaluated by measurement of the serum immunoglobulin levels between control, SP and PMF groups. Method: Coal workers selected for this study were emplyees of the Tae-Baek and Dong-Hae Hospital. All the patients were men of 45-76 years old and the mean duration of exposure to coal dust were 23.2 years. By X-ray examination, 51 patients were classified in SP, 59 in PMF category. The normal controls examined were 58 men of 26-70 years old. Serum Ig levels were estimated by using Nephelometer(Behring Nephelometer : Germany) and serum were collected 51 in SP, 49 in PMF and 57 cases in control group. Results: The levels of IgG were increased but the levels of IgM were decreased with increasing age in control groups. There were no statistical difference of immunoglobulin levels between smokers and nonsmokers in control groups. There were no statistical difference of immunoglobulin levels between Control, SP and PMF groups. Multiple regression analysis were undertaken to determine the statistical significance of the apparent trends and estimate the effects associated with age, smoking habit and radiological category of CWP. According to this analysis, the levels of IgG were decreased significantly in SP group and had decreasing tendancy, but not statistically significant in PMF group. Conclusion : From the observations described, CWP patients had decreased IgG concentration compared to control gorup. Therefore, there was some relation between CWP and immunoglobulin concentration.