• Korean Journal of Clinical Laboratory Science
• /
• v.50 no.3
• /
• pp.245-252
• /
• 2018

We evaluated the possible clinical application of Non HDL-cholesterol and triglyceride to HDL-cholesterol ratio as a metabolic syndrome predictor for the elderly in Korea. 1,543 elderly persons aged 65 years or older who visited the health examination center of Gyeonggi Regional General Hospital from January 2015 to December 2017 and had a health checkup were enrolled in this study. Metabolic syndrome was diagnosed based on the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) standards. Abdominal obesity was assessed by the Asia-Pacific standards presented at the World Health Organization (WHO) West Pacific Region. Non-HDL-cholesterol was calculated as the difference between total cholesterol and HDL-cholesterol. The metabolic syndrome predictive power was higher for triglyceride to HDL-cholesterol ratio than for Non HDL-cholesterol. After correcting for related factors, triglyceride to HDL-cholesterol ratio was higher in the $4^{th}$ quartile, which had a higher risk of developing metabolic syndrome, than in the $1^{st}$ quartile. The optimal cutoff value for the triglyceride to HDL-cholesterol ratio that predicts the onset of metabolic syndrome was 2.8. triglyceride to HDL-cholesterol ratio can be a simple and practical indicator of the risk of metabolic syndrome.

• The Korean Journal of Food And Nutrition
• /
• v.10 no.2
• /
• pp.246-253
• /
• 1997

This study was conducted to investigate the effect of protein kinds and levels on lipid metabolism in hypercholesterolemia rats. Male Sprague Dawley rats were administrated 1% cholesterol and 0.25% sodium cholate to induce hypercholesterolemia and were fed on diet containing two levels(7, 20%) of casein and soy protein respectively. The rats were sacrified after 5 weeks of feeding periods. Total lipid content in serum was decreased in proportion to level of protein and soy protein was more effective than casein in lipid-lowering effect. Serum triglyceride content was significantly decreased in proportion to level of protein and did not show significance by protein kind. Serum phospholipid content was more significantly decreased in 20% protein groups than that of 7% protein groups. Total cholesterol content in serum was significantly decreased by protein and were decreased in proportion to level of soy protein. Free cholesterol content did not show significance by protein level. The degree of decrease predominated in soy protein groups. Serum HDL-cholesterol content and RL-cholesterol were increased in proportion to level of protein and effect of soy protein was not more significantly than that of casein. Atherogenic index was significantly decreased in proportion to level of protein and soy protein groups were more effective. Serum LDL-, VLDL-cholesterol contents were more significantly decreased in 20% protein groups than that of 7% protein groups. Serum $\beta$-lipoprotein and chylomicrone-cholesterol contents also showed significantly decrease by soy protein.

• Bulletin of Food Technology
• /
• v.12 no.3
• /
• pp.8-13
• /
• 1999

키틴/키토산은 지질흡수의 억제, 혈중 콜레스테롤의 저하, 항고혈압활성, 면역활성, 항종양/항암활성 등 다양한 생체기능성을 나타내어 건강지향적인 기능성 식품으로서의 이용가치가 매우 큰것으로 평가되고 있다. 키토산은 성인남자의 혈중 콜레스테롤을 감소시키고 HDL cholesterol은 증가시켜 동맥경화지수를 낮추며 비만환자에게 투여시 체중, 중성지질, LDL cholesterol을 유의하게 낮춤으로서 고지혈증과 비만증의 개선에 유용한 것으로 평가된다. 키토산은 또한 성인의 고염식에 의한 혈압상승을 억제하며 3량체 내외의 키틴/키토산 올리고당은 혈압상승의 중요인자인 angiotensin converting enzyme과 직접 반응하여 활성을 현저히 저하시키고 SHR에서의 혈압을 유의하게 억제하는 특성을 보여 고혈압의 억제 및 치료에도 응용가치가 클 것으로 생각된다. 키틴/키토산 및 그 올리고당은 sarcoma 180, Meth-A solid tumor의 성장을 저해하고 L1210와 같은 negative charge를 갖는 malignant cell을 흡착시키는 등 항종양/항암활성을 보이는데 이는 tumoricidal immunocite의 활성화에 의한 것으로 추정되고 있다. 키틴/키토산의 생체활성은 분자크기, 탈아세틸화도, 유도체의 종류 및 적용방법 등에 따라 차이를 보이기 때문에 키틴/키토산을 기능성 식품으로서 폭넓게 이용하게 위해서는 용도에 맞는 적절한 규격 설정이 요구되고 있다.

• Proceedings of the Korean Society for Food Science of Animal Resources Conference
• /
• 2004.05a
• /
• pp.337-340
• /
• 2004

본 연구는 키토올리고당이 우유에 첨가되었을 때에 색과 점도에 영향을 미치는 것을 방지하기 위하여 키토올리고당을 나노캡슐화하여 우유에 첨가하여 그 변화를 연구하였다. 혈중 콜레스테롤의 저하 기능이 있는 키토올리고당은 우유 첨가 시 원래의 특성을 변형시키나 나노캡슐 첨가시에는 88.08%의 높은 수율을 나타내며 0.5% 첨가시 점도와 색에 유의적 차이가 없는 것으로 나타났다. 또한 키토올리고당 나노캡슐은 온도에 크게 영향 받지 않으며 저장기간이 동안에(증류수 25일, 우유 15일)캡슐의 감소가 크지 않는 것으로 나타났다. 관능 평가시에는 나노캡슐 1.5%의 농도까지 시유와 유의적 차이를 느끼지 못하였다. 실험 결과, 키토올리고당의 우유 적용시 적색화와 점도 저하를 나노캡슐 적용을 통해 해결하고 나노캡슐의 저장에 따른 안정성이 온도에 안정한 물질이라 판단된다. 또한 나노캡슐을 우유에 적용시 관능적으로도 긍정적으로 평가되었다. 결과적으로 키토올리고당의 나노캡슐화는 우유에 적용이 가능하여 이화학적 및 관능적인 면에서 혈중 콜레스테롤 저하 기능성 우유로 가능성을 시사하였다.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.33 no.3
• /
• pp.587-592
• /
• 2004

This research was aimed to manufacture the cholesterol free Mozzarella cheese with corn oil that contains high unsaturated fatty acid helping the reduction of serum cholesterol. Cheese stored at 1$0^{\circ}C$ was evaluated with general analysis, volatile free fatty acid, cholesterol, meltability, stretchability, color, rheological properties, and sensory evaluation. Moisture contents decreased during cheese storage period, whereas protein contents and pH value increased significantly (P < 0.05), but fat contents did not show any significant change. Linoleic acid was tile main volatile free fatty acid in a fat of cheese, and cholesterol contents were measured 4.34$\pm$ 0.04 mg/100 g in cheese. The meltability of cheese gradually increased during ripening, while the stretchability decreased. The color of cheese showed translucent yellow. Hardness, springiness, and cohesiveness increased significantly up to 21 days of storage. Compared to control cheese made by conventional way, QDA scores of shiny, oiling off, and melting of cholesterol free cheese were significantly different. These results suggested that health-oriented cholesterol free Mozzarella cheese would be made by addition of the corn oil.

• Korean Journal of Food Science and Technology
• /
• v.32 no.1
• /
• pp.200-205
• /
• 2000

Ethanol extract of Alpiniae Katsumadaii semen inhibited potently cholesterol esterase activity in vitro. Chloroform fraction of ethanol extract showed the stronger inhibitory effect than other solvent fractions-ethylacetate fraction, butanol fraction, and aqueous fraction. The chloroform frac ion of Alpiniae katsumadaii semen were studied as a candidator of plasma cholesterol lowering material in high cholesterol-fed rats. In high cholesterol-fed rats, the diet with chloroform fraction of 100 mg/kg and 150 mg/kg lowered not only plasma neutral lipids contents 25.9% and 26.5% but also plasma total cholesterol level 11.8% and 20.8%, respectively. Plasma HDL-cholesterol level and Atherogenic Index(AI) in Alpiniae chloroform fraction-fed rats were recovered as those level of normal rats.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.29 no.2
• /
• pp.252-256
• /
• 2000

Coronary heart disease (CHD) is caused by elevated blood lipids and the death rate from CHD is continuously increasing in recent years. In Korea, death rate from CHD is more than 30%. Recently, it has been reported that Job's tear decreaseds blood cholesterol level. However, most of the reports used Job's tear itself. Therefore, we have examined the effect of extruded Job's-tear cereal on blood and liver lipid levels in rats fed with a high fat diet for 5 weeks. The energy intake and body weight gain were higher in Job's tear cereal group (JFD) than in high fat fed group(HFD). Blood triglyceride concentration was significantly reduced in JFD group (p<0.05). And Atherogenic Index was decreased about 20% in JFD suggesting favorable effect of Job's-tear cereal on hyperlipidemia. Liver lipids levels were not affected by Job's-tear cereal.

• Journal of Digital Convergence
• /
• v.18 no.12
• /
• pp.615-630
• /
• 2020

This study analyzes the difference in total cholesterol blood concentration according to dietary characteristics and health characteristics, as well as general characteristics, and the relationship between that factor and total cholesterol level according to the diagnostic criteria for dyslipidemia, and then compares and analyzes the relative risk ratio of significant factors for the occurrence of dyslipidemia. As a result, the total cholesterol blood concentration increases with age, so continuous management is necessary. Mainly, waist circumference level in early adulthood, regular exercise of appropriate intensity in late adulthood, and subjective health level management in the elderly are necessary. It was found that it was necessary to manage BMI level and eating-out level overall.

• The Journal of Internal Korean Medicine
• /
• v.19 no.2
• /
• pp.17-27
• /
• 1998

• Journal of the Korean Applied Science and Technology
• /
• v.38 no.6
• /
• pp.1512-1523
• /
• 2021

The purpose of this study was to investigate the effect of Saengmaeg-san intake on blood lipids and arteriosclerosis index in male tennis players. Seventeen male tennis players enrolled in university were assigned to a Saengmaeg-san intake group (n=9) and a placebo control group (n=8) according to whether they took Saengmaeg-san during 4-week high-intensity tennis training. Tennis training was conducted 5 times a week for 4 weeks, and the exercise intensity was performed at 70-90% of the spare heart rate. The intake of Saengmaeg-san was 110ml at a time before breakfast, before, during, during, and after exercise, and after dinner, a total of 7 times, 770ml per day. For all data, mean and standard deviation were used. Two-way repeated measures ANOVA was used to examine the effect of time and treatment, and Pearson's Correlation was used to examine the relevance of differences in blood lipid responses after treatment. As a result of this study, the Saengmaeg-san intake group significantly improved blood lipids (triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol) and arteriosclerosis index, and there was a significant correlation appeared between ∆TG, ∆LDL-C, and ∆TC. As a result, the intake of Saengmaeg-san during high-intensity training of male college student tennis players can have a positive effect on blood lipids and arteriosclerosis index, suggesting that it can be an effective sports drink as an exercise supplement.