• Title, Summary, Keyword: 혈액 투석

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혈액투석 및 복막투석 환자에서의 carumonam(AMA-1080)의 약동 학적 변화에 관한 연구

  • 김성권;조종태;신상구;이경훈
    • Proceedings of the Korean Society of Applied Pharmacology
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    • pp.59-59
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    • 1992
  • 간헐적 혈액투석 또는 지속적 복막투석 요법을 받고 있는 만성 신부전 환자에서 carumonam의 약동학적 변화를 분석하여 이 환자들에서 적절한 투여용법을 고안하고, 이들 특수 질환군에서의 임상시험모형을 도굴하고자 하였다. 혈액투석환자는 carumonam 1g을 20분간 지속 정주 후 약물의 분포기 종료가 예상되는 시간에 혈액투석을 4-5시간 시행하였으며, 혈액, 투석액, 뇨를 경시적으로 채취하였다. 지속적 복막투석 환자군에 있어서는 1일 3회(6, 6, 12시간) 복막 투석을 시행하는 환자를 대상으로 carumonam 1g을 정주하고 24시간동안 혈액 및 투석액, 뇨를 경시적으로 채취하였다. 혈액, 투석액 및 뇨중 carumonam의 농도는 HPLC방법으로 측정하였으며, 경시적인 혈장 carumonam 농도변화 및 투석에 따른 약물의 제거를 혈액 투석환자는 2 compartmental model, 복막투석환자에서는 bidirectional 2 compartmental model에 의해 그 약동학적 성상을 분석하였다.

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The Development of Hemodiafiltration Treatment Compliance Indicators and Discriminant Standards, Development of Hemodiafiltration Treatment Compliance Measurement - Convergent Form(HDFTCM-CF) : Focused on On-line Hemodiafiltration (혈액여과투석 환자의 치료이행 지표와 분류기준, 융합형 혈액여과투석 치료이행 측정도구 개발 : 온라인 혈액여과투석을 중심으로)

  • Hur, Jung
    • Journal of Digital Convergence
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    • v.13 no.7
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    • pp.269-282
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    • 2015
  • This study is to define the hemodiafiltration treatment compliance indicators and discriminate standards for hemodiafiltration patients and development of hemodiafiltration treatment compliance measurement-convergent form. Date was collected from 300 on-line hemodiafiltration patients. To verify the hemodiafiltration treatment compliance indicators and discriminate standards, used construct validity and content validity by clinical professional group. Discriminant ability of 3 indicators-interdialysis weight gain rate(IWGR), serum phosphate level, rate of self change of total hemodiafiltration treatment time(SCR-HEFTT)- is 95.6%(wilks ramda=.256, p=.002). And hemodiafiltration treatment compliance measurement-convergent form has 91.7% discriminant accuracy. Hemodiafiltration treatment compliance is important that nurses can aware pre-stage of complication and give appropriate nursing intervention. Also this measurement can be used for foundation data of the nursing intervention development that prevent dialysis patient's complication.

The effect of walking on body composition and hematological index in hemodialysis patients (혈액투석환자에서 걷기가 체성분 및 혈액학적 지수에 미치는 영향)

  • Park, Young-Joo
    • Journal of Digital Convergence
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    • v.18 no.11
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    • pp.433-441
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    • 2020
  • The specific purpose was to determine the effect of walking on the body composition and hematological index of hemodialysis patients in order to confirm the relationship between activity and health level of hemodialysis patients. The research method is a cross-sectional descriptive survey conducted in hemodialysis patients.The subjects were 66 hemodialysis patients undergoing hemodialysis treatment in B city. As a result of the study, walking was decreased in hemodialysis patients, and there was a difference in hematological index according to walking, but there was no difference in body composition. As body weight increased, skeletal mass, body fat mass, body mass index, abdominal fat percentage, basal metabolism, and protein increased, but total cholesterol and high-density cholesterol decreased. This study proposes to expand the number of subjects of hemodialysis patients to investigate by adding nutritional intake in addition to walking, body composition and hematological index.

혈액 투석 및 지속성 복막투석 환자에서 Carumonam (AMA-1080)의 약동학적 특성에 관한 연구

  • 김성권;이정상;한진석;조종태;임동석;이경훈;장인진;신상구
    • Proceedings of the Korean Society of Applied Pharmacology
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    • pp.333-333
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    • 1994
  • 목적 : 만성신부전환자에서 carumonam의 약동학적 특성을 검토하고, 동시에 투석에 의한 carumonam의 제거 양상을 분석하여 이들 환자에서 carumonam의 적절한 투여용량 및 용법을 고안하고자 하였다. 방법 : 혈액투석(HD) 또는 지속성 복막투석(CAPD)을 받고 있는 14명의 말기 신부전중 환자를 대상으로 하였다. HD환자에서는 carumonam 1 g을 20분간 지속정주하고 4시간 이후 혈액투석을 4 또는 5 시간 시행하였으며 투약 후 36시간까지 경시적으로 혈액 및 투석액을 채취하여 체액내 약물 농도를 측정하였다. CAPD환자는 1일 3회 (6.6, 12 시간) 투석액을 교환하는 환자를 대상으로 하였고 투석직후 carumonam 1g을 지속정주하고, 투약후 36시간 후까지 경시적으로 혈액 및 투석액을 채취하여 CAPD 환자에서 carumonam의 약동학적 특성을 검토하였다. 체내 동태는 HD의 경우 dialyser를 포함하는 2-compartmental model에 의한 분석을 시행하였고, CAPD를 시행받는 환자의 경우에는 체액과 투석액사이에 bidirectional clearance 개념을 도입한 모델을 이용하여 분석하였다.

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Experience of Dialysis in Long-Term Hemodialysis Patients (장기혈액투석환자의 투석경험)

  • Park, Gyeong-Yub;Yoo, Eun-Kwang
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.4
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    • pp.265-275
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    • 2018
  • This study is a qualitative investigation that used Colaizzi's (1978) phenomenological method to evaluate the meaning and nature of the experience of dialysis of eight long-term (>30 years) hemodialysis patients with chronic renal failure. Data were collected from February 27, 2017 to May 30, 2017 by in-depth interviews. Respondents were then divided into three categories, 'entirely different life', 'getting back up again' and 'focusing on survival' with nine theme clusters and 22 themes. In general, patients initially experienced an entirely different life and overcame a difficult situation when beginning dialysis, then came to know methods for self-care, shared the experience of dialysis, and focused on survival while receiving dialysis over the long-term. Development of variety of education methods depending on long-term experience of dialysis and nursing care intervention to enable chronic patients to adapt to dialysis and continue their own self-management is necessary.

Factors Affecting the Life Satisfaction of Hemodialysis Patients by Gender (성별에 따른 혈액투석 환자의 삶의 만족도에 미치는 영향요인)

  • Cho, Yun-Hee;Park, Yeon-Suk
    • The Journal of the Korea Contents Association
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    • v.17 no.8
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    • pp.631-643
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    • 2017
  • The purpose of this study is to examine factors affecting the life satisfaction of patients with hemodialysis in order to improve the quality of life for patients with hemodialysis. The subjects of this study are 168 patients who have undergone hemodialysis treatment in the hemodialysis rooms in D-city and C-providence. The data are collected between August 20th to September 5th, 2015. By using SAS 9.3 statistics program for data analysis, frequency, ${\chi}^2$-test, variance analysis and multiple regression analysis are conducted. Based on the analysis, it is found that family support(t=5.33, p<.001) and self-efficacy(t=3.52, p<.001) are statistically significant to the quality of life for male patients. Family support(t=2.58, p<.012) and adherence to self-care(t=4.08, p<.001) are statistically significant to the quality of life for female patients. With the study results, it suggests that nurses can help improve the affective and psychological stability of patients with hemodialysis by recognizing the factors affecting the life satisfaction of patients with hemodialysis by gender, developing and utilizing a nursing intervention.

The Study on the Elderly Homodialysis Patients' Transition of Health Condition and Health-related Quality of Life (혈액투석노인의 건강상태 변화인식과 건강관련 삶의 질에 관한 연구)

  • Shim, Ok Su
    • 한국노년학
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    • v.30 no.1
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    • pp.179-194
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    • 2010
  • The purpose of this study examines the elderly hemodialysis patients' Health-related quality in life(HRQL) and investigates the relationship between HRQL and transition of health condition. The subject were 443 elderly hemodialysis patients(over 65 years old) in Seoul and Gyeonggi province. The Health-related quality of life scale was used in this research, in which were analysed a wide range of statistical descriptive analysis, Pearson's correlation, reliability analysis, multiple regression and the Scheffe test. The results were as follows. The HRQL were statiscally significant difference by Gender, Educational level, Live with spouse, Best supporter, and Number of Disease. Also the factor related to transition of health condition was Number of Disease. The transition of health condition accounted for 13.9% of variance in HRQL and Number of Disease accounted for an additional 7.4% of HRQL. The factors, which influenced finally on the HRQL in the elderly hemodialysis patients, were transition of health condition and number of disease. In conclusion adequate hemodialysis treatment and social services should be provided in accordance with the factors affecting HRQL in order to improve the HRQL for elderly hemodialysis patients.

Knowledge and Adherence to Evidence Based Practice Guidelines for Hemodialysis among Nurses in Dialysis Units (혈액투석실 간호사의 근거중심 혈액투석간호에 대한 지식과 수행도)

  • Chu, Hyesuk;Park, Myonghwa
    • Journal of Digital Convergence
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    • v.16 no.7
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    • pp.277-288
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    • 2018
  • This study was to investigate the level of knowledge and adherence to EBP guidelines for hemodialysis among nurses in dialysis units. Self-administered questionnaire was used that data were collected. The sample consisted of 173 nurses who worked in hemodialysis units located in three different district areas in Korea. Using SPSS/WIN 20.0, t-test, ANOVA and Scheff's analysis were performed. About 98.8% of nurses in dialysis units had received education mostly from dialysis conferences or symposium. The knowledge score for EBP was 15.77 (out of 23) on average. Subjects with more than 8 years of work experience, master degree and those working in tertiary hospital showed significantly higher scores. Despite that there are internationally acknowledge evidence based guidelines for hemodialysis, the actual adherence to guidelines varies by experience, education level and types of hospital. The findings of this study can be baseline data for further research into development of strategies to enhance knowledge of hemodialysis nurses and utilization of EBP guidelines.

The effects of education for hemodialysis patients with a family caregiver on self-care practice and blood biochemical parameters (혈액투석 환자의 가족참여교육이 자가간호수행과 혈액생화학적 지표에 미치는 영향)

  • Park, Ji Hyun;Choi, Hyunkyung
    • Journal of the Korean Data and Information Science Society
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    • v.27 no.2
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    • pp.487-498
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    • 2016
  • The purpose of this study was to identify the effects of education for hemodialysis patient with a family caregiver on self-care practice and on blood biochemical parameters. A nonequivalent control group pretest and posttest design has been employed for analysis. Among hemodialysis patients in C university hospital located in Daegu, 56 subjects, 28 in experimental and 28 in control group, participated in the study from April to May in 2015. The experimental group whose family caregiver participated in education for hemodialysis patient reported significant differences in self-care practice (t=3.36, p=.001) and serum potassium level (t=2.78, p=.007) from the control group whose family caregiver did not participate. Considering positive effects of family education, we suggest education programs incorporating family caregivers be used as an effective nursing intervention.

Immediate Effect of Hemodialysis on Pulmonary Function and Bronchodilator Response in Patients with Chronic Renal Failure (만성신부전 환자에서 혈액투석이 폐기능 및 기관지확장제에 대한 반응에 미치는 영향)

  • Jeon, Ho Seok;Lee, Yang Deok;Cho, Yongseon;Han, Min Soo
    • Tuberculosis and Respiratory Diseases
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    • v.56 no.1
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    • pp.77-84
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    • 2004
  • Background : We hypothesized that there was a relationship between body weight change and bronchodilator response (BDR) in patients with chronic renal failure (CRF) on hemodialysis (HD). Several mechanisms such as pulmonary edema due to water retention or increased permeability of alveolar capillary may play a important role in pulmonary function impairment and bronchial hyperresponsiveness in patients with CRF on HD. But, no studies have been published concerning BDR in patients with CRF on HD. This study was aimed to know the immediate effect of hemodialysis on pulmonary function and BDR in patients with CRF on HD. Methods : This study included 30 patients with CRF on HD. We collected data including age, sex, height, pretibial and pedal pitting edema, interdialysis weight gain, postdialysis weight loss, underlying diseases, duration of HD, $FEV_1$, FVC, $FEV_1/FVC$, and BDR before and after HD. Results : Interdialysis weight gain of the patients was $3.4{\pm}1.0kg$, and postdialysis weight loss was $3.2{\pm}0.7kg$. Before HD,$FEV_1$, FVC, and $FEV_1/FVC$ of the patients were $89{\pm}22%$, $86{\pm}19%$ of predicted, and $87{\pm}10%$. After bronchodilator inhalation, these parameters were changed to $95{\pm}22%$, $90{\pm}19%$ of predicted, and $88{\pm}9%$ respectively. BDR was positive in 15 patients. After HD, $FEV_1$, FVC, and $FEV_1/FVC$ of the patients were $100{\pm}23%$, $94{\pm}18%$ of predicted, and $88{\pm}11%$. After bronchodilator inhalation, these parameters were changed to $102{\pm}23%$, $96{\pm}18%$ of predicted, and $89{\pm}8%$ respectively. BDR was positive in 9 patients. Conclusion : First, HD increases $FEV_1$, FVC, and $FEV_1/FVC$ but little affects BDR. Second, there is no correlation between postdialysis weight loss and increases in $FEV_1$, FVC, and $FEV_1/FVC$ after HD. Third, there is also no correlation not only between interdialysis weight gain and BDR before HD but between postdialysis weight loss and BDR after HD.