• 유변학
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• 제7권2호
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• pp.150-157
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• 1995

본 논문의 목적은 협착이 발생괸 원관과 분기관내 혈액과 혈액대용유체의 유동문제 에 수치해석방법을 적용하여 유동특성을 파악하는데 있다. 혈액대용유체로서는 Separan AP-273 500wppm 수용액과 Carpobol 934 1.0w% 수용액을 사용하였다. Carbopol 수용액의 유변학적 성질은 수정멱법칙모델, 그리고 혈액과 Separan 수용액의 유변학적 성질은 Carreau 모델로 나타내었다. 협착관유동에서 Carbopol 수용액의 재부착거리는 혈액이나 Separan 수용액의 경우보다 길고 협착으로 인한 압력강하는 Carbopol 수용액, 혈액, Separan 수용액의 순으로 작게 나타난다. 분기관유동에서 Separan 수용액의 압력손실은 혈 액과 Carbopol 수용액보다 작게 나탄나고 협착이 발생괸 부기관내에서 혈액과 Separan 수 용액의 압력손실은 협착이 없는 분기관의 압력손실보다 크게 증가한다.

• 유변학
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• 제6권2호
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• pp.157-164
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• 1994

인체 동맥혈관내 혈액의 유동현상을 수치적으로 해석하기 위해서는 혈액의 유변학 적 성질을 구성방정식으로 나타내어야한다. 본 연구에서는 혈액의 점성계수를 표현하기 위 하여 비뉴턴유체의 점성을 나타내는 식으로서 Carreau 모델, 수정 Cross 모델, 수정 Powell-Eyring 모델과 수정멱법칙모델을 사용하였고 원형관내 혈액의 정상유동을 수치모사 하기 위하여 겉보기점성계수를 이용하는 구성방정식을 운동량방정식에 적용하였다. Carreau 모델과 수정멱법칙모델을 적용할 때 레이놀즈수의 변화가 중심선상의 속도와 길이방향의 압 력변화에 미치는 영향을 고찰하였다. 전단율이 높은영역에서 혈액의 겉보기점성계수를 효과 적으로 나타낼수 있는 수정멱법칙모델을 제시하였다.

• 혜화의학회지
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• 제1권1호
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• pp.329-335
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• 1992

• 한국정밀공학회지
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• 제19권4호
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• pp.34-43
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• 2002

• 대한의용생체공학회:의공학회지
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• 제31권2호
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• pp.99-105
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• 2010

In order to obtain velocity profile of blood flow with high spatial resolution, a micro PIV technique consisted of a fluorescent microscope, double-pulsed YAG laser, cooled CCD camera was applied to in-vitro blood flow experiment through a micro round tube of a diameter $100{\mu}m$. Velocity distributions of blood flow for rabbit were obtained. The viscosity profiles for shear rate were found at flowing condition. To provide hemorheological characteristics of blood flow, the viscosities for shear rate were evaluated. The viscosity of blood also steeply increase by decreasing shear rate resulting in Non-Newtonian flow, especially in low shear rate region caused by RBC rheological properties. The results show typical characteristics of Non-Newtonian characteristics from the results of velocity profile and viscosity for blood flow. From the inflection points, cell free layer and two-phase flow consisted with plasma and suspensions including RBCs can be separated.

• 대한기계학회논문집B
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• 제30권11호
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• pp.1027-1034
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• 2006

In order to investigate flow characteristics of chicken blood in a micro tube of 100$\mu$m in diameter, in-vitro experiments were carried out using a micro-PIV technique. The micro-PIV system consists of a microscope, 2-head Nd:YAG laser, 12 bit cooled CCD camera and a delay generator. Chicken blood with 40% hematocrit was supplied into a micro tube using a syringe pump. The blood flow shows clearly the cell free layer near the tube wall and its thickness is increased with increasing the flow speed. The hemorheological characteristics of chicken blood, including shear rate and shear stress were estimated from the PIV velocity field data obtained. Since the aggregation index of chicken blood is less than 50% of human blood, non-Newtonian flow characteristics of chicken blood are smaller than those of human blood. As the flow rate increases, the degree of flatness in the velocity profile at the center region is decreased and the parabola-shaped shear stress distribution becomes to have a linear profile. Under the same flow rate, chicken blood shows higher shear stress, compared with human blood.

• 한국가시화정보학회:학술대회논문집
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• 한국가시화정보학회 2006년도 추계학술대회 논문집
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• pp.111-112
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• 2006

In order to investigate flow characteristics of blood flow in a micro tube ($100{\mu}m$ in diameter) according to hematocrit, in-vitro experiments were carried out using a micro-PIV technique. The micro-PIV system consists of a microscope, a 2 head Nd:YAG laser, a 12 bit cooled CCD camera and a delay generator. Blood was supplied into the micro tube using a syringe pump. Hematocrit of blood was controlled to be 20%, 30% and 40%. The blood flow has a cell free layer near the tube wall and its thickness was changed with increasing the flow rate and hematocrit. The hemorheological characteristics such as shear rate and viscosity were evaluated using the velocity field data measured. As the flow rate increased, the blunt velocity profile in the tube center was sharpened. The viscosity of blood was rapidly increased with decreasing shear rate, especially in the region of low shear rate, changing RBC rheological properties. The variation of velocity profile and blood viscosity shows typical characteristics of Non-Newtonian fluids. On the basis of inflection points, the cell free layer and two-phase flow consisting of plasma and suspensions including RBCs were clearly discriminated.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 추계학술대회
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• pp.1505-1509
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• 2004

The suspension of hardened red blood cells (RBCs) differs from the suspension of normal RBCs with respect to their rheological behavior. The deformability of normal and hardened RBCs (obtained by heating blood at $49^{\circ}C$ or by incubating RBCs in a solution of hydrogen peroxide) was measured with a slit diffractometer and RBC suspension viscosity was measured with a rotational viscometer. The peroxide-treated RBCs showed a significant decrease of the deformability and their suspension viscosity increased over a range of shear rates. The suspension viscosity of the heated RBCs, however, where the deformability is even lower than that of the peroxide-treated RBCs, was slightly higher than that of the normal RBC suspension in the high shear rates. The present study found that not all rigid cells cause an increase of blood viscosity at high shear rate, and therefore that decreased membrane deformability is not predictive of high-shear blood viscosity.